MICHAEL SOFRONIEW

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP
    Tetsuya Imura
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 23:2824-32. 2003
  2. pmc Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
    Gregoire Courtine
    Department of Physiological Sciences, University of California, Los Angeles, California 90095 1763, USA
    Nat Med 14:69-74. 2008
  3. pmc STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    Julia E Herrmann
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:7231-43. 2008
  4. pmc Astrocytes: biology and pathology
    Michael V Sofroniew
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1763, USA
    Acta Neuropathol 119:7-35. 2010
  5. ncbi request reprint Nerve growth factor signaling, neuroprotection, and neural repair
    M V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    Annu Rev Neurosci 24:1217-81. 2001
  6. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
  7. doi request reprint Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types
    Michael V Sofroniew
    Department of Neurobiology, University of California, Los Angeles, CA, USA
    Methods Mol Biol 814:531-44. 2012
  8. ncbi request reprint Reactive astrocytes in neural repair and protection
    Michael V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, CA 90095 1763, USA
    Neuroscientist 11:400-7. 2005
  9. ncbi request reprint PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase
    J D Dougherty
    Interdepartmental Program in the Neurosciences, Program in Neurogenetics, Neurology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 25:10773-85. 2005
  10. pmc Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
    Ichiro Nakano
    Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 170:413-27. 2005

Research Grants

  1. Reactive scar-forming astrocytes after spinal cord injur
    MICHAEL SOFRONIEW; Fiscal Year: 2003
  2. Biology of GFAP-expressing neural progenitors
    MICHAEL SOFRONIEW; Fiscal Year: 2007
  3. Molecular Dissection of Reactive Astrogliosis: STAT3
    Michael V Sofroniew; Fiscal Year: 2010
  4. Molecular Dissection of Reactive Astrogliosis: STAT3
    MICHAEL SOFRONIEW; Fiscal Year: 2009
  5. Molecular Dissection of Reactive Astrogliosis: STAT3
    MICHAEL SOFRONIEW; Fiscal Year: 2009

Collaborators

  • Michael R Drew
  • Eric M Wexler
  • CHARLES LEE HOWE
  • Harley Kornblum
  • Jessica Carmen
  • Tor C Savidge
  • Douglas Kerr
  • C M Morshead
  • V Reggie Edgerton
  • R R Roy
  • Daniel Geschwind
  • Tetsuya Imura
  • Julia E Herrmann
  • Michael D Saxe
  • Ichiro Nakano
  • A Denise R Garcia
  • Yan Ao
  • Eiji Shigetomi
  • Gregoire Courtine
  • Angelo C Lepore
  • Jingwei Qi
  • Bingbing Song
  • Eric R Kandel
  • Gael Malleret
  • Rene Hen
  • J D Dougherty
  • Ngan B Doan
  • Jill R Faulkner
  • Nicholas J Maragakis
  • Kiyoshi Takeda
  • Baljit S Khakh
  • David N Bowser
  • Britta Rauck
  • Rose A Korsak
  • Shizuo Akira
  • Hui Zhong
  • Thu K Nguyen
  • Christine Dejea
  • Indira Mendez
  • Svetlana Vronskaya
  • A Denise Garcia
  • Jing Wen Wang
  • James E Monckton
  • Denis J David
  • Fortunato Battaglia
  • Luca Santarelli
  • Theresa K Kelly
  • Hong Wu
  • A D R Garcia
  • Andres A Paucar
  • Xin Liu
  • M Livingstone
  • Joseph D Dougherty
  • Stanley F Nelson
  • Amani Zewail
  • Matthias Groszer
  • R Polakiewicz
  • Jing Ou
  • I Nakano
  • Ruchi Bajpai
  • Kevin J Kim
  • Alexey V Terskikh
  • William A Freije
  • B Norris
  • Toby G Bush
  • Keith E Tansey
  • Michael J Woo

