JAY SOLNICK

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The impact of Helicobacter pylori infection on the gastric microbiota of the rhesus macaque
    Miriam E Martin
    Department of Medicine, University of California Davis, Davis, California, United States of America Department of Microbiology and Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e76375. 2013
  2. pmc Functional plasticity in the type IV secretion system of Helicobacter pylori
    Roberto M Barrozo
    Center for Comparative Medicine, University of California Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003189. 2013
  3. pmc Serum glycan signatures of gastric cancer
    Sureyya Ozcan
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616 or Carlito B Lebrilla
    Cancer Prev Res (Phila) 7:226-35. 2014
  4. pmc In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer
    Francisco Aviles-Jimenez
    Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, UMAE Pediatria, IMSS, Mexico City, Mexico
    Infect Immun 80:594-601. 2012
  5. pmc Acquisition of Helicobacter pylori infection in rhesus macaques is most consistent with oral-oral transmission
    Jay V Solnick
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    J Clin Microbiol 44:3799-803. 2006
  6. pmc The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence
    J V Solnick
    Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
    J Bacteriol 179:6196-200. 1997
  7. pmc Natural acquisition of Helicobacter pylori infection in newborn rhesus macaques
    Jay V Solnick
    Department of Internal Medicine, California National Primate Research Center, University of California Davis, California 95616, USA
    J Clin Microbiol 41:5511-6. 2003
  8. pmc Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatta)
    J V Solnick
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California 95616, USA
    Infect Immun 69:6887-92. 2001
  9. pmc Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases
    J V Solnick
    Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, California 95616, USA
    Clin Microbiol Rev 14:59-97. 2001
  10. pmc Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free rhesus monkeys (Macaca mulatta)
    J V Solnick
    Department of Internal Medicine Division of Infectious Diseases, University of California, Davis School of Medicine, Davis, California 95616, USA
    Infect Immun 68:2560-5. 2000

Collaborators

  • J L Huff
  • Julie Parsonnet
  • SATYA W DANDEKAR
  • Jonathan A Eisen
  • Javier Torres
  • M Syvanen
  • M D George
  • Glenn M Young
  • Francesco Franceschi
  • MICHAEL S VAJDY
  • Tak Wah Mak
  • R M Peek
  • NINA REDA SALAMA
  • Barry Marshall
  • Joaquin Sanchez
  • Guadalupe Ayala
  • P Vandamme
  • Jani L O'Rourke
  • B A Neilan
  • Cara L Cooke
  • Lori M Hansen
  • Jennifer M Taylor
  • Don R Canfield
  • Carlito B Lebrilla
  • Hyun Joo An
  • Cathy M Styer
  • Jenni K Boonjakuakul
  • Renee M Tsolis
  • Michael J Hornsby
  • Melanie E Ziman
  • Sureyya Ozcan
  • Margarita Camorlinga-Ponce
  • Roberto M Barrozo
  • Miriam E Martin
  • Francisco Aviles-Jimenez
  • Wendy S Axsen
  • Manuela Raffatellu
  • ANDREAS J BAUMLER
  • Charles L Bevins
  • Susan K Amundsen
  • Jaehan Kim
  • Jeffrey C Colbeck
  • Cynthia C Williams
  • Lauren M Dimapasoc
  • Serenus Hua
  • Kathy R Fernandez
  • L Renee Ruhaak
  • Jae Han Kim
  • Donald A Barkauskas
  • David Rocke
  • Giovanni Suarez
  • Srijak Bhatnagar
  • Anna M Lam
  • Taryn A Cariaga
  • Bruce J Paster
  • Timothy L Cover
  • Elizabeth M Johnson
  • Jennifer A Gaddy
  • Lourdes Cabrera
  • Javier Torres-López
  • Adriana Reyes-Leon
  • Rosa María Ribas-Aparicio
  • Hector Bermúdez
  • Erik Nieto-Patlán
  • Juan Burgueño
  • Irma P Ramos
  • Juan M Blancas
  • Amy M Gundersen
  • Mohammed Benghezal
  • Sung Sook Choi
  • Thomas Boren
  • Douglas E Berg
  • Yuko Akiyama
  • Thorsten Berger
  • Tatiane A Paixao
  • Renato L Santos
  • Sean Paul Nuccio
  • Hiutung Chu
  • Brian P Butler
  • Jutta Fero
  • Robert J Kays
  • Gareth A Cromie
  • Gerald R Smith
  • Julie Fong
  • Nathan M Moroski
  • Julie M Fong
  • Christopher L Bowlus
  • Arun Suryaprasad
  • Blaine L Beaman

