Research Topics
Species | RAJINDAR SOHALSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
The redox stress hypothesis of agingRajindar S Sohal
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
Free Radic Biol Med 52:539-55. 2012....
Mechanisms of aging: an appraisal of the oxidative stress hypothesisRajindar S Sohal
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 33:575-86. 2002..It is concluded that although there is considerable evidence implicating oxidative stress in the aging process, additional evidence is needed to clearly define the nature of the involvement...- Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of miceRajindar S Sohal
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, PSC 608, Los Angeles, CA 90089 9121, USA
Free Radic Biol Med 40:480-7. 2006.... - Coenzyme Q, oxidative stress and agingRajindar S Sohal
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, PSC 608, Los Angeles, CA 90089 9121, USA
Mitochondrion 7:S103-11. 2007..The possibility that CoQ10 intake affects certain other biological functions by as yet unelucidated mechanisms cannot be ruled out as CoQ has been shown to broadly alter gene expression in mice... - Life span extension in mice by food restriction depends on an energy imbalanceRajindar S Sohal
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
J Nutr 139:533-9. 2009..Our results suggest that ER-induced extension of life span occurs in the mouse genotype in which there is a positive imbalance between energy intake and energy expenditure... - Age-related decrease in expression of mitochondrial DNA encoded subunits of cytochrome c oxidase in Drosophila melanogasterRajindar S Sohal
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, United States
Mech Ageing Dev 129:558-61. 2008..Apparently, the stoichiometry of CcO holoprotein is dynamically altered during the aging process in D. melanogaster... - Oxidative stress hypothesis of agingRajindar S Sohal
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 33:573-4. 2002 - Role of oxidative stress and protein oxidation in the aging processRajindar S Sohal
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 33:37-44. 2002..It is hypothesized that oxidative damage to specific proteins constitutes one of the mechanisms linking oxidative stress/damage and age-associated losses in physiological functions... - Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restrictionMelissa Ferguson
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA
Exp Gerontol 43:757-63. 2008..It is hypothesized that the genotype-specific extension of life span by caloric restriction may involve modulation of oxidative stress produced as a result of an interplay between metabolic rate and energy balance during aging... - Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 miceIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90089, USA
Brain Res 1127:10-8. 2007..The current findings demonstrate that oxidative stress, as reflected by glutathione redox state, increases in the aging brain in regions linked to age-associated losses of function and neurodegenerative diseases... - Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic DrosophilaAnne Cécile V Bayne
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Biochem J 391:277-84. 2005..These findings support the notion that mitochondrial O2*-/H2O2 production at physiological levels is essential for normal biological processes leading to the attainment of a normal lifespan... - Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevityRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 34:207-17. 2003..The main inferences drawn are that: (i) levels of stress resistance may neither be a cause nor a reliable indicator of the rate of aging, and (ii) bolstering antioxidant levels in Drosophila may not delay or slow down the aging process... - Effect of antioxidant-enriched diets on glutathione redox status in tissue homogenates and mitochondria of the senescence-accelerated mouseIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Free Radic Biol Med 39:549-57. 2005..Whether corresponding attenuations occur in age-associated deleterious changes in physiological functions or life span remains unknown... - Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young miceSergey Kamzalov
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles CA 90089-9121, USA
J Nutr 133:3175-80. 2003..Furthermore, CoQ intake enhances the antioxidative potential of tissues by elevating the endogenous amounts of alpha-tocopherol... - Effects of age and caloric restriction on glutathione redox state in miceIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 35:626-35. 2003..Caloric restriction (CR) lowered the GSSG and protein-SSG content. Results suggest that the aging process in the mouse is associated with a gradual pro-oxidizing shift in the glutathione redox state and that CR attenuates this shift... - Effect of age and caloric restriction on coenzyme Q and alpha-tocopherol levels in the ratSergey Kamzalov
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Exp Gerontol 39:1199-205. 2004.... - Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevitiesIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Exp Gerontol 39:1513-9. 2004..Intra-species comparisons may be useful for the identification of biochemical characteristics associated with the variations in life spans... - Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogasterMelissa Ferguson
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Biochem J 390:501-11. 2005..Collectively, these results support the hypothesis that impairment of mitochondrial respiration may be a causal factor in the aging process, and that such impairment may result from and contribute to increased H2O2 production in vivo... - Pro-oxidant shift in glutathione redox state during agingIgor Rebrin
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
Adv Drug Deliv Rev 60:1545-52. 2008..Over-expression of GCL has been shown to prolong the life span of Drosophila by up to 50%, suggesting that perturbations in glutathione metabolism play a causal role in the aging process... - Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of miceMelissa Ferguson
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, United States