Detail Information

Publications20

  1. ncbi request reprint The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP
    Tetsuya Imura
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 23:2824-32. 2003
    ....
  2. pmc Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury
    Gregoire Courtine
    Department of Physiological Sciences, University of California, Los Angeles, California 90095 1763, USA
    Nat Med 14:69-74. 2008
    ..Targeting interventions toward augmenting the remodeling of relay connections may provide new therapeutic strategies to bypass lesions and restore function after SCI and in other conditions such as stroke and multiple sclerosis...
  3. pmc STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    Julia E Herrmann
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:7231-43. 2008
    ..These findings indicate that STAT3 signaling is a critical regulator of certain aspects of reactive astrogliosis and provide additional evidence that scar-forming astrocytes restrict the spread of inflammatory cells after SCI...
  4. pmc Astrocytes: biology and pathology
    Michael V Sofroniew
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1763, USA
    Acta Neuropathol 119:7-35. 2010
    ....
  5. ncbi request reprint Nerve growth factor signaling, neuroprotection, and neural repair
    M V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    Annu Rev Neurosci 24:1217-81. 2001
    ..The analysis points to many interesting unanswered questions and to the potential for continuing research on NGF to substantially enhance our understanding of the mechanisms and treatment of neurological disorders...
  6. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
    ..This article reviews developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis and highlights the potential to identify novel therapeutic molecular targets for diverse neurological disorders...
  7. doi request reprint Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types
    Michael V Sofroniew
    Department of Neurobiology, University of California, Los Angeles, CA, USA
    Methods Mol Biol 814:531-44. 2012
    ....
  8. ncbi request reprint Reactive astrocytes in neural repair and protection
    Michael V Sofroniew
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, CA 90095 1763, USA
    Neuroscientist 11:400-7. 2005
    ..Recent studies point toward roles for reactive astrocytes in restricting inflammation and protecting neurons and oligodendrocytes, thereby helping to limit tissue degeneration and preserve function after CNS injury...
  9. ncbi request reprint PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase
    J D Dougherty
    Interdepartmental Program in the Neurosciences, Program in Neurogenetics, Neurology Department, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 25:10773-85. 2005
    ..Additionally, they suggest that PBK/TOPK plays an important role in these progenitors, and further implicates the P38 MAPK pathway in general, as an important regulator of progenitor proliferation and self-renewal...
  10. pmc Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
    Ichiro Nakano
    Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 170:413-27. 2005
    ..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain...
  11. ncbi request reprint Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....
  12. ncbi request reprint The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells
    Cindi M Morshead
    Department of Surgery, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 18:76-84. 2003
    ..Exposure to GCV in vitro has no effect on adult retinal stem cells hence, we conclude that adult forebrain NSCs comprise a subpopulation of the GFAP-positive cells within the subependyma...
  13. pmc Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons
    Eiji Shigetomi
    Departments of Physiology and Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1751, USA
    J Neurosci 28:6659-63. 2008
    ..The data thus provide a basis to rationalize recent contradictory data on astrocyte-neuron interactions...
  14. doi request reprint Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
    Angelo C Lepore
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6 119, Baltimore, MD 21287, USA
    Exp Neurol 211:423-32. 2008
    ..These findings demonstrate that while normal astrocyte function is an important factor in the etiology of motor neuron diseases such as ALS, astrocyte proliferation itself does not play a significant role...
  15. ncbi request reprint Starring roles for astroglia in barrier pathologies of gut and brain
    Tor C Savidge
    Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Lab Invest 87:731-6. 2007
    ....
  16. ncbi request reprint Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione
    Tor C Savidge
    Division of Gastroenterology, The University of Texas Medical Branch, Galveston, Texas, USA
    Gastroenterology 132:1344-58. 2007
    ..Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not known...
  17. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  18. ncbi request reprint Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes
    Tetsuya Imura
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    Glia 53:277-93. 2006
    ..The findings provide evidence that GFAP-expressing NSCs are phenotypically and functionally distinct from non-neurogenic astrocytes...
  19. ncbi request reprint GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
    A Denise R Garcia
    Department of Neurobiology and Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
    Nat Neurosci 7:1233-41. 2004
    ..These findings identify morphologically distinctive GFAP-expressing progenitor cells as the predominant sources of constitutive adult neurogenesis, and provide new methods for manipulating and investigating these cells...
  20. pmc Paradoxical influence of hippocampal neurogenesis on working memory
    Michael D Saxe
    Center for Neurobiology and Behavior and Howard Hughes Medical Institute, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:4642-6. 2007
    ..These findings suggest that adult-born cells in the dentate gyrus have different, and in some cases, opposite roles in distinct types of memory...

Research Grants11

  1. Reactive scar-forming astrocytes after spinal cord injur
    MICHAEL SOFRONIEW; Fiscal Year: 2003
    ....
  2. Biology of GFAP-expressing neural progenitors
    MICHAEL SOFRONIEW; Fiscal Year: 2007
    ..abstract_text> ..
  3. Molecular Dissection of Reactive Astrogliosis: STAT3
    Michael V Sofroniew; Fiscal Year: 2010
    ....
  4. Molecular Dissection of Reactive Astrogliosis: STAT3
    MICHAEL SOFRONIEW; Fiscal Year: 2009
    ....
  5. Molecular Dissection of Reactive Astrogliosis: STAT3
    MICHAEL SOFRONIEW; Fiscal Year: 2009
    ....