Burton E Sobel

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis
    Burton E Sobel
    Department of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 23:1979-89. 2003
  2. ncbi request reprint Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus
    Friederike K Keating
    Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    Am J Cardiol 92:1362-5. 2003
  3. ncbi request reprint Cardiovascular complications in diabetes mellitus
    Burton E Sobel
    University of Vermont, Colchester, VT 05446, USA
    Curr Opin Pharmacol 5:143-8. 2005
  4. ncbi request reprint wnt3a but not wnt11 supports self-renewal of embryonic stem cells
    Dinender K Singla
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 345:789-95. 2006
  5. ncbi request reprint Conundrums in the combined use of anticoagulants and antiplatelet drugs
    David J Schneider
    Cardiology Division and Cardiovascular Research Institute, University of Vermont, Burlington, USA
    Circulation 116:305-15. 2007
  6. pmc Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease
    Feliciano A Serrano
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Thromb J 5:7. 2007
  7. ncbi request reprint Optimizing cardiovascular outcomes in diabetes mellitus
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont, Colchester, Vermont 05446, USA
    Am J Med 120:S3-11. 2007
  8. doi request reprint Coronary revascularization in patients with type 2 diabetes and results of the BARI 2D trial
    Burton E Sobel
    Department of Medicine, University of Vermont College of Medicine, University of Vermont, Colchester Research Facility, Colchester, Vermont 05446, USA
    Coron Artery Dis 21:189-98. 2010
  9. doi request reprint Attenuation of apoptosis and the eye of the beholder
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont College of Medicine, Burlington, Vermont, USA
    Coron Artery Dis 19:55-8. 2008
  10. doi request reprint Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont, Colchester Research Facility, Colchester, VT 05446, USA
    Circulation 124:695-703. 2011

Detail Information

Publications87

  1. ncbi request reprint Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis
    Burton E Sobel
    Department of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 23:1979-89. 2003
    ....
  2. ncbi request reprint Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus
    Friederike K Keating
    Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    Am J Cardiol 92:1362-5. 2003
    ....
  3. ncbi request reprint Cardiovascular complications in diabetes mellitus
    Burton E Sobel
    University of Vermont, Colchester, VT 05446, USA
    Curr Opin Pharmacol 5:143-8. 2005
    ....
  4. ncbi request reprint wnt3a but not wnt11 supports self-renewal of embryonic stem cells
    Dinender K Singla
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 345:789-95. 2006
    ..Thus, our results show that conditioned medium from wnt3a but not wnt11 expressing cells can maintain ES cells in self-renewal and in a pluripotent state...
  5. ncbi request reprint Conundrums in the combined use of anticoagulants and antiplatelet drugs
    David J Schneider
    Cardiology Division and Cardiovascular Research Institute, University of Vermont, Burlington, USA
    Circulation 116:305-15. 2007
  6. pmc Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease
    Feliciano A Serrano
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Thromb J 5:7. 2007
    ..To determine whether expression of FcGammaRIIA impacts platelet reactivity we quantified its expression and platelet reactivity in 33 patients with ESRD who were undergoing hemodialysis...
  7. ncbi request reprint Optimizing cardiovascular outcomes in diabetes mellitus
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont, Colchester, Vermont 05446, USA
    Am J Med 120:S3-11. 2007
    ....
  8. doi request reprint Coronary revascularization in patients with type 2 diabetes and results of the BARI 2D trial
    Burton E Sobel
    Department of Medicine, University of Vermont College of Medicine, University of Vermont, Colchester Research Facility, Colchester, Vermont 05446, USA
    Coron Artery Dis 21:189-98. 2010
    ..It also addresses the implications of some of the data in the Bypass Angioplasty Revascularization Investigation in type 2 diabetes (BARI 2D) trial...
  9. doi request reprint Attenuation of apoptosis and the eye of the beholder
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont College of Medicine, Burlington, Vermont, USA
    Coron Artery Dis 19:55-8. 2008
    ....
