S S Solomon

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. doi request reprint TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome
    S S Solomon
    Department of Medicine, University of Tennessee Health Science Center, Veterans Affairs Medical Center, Memphis, USA
    Horm Metab Res 42:115-21. 2010
  2. doi request reprint A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones
    Solomon S Solomon
    Research Service, VA Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    Life Sci 83:305-12. 2008
  3. ncbi request reprint Impact of medical student research in the development of physician-scientists
    Solomon S Solomon
    Department of Medicine, Veterans Affairs Medical Center, Memphis TN 38104, USA
    J Investig Med 51:149-56. 2003
  4. ncbi request reprint Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s)
    S S Solomon
    Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Med Sci 322:75-8. 2001
  5. ncbi request reprint Pioglitazone and metformin reverse insulin resistance induced by tumor necrosis factor-alpha in liver cells
    S S Solomon
    Research Service, VAMC, Memphis, USA
    Horm Metab Res 29:379-82. 1997
  6. ncbi request reprint Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat
    X Pan
    Research, Medical, and Pathology Services, Veterans Affairs Medical Center of Memphis, University of Tennessee, Memphis, Tennessee 38104, USA
    Endocrinology 142:1635-42. 2001
  7. ncbi request reprint Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
  8. ncbi request reprint Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice
    Ivan C Gerling
    Division of Endocrinology, University of Tennessee Health Science Center, VAMC Research 151, 1030 Jefferson Ave, Memphis, TN 38104, USA
    Arch Intern Med 163:190-8. 2003
  9. ncbi request reprint Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistance
    Solomon S Solomon
    Research and Medical Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Lab Clin Med 145:275-83. 2005
  10. ncbi request reprint Paradoxical regulation of Sp1 transcription factor by glucagon
    Chithra N Keembiyehetty
    Veterans Affairs Medical Center, Research Services, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Endocrinology 143:1512-20. 2002

Research Grants

  1. Short-Term Research Training for Medical Students
    Solomon Solomon; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. doi request reprint TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome
    S S Solomon
    Department of Medicine, University of Tennessee Health Science Center, Veterans Affairs Medical Center, Memphis, USA
    Horm Metab Res 42:115-21. 2010
    ....
  2. doi request reprint A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones
    Solomon S Solomon
    Research Service, VA Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    Life Sci 83:305-12. 2008
    ....
  3. ncbi request reprint Impact of medical student research in the development of physician-scientists
    Solomon S Solomon
    Department of Medicine, Veterans Affairs Medical Center, Memphis TN 38104, USA
    J Investig Med 51:149-56. 2003
    ..Few have emphasized early medical student research experiences as a contributing solution...
  4. ncbi request reprint Mechanisms involved in tumor necrosis factor-alpha induction of insulin resistance and its reversal by thiazolidinedione(s)
    S S Solomon
    Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Med Sci 322:75-8. 2001
    ..These data support the efficacy of using thiazolidinediones (TRG) in human type 2 diabetes, and support the use of this cell culture model to further study the effects of thiazolidinediones on TNF-alpha-induced insulin resistance...
  5. ncbi request reprint Pioglitazone and metformin reverse insulin resistance induced by tumor necrosis factor-alpha in liver cells
    S S Solomon
    Research Service, VAMC, Memphis, USA
    Horm Metab Res 29:379-82. 1997
    ....
  6. ncbi request reprint Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat
    X Pan
    Research, Medical, and Pathology Services, Veterans Affairs Medical Center of Memphis, University of Tennessee, Memphis, Tennessee 38104, USA
    Endocrinology 142:1635-42. 2001
    ..In summary, insulin stimulates Sp1 protein, a transcription factor that is shown to regulate calmodulin gene expression and most likely other, as yet untested, genes...
  7. ncbi request reprint Growth hormone and carbohydrate intolerance in cirrhosis
    T P Shankar
    Department of Medicine, VA Medical Center, Memphis, Tennessee
    Horm Metab Res 20:579-83. 1988
    ..5 +/- 1.5 mg/kg/min during somatostatin infusion, P less than 0.025. We conclude that patients with alcohol induced cirrhosis have sustained GH elevations resulting in insulin resistance which improves after GH suppression...
  8. ncbi request reprint Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice
    Ivan C Gerling
    Division of Endocrinology, University of Tennessee Health Science Center, VAMC Research 151, 1030 Jefferson Ave, Memphis, TN 38104, USA
    Arch Intern Med 163:190-8. 2003
    ..Their potential use and impact are demonstrated by using diabetes mellitus as an example of a common and serious medical disorder. Finally, several potentially adverse consequences of "excessive" knowledge are discussed...
  9. ncbi request reprint Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistance
    Solomon S Solomon
    Research and Medical Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Lab Clin Med 145:275-83. 2005
    ..Although one cannot detail the mechanism or mechanisms of TNF-alpha induced IR from this data alone, it is easy to relate all of these proteins to a role in insulin signal transduction and, hence, insulin resistance...
  10. ncbi request reprint Paradoxical regulation of Sp1 transcription factor by glucagon
    Chithra N Keembiyehetty
    Veterans Affairs Medical Center, Research Services, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Endocrinology 143:1512-20. 2002
    ..Finally, as judged by immunoblotting to specific antibody, insulin but not glucagon, stimulated O-glycosylation of Sp1. Thus, unique signaling mechanisms mediate the response of Sp1 to glucagon in the presence or absence of insulin...
  11. ncbi request reprint O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon
    Gipsy Majumdar
    Research Services, Veterans Affairs Medical Center, Memphis, TN 38104, USA
    Am J Physiol Endocrinol Metab 285:E584-91. 2003
    ..Thus O-glycosylation of Sp1 by insulin, but not glucagon, apparently enhances its (Sp1) nuclear recruitment and results in activation of CaM gene transcription...
  12. ncbi request reprint Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1
    Gipsy Majumdar
    Research Services, VA Medical Center, Memphis, Tennessee, USA
    Diabetes 53:3184-92. 2004
    ..We conclude that insulin stimulates CaM gene transcription via a dynamic interplay between O-glycosylation and phosphorylation of Sp1 that modulates stability, mobility, subcellular compartmentalization, and activity...
  13. ncbi request reprint Sounding board: diabetes mellitus in the elderly: a truly heterogeneous entity?
    Sanjay Ratnakant
    Medical Services, Department of Veterans Affairs Medical Center, Memphis, TN, USA
    Diabetes Obes Metab 5:81-92. 2003

Research Grants2

  1. Short-Term Research Training for Medical Students
    Solomon Solomon; Fiscal Year: 2007
    ..5 million in annual grant awards and $33.0 million in pending grants, are available as research preceptors. Additional faculty members who meet these high standards will be included as preceptors in the future. ..