Merav Socolovsky

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Negative autoregulation by FAS mediates robust fetal erythropoiesis
    Merav Socolovsky
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 5:e252. 2007
  2. ncbi Molecular insights into stress erythropoiesis
    Merav Socolovsky
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Hematol 14:215-24. 2007
  3. ncbi A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression
    Ramona Pop
    Department of Pediatrics and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 8:. 2010
  4. ncbi Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways
    Miroslav Koulnis
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Blood 119:1228-39. 2012
  5. ncbi Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response
    Miroslav Koulnis
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e21192. 2011
  6. ncbi Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
  7. ncbi Global DNA demethylation during mouse erythropoiesis in vivo
    Jeffrey R Shearstone
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 334:799-802. 2011
  8. ncbi Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities
    Ermelinda Porpiglia
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 10:e1001383. 2012
  9. ncbi Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein
    Byoung Heon Kang
    Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:16758-67. 2011
  10. ncbi Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system
    Jing Zhang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Blood 102:3938-46. 2003

Research Grants

  1. Molecular Analysis of Erythropoiesis In Vivo
    Merav Socolovsky; Fiscal Year: 2006
  2. Molecular Analysis of the Erythropoietic Stress Response in vivo
    Merav Socolovsky; Fiscal Year: 2007
  3. Molecular Analysis of the Erythropoietic Stress Response in vivo
    Merav Socolovsky; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Negative autoregulation by FAS mediates robust fetal erythropoiesis
    Merav Socolovsky
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 5:e252. 2007
    ..We suggest that apoptosis in erythroid development mediates robust homeostasis regulating the number of red blood cells reaching maturity...
  2. ncbi Molecular insights into stress erythropoiesis
    Merav Socolovsky
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Hematol 14:215-24. 2007
    ..A mechanistic understanding of stress erythropoiesis would benefit multiple clinical settings, and may aid in understanding leukemogenesis...
  3. ncbi A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression
    Ramona Pop
    Department of Pediatrics and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 8:. 2010
    ..1 expression and S-phase progression provides a "synchromesh" mechanism that "locks" the erythroid differentiation program to the cell cycle clock, ensuring precise coordination of critical differentiation events...
  4. ncbi Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways
    Miroslav Koulnis
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Blood 119:1228-39. 2012
    ..Furthermore, pathologic elevation of Bcl-x(L) may be the result of impaired adaptation, with implications for myeloproliferative disease mechanisms...
  5. ncbi Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response
    Miroslav Koulnis
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e21192. 2011
    ....
  6. ncbi Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
    Ying Liu
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 108:123-33. 2006
    ..Therefore, Fas and FasL are negative regulators of erythropoiesis. Epo-mediated suppression of erythroblast Fas and FasL is a novel stress response pathway that facilitates erythroblast expansion in vivo...
  7. ncbi Global DNA demethylation during mouse erythropoiesis in vivo
    Jeffrey R Shearstone
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 334:799-802. 2011
    ..Hence, DNA demethylation can occur globally during somatic cell differentiation, providing an experimental model for its study in development and disease...
  8. ncbi Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities
    Ermelinda Porpiglia
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 10:e1001383. 2012
    ..They suggest that dynamic behavior may encode information during STAT signal transduction...
  9. ncbi Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein
    Byoung Heon Kang
    Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:16758-67. 2011
    ..Therefore, an AIP-Tom20 recognition contributes to cell survival in development and cancer by mediating the mitochondrial import of survivin...
  10. ncbi Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system
    Jing Zhang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Blood 102:3938-46. 2003
    ..Rather, oncogenic H-ras promotes abnormal proliferation of CFU-E progenitors and early erythroblasts and supports their erythropoietin (Epo)-independent growth...
  11. ncbi Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells
    Lev Silberstein
    Department of Hematology, Cambridge Institute for Medical Research, Cambridge University, Hills Road, Cambridge CB2 2XY, UK
    Stem Cells 23:1378-88. 2005
    ..Moreover, activity in a proportion of thymocytes and other SCL-negative cell types suggests the existence of a silencer elsewhere in the SCL locus...
  12. ncbi Rb and N-ras function together to control differentiation in the mouse
    Chiaki Takahashi
    Department of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 23:5256-68. 2003
    ..Our findings suggest that the control of differentiation and proliferation by Rb are genetically separable...
  13. ncbi The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium
    Cathrin Brisken
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:14241-5. 2002
    ....

Research Grants7

  1. Molecular Analysis of Erythropoiesis In Vivo
    Merav Socolovsky; Fiscal Year: 2006
    ..Components of the apoptotic machinery will be assessed as candidate modulators of erythropoietic rate and/or leukemogenic transformation. ..
  2. Molecular Analysis of the Erythropoietic Stress Response in vivo
    Merav Socolovsky; Fiscal Year: 2007
    ..The proposed work aims to understand mechanisms regulating the rapid production of red cells. This may contribute to future therapies of anemias, including anemia and fatigue associated with cancer. ..
  3. Molecular Analysis of the Erythropoietic Stress Response in vivo
    Merav Socolovsky; Fiscal Year: 2010
    ..The proposed work aims to understand mechanisms regulating the rapid production of red cells. This may contribute to future therapies of anemias, including anemia and fatigue associated with cancer. ..