  10. doi request reprint Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
    Burton E Sobel
    Cardiovascular Research Institute, University of Vermont, Colchester Research Facility, Colchester, VT 05446, USA
    Circulation 124:695-703. 2011
    ....
  11. doi request reprint Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation
    David J Schneider
    Department of Medicine, Cardiology Unit and Cardiovascular Research Institute, University of Vermont, Burlington, Vermont 05446, USA
    Coron Artery Dis 20:175-8. 2009
    ..These results and this approach to selection of promising interventions should be helpful in streamlining the design of clinical trials...
  12. ncbi request reprint The effects of bivalirudin compared with those of unfractionated heparin plus eptifibatide on inflammation and thrombin generation and activity during coronary intervention
    Friederike K Keating
    Cardiology Unit, Department of Medicine, University of Vermont Burlington, Colchester, Vermont 05446, USA
    Coron Artery Dis 16:401-5. 2005
    ..To characterize effects of bivalirudin compared with unfractionated heparin plus eptifibatide on inflammation, and thrombin generation and activity after percutaneous coronary intervention...
  13. doi request reprint A profibrotic effect of plasminogen activator inhibitor type-1 (PAI-1) in the heart
    A K M Tarikuz Zaman
    University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Exp Biol Med (Maywood) 234:246-54. 2009
    ..05). Thus, PAI-1 is profibrotic in the heart subjected to infarction. Accordingly, overexpression of PAI-1 is a promising target for attenuation of heart failure after MI that may be exacerbated by fibrosis...
  14. ncbi request reprint Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin
    Friederike K Keating
    Cardiology Unit, Department of Medicine, University of Vermont Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401, USA
    Thromb Res 118:361-9. 2006
    ....
  15. pmc Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy
    David J Schneider
    Cardiology Division and Cardiovascular Research Institute, University of Vermont, Burlington, Vermont, USA
    Diabetes Care 32:944-9. 2009
    ..To determine whether obesity increases platelet reactivity and thrombin activity in patients with type 2 diabetes plus stable coronary artery disease...
  16. ncbi request reprint Relation of leukocytosis to C-reactive protein and interleukin-6 among patients undergoing percutaneous coronary intervention
    Prospero B Gogo
    Division of Cardiology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Am J Cardiol 96:538-42. 2005
    ..78, 95% confidence interval 1.07 to 13.3, p = 0.04). In conclusion, in patients with troponin I negative coronary syndromes, a pre-PCI elevation in the WBC count reflected cytokine-mediated inflammation...
  17. doi request reprint Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin
    David J Schneider
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Thrombolysis 28:6-9. 2009
    ....
  18. ncbi request reprint Variation in the ability of glycoprotein IIb-IIIa antagonists to exert and maintain their inhibitory effects on the binding of fibrinogen
    David J Schneider
    Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    J Cardiovasc Pharmacol 46:41-5. 2005
    ..01). The differences are consistent with the biphasic binding of fibrinogen to GP IIb-IIIa. The clinical implications of this observation merit evaluation to potentially improve care of patients and to guide future drug development...
  19. ncbi request reprint Attenuation of platelet reactivity by enoxaparin compared with unfractionated heparin in patients undergoing haemodialysis
    Atul Aggarwal
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Nephrol Dial Transplant 19:1559-63. 2004
    ..Because both haemodialysis and unfractionated heparin (UFH) can increase platelet reactivity, we compared platelet reactivity during haemodialysis when patients were anticoagulated with UFH or enoxaparin...
  20. ncbi request reprint Insulin resistance increases PAI-1 in the heart
    Burton E Sobel
    University of Vermont, Cardiovascular Research Institute Burlington, VT, USA
    Biochem Biophys Res Commun 346:102-7. 2006
    ..Such increases may contribute to fibrosis and diastolic dysfunction typical late after infarction in patients with insulin resistance...
