M Soleimani

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Proximal tubule specific knockout of the Na(+)/H (+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
    Hong C Li
    Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Mol Med (Berl) 91:951-63. 2013
  2. pmc Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure
    Manoocher Soleimani
    Research Services, Veterans Affairs Medical Center, Cincinnati, OH 45202, USA
    Proc Natl Acad Sci U S A 109:13368-73. 2012
  3. pmc The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane
    Hong C Li
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Cell Physiol 302:C1713-30. 2012
  4. pmc Deletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting
    Sharon Barone
    Research Services, Veterans Administration Medical Center, Cincinnati, OH, USA
    Nephrol Dial Transplant 27:1368-79. 2012
  5. pmc cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cells
    Oliver Bachmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    BMC Cell Biol 9:70. 2008
  6. ncbi request reprint Na+:HCO(3-) cotransporters (NBC): cloning and characterization
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    J Membr Biol 183:71-84. 2001
  7. ncbi request reprint Functional and molecular properties of Na+:HCO-3 cotransporters (NBC)
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, OH, USA and Veterans Affair Medical Center, Cincinnati, OH 45267 0585, USA
    Minerva Urol Nefrol 55:131-40. 2003
  8. pmc The role of SLC26A6-mediated chloride/oxalate exchange in causing susceptibility to nephrolithiasis
    Manoocher Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati Medical Center, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    J Physiol 586:1205-6. 2008
  9. ncbi request reprint Impaired pancreatic ductal bicarbonate secretion in cystic fibrosis
    M Soleimani
    Department of Medicine, University of Cincinnati, and Veterans Affairs Medical Center at Cincinnati, Cincinnati, OH 45267 0585, USA
    JOP 2:237-42. 2001
  10. ncbi request reprint Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney
    Manoocher Soleimani
    Department of Medicine, Division of Nephrology and Hypertension, University of Cincinnati, OH 45267 0585, USA
    J Nephrol 15:S32-40. 2002

Research Grants

  1. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
  2. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
  3. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001
  4. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007

Collaborators

Detail Information

Publications87

  1. pmc Proximal tubule specific knockout of the Na(+)/H (+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
    Hong C Li
    Center on Genetics of Transport and the Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Mol Med (Berl) 91:951-63. 2013
    ..Our results suggest that the Na(+)/H(+) exchanger NHE3 plays an important role in fluid and bicarbonate reabsorption in the proximal convoluted tubule but does not play an important role in NH4 excretion. ..
  2. pmc Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure
    Manoocher Soleimani
    Research Services, Veterans Affairs Medical Center, Cincinnati, OH 45202, USA
    Proc Natl Acad Sci U S A 109:13368-73. 2012
    ....
  3. pmc The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane
    Hong C Li
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Cell Physiol 302:C1713-30. 2012
    ..These studies demonstrate that aspartic acid residues 405 and 416 in the NH(2) terminus of NBCe1A are important in its accurate targeting to the plasma membrane...
  4. pmc Deletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting
    Sharon Barone
    Research Services, Veterans Administration Medical Center, Cincinnati, OH, USA
    Nephrol Dial Transplant 27:1368-79. 2012
    ....
  5. pmc cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cells
    Oliver Bachmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    BMC Cell Biol 9:70. 2008
    ..After having shown activation of NBC by carbachol and forskolin in murine colon, we now investigated these pathways in HEK293 cells transiently expressing a GFP-tagged pNBC1 construct...
  6. ncbi request reprint Na+:HCO(3-) cotransporters (NBC): cloning and characterization
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    J Membr Biol 183:71-84. 2001
    ..The purpose of this review is to summarize recent advances on the cloning of NBC isoforms and related proteins and their role and regulation in physiologic and pathologic states...
  7. ncbi request reprint Functional and molecular properties of Na+:HCO-3 cotransporters (NBC)
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, OH, USA and Veterans Affair Medical Center, Cincinnati, OH 45267 0585, USA
    Minerva Urol Nefrol 55:131-40. 2003
    ..The purpose of this review is to summarize functional and molecular properties of NBC isoforms and related proteins, and discuss their role and regulation in pathophysiologic states...