Detail Information

Publications34

  1. pmc The impact of Helicobacter pylori infection on the gastric microbiota of the rhesus macaque
    Miriam E Martin
    Department of Medicine, University of California Davis, Davis, California, United States of America Department of Microbiology and Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e76375. 2013
    ..pylori infection. ..
  2. pmc Functional plasticity in the type IV secretion system of Helicobacter pylori
    Roberto M Barrozo
    Center for Comparative Medicine, University of California Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003189. 2013
    ..pylori T4SS. We propose that CagY functions as a sort of molecular switch or perhaps a rheostat that alters the function of the T4SS and "tunes" the host inflammatory response so as to maximize persistent infection...
  3. pmc Serum glycan signatures of gastric cancer
    Sureyya Ozcan
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616 or Carlito B Lebrilla
    Cancer Prev Res (Phila) 7:226-35. 2014
    ..Further studies will be needed to validate these findings as biomarkers and identify the role of protein glycosylation in gastric cancer pathology. Cancer Prev Res; 7(2); 226-35. ©2013 AACR. ..
  4. pmc In vivo expression of Helicobacter pylori virulence genes in patients with gastritis, ulcer, and gastric cancer
    Francisco Aviles-Jimenez
    Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, UMAE Pediatria, IMSS, Mexico City, Mexico
    Infect Immun 80:594-601. 2012
    ..pylori colonization than the acidic environment in patients with NAG or DU...
  5. pmc Acquisition of Helicobacter pylori infection in rhesus macaques is most consistent with oral-oral transmission
    Jay V Solnick
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    J Clin Microbiol 44:3799-803. 2006
    ..Since the concentrations of H. pylori in vomit were compatible with what is known about the infectious dose, our results are most consistent with an oral-oral means of transmission...
  6. pmc The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence
    J V Solnick
    Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
    J Bacteriol 179:6196-200. 1997
    ..This suggests that RpoD from gram-negative bacteria is functionally less constrained than that from gram-positive bacteria...
  7. pmc Natural acquisition of Helicobacter pylori infection in newborn rhesus macaques
    Jay V Solnick
    Department of Internal Medicine, California National Primate Research Center, University of California Davis, California 95616, USA
    J Clin Microbiol 41:5511-6. 2003
    ..Furthermore, breastfeeding seems to offer little protection, since newborn macaques breastfeed during the first year of life and typically are fully weaned only when another newborn arrives the following spring...
  8. pmc Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatta)
    J V Solnick
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California 95616, USA
    Infect Immun 69:6887-92. 2001
    ..pylori vaccination...
  9. pmc Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases
    J V Solnick
    Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis, California 95616, USA
    Clin Microbiol Rev 14:59-97. 2001
    ..pylori infection in humans...
  10. pmc Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free rhesus monkeys (Macaca mulatta)
    J V Solnick
    Department of Internal Medicine Division of Infectious Diseases, University of California, Davis School of Medicine, Davis, California 95616, USA
    Infect Immun 68:2560-5. 2000
    ..pylori. An effective vaccine to prevent H. pylori infection will require different or more likely additional antigens, as well as improvements in the stimulation of the host immune response...
  11. ncbi Clinical significance of Helicobacter species other than Helicobacter pylori
    Jay V Solnick
    Department of Internal Medicine Infectious Diseases, School of Medicine, University of California, Davis, CA 95616, USA
    Clin Infect Dis 36:349-54. 2003
    ....
  12. pmc Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques
    Jay V Solnick
    Departments of Medicine and Medical Microbiology and Immunology, and Center for Comparative Medicine, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 101:2106-11. 2004
    ..We suggest that changes in babA and babB after experimental infection of macaques represent a dynamic response in the H. pylori outer membrane that facilitates adherence to the gastric epithelium and promotes chronic infection...
  13. pmc Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner
    Michael J Hornsby
    Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA
    Gastroenterology 134:1049-57. 2008
    ..We used the rhesus macaque model to study the effects of the cag pathogenicity island (cag PAI) on the H pylori host-pathogen interaction...
  14. ncbi Transcription profile of Helicobacter pylori in the human stomach reflects its physiology in vivo
    Jenni K Boonjakuakul
    Department of Medical Microbiology and Immunology, University of California, Davis, USA
    J Infect Dis 190:946-56. 2004
    ..We therefore developed a quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) assay to measure transcript profiles of H. pylori in the human stomach...
  15. pmc Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque
    Jennifer L Huff
    Department of Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    Infect Immun 72:5216-26. 2004
    ..These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection...
  16. pmc Expression of the BabA adhesin during experimental infection with Helicobacter pylori
    Cathy M Styer
    Department of Medicine and Microbiology, Center for Comparative Medicine, University of California, Davis School of Medicine, Davis, California 95616, USA
    Infect Immun 78:1593-600. 2010
    ..We hypothesize that modification of BabA expression during H. pylori infection is a mechanism to adapt to changing conditions of inflammation and glycan expression at the epithelial surface...
  17. ncbi [14C]Urea breath test is not sensitive for detection of acute Helicobacter pylori infection in rhesus monkeys (Macaca mulatta)
    Jay V Solnick
    Department of Internal Medicine, University of California, Davis School of Medicine, USA
    Dig Dis Sci 47:298-303. 2002
    ..pylori infection in rhesus monkeys until 10 weeks after inoculation. While this may reflect a gradual increase in bacterial load that was not detected by limited sampling, our data are not consistent with this hypothesis...
  18. pmc Captive rhesus monkeys (Macaca mulatta) are commonly infected with Helicobacter cinaedi
    Kathy R Fernandez
    Department of Medicine, School of Medicine, University of California, Davis, Davis, California 95616, USA
    J Clin Microbiol 40:1908-12. 2002
    ..cinaedi. These results show that H. cinaedi frequently colonizes asymptomatic captive rhesus monkeys, which may serve as another potential reservoir for human infection...
  19. ncbi Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori
    Cara L Cooke
    Department of Internal Medicine, University of California, Davis, California, USA
    Gastroenterology 137:1061-71, 1071.e1-8. 2009
    ..We used the rhesus macaque model to characterize the effect of H. pylori infection on gastric mucin oligosaccharides during acute and chronic infection...
  20. ncbi Extragastric manifestations of Helicobacter pylori infection--other Helicobacter species
    Jay V Solnick
    Medicine and Medical Microbiology, Center for Comparative Medicine, University of California, USA
    Helicobacter 11:46-51. 2006
    ..Finally, enterohepatic Helicobacter species have also been exploited to better understand inflammatory bowel disease...
  21. pmc Comparison of Helicobacter pylori virulence gene expression in vitro and in the Rhesus macaque
    Jenni K Boonjakuakul
    Department of Medicine, Division of Infectious Disease, 513 Parnassus Avenue, HSE 418 Box 0654, University of California, San Francisco, San Francisco, CA 94143, USA
    Infect Immun 73:4895-904. 2005
    ..These results suggest the possibility that some genes encoding the H. pylori type IV structural pilus and accessory proteins may form an operon that is induced during growth in vivo...
  22. ncbi Method for profiling mucin oligosaccharides from gastric biopsies of rhesus monkeys with and without Helicobacter pylori infection
    Cara L Cooke
    Department of Internal Medicine, University of California, Davis, California 95616, USA
    Anal Chem 79:8090-7. 2007
    ..This method can be applied to characterize the glycans associated with the mucin lining of live animals and allows for repeated analysis of the same animal over the course of infection...
  23. ncbi The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori
    Cara L Cooke
    Departments of Internal Medicine and Medical Microbiology and Immunology, Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    FEMS Immunol Med Microbiol 45:11-23. 2005
    ..We suggest that H. pylori finely modulates the extent to which it interacts with the host in order to promote chronic infection, and that it uses diverse mechanisms to do so...
  24. ncbi Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques
    Satya Dandekar
    Department of Medical Microbiology and Immunology, University of California, Davis, California 95616, USA
    Dig Dis Sci 48:1073-80. 2003
    ..We propose that transient, Fas-mediated apoptosis in gastric lymphocytes is a compensatory response to the initial T-cell inflammatory response after acute H. pylori infection...
  25. pmc Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
    Cell Host Microbe 5:476-86. 2009
    ..Thus, resistance to lipocalin-2 defines a specific adaptation of S. Typhimurium for growth in the inflamed intestine...
  26. doi From bench to bedside: stealth of enteroinvasive pathogens
    Renee M Tsolis
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA
    Nat Rev Microbiol 6:883-92. 2008
    ..Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside...
  27. pmc Effects of a Th1- versus a Th2-biased immune response in protection against Helicobacter pylori challenge in mice
    Jennifer M Taylor
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Microb Pathog 44:20-7. 2008
    ..pylori sonicate combined with cholera toxin (CT). We demonstrate that although the Th2-promoting vaccine induced stronger systemic and local immune responses, only the Th1-promoting vaccine was protective...
  28. pmc Possible correlates of long-term protection against Helicobacter pylori following systemic or combinations of mucosal and systemic immunizations
    Jennifer M Taylor
    Departments of Internal Medicine and Medical Microbiology and Immunology, Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
    Infect Immun 75:3462-9. 2007
    ..This study demonstrates the ability to induce long-term immunity against H. pylori, provides correlates of protection, and illustrates the crucial role of the immunization route(s)...
  29. ncbi Helicobacter pylori lipopolysaccharide promotes a Th1 type immune response in immunized mice
    Jennifer M Taylor
    Department of Internal Medicine, Center for Comparative Medicine, University of California, Davis, USA
    Vaccine 24:4987-94. 2006
    ..Together these studies suggest that H. pylori LPS in a whole cell sonicate vaccine promotes a Th1 immune response that may aid in protection or clearance of H. pylori infection...
  30. pmc Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori
    Jeffrey C Colbeck
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    Infect Immun 74:4375-8. 2006
    ..We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time...
  31. doi Inhibition of heat shock protein expression by Helicobacter pylori
    Wendy S Axsen
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Microb Pathog 47:231-6. 2009
    ..Typhimurium up-regulated HSP expression. Since HSPs are thought to function as danger signals during microbial infection, H. pylori down-regulation of HSPs may be a mechanism of immune evasion that promotes chronic infection...
  32. pmc Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization
    Susan K Amundsen
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Microbiol 69:994-1007. 2008
    ..Our results reveal requirements for double-strand break repair and recombination during both acute and chronic phases of H. pylori stomach infection...
  33. ncbi Description of 'Candidatus Helicobacter heilmannii' based on DNA sequence analysis of 16S rRNA and urease genes
    Jani L O'Rourke
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia, 2052
    Int J Syst Evol Microbiol 54:2203-11. 2004
    ..The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name 'Candidatus Helicobacter heilmannii' is proposed...
  34. ncbi Quantitation of H. pylori cytotoxin mRNA by real-time RT-PCR shows a wide expression range that does not correlate with promoter sequences
    Guadalupe Ayala
    Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Av Universidad 655 Cuernavaca, Mor C P 62508, Mexico
    Microb Pathog 37:163-7. 2004
    ..The lack of correlation between promoter sequences and the vacA expression levels suggest the potential existence of a bacterial strain-specific factor, as earlier proposed by others on the basis of reporter gene fusions...

