Konstantin Sokolov

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Optical spectroscopy for detection of neoplasia
    Konstantin Sokolov
    Department of Biomedical Engineering, The University of Texas, Austin 78712, USA
    Curr Opin Chem Biol 6:651-8. 2002
  2. ncbi request reprint Polarized reflectance spectroscopy for pre-cancer detection
    Konstantin Sokolov
    Department of Imaging Physics, M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 56, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:1-14. 2004
  3. doi request reprint Cancer imaging and therapy with metal nanoparticles
    Konstantin Sokolov
    Department of Imaging Physics, The UT M D Anderson Cancer Center, Houston, TX 77030, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2005-7. 2009
  4. pmc Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer
    Srivalleesha Mallidi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 9:2825-31. 2009
  5. pmc Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 18:8867-78. 2010
  6. doi request reprint Molecular therapeutic agents for noninvasive photoacoustic image-guided photothermal therapy
    Pratixa P Joshi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4106-9. 2009
  7. doi request reprint On sensitivity of molecular specific photoacoustic imaging using plasmonic gold nanoparticles
    Srivalleesha Mallidi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6338-40. 2009
  8. ncbi request reprint Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo
    Jesse Aaron
    University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA
    J Biomed Opt 12:034007. 2007
  9. pmc Photoacoustic imaging and temperature measurement for photothermal cancer therapy
    Jignesh Shah
    University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA
    J Biomed Opt 13:034024. 2008
  10. pmc Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood
    Doug Yeager
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    J Biomed Opt 17:106016. 2012