  8. pmc The role of SLC26A6-mediated chloride/oxalate exchange in causing susceptibility to nephrolithiasis
    Manoocher Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati Medical Center, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    J Physiol 586:1205-6. 2008
  9. ncbi request reprint Impaired pancreatic ductal bicarbonate secretion in cystic fibrosis
    M Soleimani
    Department of Medicine, University of Cincinnati, and Veterans Affairs Medical Center at Cincinnati, Cincinnati, OH 45267 0585, USA
    JOP 2:237-42. 2001
    ....
  10. ncbi request reprint Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney
    Manoocher Soleimani
    Department of Medicine, Division of Nephrology and Hypertension, University of Cincinnati, OH 45267 0585, USA
    J Nephrol 15:S32-40. 2002
    ....
  11. doi request reprint Dietary fructose, salt absorption and hypertension in metabolic syndrome: towards a new paradigm
    M Soleimani
    Center on Genetics of Transport and Epithelial Biology, Department of Medicine, University of Cincinnati, OH 45267 0585, USA
    Acta Physiol (Oxf) 201:55-62. 2011
    ....
  12. ncbi request reprint How cystic fibrosis affects pancreatic ductal bicarbonate secretion
    M Soleimani
    Department of Medicine, University of Cincinnati, Ohio, USA
    Med Clin North Am 84:641-55, x. 2000
    ..Pancreatic bicarbonate secretion is impaired in patients with cystic fibrosis. This article reviews recent advances in bicarbonate dependent transporters in pancreatic duct cells and discusses their regulation in cystic fibrosis...
  13. ncbi request reprint Molecular physiology of the renal chloride-formate exchanger
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Curr Opin Nephrol Hypertens 10:677-83. 2001
    ..In the present review, recent studies regarding the renal distribution and membrane localization of pendrin, and its functional properties, including its roles in chloride reabsorption and base excretion, are addressed...
  14. ncbi request reprint SLC26 chloride/base exchangers in the kidney in health and disease
    Manoocher Soleimani
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Semin Nephrol 26:375-85. 2006
    ..Specifically, the roles of A4 (pendrin), A6 (PAT1), and A7 (PAT2) in chloride homeostasis, oxalate excretion, and acid-base balance are discussed...
  15. ncbi request reprint Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes
    M Soleimani
    Department of Medicine, University of Cincinnati, and the Veterans Affairs Medical Center, Cincinnati, Ohio 45267 0585, USA
    Kidney Int 57:371-84. 2000
    ..Possible signals responsible for the regulation of NBCs in these conditions are examined. Furthermore, the possible role of this transporter in acid-base disorders (such as proximal renal tubular acidosis) is discussed...
  16. ncbi request reprint Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex
    M Soleimani
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Renal Physiol 280:F356-64. 2001
    ..The conclusion is that pendrin is an apical Cl-/base exchanger in the kidney proximal tubule and CCD and mediates Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange...
  17. ncbi request reprint Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells
    T Greeley
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1301-8. 2001
    ..We propose that the pancreatic HCO secretion defect in CF patients is partly due to the downregulation of apical Cl(-)/HCO exchange activity mediated by DRA (and possibly PAT1)...
  18. ncbi request reprint Mouse Na+: HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution
    Z Wang
    Division of Nephrology, Department of Internal Medicine, University of Cincinnati, and the Veterans Affairs Medical Center, Cincinnati, Ohio, USA
    Kidney Int 59:1405-14. 2001
    ..The purpose of the present studies was to clone the mouse kNBC-3 and to examine its properties and expression in the kidney...
  19. ncbi request reprint Cloning, renal distribution, and regulation of the rat Na+-HCO3- cotransporter
    C E Burnham
    Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol 274:F1119-26. 1998
    ..In the kidney, NBC-1 is expressed mainly in the proximal tubule, with traces found in medullary thick ascending limb and papilla. HCO3- loading decreased NBC-1 mRNA levels, which were unchanged either by metabolic acidosis or by CDA...
