A Solomon

Summary

Affiliation: University of Tennessee Graduate School of Medicine
Country: USA

Publications

  1. pmc Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:1240-7. 2007
  2. pmc Amyloidogenic potential of foie gras
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Proc Natl Acad Sci U S A 104:10998-1001. 2007
  3. doi request reprint Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains
    Luis del Pozo Yauner
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca 62210, Morelos, Mexico
    Proteins 72:684-92. 2008
  4. ncbi request reprint Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville 37920, USA
    J Lab Clin Med 142:348-55. 2003
  5. ncbi request reprint Therapeutic potential of chimeric amyloid-reactive monoclonal antibody 11-1F4
    Alan Solomon
    Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Clin Cancer Res 9:3831S-8S. 2003
  6. pmc Transgenic mouse model of AA amyloidosis
    A Solomon
    Department of Medicine, University of Tennessee Medical Center Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Am J Pathol 154:1267-72. 1999
  7. ncbi request reprint Immunotherapy in systemic primary (AL) amyloidosis using amyloid-reactive monoclonal antibodies
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Cancer Biother Radiopharm 18:853-60. 2003
  8. ncbi request reprint Amyloid contained in the knee joint meniscus is formed from apolipoprotein A-I
    Alan Solomon
    University of Tennessee Center for Health Sciences, College of Medicine, Knoxville, USA
    Arthritis Rheum 54:3545-50. 2006
  9. pmc Antibody-mediated resolution of light chain-associated amyloid deposits
    R Hrncic
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
    Am J Pathol 157:1239-46. 2000
  10. ncbi request reprint Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens
    C L Murphy
    University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Am J Clin Pathol 116:135-42. 2001