Mech Ageing Dev 128:539-45. 2007..The results of this study indicate that CR indeed lowers the rate of metabolism; however, this effect by CR does not necessarily entail the prolongation of the life span of mice... - Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from miceConnie S Yarian
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Mech Ageing Dev 127:79-84. 2006.... - Free aminothiols, glutathione redox state and protein mixed disulphides in aging Drosophila melanogasterIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90089, USA
Biochem J 382:131-6. 2004.... - Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic DrosophilaRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles 90033, USA
Proc Natl Acad Sci U S A 100:301-6. 2003..However, the dominant gain of function by mutant SOD, which occurs in human patients and in the transgenic mouse model of FALS, is not observed in Drosophila... - Coenzyme Q and vitamin E interactionsRajindar S Sohal
Department of Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90089, USA
Methods Enzymol 378:146-51. 2004 - Effects of age and calorie restriction on tryptophan nitration, protein content, and activity of succinyl-CoA:3-ketoacid CoA transferase in rat kidney mitochondriaCatherine Bregere
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 48:609-18. 2010..Loss of SCOT protein in the aged rats may attenuate the capacity of kidney mitochondria to utilize ketone bodies for energy production... - Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domesticaAnne Cécile V Bayne
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA 90089 9121, USA
Free Radic Biol Med 32:1229-34. 2002..Thus, the effect of these SOD/catalase mimetics on the life span of animals seem to be species-specific... - Tissue-specific mitochondrial production of H2O2: its dependence on substrates and sensitivity to inhibitorsLinda K Kwong
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
Methods Enzymol 349:341-6. 2002 - Age-associated perturbations in glutathione synthesis in mouse liverDikran Toroser
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089 9121, USA
Biochem J 405:583-9. 2007..The results suggest that perturbation of the catalytic efficiency of GCL and accumulation of homocysteine from the trans-sulfuration pathway may adversely affect de novo GSH synthesis during aging... - Effects of caloric restriction are species-specificRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Biogerontology 7:157-60. 2006.... - Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogasterJian Ching Ren
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033, USA
Biochem Biophys Res Commun 401:64-8. 2010..These and previous results suggest that CcO is a specific intra-mitochondrial site of age-related deterioration, which may have a broad impact on mitochondrial physiology... - Temperature-dependent trade-offs between longevity and fertility in the Drosophila mutant, methuselahRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Exp Gerontol 41:566-73. 2006.... - Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogasterIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, PSC608, Los Angeles, CA 90089-9121, USA
Mech Ageing Dev 127:869-74. 2006.... - Carbonylation of mitochondrial proteins in Drosophila melanogaster during agingDikran Toroser
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Biochem Biophys Res Commun 363:418-24. 2007..Overall, the results indicate that HNE shows robust age-associated increases in adductation with mitochondrial proteins, and is a good marker for monitoring protein oxidative damage during aging... - Overexpression of Cu,ZnSOD and MnSOD in transgenic DrosophilaRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
Methods Enzymol 349:213-20. 2002 - Biochemical assay of superoxide dismutase activity in DrosophilaRobin J Mockett
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033, USA
Methods Enzymol 349:287-92. 2002 - Specificity of age-related carbonylation of plasma proteins in the mouse and ratChandan K Jana
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90033, USA
Arch Biochem Biophys 397:433-9. 2002..Results of this study indicate that age-associated increase in protein carbonylation is a selective and not a random phenomenon. However, the set of proteins that become carbonylated differs in different species... - Mechanisms of gamma-glutamylcysteine ligase regulationDikran Toroser
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Biochim Biophys Acta 1760:233-44. 2006..Results of this study suggest that mechanisms of modulation of eukaryotic GCL enzymes may include specific binding of ligands such as pyridine dinucleotide phosphates and reversible protein phosphorylation... - Detection and characterization of in vivo nitration and oxidation of tryptophan residues in proteinsCatherine Bregere
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA
Methods Enzymol 441:339-49. 2008..Similar methodology can be applied to the identification of nitrohydroxytryptophan in other proteins... - Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondriaConnie S Yarian
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
Biochem Biophys Res Commun 330:151-6. 2005..The biological consequences of an age-related decrease in aconitase and ATP synthase activities may contribute to the decline in mitochondrial bioenergetics evident during aging... - Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondriaIgor Rebrin
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA
Biochemistry 46:10130-44. 2007.... - Tissue bioavailability and detection of coenzyme QIgor Rebrin
Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles 90089, USA
Methods Enzymol 378:138-45. 2004 - Kinetic characteristics of native gamma-glutamylcysteine ligase in the aging housefly, Musca domestica LDikran Toroser
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA
Biochem Biophys Res Commun 326:586-93. 2005..The age-associated differences in the affinity of native gamma-GCL towards its substrates suggest that de novo synthesis of glutathione would be relatively less efficient in the old houseflies... - In the aging housefly aconitase is the only citric acid cycle enzyme to decline significantlyConnie S Yarian
Department of Molecular Pharmacology and Toxicology, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