  20. ncbi request reprint HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response
    S Nakamura
    Department of Internal Medicine, Biochemistry and Microbiology, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267, USA
    Am J Physiol 276:F914-21. 1999
    ..In CCD, H+-ATPase, and in the OMCD, both H+-ATPase and gastric H+-K+-ATPase contribute to the enhanced compensatory HCO-3 reabsorption in NHE-3-deficient animals...
  21. ncbi request reprint Cloning and functional expression of a human kidney Na+:HCO3- cotransporter
    C E Burnham
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    J Biol Chem 272:19111-4. 1997
    ..6-kilobase mRNA is highly expressed in kidney and pancreas, with detectable levels in brain. Functional studies in transiently transfected HEK-293 cells demonstrate that the cloned transporter mediates Na+:HCO3- cotransport...
  22. ncbi request reprint Fasting downregulates renal water channel AQP2 and causes polyuria
    H Amlal
    Department of Medicine, University of Cincinnati Medical Center, 231 Bethesda Ave, MSB 5502, Cincinnati OH45267 0585, USA
    Am J Physiol Renal Physiol 280:F513-23. 2001
    ..We conclude that 1) fasting impairs the urinary concentrating ability in rats, and 2) the renal water-handling defect in fasting results specifically from the downregulation of AQP2 in the cortical and outer medullary collecting duct...
  23. pmc Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct
    Hassane Amlal
    Research Services, Cincinnati Department of Veterans Affairs Medical Center, Cincinnati, OH, USA
    Am J Physiol Cell Physiol 299:C33-41. 2010
    ..Additional apical Cl(-)/HCO(3)(-) exchanger(s) is (are) present in the CCD...
  24. ncbi request reprint Activation of the apical Na+/H+ exchanger NHE3 by formate: a basis of enhanced fluid and electrolyte reabsorption by formate in the kidney
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, and Veterans Affairs Medical Center, Cincinnati, Ohio, USA
    Am J Physiol Renal Physiol 287:F336-46. 2004
    ....
  25. ncbi request reprint Identification of a novel signal in the cytoplasmic tail of the Na+:HCO3- cotransporter NBC1 that mediates basolateral targeting
    Hong C Li
    Dept of Internal Medicine, Div of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    Am J Physiol Renal Physiol 292:F1245-55. 2007
    ..We propose that the FL motif in the COOH-terminal tail of NBC1 is essential for the targeting of NBC1 to the basolateral membrane but is distinct from the membrane-targeting di-leucine motif identified in other membrane proteins...
  26. ncbi request reprint Characterization of Na+/HCO-3 cotransporter isoform NBC-3
    H Amlal
    Division of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol 276:F903-13. 1999
    ..We further propose that enhanced expression of NBC-3 in severe acid stress could play an important role in cell survival by mediating the influx of HCO-3 into the cells...
  27. ncbi request reprint Coordinated down-regulation of NBC-1 and NHE-3 in sodium and bicarbonate loading
    H Amlal
    Department of Medicine, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267 0585, USA
    Kidney Int 60:1824-36. 2001
    ..The purpose of these studies was to examine the effects of Na+ load and altered acid-base status on the expression of NHE-3 and NBC-1 in the kidney...
  28. ncbi request reprint Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation
    Catherine Wilke
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    Kidney Int 67:201-16. 2005
    ....
  29. ncbi request reprint Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Ohio 45267 0485, USA
    Am J Physiol Renal Physiol 284:F103-12. 2003
    ..Adaptive downregulation of pendrin in metabolic acidosis indicates the important role of this exchanger in acid-base regulation in the CCD...
  30. ncbi request reprint Identification of an apical Cl-/HCO-3 exchanger in rat kidney proximal tubule
    Snezana Petrovic
    Department of Medicine, University of Cincinnati and Veteran Affairs Medical Center, Cincinnati, OH, USA
    Am J Physiol Cell Physiol 285:C608-17. 2003
    ..We propose that SLC26A6 is likely responsible for the apical Cl-/HCO3- (and Cl-/OH-) exchanger activities in kidney proximal tubule...
  31. ncbi request reprint Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2
    C Ledoussal
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Renal Physiol 281:F718-27. 2001
    ....