  21. ncbi request reprint Attenuation of neointimal vascular smooth muscle cellularity in atheroma by plasminogen activator inhibitor type 1 (PAI-1)
    David J Schneider
    University of Vermont, Colchester Research Facility, 208 S Park Drive, Colchester, VT 05446, USA
    J Histochem Cytochem 52:1091-9. 2004
    ..03). Accordingly, increased expression of PAI-1 protein by VSMCs reduces their migration in vitro and their contribution to neointimal cellularity in vivo...
  22. ncbi request reprint Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E
    Maria H Clough
    Department of Pathology, 89 Beaumont Avenue, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Histochem Cytochem 53:603-10. 2005
    ..018. Accordingly, genetically induced intensification of insulin resistance increases atheroma formation. Furthermore, attenuation of insulin resistance by treatment with pioglitazone decreases accumulation of lipid in the neointima...
  23. ncbi request reprint Increased plasminogen activator inhibitor type-1 (PAI-1) in the heart as a function of age
    Burton E Sobel
    University of Vermont, Cardiovascular Research Institute, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Life Sci 79:1600-5. 2006
    ....
  24. ncbi request reprint Comparison of inflammatory markers in patients with diabetes mellitus versus those without before and after coronary arterial stenting
    Atul Aggarwal
    Cardiology Unit, University of Vermont, Burlington, Vermont 05401, USA
    Am J Cardiol 92:924-9. 2003
    ..Thus, patients with and without diabetes exhibit different inflammatory responses to stenting, reflecting the lower preprocedural inflammation in those without diabetes versus those with diabetes...
  25. doi request reprint Vascular rhexis: loss of integrity of coronary vasculature in mice subjected to myocardial infarction
    Christopher J French
    Department of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, 05446, USA
    Exp Biol Med (Maywood) 235:966-73. 2010
    ..Capillary degradation was evident as well, as judged from CD31 and TUNEL co-localization. Vascular rhexis occurs within 48 h after the onset of MI. It may contribute to the early no-reflow phenomenon and to late negative LV remodeling...
  26. ncbi request reprint Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents
    Nathaniel J Madsen
    Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Am J Cardiol 100:722-7. 2007
    ..The accuracy of platelet function testing may be improved by performance in whole blood...
  27. ncbi request reprint Increased tissue-type plasminogen activator: a facade in the fibrinolytic system in type 2 diabetes
    Burton E Sobel
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Coron Artery Dis 16:31-5. 2005
    ..The increased total t-PA occurred in the absence of an increase in t-PA activity detectable in venous blood samples despite the increase in the concentration of total t-PA protein...
  28. ncbi request reprint Increased ability of tirofiban to maintain its inhibitory effects on the binding of fibrinogen to platelets in blood from patients with and without diabetes mellitus
    David J Schneider
    Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    Coron Artery Dis 17:57-61. 2006
    ..To determine the influence of affinity on inhibitory effects in blood from patients with (n=20) and without (n=20) diabetes mellitus, we characterized the extent of inhibition as a function of time...
  29. ncbi request reprint Greater inhibitory effects of bivalirudin compared with unfractionated heparin plus eptifibitide on thrombin-induced platelet activation
    David J Schneider
    Department of Medicine, Cardiology Unit and Cardiovascular Research Institute, University of Vermont, Burlington, Vermont, USA
    Coron Artery Dis 17:471-6. 2006
    ..The effects of antithrombotic agents on the activation of platelets by thrombin were determined in blood from patients (n=12) with symptomatic coronary artery disease...
  30. ncbi request reprint Deleterious effects of lack of cardiac PAI-1 after coronary occlusion in mice and their pathophysiologic determinants
    A K M Tarikuz Zaman
    Cardiovascular Research Institute, University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Histochem Cell Biol 128:135-45. 2007
    ..006 vs. 0.022 microg hydroxyproline/mg dry weight). Thus, lack of PAI-1 in the heart exerted deleterious effects mediated, at least in part by increased inflammation and hemorrhage and attenuating of fibrosis...