J Bioenerg Biomembr 37:91-6. 2005.... - Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogasterWilliam C Orr
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
J Biol Chem 280:37331-8. 2005..These results demonstrate that enhancement of the glutathione biosynthetic capability, particularly in neuronal tissues, can extend the life span of flies, and thus support the oxidative stress hypothesis of aging... - Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the ratLinda K Kwong
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA
Free Radic Biol Med 33:627-38. 2002..Thus, CoQ supplementation resulted in an elevation of CoQ homologues in tissues and their mitochondria, a selective decrease in protein oxidative damage, and an increase in antioxidative potential in the rat... - Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damageLiang Jun Yan
Department of Internal Medicine, Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
EMBO J 21:5164-72. 2002.... - Short-term vitamin E intake fails to improve cognitive or psychomotor performance of aged miceNathalie Sumien
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Free Radic Biol Med 36:1424-33. 2004..Moreover, the current findings indicate that vitamin E could have detrimental effects on some brain functions when implemented in older animals... - Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?William C Orr
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
Exp Gerontol 38:227-30. 2003..Other shortcomings of the transgenic approaches adopted to date will be summarized... - Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged miceShelley R McDonald
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Free Radic Biol Med 38:729-36. 2005..Overall, the findings suggest that concurrent supplementation of alpha-tocopherol with CoQ is more likely to be effective as a potential treatment for age-related learning deficits than supplementation with CoQ or alpha-tocopherol alone... - Analysis of oxidative modification of proteinsLiang-Jun Yan
Southern Methodist University, Dallas, Texas, USA
Curr Protoc Cell Biol . 2002..Methods described in this unit include spectrophotometry, immunoblotting, radiolabeling, GC/MS, ELISA adapted for analysis of oxidative modification... - Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogasterWilliam C Orr
Department of Biological Sciences, Dedman Life Sciences Building, Southern Methodist University, Dallas, Texas 75275, USA
J Biol Chem 278:26418-22. 2003.... - Supplementation with vitamin E fails to attenuate oxidative damage in aged miceNathalie Sumien
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA
Exp Gerontol 38:699-704. 2003..This difference could explain why alpha-tocopherol administration has been found to be ineffective in the extension of the life span... - Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespanJoel D Parker
Department of Ecology and Evolution, Biology Building, University of Lausanne, 1015 Lausanne, Switzerland
Proc Natl Acad Sci U S A 101:3486-9. 2004.... - Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondriaSvetlana N Radyuk
Department of Biological Sciences, Southern Methodist University, Dedman Life Sciences Building, Room 338, 6501 Airline, Dallas, TX 75275, USA
Free Radic Biol Med 41:757-64. 2006..These results suggest that ectopic expression of one of the constituents of the DNA repair system in mitochondria may cause a perturbation in the base excision repair pathway and lower, rather than enhance, survivability... - Modulating longevity in Drosophila by over- and underexpression of glutamate-cysteine ligaseJames M Luchak
Department of Biological Sciences, Southern Methodist University, 6501 Airline Dr, Dallas, TX 75275, USA
Ann N Y Acad Sci 1119:260-73. 2007.... - Genotype and age influence the effect of caloric intake on mortality in miceMichael J Forster
Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, 76107, USA
FASEB J 17:690-2. 2003..Results of this study indicate that CR does not have beneficial effects in all strains of mice, and it increases rather than decreases mortality if initiated in advanced age... - Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cellsSvetlana N Radyuk
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA
Biochem J 371:743-52. 2003..Manipulations in the levels of TPxs demonstrated that, under different stress conditions, these enzymes might have both beneficial and detrimental effects on Drosophila cell viability... - Effect of caloric restriction on life span of the housefly, Musca domesticaT Michael Cooper
Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275, USA
FASEB J 18:1591-3. 2004..Results of this study contradict the widely held view that CR has a life-extending effect in all species...
Research Grants
- COENZYME Q INTAKE, OXIDATIVE STRESS, AND AGING IN MICERAJINDAR SOHAL; Fiscal Year: 2004..Results of this study will provide an understanding of the mechanisms by which CoQ intake may have a beneficial or deleterious effect on the aging process in mice. ..
- CELLULAR AGING AND OXYGEN FREE RADICALSRAJINDAR SOHAL; Fiscal Year: 2005..The significance of this study is that it will provide a direct test of a basic tenet of the oxidative stress hypothesis of aging, namely that mitochondrial oxidative damage plays a key role in the aging process. ..
- CELLULAR AGING AND OXYGEN FREE RADICALSRAJINDAR SOHAL; Fiscal Year: 2007..More broadly, results should provide a direct test of the validity of oxidative stress hypothesis. ..
- DIETARY MODULATION OF CELLULAR OXIDATIVE STRESS IN AGINGRAJINDAR SOHAL; Fiscal Year: 2007..Thus, it will also provide a further critical test of the validity of oxidative stress hypothesis of aging. ..
- PROTEIN TARGETS OF OXIDATIVE DAMAGE DURING AGINGRAJINDAR SOHAL; Fiscal Year: 2003..abstract_text> ..
- CELLULAR AGING AND OXYGEN FREE RADICALSRAJINDAR SOHAL; Fiscal Year: 2000..Such knowledge may also contribute to the explorations of the feasibility of genetic interventions in the aging process. ..
- DIETARY MODULATION OF CELLULAR OXIDATIVE STRESS IN AGINGRAJINDAR SOHAL; Fiscal Year: 2002..Results will also provide a test of the validity of oxidative stress hypothesis of aging. ..
- CELLULAR AGING AND OXYGEN FREE RADICALSRajindar S Sohal; Fiscal Year: 2010..More broadly, results should provide a direct test of the validity of oxidative stress hypothesis. ..