  32. pmc Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-)
    Elise S Demitrack
    Department of Molecular and Cellular Physiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 299:G255-64. 2010
    ..We conclude that cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby surface pH transiently increases in response to photodamage...
  33. ncbi request reprint Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct
    Sharon Barone
    Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    J Am Soc Nephrol 15:2002-11. 2004
    ....
  34. ncbi request reprint Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Renal Physiol 282:F133-43. 2002
    ..These data indicate the presence of a previously unrecognized K(+)-dependent SCH-28080 and ouabain-insensitive proton secretory mechanism in the cortical collecting tubule that may play an important role in acid-base homeostasis...
  35. ncbi request reprint Renal and intestinal transport defects in Slc26a6-null mice
    Zhaohui Wang
    Department of Internal Medicine, Division of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati OH 45267 0585, USA
    Am J Physiol Cell Physiol 288:C957-65. 2005
    ..We conclude that Slc26a6 mediates oxalate-stimulated NaCl absorption, contributes to apical membrane Cl-/base exchange in the kidney proximal tubule, and also plays an important role in HCO3- secretion in the duodenum...
  36. ncbi request reprint SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+
    Jie Xu
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Am J Physiol Cell Physiol 289:C493-505. 2005
    ..Disease states that are associated with increased ammonia (NH3)/NH4+ generation (e.g., Helicobacter pylori) may impair gastric HCO3- secretion and therefore predispose patients to peptic ulcer by inhibiting SLC26A9...
  37. ncbi request reprint Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis
    Hong C Li
    Dept of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Am J Physiol Renal Physiol 289:F61-71. 2005
    ....
  38. ncbi request reprint SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct
    Snezana Petrovic
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    Am J Physiol Renal Physiol 286:F161-9. 2004
    ..02 vs. normal condition). We propose that SLC26A7 is a basolateral Cl-/HCO3- exchanger in intercalated cells of the OMCD and may play an important role in bicarbonate reabsorption in medullary collecting duct...
  39. ncbi request reprint Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Cincinnati 45267, USA
    Am J Physiol Gastrointest Liver Physiol 284:G1093-103. 2003
    ..On the basis of its unique expression pattern and function, we propose that SLC26A7 is a basolateral Cl(-)/HCO(3)(-) exchanger in gastric parietal cells and plays a major role in gastric acid secretion...
  40. ncbi request reprint Effect of long-term hyperosmolality on the Na+/H+ exchanger isoform NHE-3 in LLC-PK1 cells
    M Soleimani
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Kidney Int 53:423-31. 1998
    ....
  41. ncbi request reprint Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine
    Zhaohui Wang
    Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 282:G573-9. 2002
    ..Immunohistochemical studies localized PAT1 to the brush border membranes of the villus cells of the duodenum. We propose that PAT1 is an apical Cl(-)/HCO3(-) exchanger in the small intestine...
  42. ncbi request reprint Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant
    Jie Xu
    Division of Nephrology, Department of Medicine, University of Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Renal Physiol 284:F41-50. 2003
    ..We propose that NBC4 is expressed in the thick ascending limb of the loop of Henle and mediates cellular HCO(3)(-) uptake in this segment...
  43. ncbi request reprint Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Am J Physiol Renal Physiol 284:F1046-55. 2003
    ..Our results suggest that SSAT is likely a new marker of tubular cell injury that distinguishes acute prerenal from intrarenal failure...
  44. ncbi request reprint Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Am J Physiol Cell Physiol 292:C1204-15. 2007
    ..We propose that in kidneys subjected to IRI, one mechanism through which increased expression of SSAT may cause cellular injury and organ damage is through induction of DNA damage and the disruption of cell cycle...
  45. ncbi request reprint Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury
    Zhaohui Wang
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    J Am Soc Nephrol 15:1844-52. 2004
    ..These data point to the inhibition of polyamine catabolism as a therapeutic approach for the prevention of tissue injury in kidney IRI...
  46. ncbi request reprint Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane
    Hong C Li
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 279:43190-7. 2004
    ....