  31. ncbi request reprint Increased coronary arterial release of interleukin-1 receptor antagonist and soluble CD40 ligand indicative of inflammation associated with culprit coronary plaques
    Atul Aggarwal
    Cardiac Unit, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Am J Cardiol 93:6-9. 2004
    ....
  32. ncbi request reprint Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary intervention
    Atul Aggarwal
    Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USA
    J Thromb Thrombolysis 13:161-5. 2002
    ..This study was designed to determine the effects of therapeutic concentrations of unfractionated heparin (UFH), bivalirudin, or enoxaparin alone or in combination with tirofiban on platelet reactivity...
  33. doi request reprint Absence of altered autophagy after myocardial ischemia in diabetic compared with nondiabetic mice
    Christopher J French
    Cardiovascular Research Institute, University of Vermont College of Medicine, Vermont 05466, USA
    Coron Artery Dis 22:479-83. 2011
    ..It has been conjectured that diminution of autophagy early after the onset of MI may preserve jeopardized myocardium thereby improving prognosis...
  34. ncbi request reprint Efficiency in clinical research: assessment in vitro of potential anti-thrombotic drug interactions
    David J Schneider
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Coron Artery Dis 15:177-81. 2004
    ....
  35. ncbi request reprint Systemic inflammation after drug-eluting stent placement
    Prospero B Gogo
    Division of Cardiology, University of Vermont College of Medicine, 111 Colchester Avenue, Burlington, Vermont 05401, USA
    J Thromb Thrombolysis 19:87-92. 2005
    ..Thus, we sought to determine whether attenuation of the systemic inflammatory response was contributing to the improved outcomes...
  36. ncbi request reprint A novel dual staining method for identification of apoptotic cells reveals a modest apoptotic response in infarcted mouse myocardium
    Douglas J Taatjes
    Department of Pathology, College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 128:275-83. 2007
    ..Again, only scattered cells were found displaying both markers in the zones of infarction, suggesting that 3 days of persistent ischemia results in a robust necrotic response, but only a very minor apoptotic response in this mouse model...
  37. doi request reprint Failure of erythropoietin to render jeopardized ischemic myocardium amenable to incremental salvage by early reperfusion
    Christopher J French
    Department of Medicine, Cardiovascular Research Institute, University of Vermont, Burlington, Vermont 05446, USA
    Coron Artery Dis 20:295-9. 2009
    ..We sought to characterize the effect of EPO on infarct size after myocardial ischemia and reperfusion with the use of assessment of left-ventricular (LV) creatine kinase (CK) depletion and echocardiography...
  38. doi request reprint Gender-dependent differences in echocardiographic characteristics of murine hearts
    Patricia Q Baumann
    Cardiovascular Research Institute, University of Vermont, Burlington, Vermont 05446, USA
    Echocardiography 25:739-48. 2008
    ..Furthermore, the results suggest that gender-dependent differences are likely to be present in other species, including humans, and accordingly, that normal values should be established separately for males and females...
  39. ncbi request reprint Relation of augmented platelet reactivity to the magnitude of distribution of atherosclerosis
    Friederike K Keating
    Cardiology Unit, University of Vermont College of Medicine, 111 Colchester Avenue, Burlington, VT 05401 USA
    Am J Cardiol 94:725-8. 2004
    ..Accordingly, patients who have more widely distributed vascular disease are likely to derive particular benefit from antiplatelet regimens that suppress platelet function to a greater extent...
  40. ncbi request reprint Osteoprotegerin is not associated with angiographic coronary calcification
    Prospero B Gogo
    Division of Cardiology, University of Vermont College of Medicine, Burlington, VT 05401, USA
    J Thromb Thrombolysis 22:177-83. 2006
    ..After PCI, osteoprotegerin decreased while proinflammatory cytokines increased, which may be consistent with a counterregulatory role for osteoprotegerin...
