Research Topics
Genomes and Genes | Jonathan SoboloffSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Location and function of STIM1 in the activation of Ca2+ entry signalsThamara Hewavitharana
Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Biol Chem 283:26252-62. 2008..This suggests that PM-STIM1 may play a regulatory role in SOC activation...
Orai1 and STIM reconstitute store-operated calcium channel functionJonathan Soboloff
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, 21201, USA
J Biol Chem 281:20661-5. 2006..The suppression of SOC function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1...- Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cellsYicheng Zhang
Arthritis and Immune Disorder Research Centre, University Health Network and Department of Immunology, University of Toronto, Medical Discovery Tower, 8th Floor, Rm 8-356, 101 College St, Toronto, ON, Canada M5G 1L7
Mol Pharmacol 70:1424-34. 2006..Taken together, these results demonstrate that combined mitochondrial ROS generation and Ca2+ influx blockade by Ec is required for cell death... - STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ EntryJonathan Soboloff
Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, 21201, USA
Curr Biol 16:1465-70. 2006..The opposing functions of STIM1 and STIM2 suggest they may play a coordinated role in controlling SOC-mediated Ca(2+) entry signals... - STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channelsMaria A Spassova
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:4040-5. 2006..As a cell surface signaling protein, STIM1 represents a key pharmacological target to control fundamental Ca(2+)-regulated processes including secretion, contraction, metabolism, cell division, and apoptosis... - Role of STIM and Orai proteins in the store-operated calcium signaling pathwayThamara Hewavitharana
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States
Cell Calcium 42:173-82. 2007..Here we discuss recent information and ideas about the coupling between these proteins that leads to store-operated channel activation... - Signal transduction. Calcium entry signals--trickles and torrentsDonald L Gill
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Science 313:183-4. 2006 - A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2Li Ping He
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 280:10997-1006. 2005..The results indicate a strong functional link between the operation of expressed TRPC channels and endogenous SOC activity... - Calcium entry mediated by SOCs and TRP channels: variations and enigmaMaria A Spassova
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
Biochim Biophys Acta 1742:9-20. 2004..Here we discuss recent information and ideas on the exchange of signals between the plasma membrane (PM) and ER that results in activation of Ca(2+) entry channels following receptor stimulation and/or store emptying... - Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communicationJonathan Soboloff
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
Biochim Biophys Acta 1763:1161-8. 2006..This molecular pas-de-deux between ER and PM components represents not only a crucial signaling pathway, but also a new paradigm in inter-organelle communication... - Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cellsJonathan Soboloff
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 280:39786-94. 2005..This tight coupling between TRPC6 and L-type channels is probably important in mediating smooth muscle cell membrane potential and muscle contraction... - A common mechanism underlies stretch activation and receptor activation of TRPC6 channelsMaria A Spassova
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:16586-91. 2006..The mechanosensing properties of TRPC6 channels highly expressed in smooth muscle cells are likely to play a key role in regulating myogenic tone in vascular tissue... - CRACM1 multimers form the ion-selective pore of the CRAC channelMonika Vig
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Biol 16:2073-9. 2006..Our data provide unequivocal evidence that CRACM1 multimers form the Ca(2+)-selective CRAC-channel pore... - STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activationSuhel Parvez
Center for Biomedical Research and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
FASEB J 22:752-61. 2008..The results reveal a novel bimodal control of CRAC channels by STIM2, the store dependence and CaM regulation, which indicates that the STIM2/CRACM1 complex may be under the control of both luminal and cytoplasmic Ca2+ levels... - Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsHwei Ling Ong
Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 282:9105-16. 2007..Thus, these data suggest a common molecular basis for SOC and CRAC channels... - Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purgingJonathan Soboloff
AIDRC, University Health Network and the Department of Immunology, University of Toronto, Toronto, Ontario, Canada
Exp Hematol 30:1219-26. 2002..CONCLUSIONS: These studies suggest that SOC antagonists have potential as purging agents for residual leukemia cells present in bone marrow in the context of high-dose chemotherapy and autologous transplantation for leukemia... - Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cellsJonathan Soboloff
Arthritis and Immune Disorder Research Centre, University Health Network and the Department of Immunology, University of Toronto, Ontario M5G 2M9, Canada
J Biol Chem 277:13812-20. 2002....