  47. ncbi request reprint Molecular and functional characterization of sodium--hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes
    R Sarangarajan
    Department of Dermatology, University of Cincinnati College of Medicine, OH 45267 0592, USA
    Biochim Biophys Acta 1511:181-92. 2001
    ..These results indicate that cultures of human keratinocytes and melanocytes established from human skin and melanoma cells express the NHE-1 isoform of the sodium--hydrogen exchanger...
  48. pmc Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach
    Jie Xu
    Research Services, Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    Proc Natl Acad Sci U S A 105:17955-60. 2008
    ..We propose that Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells...
  49. pmc Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabine Way, MSB 259G, Cincinnati, OH 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 296:G899-909. 2009
    ..These studies indicate that SSAT-deficient animals are protected against IRI and suggest that SSAT is an important mediator of the tissue damage in IRI...
  50. pmc Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Nephrol 28:330-8. 2008
    ....
  51. doi request reprint Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure
    Hong C Li
    Center on Genetics of Transport, University of Cincinnati, Cincinnati, OH 45267, USA
    J Membr Biol 228:111-24. 2009
    ....
  52. pmc The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0585, USA
    Am J Physiol Cell Physiol 299:C164-74. 2010
    ....
  53. pmc Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter
    Kuppuswami Girijashanker
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 73:1413-23. 2008
    ....
  54. ncbi request reprint Regulation of acid-base transporters by vasopressin in the kidney collecting duct of Brattleboro rat
    Hassane Amlal
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Nephrol 26:194-205. 2006
    ..The objective of these studies was to examine the effects of long-term vasopressin treatment on acid-base transporters in the collecting duct of rat kidney...
  55. ncbi request reprint Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats
    Snezana Petrovic
    Div of Nephrology and Hypertension, Dept of Medicine, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, OH 45267 0585, USA
    Am J Physiol Renal Physiol 290:F1194-201. 2006
    ..The induction of SLC26A7 by vasopressin in OMCD cells of Brattleboro rats is likely an attempt by cells to regulate their cell volume and maintain HCO(3)(-) absorption in a state associated with increased interstitial medullary tonicity...
  56. pmc Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
    Charuhas V Thakar
    Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0585, USA
    J Clin Invest 115:3451-9. 2005
    ..We propose that TSP-1 is a novel regulator of ischemic damage in the kidney and may play an important role in the pathophysiology of ischemic kidney failure...
  57. ncbi request reprint ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
    Lei He
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 70:171-80. 2006
    ....
  58. ncbi request reprint Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent
    Roger T Worrell
    Epithelial Pathobioloby Group, Dept of Surgery, University of Cincinnati, OH 45219, USA
    Am J Physiol Gastrointest Liver Physiol 289:G768-78. 2005
    ..DRA and PAT1 appear to associate with CFTR in the apical membrane. We conclude that the HCO(3)(-) dependence of apical NH(4)(+) inhibition of secretion is due to the action of NH(4)(+) on an apical anion exchanger...
  59. pmc Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3
    Hassane Amlal
    Departments of Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
    J Physiol 553:511-22. 2003
    ..These defects occur despite increased circulating levels of vasopressin. We propose that an ADH-independent mechanism is responsible for the downregulation of AQP2 and the resulting polyuria in NHE3 null mice...
  60. ncbi request reprint Upregulation of collecting duct aquaporin-2 by metabolic acidosis: role of vasopressin
    Hassane Amlal
    Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0585, USA
    Am J Physiol Cell Physiol 286:C1019-30. 2004
    ..A concomitant increase in AVP synthesis and secretion likely plays an essential role in the adaptation of AQP-2 in metabolic acidosis...
  61. ncbi request reprint Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion
    Jie Xu
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, OH 45267 0585, USA
    J Am Soc Nephrol 17:956-67. 2006
    ....
  62. pmc Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia
    S Faroqui
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Kidney Int 73:1141-50. 2008
    ..These effects are independent of food intake or parathyroid hormone levels and likely not mediated through the activation of estrogen receptor alpha subtype...