  41. ncbi request reprint Quantitative analysis of atherosclerotic lesion composition in mice
    Marilyn P Wadsworth
    Department of Pathology, University of Vermont, Burlington, USA
    Methods Mol Biol 319:137-52. 2006
    ..This method can be expanded to employ a rich variety of histochemical and immunohistochemical staining protocols...
  42. pmc Imaging aspects of cardiovascular disease at the cell and molecular level
    Douglas J Taatjes
    Department of Pathology, College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 130:235-45. 2008
    ....
  43. ncbi request reprint Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1
    Yabing Chen
    Department of Medicine and Cardiovascular Research Institute, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 26:1777-83. 2006
    ..Because apoptosis and proliferation appear to be linked, we sought to determine whether increased PAI-1 would affect VSMC proliferation...
  44. ncbi request reprint Platelet function, coagulopathy, and impaired fibrinolysis in diabetes
    Burton E Sobel
    Department of Medicine, University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Cardiol Clin 22:511-26. 2004
    ..In aggregate,these derangements contribute to accelerated atherosclerosis, premature coronary artery dis-ease, and a profound toll from both...
  45. doi request reprint Vascular rhexis in mice subjected to non-sustained myocardial ischemia and its therapeutic implications
    A K M Tarikuz Zaman
    Department of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, 05446, USA
    Exp Biol Med (Maywood) 236:598-603. 2011
    ....
  46. ncbi request reprint Biphasic effects of hemodialysis on platelet reactivity in patients with end-stage renal disease: a potential contributor to cardiovascular risk
    Atul Aggarwal
    Department of Medicine, The University of Vermont College of Medicine, Burlington, VT 05401, USA
    Am J Kidney Dis 40:315-22. 2002
    ..This study is designed to determine effects of hemodialysis in patients with ESRD on platelet reactivity per se...
  47. pmc The magnitude and temporal dependence of apoptosis early after myocardial ischemia with or without reperfusion
    Christopher J French
    Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    FASEB J 23:1177-85. 2009
    ..Thus, antiapoptotic interventions per se are not likely to preserve substantial amounts of myocardium early after ischemic insults...
  48. ncbi request reprint Delineation of the evolution of compositional changes in atheroma
    Marilyn P Wadsworth
    Department of Pathology, College of Medicine, HSRF 208, 89 Beaumont Avenue, University of Vermont, Burlington, VT 05405, USA
    Histochem Cell Biol 118:59-68. 2002
    ..However, the percentage composition of plaque attributable to collagen increased 2.5-fold in 20-week-old female animals compared with that in males or females of 10 weeks of age and males of 20 weeks of age...
  49. ncbi request reprint Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington 05401, USA
    Diabetes Care 25:2123-8. 2002
    ..We sought to determine whether metabolic control, independent of its oral mode of implementation, affects PAI-1 in patients with marked hyperglycemia...
  50. pmc Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
    Scott S Wagers
    Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0075, USA
    J Clin Invest 114:104-11. 2004
    ..These results are consistent with the hypothesis that leakage of fibrinogen and thrombin and their accumulation on the airway surface can contribute to the pathogenesis of airway hyperresponsiveness...
  51. ncbi request reprint Contributions of young platelets and of previously activated platelets to platelet reactivity in patients with coronary artery disease
    David J Schneider
    Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Thromb Res 121:455-62. 2008
    ....
  52. doi request reprint The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaques
    Christopher J French
    Department of Medicine, Cardiovascular Research Institute, University of Vermont, Burlington, VT, USA
    J Cardiovasc Pharmacol 58:143-8. 2011
    ..Accordingly, the suppression of PAI-1 expression by AZL-M may attenuate the evolution of atherosclerotic plaques vulnerable to rupture...
  53. doi request reprint Biomarker profiles as descriptors of left ventricular remodeling after acute myocardial infarction
    Phillip H Lam
    Cardiology Division, Department of Medicine, University of Vermont, Burlington, USA
    Coron Artery Dis 22:311-6. 2011
    ....
