James W Smyth

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Forward trafficking of ion channels: what the clinician needs to know
    James W Smyth
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Heart Rhythm 7:1135-40. 2010
  2. pmc Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane
    James W Smyth
    University of California San Francisco, Cardiovascular Research Institute, 555 Mission Bay Boulevard South, San Francisco, CA 94158, USA
    Circ Res 110:978-89. 2012
  3. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
  4. pmc BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes
    Ting Ting Hong
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Heart Rhythm 9:812-20. 2012
  5. doi request reprint Visualizing cardiac ion channel trafficking pathways
    James W Smyth
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 505:187-202. 2012
  6. pmc Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
    Shan Shan Zhang
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:13576-81. 2011
  7. pmc Autoregulation of connexin43 gap junction formation by internally translated isoforms
    James W Smyth
    Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94148, USA
    Cell Rep 5:611-8. 2013
  8. pmc BIN1 localizes the L-type calcium channel to cardiac T-tubules
    Ting Ting Hong
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 8:e1000312. 2010
  9. pmc TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    Samy Lamouille
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    J Cell Sci 125:1259-73. 2012
  10. pmc Visualizing ion channel dynamics at the plasma membrane
    James W Smyth
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Heart Rhythm 5:S7-11. 2008

Collaborators

  • Neil C Chi
  • Stuart D Russell
  • Yonghong Zhu
  • Chi chung Hui
  • Henry M Colecraft
  • Didier Y R Stainier
  • Yu Qing Zhou
  • Lucile Miquerol
  • Ting Ting Hong
  • Robin M Shaw
  • Samy Lamouille
  • Shan Shan Zhang
  • Jacob M Vogan
  • Tina S Fong
  • Brian C Jensen
  • Kevin Y Chu
  • Marc K Halushka
  • Charles W Hoopes
  • Erin Connolly
  • Kun Fang
  • Rosemary J Akhurst
  • Karen Ocorr
  • Rik Derynck
  • Benoit G Bruneau
  • Gerrie P Farman
  • Kyoung Han Kim
  • Peter H Backx
  • Mark Davis
  • Tatyana Sukonnik
  • Jieun Kim
  • Anna Rosén
  • Koroboshka Brand-Arzamendi
  • John N Wylie
  • Vijitha Puviindran
  • R Mark Henkelman
  • Robert A Rose
  • Paul Delgado-Olguín
  • Phillip A Marsden
  • Rui Sakuma
  • Nathalie Gaborit
  • Danchen Gao

Detail Information

Publications10

  1. pmc Forward trafficking of ion channels: what the clinician needs to know
    James W Smyth
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Heart Rhythm 7:1135-40. 2010
    ..In this brief review, we provide an overview of the current understanding of the cellular biology governing the forward trafficking of ion channels...
  2. pmc Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane
    James W Smyth
    University of California San Francisco, Cardiovascular Research Institute, 555 Mission Bay Boulevard South, San Francisco, CA 94158, USA
    Circ Res 110:978-89. 2012
    ..Although it is known that Cx43 hemichannels are transported along microtubules to the plasma membrane, the role of actin in Cx43 forward trafficking is unknown...
  3. pmc Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
    James W Smyth
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 120:266-79. 2010
    ..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias...
  4. pmc BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes
    Ting Ting Hong
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Heart Rhythm 9:812-20. 2012
    ..2 channels at cardiac T tubules. Bridging integrator 1 (BIN1) is a membrane scaffolding protein that causes Cav1.2 to traffic to T tubules in healthy hearts. The mechanisms of Cav1.2 trafficking in heart failure are not known...
  5. doi request reprint Visualizing cardiac ion channel trafficking pathways
    James W Smyth
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 505:187-202. 2012
    ..In this chapter, we discuss the structure of cardiomyocytes and their submembrane domains, the ion channels that we study, and the techniques that can be employed to visualize cardiac ion channel trafficking in real time...
  6. pmc Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
    Shan Shan Zhang
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:13576-81. 2011
    ..Irx3 directly represses Cx43 transcription and indirectly activates Cx40 transcription. Our results reveal a critical role for Irx3 in the precise regulation of intercellular gap junction coupling and impulse propagation in the heart...
  7. pmc Autoregulation of connexin43 gap junction formation by internally translated isoforms
    James W Smyth
    Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94148, USA
    Cell Rep 5:611-8. 2013
    ..The results suggest that internal translation is a mechanism of membrane protein autoregulation and a potent target for therapies aimed at restoring normal electrical coupling in diseased hearts. ..
  8. pmc BIN1 localizes the L-type calcium channel to cardiac T-tubules
    Ting Ting Hong
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 8:e1000312. 2010
    ..2 delivery to T-tubules. This novel Cav1.2 trafficking pathway should serve as an important regulatory aspect of EC coupling, affecting cardiac contractility in mammalian hearts...
  9. pmc TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    Samy Lamouille
    Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    J Cell Sci 125:1259-73. 2012
    ..Our results suggest that the mTORC2 pathway is an essential downstream branch of TGF-β signaling, and represents a responsive target to inhibit EMT and prevent cancer cell invasion and metastasis...
  10. pmc Visualizing ion channel dynamics at the plasma membrane
    James W Smyth
    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Heart Rhythm 5:S7-11. 2008
    ..With revolutionary advances in fluorescence microscopy, ion channel biologists are now entering a new realm of studying channel function, which is to understand the mechanisms of channel trafficking...