  63. ncbi request reprint Expression, regulation and the role of SLC26 Cl-/HCO3- exchangers in kidney and gastrointestinal tract
    Manoocher Soleimani
    Department of Medicine, University of Cincinnati and Veterans Affair Medical Center, Cincinnati, OH, USA
    Novartis Found Symp 273:91-102; discussion 103-6, 261-4. 2006
    ..This review in particular focuses on the role and regulation of SLC26A6, A7 and A9 in the kidney and/or gastrointestinal tract...
  64. pmc Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion
    Jie Xu
    Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 284:29470-9. 2009
    ..We propose that SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis or decreased gastric acid secretion in humans...
  65. ncbi request reprint Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury
    Sharon Barone
    Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Cell Physiol 289:C826-35. 2005
    ..The data further suggest that SSAT may play a role in the initiation of injury, whereas p21 and stathmin may be involved in the resolution and recovery after liver IRI...
  66. ncbi request reprint Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Renal Physiol 290:F1559-67. 2006
    ....
  67. doi request reprint Decreased expression of Slc26a4 (Pendrin) and Slc26a7 in the kidneys of carbonic anhydrase II-deficient mice
    Xuming Sun
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Cell Physiol Biochem 21:95-108. 2008
    ..Both exchangers are expressed on the basolateral membrane of A-ICs. The aim of this study was to examine the expression of pendrin, Slc26a7, and AE1 in the kidneys of CAII-deficient (CAR2-null) mice...
  68. ncbi request reprint Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells
    Snezana Petrovic
    Department of Medicine, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1207-16. 2002
    ....
  69. ncbi request reprint Studies of renal injury IV: The GLUT1 gene protects renal cells from cyclosporine A toxicity
    Jesus H Dominguez
    Department of Medicine, VA Medical Center, Indiana University, 1481 W 10th Street, Indianapolis, IN 46202, USA
    Kidney Int 62:127-36. 2002
    ..However, further inhibition of Na+/H+ exchange with amiloride greatly magnified CsA toxicity and GLUT1 gene transcription...
  70. ncbi request reprint Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac
    Hongwei Dou
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 52:1377-84. 2004
    ....
  71. pmc Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking
    Zhiwei Liu
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 365:814-20. 2008
    ....
  72. ncbi request reprint Short-term exposure to a high-protein diet differentially affects glomerular filtration rate but not Acid-base balance in older compared to younger adults
    Erin A Wagner
    Department of Nutritional Sciences, University of Cincinnati Medical Center, Cincinnati, OH 45267 0394, USA
    J Am Diet Assoc 107:1404-8. 2007
    ....
  73. ncbi request reprint Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion
    Sharon Barone
    Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267 0585, USA
    Nephrol Dial Transplant 22:3462-70. 2007
    ....
  74. ncbi request reprint Identification of an apical Cl-/HCO3- exchanger in gastric surface mucous and duodenal villus cells
    Jie Xu
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1225-34. 2003
    ..These data show that AE4 is an apical Cl-/HCO3- exchanger in gastric mucous cells and duodenal villus cells. On the basis of its function and location, we propose that AE4 may play an important role in mucosal protection...
  75. pmc Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension
    Sharon Barone
    Center on Genetics of Transport and Epithelial Biology and the Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Biol Chem 284:5056-66. 2009
    ....
  76. ncbi request reprint slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
    Clifford W Schweinfest
    Hollings Cancer Center and the Departments of Pathology and Laboratory Medicine and of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:37962-71. 2006
    ..In addition, slc26a3 regulates colonic crypt proliferation. Deletion of slc26a3 results in chloride-rich diarrhea and is associated with compensatory adaptive up-regulation of ion-absorbing transporters...
  77. ncbi request reprint Impaired mucus-bicarbonate barrier in Helicobacter pylori-infected mice
    Johanna Henriksnäs
    Dept of Medical Cell Biology, Uppsala Univ, PO Box 571, Uppsala SE 751 23, Sweden
    Am J Physiol Gastrointest Liver Physiol 291:G396-403. 2006
    ..The upregulation of SLC26A9 in H. pylori-infected epithelium might be a result of continuous inhibition of the transporter, e.g., by ammonium, a H. pylori product, which has been previously shown to inhibit SLC26A9...