  54. ncbi request reprint Comparison of effects of abciximab versus eptifibatide on C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist after coronary arterial stenting
    Atul Aggarwal
    Cardiac Unit, University of Vermont College of Medicine, 111 Colchester Avenue, Burlington, VT 05401, USA
    Am J Cardiol 91:1346-9. 2003
  55. ncbi request reprint The effect of plasminogen activator inhibitor type 1 on apoptosis
    David J Schneider
    Department of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
    Thromb Haemost 100:1037-40. 2008
    ..Inhibition of caspase 3 by PAI-1 may divert intracellular signalling from induction of apoptosis to induction of proliferation...
  56. ncbi request reprint On rendering continuous glucose monitoring ready for prime time in the cardiac care unit
    Michaelanne Rowen
    Cardiovascular Research Institute, University of Vermont College of Medicine, Burlington, Vermont 05446, USA
    Coron Artery Dis 18:405-9. 2007
    ..We therefore explored the potential value of use of a continuous glucose monitoring system to enhance glycemic control in the CCU and sought to identify pitfalls that could be overcome to increase its utility...
  57. doi request reprint Autophagy in myocardium of murine hearts subjected to ischemia followed by reperfusion
    Christopher J French
    Department of Medicine, Cardiovascular Research Institute, University of Vermont, 208 South Park Drive, Colchester, VT 05446, USA
    Histochem Cell Biol 134:519-26. 2010
    ..Autophagy is virtually absent within 24 h in the center of zones of infarction and is decreased significantly in the peri-infarct zones compared with that in normal hearts...
  58. ncbi request reprint Synergistic treatment of ST-segment elevation myocardial infarction with pharmacoinvasive recanalization
    Harold L Dauerman
    Department of Medicine, University of Vermont College of Medicine, Burlington 05446, USA
    J Am Coll Cardiol 42:646-51. 2003
    ....
  59. ncbi request reprint Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1
    Yabing Chen
    Department of Medicine, The University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 92:178-88. 2004
    ..Accordingly, attenuated apoptosis resulting from elevated expression of PAI-1 by VSMC may be attributable, at least in part, to reversible inhibition of caspase-3 by active PAI-1...
  60. ncbi request reprint Effects of glycemic control and other determinants on vascular disease in type 2 diabetes
    Burton E Sobel
    Department of Medicine, Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Am J Med 113:12S-22S. 2002
    ..Amelioration of diabetic cardiomyopathy by correction of impaired myocardial energy metabolism and limiting the accumulation of advanced glycation end products is being evaluated as well...
  61. ncbi request reprint Usefulness of platelet reactivity before percutaneous coronary intervention in determining cardiac risk one year later
    Samer S Kabbani
    University of Vermont College of Medicine, Burlington, USA
    Am J Cardiol 91:876-8. 2003
  62. ncbi request reprint Bleeding complications after contemporary pharmacoinvasive therapy for ST elevation myocardial infarction
    Matthew J Gutierrez
    University of Vermont College of Medicine, Burlington, VT 05401, USA
    J Thromb Thrombolysis 18:187-92. 2004
    ....
  63. ncbi request reprint Suboptimal early inhibition of platelets by treatment with tirofiban and implications for coronary interventions
    Samer S Kabbani
    University of Vermont, Burlington, Vermont 05446, USA
    Am J Cardiol 89:647-50. 2002
  64. doi request reprint Toward a comprehensive approach to pharmacoinvasive therapy for patients with ST segment elevation acute myocardial infarction
    Harold L Dauerman
    Cardiac Unit, Fletcher Allen Health Care, University of Vermont, McClure 1, 111 Colchester Avenue, Burlington, VT 05401, USA
    J Thromb Thrombolysis 34:180-6. 2012
    ..It entails immediate use of full doses of fibrinolytic agents followed by prompt transfer to a PCI center and a plan to implement PCI within 2-12 h of the time of onset of initial therapy...