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Optical spectroscopy for detection of neoplasia
    Konstantin Sokolov
    Department of Biomedical Engineering, The University of Texas, Austin 78712, USA
    Curr Opin Chem Biol 6:651-8. 2002
    ..In the future, improving our understanding of the biological changes that can be assessed using spectroscopy will not only improve optical techniques but also provide new tools to better understand cancer biology...
  2. ncbi request reprint Polarized reflectance spectroscopy for pre-cancer detection
    Konstantin Sokolov
    Department of Imaging Physics, M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 56, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:1-14. 2004
    ..We gradually progress from cell suspensions to realistic three-dimensional tissue models of epithelium, then to cervical biopsies and, finally to in vivo studies on normal volunteers and clinical patients...
  3. doi request reprint Cancer imaging and therapy with metal nanoparticles
    Konstantin Sokolov
    Department of Imaging Physics, The UT M D Anderson Cancer Center, Houston, TX 77030, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2005-7. 2009
    ..Here, we will present a case study of plasmonic nanoparticles in cancer imaging and therapy...
  4. pmc Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer
    Srivalleesha Mallidi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 9:2825-31. 2009
    ..The results of our study suggest that highly selective and sensitive detection of cancer cells is possible using multiwavelength photoacoustic imaging and molecular specific gold nanoparticles...
  5. pmc Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 18:8867-78. 2010
    ....
  6. doi request reprint Molecular therapeutic agents for noninvasive photoacoustic image-guided photothermal therapy
    Pratixa P Joshi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4106-9. 2009
    ....
  7. doi request reprint On sensitivity of molecular specific photoacoustic imaging using plasmonic gold nanoparticles
    Srivalleesha Mallidi
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6338-40. 2009
    ..The results of our study indicate that highly sensitive detection of cancer cells is feasible using photoacoustic imaging and plasmonic gold nanoparticles...
  8. ncbi request reprint Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo
    Jesse Aaron
    University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA
    J Biomed Opt 12:034007. 2007
    ....
  9. pmc Photoacoustic imaging and temperature measurement for photothermal cancer therapy
    Jignesh Shah
    University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA
    J Biomed Opt 13:034024. 2008
    ..The results of our study suggest that photoacoustic imaging, augmented by ultrasound imaging, is a viable candidate to guide photoabsorber-enhanced photothermal therapy...
  10. pmc Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood
    Doug Yeager
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    J Biomed Opt 17:106016. 2012
    ..Results demonstrate that AUNR detection within the arterial wall can be achieved using both methods, even in the case of imaging through luminal blood...
  11. ncbi request reprint Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles
    Konstantin Sokolov
    Department of Imaging Physics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 63:1999-2004. 2003
    ..They can potentially enable combined screening, detection, and therapy of disease using inexpensive imaging systems; such tools could allow mass screening of diseases such as cancer in resource-poor settings...
  12. doi request reprint Multispectral optical imaging device for in vivo detection of oral neoplasia
    Darren Roblyer
    Rice University, Department of Bioengineering, 6100 Main St, Houston, Texas 77251 1892, USA
    J Biomed Opt 13:024019. 2008
    ....
  13. ncbi request reprint Molecular optical imaging of therapeutic targets of cancer
    Konstantin Sokolov
    Department of Imaging Physics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Adv Cancer Res 96:299-344. 2007
    ....
  14. ncbi request reprint Optical imaging of cervical pre-cancers with structured illumination: an integrated approach
    Mohammed Rahman
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Gynecol Oncol 99:S112-5. 2005
    ....
  15. doi request reprint Intravascular ultrasound and photoacoustic imaging
    STANISLAV EMELIANOV
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:2-5. 2008
    ..Finally, molecular and cellular IVPA imaging was demonstrated using plasmonic nanoparticles. Overall, our studies suggest that plaque detection and characterization can be improved using the combined IVPA/IVUS imaging...
  16. ncbi request reprint Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy
    Ina Pavlova
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA
    Photochem Photobiol 77:550-5. 2003
    ..These changes can explain differences in in vivo fluorescence spectra of normal and precancerous cervical tissue...
  17. pmc Dynamic imaging of molecular assemblies in live cells based on nanoparticle plasmon resonance coupling
    Jesse Aaron
    Department of Biomedical Engineering, Department of Physics, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 9:3612-8. 2009
    ....
  18. doi request reprint Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques
    Bo Wang
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 9:2212-7. 2009
    ....
  19. pmc Preventing protein adsorption and macrophage uptake of gold nanoparticles via a hydrophobic shield
    Timothy A Larson
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    ACS Nano 6:9182-90. 2012
    ..The mPEG-alkyl-thiol coating greatly reduces protein adsorption on GNPs and their macrophage uptake. This has important implications for the design of GNP for biological systems...
  20. ncbi request reprint Compact beveled fiber optic probe design for enhanced depth discrimination in epithelial tissues
    Linda T Nieman
    Department of Biomedical Engineering, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Austin, TX 77030, USA
    Opt Express 17:2780-96. 2009
    ....
  21. pmc Adaptive spectral window sizes for extraction of diagnostic features from optical spectra
    Chih Wen Kan
    The University of Texas, Department of Biomedical Engineering, Austin, Texas 78712 1084, USA
    J Biomed Opt 15:047012. 2010
    ..Because adaptive windows retain most diagnostic information while reducing the number of windows needed for feature extraction, our results suggest that it isolates unique diagnostic features in optical spectra...
  22. doi request reprint Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial
    Linda T Nieman
    The University of Texas M D Anderson Cancer Center, Department of Biomedical Engineering, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    J Biomed Opt 13:024011. 2008
    ..These promising results suggest that OPRS has the potential to aid screening and diagnosis of oral precancer and cancer...
  23. pmc Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods
    Nicholas J Durr
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 7:941-5. 2007
    ....
  24. ncbi request reprint Endoscopic microscopy
    Konstantin Sokolov
    Department of Imaging Physics, UT M D Anderson Cancer Center, Houston, TX 77030, USA
    Dis Markers 18:269-91. 2002
    ..In conclusion, we discuss future improvements to the technology needed to develop robust clinical devices...
  25. doi request reprint Combined photoacoustic and magneto-acoustic imaging
    Min Qu
    Ultrasound Imaging and Therapeutics Research Laboratory in the Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712 0238, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4763-6. 2009
    ..Therefore, the developed imaging technique can be used in wide range of biomedical and clinical application...
  26. pmc Function of mesenchymal stem cells following loading of gold nanotracers
    Laura M Ricles
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, Austin, TX, USA
    Int J Nanomedicine 6:407-16. 2011
    ..The objective of the current study was to assess the effects of loading MSCs with gold nanoparticles on cellular function...
  27. ncbi request reprint Ultrasound imaging to monitor photothermal therapy - feasibility study
    Jignesh Shah
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Opt Express 16:3776-85. 2008
    ..The results of our study suggest that ultrasound imaging is a candidate approach to remotely guide photothermal therapy...
  28. ncbi request reprint Plasmonic nanosensors for imaging intracellular biomarkers in live cells
    Sonia Kumar
    Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
    Nano Lett 7:1338-43. 2007
    ..These multifunctional nanosensors can be adapted to target various intracellular processes especially where transfection or cytotoxic labels are not feasible...
  29. ncbi request reprint A far-red fluorescent contrast agent to image epidermal growth factor receptor expression
    Elizabeth R Hsu
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
    Photochem Photobiol 79:272-9. 2004
    ..This contrast agent should have important clinical applications for use in conjunction with fluorescence spectroscopy or imaging (or both) to facilitate tumor detection and demarcation...

Research Grants6

  1. Polarization Spectroscopy and Imaging of Pre-Cancer
    Konstantin Sokolov; Fiscal Year: 2007
    ..The inexpensive optical sensors proposed here can immediately benefit health care by reducing the number of unnecessary biopsies, enabling combined diagnosis and therapy, and reducing the need for clinical expertise. ..
  2. Biodegradable Plasmonic Nanoparticles for Cancer Imaging and Therapy
    Konstantin V Sokolov; Fiscal Year: 2010
    ....