Collaborators

Detail Information

Publications40

  1. pmc Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:1240-7. 2007
    ..Our delineation of this LC fibril-associated epitope provides the rationale for the design of novel amyloid-reactive antibodies with diagnostic and therapeutic potential for patients with LC-associated and other forms of amyloidosis...
  2. pmc Amyloidogenic potential of foie gras
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Proc Natl Acad Sci U S A 104:10998-1001. 2007
    ..On this basis, we posit that this and perhaps other forms of amyloidosis may be transmissible, akin to the infectious nature of prion-related illnesses...
  3. doi request reprint Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains
    Luis del Pozo Yauner
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca 62210, Morelos, Mexico
    Proteins 72:684-92. 2008
    ....
  4. ncbi request reprint Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville 37920, USA
    J Lab Clin Med 142:348-55. 2003
    ..Our studies provide unequivocal evidence that CEOT-associated amyloid consists of a unique and previously undescribed protein that we provisionally designate APin...
  5. ncbi request reprint Therapeutic potential of chimeric amyloid-reactive monoclonal antibody 11-1F4
    Alan Solomon
    Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Clin Cancer Res 9:3831S-8S. 2003
    ..To develop this reagent for clinical use, the 11-1F4 mAb was chimerized and its activity compared with that of the unmodified antibody...
  6. pmc Transgenic mouse model of AA amyloidosis
    A Solomon
    Department of Medicine, University of Tennessee Medical Center Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Am J Pathol 154:1267-72. 1999
    ....
  7. ncbi request reprint Immunotherapy in systemic primary (AL) amyloidosis using amyloid-reactive monoclonal antibodies
    Alan Solomon
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Cancer Biother Radiopharm 18:853-60. 2003
    ....
  8. ncbi request reprint Amyloid contained in the knee joint meniscus is formed from apolipoprotein A-I
    Alan Solomon
    University of Tennessee Center for Health Sciences, College of Medicine, Knoxville, USA
    Arthritis Rheum 54:3545-50. 2006
    ..To determine the chemical nature of amyloid deposits found in knee joint menisci...
  9. pmc Antibody-mediated resolution of light chain-associated amyloid deposits
    R Hrncic
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
    Am J Pathol 157:1239-46. 2000
    ....
  10. ncbi request reprint Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens
    C L Murphy
    University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Am J Clin Pathol 116:135-42. 2001
    ..The ability to identify precisely the nature of the tissue deposits has diagnostic, therapeutic, and prognostic implications for patients with amyloid-associated disorders...
  11. doi request reprint Effect of lysine modification on the stability and cellular binding of human amyloidogenic light chains
    S Davern
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, TN 37920, USA
    Biochim Biophys Acta 1812:32-40. 2011
    ....
  12. pmc Light chain-associated amyloid deposits comprised of a novel kappa constant domain
    A Solomon
    Human Immunology and Cancer Program, University of Tennessee Medical Center Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA
    Proc Natl Acad Sci U S A 95:9547-51. 1998
    ..Additionally, we posit that the previously unrecognized Asn177 substitution represents yet another Ckappa allotype, provisionally designated Km4...
  13. pmc Immunoglobulin heavy-chain-associated amyloidosis
    M Eulitz
    Department of Medicine, University of Tennessee Medical Center, Knoxville 37920
    Proc Natl Acad Sci U S A 87:6542-6. 1990
    ..This heavy-chain-related form of immunoglobulin-associated amyloidosis is tentatively designated AH amyloidosis...
  14. ncbi request reprint Thermodynamic instability of human lambda 6 light chains: correlation with fibrillogenicity
    J Wall
    Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine at Knoxville 37920 6999, USA
    Biochemistry 38:14101-8. 1999
    ..Our studies provide the first evidence that stabilizing interactions within the V L domain can influence the kinetics of light chain fibrillogenicity...
  15. ncbi request reprint Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004
    Morie A Gertz
    Dysproteinemia Clinic, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hematol 79:319-28. 2005
    ..We report criteria that centers can now use to define organ involvement and uniform response criteria for reporting outcomes in patients with light-chain AL...
  16. ncbi request reprint Chemical typing of porcine systemic amyloid as AA-amyloid
    Theo A Niewold
    Animal Sciences Group of Wageningen UR, AB Lelystad, The Netherlands
    Amyloid 12:164-6. 2005
    ..This is the first report on chemical identification of porcine amyloid...
  17. ncbi request reprint Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is associated with distinct amyloid morphology
    Joakim Bergström
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    J Pathol 206:224-32. 2005
    ....
  18. pmc Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Alzheimer s Disease and Amyloid Related Disorders Research Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Biochemistry 46:13049-58. 2007
    ..The identification of an 11-1F4-related mimotope should facilitate development of pan-light chain fibril-reactive antibodies that could be used in the diagnosis and treatment of patients with AL amyloidosis...
  19. ncbi request reprint Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera
    BRIAN O'NUALLAIN
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Center for Health Science, College of Medicine, Knoxville, TN 37920, USA
    J Immunol 176:7071-8. 2006
    ..These promising experimental results suggest that fibril affinity-purified IGIV has potential as a diagnostic and therapeutic agent for patients with amyloid-associated disease...
  20. pmc Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody
    Jonathan S Wall
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    J Nucl Med 47:2016-24. 2006
    ..The goal of this study was to determine the pharmacokinetics, biodistribution, and ability of this reagent to target the type of amyloid that is formed from immunoglobulin light chains, that is, AL...
  21. doi request reprint Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles
    Charles L Murphy
