Jonathan Soboloff

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Location and function of STIM1 in the activation of Ca2+ entry signals
    Thamara Hewavitharana
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 283:26252-62. 2008
  2. ncbi request reprint Orai1 and STIM reconstitute store-operated calcium channel function
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Biol Chem 281:20661-5. 2006
  3. ncbi request reprint Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells
    Yicheng Zhang
    Arthritis and Immune Disorder Research Centre, University Health Network and Department of Immunology, University of Toronto, Medical Discovery Tower, 8th Floor, Rm 8 356, 101 College St, Toronto, ON, Canada M5G 1L7
    Mol Pharmacol 70:1424-34. 2006
  4. ncbi request reprint STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, 21201, USA
    Curr Biol 16:1465-70. 2006
  5. pmc STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:4040-5. 2006
  6. ncbi request reprint Role of STIM and Orai proteins in the store-operated calcium signaling pathway
    Thamara Hewavitharana
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States
    Cell Calcium 42:173-82. 2007
  7. ncbi request reprint Signal transduction. Calcium entry signals--trickles and torrents
    Donald L Gill
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 313:183-4. 2006
  8. ncbi request reprint Calcium entry mediated by SOCs and TRP channels: variations and enigma
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1742:9-20. 2004
  9. ncbi request reprint Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1763:1161-8. 2006
  10. ncbi request reprint A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2
    Li Ping He
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 280:10997-1006. 2005

Collaborators

Detail Information

Publications17

  1. pmc Location and function of STIM1 in the activation of Ca2+ entry signals
    Thamara Hewavitharana
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 283:26252-62. 2008
    ..This suggests that PM-STIM1 may play a regulatory role in SOC activation...
  2. ncbi request reprint Orai1 and STIM reconstitute store-operated calcium channel function
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Biol Chem 281:20661-5. 2006
    ..The suppression of SOC function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1...
  3. ncbi request reprint Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells
    Yicheng Zhang
    Arthritis and Immune Disorder Research Centre, University Health Network and Department of Immunology, University of Toronto, Medical Discovery Tower, 8th Floor, Rm 8 356, 101 College St, Toronto, ON, Canada M5G 1L7
    Mol Pharmacol 70:1424-34. 2006
    ..Taken together, these results demonstrate that combined mitochondrial ROS generation and Ca2+ influx blockade by Ec is required for cell death...
  4. ncbi request reprint STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, 21201, USA
    Curr Biol 16:1465-70. 2006
    ..The opposing functions of STIM1 and STIM2 suggest they may play a coordinated role in controlling SOC-mediated Ca(2+) entry signals...
  5. pmc STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:4040-5. 2006
    ..As a cell surface signaling protein, STIM1 represents a key pharmacological target to control fundamental Ca(2+)-regulated processes including secretion, contraction, metabolism, cell division, and apoptosis...
  6. ncbi request reprint Role of STIM and Orai proteins in the store-operated calcium signaling pathway
    Thamara Hewavitharana
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States
    Cell Calcium 42:173-82. 2007
    ..Here we discuss recent information and ideas about the coupling between these proteins that leads to store-operated channel activation...
  7. ncbi request reprint Signal transduction. Calcium entry signals--trickles and torrents
    Donald L Gill
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 313:183-4. 2006
  8. ncbi request reprint Calcium entry mediated by SOCs and TRP channels: variations and enigma
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1742:9-20. 2004
    ..Here we discuss recent information and ideas on the exchange of signals between the plasma membrane (PM) and ER that results in activation of Ca(2+) entry channels following receptor stimulation and/or store emptying...
  9. ncbi request reprint Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1763:1161-8. 2006
    ..This molecular pas-de-deux between ER and PM components represents not only a crucial signaling pathway, but also a new paradigm in inter-organelle communication...
  10. ncbi request reprint A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2
    Li Ping He
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 280:10997-1006. 2005
    ..The results indicate a strong functional link between the operation of expressed TRPC channels and endogenous SOC activity...
  11. pmc A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:16586-91. 2006
    ..The mechanosensing properties of TRPC6 channels highly expressed in smooth muscle cells are likely to play a key role in regulating myogenic tone in vascular tissue...
  12. ncbi request reprint Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 280:39786-94. 2005
    ..This tight coupling between TRPC6 and L-type channels is probably important in mediating smooth muscle cell membrane potential and muscle contraction...
  13. ncbi request reprint CRACM1 multimers form the ion-selective pore of the CRAC channel
    Monika Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 16:2073-9. 2006
    ..Our data provide unequivocal evidence that CRACM1 multimers form the Ca(2+)-selective CRAC-channel pore...
  14. pmc STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
    Suhel Parvez
    Center for Biomedical Research and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    FASEB J 22:752-61. 2008
    ..The results reveal a novel bimodal control of CRAC channels by STIM2, the store dependence and CaM regulation, which indicates that the STIM2/CRACM1 complex may be under the control of both luminal and cytoplasmic Ca2+ levels...
  15. pmc Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components
    Hwei Ling Ong
    Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:9105-16. 2007
    ..Thus, these data suggest a common molecular basis for SOC and CRAC channels...
  16. ncbi request reprint Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging
    Jonathan Soboloff
    AIDRC, University Health Network and the Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    Exp Hematol 30:1219-26. 2002
    ..The aim of this study was to assess the potential of store-operated Ca(2+) channel (SOC) antagonists as purging agents for leukemia cells...
  17. ncbi request reprint Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells
    Jonathan Soboloff
    Arthritis and Immune Disorder Research Centre, University Health Network and the Department of Immunology, University of Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 277:13812-20. 2002
    ....