  78. ncbi request reprint Acute renal failure leads to dysregulation of lung salt and water channels
    Hamid Rabb
    Nephrology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Kidney Int 63:600-6. 2003
    ..We investigated the effects of renal I/R injury on pulmonary epithelial sodium channel (ENaC), Na,K-ATPase and aquaporin expression as a first step in addressing this question...
  79. ncbi request reprint PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum
    Janet E Simpson
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1079-88. 2007
    ..We conclude that 1) PAT-1 is the major contributor to basal Cl(-)/HCO(3)(-) and SO(4)(2-)/HCO(3)(-) exchange across the apical membrane and 2) PAT-1 plays a role in pH(i) regulation in the upper villous epithelium of the murine duodenum...
  80. ncbi request reprint Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice
    Robert W Freel
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, 32610 00275, USA
    Am J Physiol Gastrointest Liver Physiol 290:G719-28. 2006
    ..We conclude that PAT1 is DIDS sensitive and mediates a significant fraction of oxalate efflux across the apical membrane in exchange for Cl(-); as such, PAT1 represents a major apical membrane pathway mediating J(sm)(Ox)...
  81. ncbi request reprint Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice
    Ursula Seidler
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Pflugers Arch 455:757-66. 2008
    ..The data strongly suggests that Slc26a6 acts in concert with NHE3 in electroneutral salt absorption in the small intestine. Slc26a6 also serves to absorb Cl(-) during glucose-driven salt absorption...
  82. pmc Role of PDZK1 in membrane expression of renal brush border ion exchangers
    R Brent Thomson
    Department of Internal Medicine and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Proc Natl Acad Sci U S A 102:13331-6. 2005
    ..In conclusion, the scaffolding protein PDZK1 is essential for the normal expression and function of Cl-anion exchanger CFEX in the proximal tubule of the mammalian kidney...
  83. ncbi request reprint Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion
    Biguang Tuo
    Department of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Gastroenterology 130:349-58. 2006
    ..The present study was designed to examine the role of SLC26A6 in prostaglandin E(2) (PGE(2))-, forskolin-, and carbachol-induced duodenal HCO(3)(-) secretion...
  84. ncbi request reprint Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct
    Hiroshi Ishiguro
    Laboratory of Human Nutrition, Nagoya Univ Graduate School of Medicine, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G447-55. 2007
    ..In conclusion, these results point to the role of Slc26a6 in HCO3- efflux at the apical membrane and also suggest the presence of a robust Slc26a3 compensatory upregulation, which can replace the function of Slc26a6 in pancreatic ducts...
  85. ncbi request reprint Interaction of membrane skeletal protein, protein 4.1B and p55, and sodium bicarbonate cotransporter1 in mouse renal S1-S2 proximal tubules
    Nobuo Terada
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
    J Histochem Cytochem 55:1199-206. 2007
    ..We propose that the 4.1B-containing membrane skeleton may play a role in regulating the Na(+) and HCO(3)(-) reabsorption in S1-S2 proximal tubules...
  86. ncbi request reprint Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line
    Bin Wang
    Department of Environmental Health, and The Center for Environmental Genetics CEG, University Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Physiol Cell Physiol 292:C1523-35. 2007
    ..Cd treatment caused acute renal failure and signs of proximal tubular damage in the BTZIP8-3 but not nontransgenic littermates. BTZIP8-3 mice should be a useful model for studying Cd-induced disease in kidney...
  87. doi request reprint Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Kidney Int 74:438-47. 2008
    ..We suggest that fructose-induced hypertension is likely caused by increased salt absorption by the intestine and kidney and the transporters Slc26a6 and Slc2a5 are essential in this process...

Research Grants13

  1. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..abstract_text> ..
  2. REGULATION OF COLONIC H-K-ATPASE IN THE KIDNEY
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
  3. CHARACTERIZATION OF NA-DEPENDENT HCO3-TRANSPORTERS
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation and gene structure of Na-coupled HCO3 transporters should enhance our knowledge on cell regulation and acid-base homeostasis. ..
  4. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..They should further facilitate future investigations into the role of this transporter in pathophysiologic states affecting electrolyte and acid-base homeostasis. ..