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Amyloid 15:89-95. 2008
    ..Our studies have provided further evidence for this unique form of odontogenic amyloid that we provisionally designate "AODAM"...
  22. pmc Micro-imaging of amyloid in mice
    Jonathan S Wall
    Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA
    Methods Enzymol 412:161-82. 2006
    ..Finally, we provide established methods for measuring organ- and tissue-specific activities with which to corroborate the microSPECT and CT images...
  23. ncbi request reprint A model for amyloid fibril formation in immunoglobulin light chains based on comparison of amyloidogenic and benign proteins and specific antibody binding
    Ritu Khurana
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Amyloid 10:97-109. 2003
    ..The antibody result indicates that each protofilament is asymmetric with different ends. A model for the formation of fibrils by SMA is proposed...
  24. ncbi request reprint Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis
    Jonathan S Wall
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA
    Amyloid 12:149-56. 2005
    ....
  25. ncbi request reprint Transthyretin-derived senile systemic amyloidosis: clinicopathologic and structural considerations
    Per Westermark
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Amyloid 10:48-54. 2003
    ..We suggest that ATTR fibrils may develop both from full-length TTR and from C-terminal TTR fragments and that the N-terminal part is not necessary for the fibril integrity...
  26. doi request reprint Unreliability of immunohistochemistry for typing amyloid deposits
    Alan Solomon
    Arch Pathol Lab Med 132:14; author reply 14-5. 2008
  27. pmc Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms
    Daniel P Kestler
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, United States of America
    Mol Med 14:318-26. 2008
    ....
  28. pmc Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies
    Sandra Davern
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USA
    Am J Clin Pathol 130:702-11. 2008
    ..Our anti-FLC mAbs, with their high degree of reactivity and versatility, may provide an invaluable tool in the diagnosis and management of light chain-associated disease...
  29. ncbi request reprint Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review
    Shafeeq S Ladha
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Peripher Nerv Syst 11:346-52. 2006
    ..The limited literature and experience among other cases is described...
  30. pmc Transmissibility of systemic amyloidosis by a prion-like mechanism
    Katarzyna Lundmark
    Division of Molecular and Immunological Pathology, Linkoping University, 581 83 Linkoping, Sweden
    Proc Natl Acad Sci U S A 99:6979-84. 2002
    ..Notably, the AEF was also effective when administered orally. Our studies have provided evidence that AA and perhaps other forms of amyloidosis are transmissible diseases, akin to the prion-associated disorders...
  31. ncbi request reprint Hepatic amyloidosis resulting from deposition of the apolipoprotein A-I variant Leu75Pro
    Daniel Coriu
    University of Medicine Carol Davila, Bucharest, Romania
    Amyloid 10:215-23. 2003
    ..Our findings provide further evidence that the Leu75Pro variant is associated with a predominant hepatic phenotype and can occur in individuals of diverse ethnic backgrounds...
  32. ncbi request reprint Two different types of amyloid deposits--apolipoprotein A-IV and transthyretin--in a patient with systemic amyloidosis
    Joakim Bergström
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Lab Invest 84:981-8. 2004
    ..These findings provide the first conclusive evidence that two separate forms of amyloid, each derived from a wild-type amyloidogenic precursor protein, were present in a patient with systemic amyloidosis...
  33. ncbi request reprint Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins
    Jonathan S Wall
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
    J Mol Recognit 17:323-31. 2004
    ..The information gleaned from our studies has provided insight into structural parameters that in addition to overall thermodynamic stability, contribute to the fibril forming propensity of immunoglobulin light chains...
  34. ncbi request reprint Clinical efficacy of high-dose dexamethasone with maintenance dexamethasone/alpha interferon in patients with primary systemic amyloidosis: results of United States Intergroup Trial Southwest Oncology Group (SWOG) S9628
    Madhav V Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University and Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 104:3520-6. 2004
    ....
  35. ncbi request reprint Renal apolipoprotein A-I amyloidosis associated with a novel mutant Leu64Pro
    Charles L Murphy
    Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
    Am J Kidney Dis 44:1103-9. 2004
    ..These studies have provided further evidence for Apo A-I amyloidogenicity and the propensity of certain mutants to deposit in renal parenchyma...
  36. pmc Elicitation of allergic asthma by immunoglobulin free light chains
    Aletta D Kraneveld
    Department of Pharmacology and Pathophysiology, Faculty of Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 102:1578-83. 2005
    ..In addition, the ability to inhibit pharmacologically LC-induced mast cell activation provides a therapeutic means to prevent or ameliorate the adverse bronchopulmonary manifestations of this incapacitating disorder...
  37. ncbi request reprint Hereditary amyloidosis
    Alan Solomon
    N Engl J Med 347:1206-7; author reply 1206-7. 2002
  38. ncbi request reprint Misclassification of amyloidosis is unwarranted
    Alan Solomon
    Blood 108:776; author reply 776-7. 2006
  39. ncbi request reprint Characterization of systemic amyloid deposits by mass spectrometry
    Charles L Murphy
    Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, 37920, USA
    Methods Enzymol 412:48-62. 2006
    ..The ability to identify precisely the protein nature of the pathologic deposits has diagnostic, therapeutic, and prognostic implications for patients with amyloid-associated disease...
  40. ncbi request reprint Senile seminal vesicle amyloid is derived from semenogelin I
    Reinhold P Linke
    Department of Structural Research, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Lab Clin Med 145:187-93. 2005
    ..The results of our research provide unequivocal evidence that SSVA is derived from SgI, and we provisionally designate this form of amyloidosis as ASgI...