  65. ncbi request reprint Burgeoning dilemmas in the management of diabetes and cardiovascular disease: rationale for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
    Burton E Sobel
    University of Vermont College of Medicine, Burlington, USA
    Circulation 107:636-42. 2003
    ..Despite challenges in study design and enrollment, intensive follow-up, and the long duration of follow-up planned, the questions being addressed are compelling and seem to merit the effort...
  66. ncbi request reprint Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones
    Andreas Zirlik
    Brigham and Women s Hospital, Harvard Medical School, Cardiovascular Medicine, Department of Medicine, Boston, Massachusetts 02115, USA
    Thromb Haemost 91:674-82. 2004
    ..Accordingly, patients with insulin resistance may benefit from treatment with thiazolidinediones with respect to diminution of PAI-1 expression in adipose tissue and consequent potential reduction of cardiovascular risk...
  67. ncbi request reprint Ancillary studies in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial: Synergies and opportunities
    Burton E Sobel
    Cardiovascular Research Institute, Department of Medicine, University of Vermont, Colchester, Vermont 05446, USA
    Am J Cardiol 97:53G-58G. 2006
    ....
  68. ncbi request reprint The conceptual basis of mathematics in cardiology III: linear systems theory and integral transforms
    Jason H T Bates
    Department of Medicine, University of Vermont, HSRF Room 228, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
    Coron Artery Dis 14:185-96. 2003
    ..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology...
  69. ncbi request reprint The conceptual basis of mathematics in cardiology IV: statistics and model fitting
    Jason H T Bates
    Department of Medicine, University of Vermont, Burlington 05405, USA
    Coron Artery Dis 14:267-77. 2003
    ..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology...
  70. ncbi request reprint The conceptual basis of mathematics in cardiology: (II). Calculus and differential equations
    Jason H T Bates
    Department of Medicine, University of Vermont, Burlington, 05405 0075, USA
    Coron Artery Dis 14:135-48. 2003
    ..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology...
  71. ncbi request reprint The conceptual basis of mathematics in cardiology: (I) algebra, functions and graphs
    Jason H T Bates
    Department of Medicine, University of Vermont, Burlington 05405 0075, USA
    Coron Artery Dis 14:41-59. 2003
    ..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology...
  72. pmc Morphological and cytochemical determination of cell death by apoptosis
    Douglas J Taatjes
    Department of Pathology, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA
    Histochem Cell Biol 129:33-43. 2008
    ..This review will highlight many of these methods, and provide a critique on the advantages and disadvantages associated with them for the specific identification of apoptotic cells in culture and tissues...
  73. ncbi request reprint Enhancement by growth factors of cardiac myocyte differentiation from embryonic stem cells: a promising foundation for cardiac regeneration
    Dinender K Singla
    Department of Medicine, Vascular Biology Unit, and Cardiovascular Research Institute, University of Vermont, Colchester, VT 05446, USA
    Biochem Biophys Res Commun 335:637-42. 2005
    ..This review addresses the current understanding of the role of growth factors in the differentiation of cardiac myocytes from ES-embryoid body cell systems in vitro as well as cardiac regeneration in vivo...
  74. ncbi request reprint The ratio of plasminogen activator inhibitor type-1 activity to the concentration of plasminogen activator inhibitor type-1 protein in diabetes: adding insult to injury
    Burton E Sobel
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA
    Coron Artery Dis 13:275-81. 2002
    ..This study was performed to delineate the relationship between plasminogen activator inhibitor type-1 (PAI-1) activity and PAI-1 protein to characterize the functional importance of elevated PAI-1 in diabetes...
  75. ncbi request reprint Fibrinolysis and diabetes
    Burton E Sobel
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Front Biosci 8:d1085-92. 2003
    ..Accordingly, normalization of the derangement in fibrinolysis typical of diabetes is an important and achievable therapeutic objective...
  76. ncbi request reprint Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene
    Thomas K Nordt
    Department of Cardiology, University of Freiburg, Germany
    Thromb Haemost 90:36-42. 2003
    ..Accordingly, modulation of PAI-1 expression is likely to be influenced predominantly by environmental factors acting on, rather than genetic factors intrinsic to the PAI-1 promoter...
