Research Topics
| MICHAEL SOFRONIEWSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAPTetsuya Imura
Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095-1763, USA
J Neurosci 23:2824-32. 2003....
Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injuryGregoire Courtine
Department of Physiological Sciences, University of California, Los Angeles, California 90095 1763, USA
Nat Med 14:69-74. 2008..Targeting interventions toward augmenting the remodeling of relay connections may provide new therapeutic strategies to bypass lesions and restore function after SCI and in other conditions such as stroke and multiple sclerosis...- STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injuryJulia E Herrmann
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
J Neurosci 28:7231-43. 2008..These findings indicate that STAT3 signaling is a critical regulator of certain aspects of reactive astrogliosis and provide additional evidence that scar-forming astrocytes restrict the spread of inflammatory cells after SCI... - Astrocytes: biology and pathologyMichael V Sofroniew
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1763, USA
Acta Neuropathol 119:7-35. 2010.... - Nerve growth factor signaling, neuroprotection, and neural repairM V Sofroniew
Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1763, USA
Annu Rev Neurosci 24:1217-81. 2001..The analysis points to many interesting unanswered questions and to the potential for continuing research on NGF to substantially enhance our understanding of the mechanisms and treatment of neurological disorders... - Molecular dissection of reactive astrogliosis and glial scar formationMichael V Sofroniew
Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
Trends Neurosci 32:638-47. 2009..This article reviews developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis and highlights the potential to identify novel therapeutic molecular targets for diverse neurological disorders... 
Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell typesMichael V Sofroniew
Department of Neurobiology, University of California, Los Angeles, CA, USA
Methods Mol Biol 814:531-44. 2012....- Reactive astrocytes in neural repair and protectionMichael V Sofroniew
Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, CA 90095 1763, USA
Neuroscientist 11:400-7. 2005..Recent studies point toward roles for reactive astrocytes in restricting inflammation and protecting neurons and oligodendrocytes, thereby helping to limit tissue degeneration and preserve function after CNS injury... - PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinaseJ D Dougherty
Interdepartmental Program in the Neurosciences, Program in Neurogenetics, Neurology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosci 25:10773-85. 2005..Additionally, they suggest that PBK/TOPK plays an important role in these progenitors, and further implicates the P38 MAPK pathway in general, as an important regulator of progenitor proliferation and self-renewal... - Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferationIchiro Nakano
Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
J Cell Biol 170:413-27. 2005..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain... - Reactive astrocytes protect tissue and preserve function after spinal cord injuryJill R Faulkner
Department of Neurobiology, University of California, Los Angeles, California 90095-1763, USA
J Neurosci 24:2143-55. 2004.... - The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cellsCindi M Morshead
Department of Surgery, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Eur J Neurosci 18:76-84. 2003..Exposure to GCV in vitro has no effect on adult retinal stem cells hence, we conclude that adult forebrain NSCs comprise a subpopulation of the GFAP-positive cells within the subependyma... - Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neuronsEiji Shigetomi
Departments of Physiology and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1751, USA
J Neurosci 28:6659-63. 2008..The data thus provide a basis to rationalize recent contradictory data on astrocyte-neuron interactions... - Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degenerationAngelo C Lepore
Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6 119, Baltimore, MD 21287, USA
Exp Neurol 211:423-32. 2008..These findings demonstrate that while normal astrocyte function is an important factor in the etiology of motor neuron diseases such as ALS, astrocyte proliferation itself does not play a significant role... - Starring roles for astroglia in barrier pathologies of gut and brainTor C Savidge
Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
Lab Invest 87:731-6. 2007.... - Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathioneTor C Savidge
Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
Gastroenterology 132:1344-58. 2007..Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not known... - Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrusMichael D Saxe
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 103:17501-6. 2006..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior... - Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytesTetsuya Imura
Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
Glia 53:277-93. 2006..The findings provide evidence that GFAP-expressing NSCs are phenotypically and functionally distinct from non-neurogenic astrocytes... - GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrainA Denise R Garcia
Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
Nat Neurosci 7:1233-41. 2004..These findings identify morphologically distinctive GFAP-expressing progenitor cells as the predominant sources of constitutive adult neurogenesis, and provide new methods for manipulating and investigating these cells... - Paradoxical influence of hippocampal neurogenesis on working memoryMichael D Saxe
Center for Neurobiology and Behavior and Howard Hughes Medical Institute, Columbia University, 722 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:4642-6. 2007..These findings suggest that adult-born cells in the dentate gyrus have different, and in some cases, opposite roles in distinct types of memory...
Research Grants
- Reactive scar-forming astrocytes after spinal cord injurMICHAEL SOFRONIEW; Fiscal Year: 2003....
- Biology of GFAP-expressing neural progenitorsMICHAEL SOFRONIEW; Fiscal Year: 2007..abstract_text> ..
- Molecular Dissection of Reactive Astrogliosis: STAT3Michael V Sofroniew; Fiscal Year: 2010....
- Molecular Dissection of Reactive Astrogliosis: STAT3MICHAEL SOFRONIEW; Fiscal Year: 2009....
- Molecular Dissection of Reactive Astrogliosis: STAT3MICHAEL SOFRONIEW; Fiscal Year: 2009....