Research Grants30

  1. Animal Models of Infection Diseases Training Program
    JAY SOLNICK; Fiscal Year: 2007
    ..Our goal is to become a pre-eminent training center in the use of animal models and the new genomic biology to better understand human infectious diseases. ..
  2. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..These experiments could lead to development of a vaccine to prevent and treat Helicobacter pylori infection, which would likely reduce the frequency of peptic ulcer disease and gastric cancer. ..
  3. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  4. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2007
    ..If the encouraging results from mouse studies can be replicated in non-human primates, they would serve as the basis for PhaseI/II clinical trials in humans. ..
  5. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  6. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  7. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    JAY SOLNICK; Fiscal Year: 2009
    ..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
  8. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    Jay V Solnick; Fiscal Year: 2010
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  9. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2010
    ..We propose to identify serum biomarkers of gastric cancer and its precursor lesions that would permit early detection and intervention before the disease has progressed to an advanced stage where it is rarely curable. ..
  10. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2010
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..
  11. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  12. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2006
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  13. DETERMINANTS OF H PYLORI INFECTION IN THE RHESUS MONKEY
    JAY SOLNICK; Fiscal Year: 1999
    ..The results will be compared in juvenile and adult animals. These studies will further understanding of the host-pathogen relationship in acute and chronic H. pylori infection. ..
  14. DETERMINANTS OF H PYLORI INFECTION IN THE RHESUS MONKEY
    JAY SOLNICK; Fiscal Year: 2000
    ..The results will be compared in juvenile and adult animals. These studies will further understanding of the host-pathogen relationship in acute and chronic H. pylori infection. ..
  15. DETERMINANTS OF H PYLORI INFECTION IN THE RHESUS MONKEY
    JAY SOLNICK; Fiscal Year: 2001
    ..The results will be compared in juvenile and adult animals. These studies will further understanding of the host-pathogen relationship in acute and chronic H. pylori infection. ..
  16. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2001
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  17. Transcription of H. pylori Genes in the Rhesus Monkey
    JAY SOLNICK; Fiscal Year: 2001
    ..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
  18. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2002
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  19. Transcription of H. pylori Genes in the Rhesus Monkey
    JAY SOLNICK; Fiscal Year: 2002
    ..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
  20. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2003
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  21. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2003
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  22. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2004
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  23. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  24. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    JAY SOLNICK; Fiscal Year: 2009
    ..This project seeks to understand some of the factors that determine the expression of these surface proteins in H. pylori. ..