  77. ncbi request reprint Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?
    Haruka Itakura
    Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Am Heart J 154:1059-64. 2007
    ..Circulating concentrations of proteins associated with coagulation and fibrinolysis may differ between individuals with coronary artery disease (CAD) who develop an acute myocardial infarction (AMI) rather than stable exertional angina...
  78. ncbi request reprint Hepatocyte growth factor regulates E box-dependent plasminogen activator inhibitor type 1 gene expression in HepG2 liver cells
    Shogo Imagawa
    The Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan 060 8638
    Arterioscler Thromb Vasc Biol 26:2407-13. 2006
    ....
  79. ncbi request reprint Comparison of rapidity of coronary recanalization in men with tenecteplase versus alteplase in acute myocardial infarction
    Azan S Binbrek
    Rashid Hospital, Dubai, United Arab Emirates
    Am J Cardiol 93:1465-8. 2004
    ..TNK-t-PA appears to induce recanalization more rapidly than alteplase, and thrombolysis initiated early after the onset of symptoms is associated with remarkably low mortality...
  80. ncbi request reprint Soluble CD40 ligand is an early initiator of inflammation after coronary intervention
    Atul Aggarwal
    Nebraska Heart Institute, Hastings, Nebraska 68901, USA
    Coron Artery Dis 15:471-5. 2004
    ..The role of soluble CD40 ligand (sCD40L) as a potential initiator of inflammation after stenting has not been described...
  81. ncbi request reprint The potential of erythropoietin for conferring cardioprotection complementing reperfusion
    Azan S Binbrek
    Department of Cardiology, Rashid Hospital, Dubai, UAE
    Coron Artery Dis 18:583-5. 2007
    ..Evidence indicating the potential for tissue protection is reviewed as is a description of a study now initiated, in which its potential benefit on the evolution of acute myocardial infarction in patients is being explored...
  82. ncbi request reprint Hypotheses, design, and methods for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial
    Maria Mori Brooks
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Cardiol 97:9G-19G. 2006
    ....
  83. ncbi request reprint Loss of insulin receptor substrate-1 signaling induces the cardiovascular and proteo(fibrino)lytic system derangements typical of insulin resistance
    Tomoo Furumoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Coron Artery Dis 16:117-23. 2005
    ..This study was performed to determine whether induction of cardiac manifestations typical of insulin resistance and increased PAI-1 expression occur developmentally or post-developmentally as a result of loss of IRS-1-mediated signaling...
  84. ncbi request reprint Maladaptive arterial remodeling with systemic hypertension associated with increased concentrations in blood of plasminogen activator inhibitor type-1 (PAI-1)
    Tomoo Furumoto
    Department of Cardiovascular Medicine, Graduate School of Medicine and College of Medical Technology, Hokkaido University, Sapporo, Japan
    Am J Cardiol 93:997-1001. 2004
    ..Thus, increased PAI-1 may attenuate a mural, adaptive response to hypertension associated with preservation of endothelial cell function...
  85. ncbi request reprint The insulin resistance syndrome and coronary artery disease
    David M Kendall
    International Diabetes Center, Park Nicollet Clinic, 3800 Park Nicollet Blvd, St Louis Park, MN 55416, USA
    Coron Artery Dis 14:335-48. 2003
    ..A proposed approach to the management of patients with the insulin resistance syndrome is discussed...
  86. ncbi request reprint IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta
    Jie Dong
    Cardiovascular Research Institute, Colchester Research Facility, University of Vermont, 208 South Park Drive, Colchester, VT 05446, USA
    Am J Physiol Cell Physiol 292:C209-15. 2007
    ..Thus IL-1 and IL-6 exert directionally similar effects on PAI-1 expression, but the induction involves distinct signaling pathways with a final common mediator, C/EBPdelta...