Shikha Snigdha

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders and
    J Neurosci 36:3611-22. 2016
  2. doi request reprint Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA Electronic address
    Neurobiol Aging 37:171-8. 2016
  3. pmc A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, CA, USA
    Neurobiol Aging 34:1891-901. 2013
  4. pmc Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain
    S Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA
    Neuroscience 202:326-33. 2012
  5. pmc Caspase-3 activation as a bifurcation point between plasticity and cell death
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 4540, USA
    Neurosci Bull 28:14-24. 2012
  6. pmc Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e24652. 2011
  7. pmc Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697 4540, USA
    Age (Dordr) 34:67-73. 2012
  8. pmc Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697 4540, USA
    J Mol Neurosci 43:337-45. 2011
  9. doi request reprint Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus
    G Aleph Prieto
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697
    Proc Natl Acad Sci U S A 112:E5078-87. 2015
  10. doi request reprint Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697 4540, USA
    Psychopharmacology (Berl) 214:843-53. 2011

Collaborators

Detail Information

Publications11

  1. doi request reprint H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders and
    J Neurosci 36:3611-22. 2016
    ..Together, these data demonstrate that SUV39H1 inhibition and the concomitant H3K9me3 downregulation mediate gene transcription in the hippocampus and reverse age-dependent deficits in hippocampal memory...
  2. doi request reprint Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA Electronic address
    Neurobiol Aging 37:171-8. 2016
    ..Overall, this study suggests that social, cognitive, and physical activity together with optimal dietary intake (rather than diet alone) promotes successful brain aging. ..
  3. pmc A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, CA, USA
    Neurobiol Aging 34:1891-901. 2013
    ..We also suggest areas in which new tests may benefit the development of a comprehensive preclinical test battery for assessment of cognitive function in animal models of aging and Alzheimer's disease...
  4. pmc Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain
    S Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA
    Neuroscience 202:326-33. 2012
    ..Together with data showing increased palmitoleic acid levels in AD patients, our data suggest that reducing palmitoleic acid levels and desaturation index in the brain may be associated with improved cognitive performance...
  5. pmc Caspase-3 activation as a bifurcation point between plasticity and cell death
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 4540, USA
    Neurosci Bull 28:14-24. 2012
    ..Specifically, we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain...
  6. pmc Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e24652. 2011
    ....
  7. pmc Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697 4540, USA
    Age (Dordr) 34:67-73. 2012
    ..This is likely to be derived from impairments in cognitive domains such as visual memory and learning and selective attention...
  8. pmc Phencyclidine (PCP)-induced disruption in cognitive performance is gender-specific and associated with a reduction in brain-derived neurotrophic factor (BDNF) in specific regions of the female rat brain
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697 4540, USA
    J Mol Neurosci 43:337-45. 2011
    ....
  9. doi request reprint Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus
    G Aleph Prieto
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697
    Proc Natl Acad Sci U S A 112:E5078-87. 2015
    ..Overall, this study demonstrates that increased AcP signaling, specifically at the synapse, underlies the augmented vulnerability to cognitive impairment by IL-1β that occurs with age. ..
  10. doi request reprint Asenapine improves phencyclidine-induced object recognition deficits in the rat: evidence for engagement of a dopamine D1 receptor mechanism
    Shikha Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697 4540, USA
    Psychopharmacology (Berl) 214:843-53. 2011
    ....