William D Snider

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Signaling the pathway to regeneration
    William D Snider
    Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA
    Neuron 35:13-6. 2002
  2. ncbi request reprint GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
  3. ncbi request reprint Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo
    Jian Zhong
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7250, USA
    Nat Neurosci 10:598-607. 2007
  4. pmc MEK Is a Key Regulator of Gliogenesis in the Developing Brain
    Xiaoyan Li
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 75:1035-50. 2012
  5. ncbi request reprint Raf and akt mediate distinct aspects of sensory axon growth
    Annette Markus
    Neuroscience Center, University of North Carolina, 103 Mason Farm Road, Chapel Hill 27599, USA
    Neuron 35:65-76. 2002
  6. ncbi request reprint Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth
    Woo Yang Kim
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 52:981-96. 2006
  7. ncbi request reprint Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents
    Tushar D Patel
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 38:403-16. 2003
  8. pmc Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
    Jason Newbern
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:17115-20. 2008
  9. ncbi request reprint Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
    Feng Quan Zhou
    Neuroscience Center, 8109 Neuroscience Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 119:2787-96. 2006
  10. pmc Specific functions for ERK/MAPK signaling during PNS development
    Jason M Newbern
    University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 69:91-105. 2011

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Signaling the pathway to regeneration
    William D Snider
    Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA
    Neuron 35:13-6. 2002
    ..Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment...
  2. ncbi request reprint GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
    ..Our results indicate that GSK-3 signaling is an essential mediator of homeostatic controls that regulate neural progenitors during mammalian brain development...
  3. ncbi request reprint Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo
    Jian Zhong
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7250, USA
    Nat Neurosci 10:598-607. 2007
    ..We conclude that Raf function is crucial for several aspects of DRG neuron development, including differentiation and axon growth...
  4. pmc MEK Is a Key Regulator of Gliogenesis in the Developing Brain
    Xiaoyan Li
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 75:1035-50. 2012
    ..We conclude that MEK is essential for acquisition of gliogenic competence by radial progenitors and that levels of MEK activity regulate gliogenesis in the developing cortex...
  5. ncbi request reprint Raf and akt mediate distinct aspects of sensory axon growth
    Annette Markus
    Neuroscience Center, University of North Carolina, 103 Mason Farm Road, Chapel Hill 27599, USA
    Neuron 35:65-76. 2002
    ..Activated Raf-1 caused axon lengthening comparable to NGF, while active Akt increased axon caliber and branching. Our results suggest that the different Trk effector pathways mediate distinct morphological aspects of developing neurons...
  6. ncbi request reprint Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth
    Woo Yang Kim
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 52:981-96. 2006
    ..Our results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all GSK-3 substrates is associated with a specific morphological outcome...
  7. ncbi request reprint Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents
    Tushar D Patel
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 38:403-16. 2003
    ..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81...
  8. pmc Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
    Jason Newbern
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:17115-20. 2008
    ..2 micro-deletion are explained by deficiencies in neural crest autonomous ERK2 signaling...
  9. ncbi request reprint Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
    Feng Quan Zhou
    Neuroscience Center, 8109 Neuroscience Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 119:2787-96. 2006
    ..Finally, our data show that the GSK-3beta-APC pathway, previously shown to mediate developing axon growth, is also necessary for axon regeneration...
  10. pmc Specific functions for ERK/MAPK signaling during PNS development
    Jason M Newbern
    University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 69:91-105. 2011
    ..Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors...
  11. ncbi request reprint Turning on the machine: genetic control of axon regeneration by c-Jun
    Feng Quan Zhou
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuron 43:1-2. 2004
    ..In this issue of Neuron, Raivich et al. use a nervous system-specific mutant to provide genetic evidence that c-Jun is necessary for efficient axon regeneration...
  12. pmc Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation
    Melinda D Willard
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    EMBO J 26:2029-40. 2007
    ..These data suggest that RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation...
  13. ncbi request reprint "Runx"ing towards sensory differentiation
    Jian Zhong
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 49:325-7. 2006
    ..These findings emphasize the importance of intrinsic genetic programs in generating the diversity of DRG neurons and specifying the circuits into which they incorporate...
  14. pmc Neuronal development: SAD kinases make happy axons
    Lei Xing
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Curr Biol 23:R720-3. 2013
    ....
  15. ncbi request reprint Neurotrophic factors and axonal growth
    Annette Markus
    Neuroscience Center, Neuroscience Research Building, 103 Mason Farm Road Campus, Box 7250, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Curr Opin Neurobiol 12:523-31. 2002
    ..Finally, recent investigations demonstrate that neurotrophic factors can enhance axon growth after spinal cord injuries...
  16. ncbi request reprint Bers-ERK Schwann cells coordinate nerve regeneration
    Jason M Newbern
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 73:623-6. 2012
    ..Moreover, the authors show that dedifferentiated Schwann cells have the potential to coordinate much of the peripheral nerve response to injury...
  17. doi request reprint Taking off the SOCS: cytokine signaling spurs regeneration
    Jason M Newbern
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 64:591-2. 2009
    ..In this issue of Neuron, Smith et al. provide an important advance by demonstrating that SOCS3 acts as a key negative regulator of adult optic nerve regeneration...
  18. ncbi request reprint NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion molecule
    Rong Yu Liu
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill 27599 7260, USA
    Mol Cell Neurosci 20:2-12. 2002
    ..These results demonstrate a novel substrate-dependent regulation of NGF-induced growth of embryonic sensory axons mediated by RhoA GTPase...
  19. ncbi request reprint NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC
    Feng Quan Zhou
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuron 42:897-912. 2004
    ..Our results demonstrate that NGF signals are transduced to the axon cytoskeleton via activation of a conserved cell polarity signaling pathway...
  20. ncbi request reprint Extracellular crosstalk: when GDNF meets N-CAM
    Feng Quan Zhou
    UNC Neuroscience Center, Neuroscience Research Building, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA
    Cell 113:814-5. 2003
    ..Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway...