Terry J Smith

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The putative role of fibroblasts in the pathogenesis of Graves' disease: evidence for the involvement of the insulin-like growth factor-1 receptor in fibroblast activation
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Building C 2, Harbor UCLA Medical Center, 1124 West Carson St, Torrance, CA 90502, USA
    Autoimmunity 36:409-15. 2003
  2. ncbi request reprint Novel aspects of orbital fibroblast pathology
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance 90502, USA
    J Endocrinol Invest 27:246-53. 2004
  3. ncbi request reprint Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 87:385-92. 2002
  4. ncbi request reprint Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 89:5076-80. 2004
  5. pmc Insights into the role of fibroblasts in human autoimmune diseases
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Exp Immunol 141:388-97. 2005
  6. ncbi request reprint Insights into the pathogenesis of thyroid-associated orbitopathy: evolving rationale for therapy
    Michael Kazim
    Division of Molecular Medicine, Bldg C 2, Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Arch Ophthalmol 120:380-6. 2002
  7. ncbi request reprint Unique properties of orbital connective tissue underlie its involvement in Graves' disease
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Minerva Endocrinol 28:213-22. 2003
  8. ncbi request reprint Orbital fibroblasts exhibit a novel pattern of responses to proinflammatory cytokines: potential basis for the pathogenesis of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502 2006, USA
    Thyroid 12:197-203. 2002
  9. ncbi request reprint Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts
    Andrew G Gianoukakis
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 148:54-62. 2007
  10. pmc B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis
    Raymond S Douglas
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Immunol 181:5768-74. 2008

Collaborators

Detail Information

Publications53

  1. ncbi request reprint The putative role of fibroblasts in the pathogenesis of Graves' disease: evidence for the involvement of the insulin-like growth factor-1 receptor in fibroblast activation
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Building C 2, Harbor UCLA Medical Center, 1124 West Carson St, Torrance, CA 90502, USA
    Autoimmunity 36:409-15. 2003
    ..Thus, IGF-1R may represent a second self-antigen with a pathogenic role in extra-thyroidal Graves' disease...
  2. ncbi request reprint Novel aspects of orbital fibroblast pathology
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance 90502, USA
    J Endocrinol Invest 27:246-53. 2004
    ..The consequences of lymphocyte-derived cytokine action may differ vastly in the orbit and other tissues manifesting clinically obvious disease...
  3. ncbi request reprint Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 87:385-92. 2002
    ..These observations enhance our understanding of orbital adipogenesis and define previously unrecognized differences between fibroblasts from the extraocular muscle and connective tissue...
  4. ncbi request reprint Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 89:5076-80. 2004
    ....
  5. pmc Insights into the role of fibroblasts in human autoimmune diseases
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Exp Immunol 141:388-97. 2005
    ....
  6. ncbi request reprint Insights into the pathogenesis of thyroid-associated orbitopathy: evolving rationale for therapy
    Michael Kazim
    Division of Molecular Medicine, Bldg C 2, Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    Arch Ophthalmol 120:380-6. 2002
  7. ncbi request reprint Unique properties of orbital connective tissue underlie its involvement in Graves' disease
    T J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Minerva Endocrinol 28:213-22. 2003
    ..In this brief article, we review some of the attributes of orbital fibroblasts and their interactions with immune cells that are currently believed to contribute to their role in the pathogenesis of Graves' disease...
  8. ncbi request reprint Orbital fibroblasts exhibit a novel pattern of responses to proinflammatory cytokines: potential basis for the pathogenesis of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502 2006, USA
    Thyroid 12:197-203. 2002
    ..Notable among these are the inductions of key inflammatory genes and their products. We hypothesize that exaggerated cellular responses represent the basis for the involvement of the orbit in Graves' disease...
  9. ncbi request reprint Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts
    Andrew G Gianoukakis
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 148:54-62. 2007
    ..Coupled with the newly identified influence exerted by hyaluronan on immunocompetent cells, our findings represent potentially important insights into the pathogenesis of autoimmune thyroid diseases...
  10. pmc B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis
    Raymond S Douglas
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Immunol 181:5768-74. 2008
    ..02) in vitro while those from control donors failed to respond. These findings suggest a potentially important role for IGF-1R display by B lymphocytes in patients with GD in supporting their expansion and abnormal Ig production...
  11. pmc Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Thyroid 18:983-8. 2008
    ..In this brief review we attempt to survey our findings. We believe that they might provide a "roadmap" for further discovery into the pathogenesis of TAO. Clearly, more questions remain than those thus far answered...
  12. ncbi request reprint Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: a putative mechanism for T-cell infiltration of the thyroid in autoimmune disease
    Andrew G Gianoukakis
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 147:1941-9. 2006
    ..These actions of GD-IgG appear to be mediated through pathways independent of the TSH receptor. Thus, in GD, thyrocytes may participate directly in lymphocyte recruitment through their expression of IL-16 and RANTES...
  13. ncbi request reprint Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway
    Jane Pritchard
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    J Immunol 170:6348-54. 2003
    ..These findings identify a novel disease mechanism involving a functional GD-IgG/IGF-IR bridge, which potentially explains T cell infiltration in GD. Interrupting this pathway may constitute a specific therapeutic strategy...
  14. ncbi request reprint Cytoplasmic prostaglandin E2 synthase is dominantly expressed in cultured KAT-50 thyrocytes, cells that express constitutive prostaglandin-endoperoxide H synthase-2. Basis for low protaglandin E2 production
    Rui Han
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Biol Chem 277:36897-903. 2002
    ..These observations indicate that naturally occurring cells can express a suboptimal profile of PGHS and PGES isoforms, resulting in diminished levels of PGE(2) generation...
  15. ncbi request reprint Synovial fibroblasts from patients with rheumatoid arthritis, like fibroblasts from Graves' disease, express high levels of IL-16 when treated with Igs against insulin-like growth factor-1 receptor
    Jane Pritchard
    Division of Molecular Medicine, Harbor University of California, Los Angeles Medical Center, Torrance, CA 90502, USA
    J Immunol 173:3564-9. 2004
    ..Immune-competent cell trafficking to synovial tissue is integral to the pathogenesis of RA. Recognition of this novel RA-IgG/fibroblast interaction and its functional consequences may help identify therapeutic targets...
  16. pmc Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17
    Neil Hoa
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America
    PLoS ONE 7:e34173. 2012
    ..We thus identify a heretofore-unrecognized behavior of IGF-1R that appears limited to GD-derived fibroblasts. Nuclear IGF-1R may play a role in disease pathogenesis...
  17. pmc Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease
    Shanli Tsui
    Division of Molecular Medicine, Division of Endocrinology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Immunol 181:4397-405. 2008
    ....
  18. pmc Increased generation of fibrocytes in thyroid-associated ophthalmopathy
    Raymond S Douglas
    Divisions of Molecular Medicine, Department of Medicine, Harbor University of California, Los Angeles, Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 95:430-8. 2010
    ..Specifically why activating antibodies are generated against self-antigens remains uncertain as does the identity of the antigen(s) that provokes orbital involvement in GD, a process known as thyroid-associated ophthalmopathy (TAO)...
  19. ncbi request reprint IL-1 beta induces IL-6 expression in human orbital fibroblasts: identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated ophthalmopathy
    Beiling Chen
    Division of Molecular Medicine, Department of Medicine, Harbor University of California at Los Angeles, Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    J Immunol 175:1310-9. 2005
    ....
  20. ncbi request reprint Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines
    Beiling Chen
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Biol Chem 281:18296-306. 2006
    ..These results may have relevance to the pathogenesis of orbital Graves disease, an inflammatory autoimmune condition that gives way to extensive fibrosis associated with a Th2 response...
  21. pmc Divergent frequencies of IGF-I receptor-expressing blood lymphocytes in monozygotic twin pairs discordant for Graves' disease: evidence for a phenotypic signature ascribable to nongenetic factors
    Raymond S Douglas
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles UCLA Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 94:1797-802. 2009
    ..The fraction of T and B cells expressing IGF-I receptor (IGF-IR) is increased in GD. It is a potentially important autoantigen in GD. Susceptibility to GD arises from both genetic and acquired factors...
  22. ncbi request reprint Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression
    Andrew G Gianoukakis
    Department of Medicine, Albany Medical College, Albany, NY 12208, USA
    Endocrinology 144:2856-64. 2003
    ..Thus, human thyrocytes, through the expression of chemoattractants, may participate in the recruitment of lymphocytes to the thyroid in inflammatory states...
  23. ncbi request reprint Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis
    Raymond S Douglas
    Department of Medicine, Division of Molecular Medicine, Harbor University of California Los Angeles Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    J Immunol 178:3281-7. 2007
    ..02) and inhibited Fas-mediated apoptosis (p < 0.02). These findings suggest a potential role for IGF-1R displayed by lymphocytes in supporting the expansion of memory T cells in GD...
  24. pmc Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy
    Dinesh Khanna
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ophthalmology 117:133-139.e2. 2010
    ..To study the effectiveness of anti-CD20 (rituximab [RTX]; Rituxan; Genentech, Inc., South San Francisco, CA) therapy in patients with severe, corticosteroid (CS)-resistant thyroid-associated ophthalmopathy (TAO)...
  25. ncbi request reprint Jak2 dampens the induction by IL-1beta of prostaglandin endoperoxide H synthase 2 expression in human orbital fibroblasts: evidence for divergent influence on the prostaglandin E2 biosynthetic pathway
    Rui Han
    Department of Medicine, Division of Molecular Medicine, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    J Immunol 179:7147-56. 2007
    ..Moreover, it is required for IL-1beta-dependent signaling to sPLA(2), the expression and activity of which are necessary for up-regulating PGE(2) synthesis in orbital fibroblasts...
  26. ncbi request reprint Induction by IL-1 beta of tissue inhibitor of metalloproteinase-1 in human orbital fibroblasts: modulation of gene promoter activity by IL-4 and IFN-gamma
    Rui Han
    Division of Molecular Medicine, Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    J Immunol 174:3072-9. 2005
    ..This might alter the natural course of tissue remodeling in TAO...
  27. ncbi request reprint Robust induction of PGHS-2 by IL-1 in orbital fibroblasts results from low levels of IL-1 receptor antagonist expression
    H James Cao
    Division of Molecular and Cellular Medicine, Department of Medicine, Albany Medical College, Samuel S Stratton Veterans Affairs Medical Center, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 284:C1429-37. 2003
    ..Thus a decreased level of IL-1ra expression in orbital fibroblasts may underlie the exaggerated responses to IL-1 observed in those cells and, therefore, the susceptibility of the orbit to inflammation...
  28. pmc Cytokines, Graves' disease, and thyroid-associated ophthalmopathy
    Andrew G Gianoukakis
    Division of Endocrinology and Metabolism, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Thyroid 18:953-8. 2008
    ..Thus cytokines and the signaling pathways they activate represent attractive therapeutic targets. Interruption of these might alter the natural course of Graves' disease and its orbital manifestations...
  29. pmc Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease
    Shanli Tsui
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Biol Chem 286:24487-99. 2011
    ..These high UGDH levels may underlie susceptibility of the orbit to localized overproduction of hyaluronan in Graves disease...
  30. ncbi request reprint T helper type 1 and type 2 cytokines exert divergent influence on the induction of prostaglandin E2 and hyaluronan synthesis by interleukin-1beta in orbital fibroblasts: implications for the pathogenesis of thyroid-associated ophthalmopathy
    Rui Han
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 147:13-9. 2006
    ..These unexpected findings indicate that the Th1-->Th2 cytokine transition exerts equivalent influence on PGE2 and hyaluronan production as TAO progresses from early to late stage...
  31. ncbi request reprint Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression
    Rui Han
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Biol Chem 277:16355-64. 2002
    ..These results indicate that the induction of PGHS-2 and mPGES by IL-1beta underlies robust PGE(2) production in orbital fibroblasts...
  32. pmc Characterization of the anaemia associated with Graves' disease
    Andrew G Gianoukakis
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Endocrinol (Oxf) 70:781-7. 2009
    ..Graves' disease (GD) is associated with hyperthyroidism. Thyrotoxicosis adversely affects multiple organ systems including haematopoiesis. Anaemia occurring specifically in GD has not been systematically studied previously...
  33. ncbi request reprint Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts
    Jane Pritchard
    Department of Medicine, Division of Molecular Medicine, Harbor University of California, Los Angeles Medical Center, Torrance, CA 90502, USA
    J Immunol 168:942-50. 2002
    ..These findings suggest a specific mechanism for activation of fibroblasts in GD resulting in the recruitment of T cells. They may provide insight into a missing link between the glandular and extrathyroidal manifestations of GD...
  34. pmc Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy
    Andrew G Gianoukakis
    Division of Endocrinology and Metabolism, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Curr Opin Endocrinol Diabetes Obes 15:446-52. 2008
    ..To identify and critique the most recent experimental findings regarding the pathogenesis and therapy of thyroid-associated ophthalmopathy...
  35. doi request reprint Integrative continuum: accelerating therapeutic advances in rare autoimmune diseases
    Katja Van Herle
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA
    Annu Rev Pharmacol Toxicol 52:523-47. 2012
    ..The application of such innovative strategies may help researchers overcome barriers to therapeutic advances in NMO and other rare autoimmune diseases...
  36. ncbi request reprint CD40 expression in human thyroid tissue: evidence for involvement of multiple cell types in autoimmune and neoplastic diseases
    T J Smith
    Department of Medicine, Albany Medical College and Samuel S Stratton Veterans Affairs Medical Center, New York 12208, USA
    Thyroid 9:749-55. 1999
    ..They imply the potential participation of the CD40/CD40 ligand bridge in the cross-talk between resident thyroid cells and bone marrow-derived cells recruited to the thyroid...
  37. ncbi request reprint Current perspective on the pathogenesis of Graves' disease and ophthalmopathy
    Bellur S Prabhakar
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612 7344, USA
    Endocr Rev 24:802-35. 2003
    ..Collectively, recent studies have led to a better understanding of the pathogenesis of GD and GO and have opened up potential new avenues for developing novel treatments for GD and GO...
  38. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
    ....
  39. ncbi request reprint Monoclonal pathogenic antibodies to the thyroid-stimulating hormone receptor in Graves' disease with potent thyroid-stimulating activity but differential blocking activity activate multiple signaling pathways
    Jacqueline A Gilbert
    King s College London, Division of Gene and Cell Based Therapy, King s College School of Medicine, London, United Kingdom
    J Immunol 176:5084-92. 2006
    ..In summary, our findings emphasize the similarities of the experimental mouse model in reproducing the human disorder and provide improved means for characterizing the molecular basis of this pathogenic response...
  40. ncbi request reprint Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes
    Laura Koumas
    Departments of Microbiology and Immunology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Eur J Immunol 32:477-85. 2002
    ..These observations suggest that fibroblast subsets in the human orbit play distinct roles in the regulation of immune and inflammatory responses crucial in the initiation and development of thyroid-associated ophthalmopathy...
  41. pmc Immune mechanisms in thyroid eye disease
    Geniece M Lehmann
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Thyroid 18:959-65. 2008
    ....
  42. doi request reprint Biologic therapeutics in thyroid-associated ophthalmopathy: translating disease mechanism into therapy
    Vibhavari Naik
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA
    Thyroid 18:967-71. 2008
    ..It is imperative that agents targeting B-and T-cell functions be further evaluated in the treatment of aggressive forms of TAO utilizing multicenter clinical trials that allow adequate statistical power and sample size...
  43. ncbi request reprint More than structural cells, fibroblasts create and orchestrate the tumor microenvironment
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, and Lymphoma Biology Program, James P Wilmot Cancer Center, Rochester, New York 14642, USA
    Immunol Invest 35:297-325. 2006
    ..This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses...
  44. ncbi request reprint Isolation and phenotypic characterization of lung fibroblasts
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester, NY, USA
    Methods Mol Med 117:115-27. 2005
    ..These subsets can then be used for experimentation to determine functional differences between fibroblasts derived from normal and pathological tissue such as scarred lung...
  45. doi request reprint A symposium on thyroid-associated ophthalmopathy, also known as Graves' orbitopathy at the Jules Stein Eye Institute at the University of California, Los Angeles
    Raymond S Douglas
    Thyroid 18:931. 2008
  46. ncbi request reprint Molecular cloning of an IL-8-like CXC chemokine and tissue factor in rainbow trout (Oncorhynchus mykiss) by use of suppression subtractive hybridization
    Amaia Sangrador-Vegas
    National Diagnostics Centre BioResearch Ireland, National University of Ireland, University Road, Galway, Ireland
    Cytokine 17:66-70. 2002
    ..These results confirm the potential of SSH to identify cytokines and immuno-regulatory genes in fish...
  47. ncbi request reprint Expression levels of mRNA for Rho A/Rho kinase and its role in isoprostane-induced vasoconstriction of human placental and maternal vessels
    Anne M Friel
    Department of Obstetrics and Gynaecology, National University of Ireland, Galway, Ireland
    Reprod Sci 15:179-88. 2008
    ..Isoprostanes exert their vasocontractile effect, in placental vasculature, in part via the Rho kinase pathway...
  48. doi request reprint Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor
    Margaret O'Brien
    National Centre for Biomedical and Engineering Science, National University of Ireland Galway, Galway, Ireland
    Reprod Sci 15:382-93. 2008
    ..These novel upregulated genes are involved in multiple pathways that may be associated with a variety of cellular processes including inflammation, transcriptional regulation, and intracellular signaling...
  49. ncbi request reprint B cell depletion in Graves' disease: the right answer to the wrong question?
    Terry J Smith
    J Clin Endocrinol Metab 92:1620-2. 2007
  50. ncbi request reprint Rosiglitazone-induced proptosis
    Flora Levin
    Arch Ophthalmol 123:119-21. 2005
  51. ncbi request reprint Transcription factor binding site identification using the self-organizing map
    Shaun Mahony
    National Centre for Biomedical Engineering Science, NUI Galway, Ireland
    Bioinformatics 21:1807-14. 2005
    ..Features identified are ranked in terms of over-representation relative to a background model...
  52. ncbi request reprint Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction
    Anne M Friel
    Department of Obstetrics and Gynaecology, National University of Ireland, Galway, Clinical Science Institute, University College Hospital, Newcastle Road, Galway, Ireland
    Reproduction 132:169-76. 2006
    ..The vasocontractile effect of 8-iso PGE(2) in pre eclampsia may in part be mediated via the Rho kinase pathway...
  53. ncbi request reprint A novel ELISpot method for adherent cells
    Chantal K Turner
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Immunol Methods 291:63-70. 2004
    ..Moreover, the assay is suitable for normal human adherent cells that are often short-lived and difficult to cultivate...