Terry J Smith

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy
    Terry J Smith
    University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Best Pract Res Clin Endocrinol Metab 26:291-302. 2012
  2. pmc Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
    Terry J Smith
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Pharmacol Rev 62:199-236. 2010
  3. ncbi request reprint Pathogenesis of Graves' orbitopathy: a 2010 update
    T J Smith
    Departments of Ophthalmology and Visual Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Endocrinol Invest 33:414-21. 2010
  4. pmc Potential role for bone marrow-derived fibrocytes in the orbital fibroblast heterogeneity associated with thyroid-associated ophthalmopathy
    T J Smith
    Department of Ophthalmology and Visual Sciences and Division of Metabolism and Endocrine Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Exp Immunol 162:24-31. 2010
  5. pmc Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease
    Terry J Smith
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Kellogg Eye Center, Brehm Tower, 1000 Wall Street, Ann Arbor, Michigan 48105, USA
    J Clin Endocrinol Metab 96:3827-37. 2011
  6. pmc Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB
    Erin F Gillespie
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan 48105, USA
    Invest Ophthalmol Vis Sci 53:7746-53. 2012
  7. pmc Human fibrocytes coexpress thyroglobulin and thyrotropin receptor
    Roshini Fernando
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Proc Natl Acad Sci U S A 109:7427-32. 2012
  8. pmc Divergent expression of IL-1 receptor antagonists in CD34⁺ fibrocytes and orbital fibroblasts in thyroid-associated ophthalmopathy: contribution of fibrocytes to orbital inflammation
    Bin Li
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    J Clin Endocrinol Metab 98:2783-90. 2013
  9. pmc Thyroid eye disease: towards an evidence base for treatment in the 21st century
    Erin F Gillespie
    Department of Ophthalmology and Visual Science, University of Michigan Medical School, 1000 Wall Street, Suite 7120, Ann Arbor, MI 48105, USA
    Curr Neurol Neurosci Rep 12:318-24. 2012
  10. pmc PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy
    Nupur Raychaudhuri
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e15296. 2010

Collaborators

Detail Information

Publications13

  1. pmc Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves' orbitopathy
    Terry J Smith
    University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Best Pract Res Clin Endocrinol Metab 26:291-302. 2012
    ..In sum, based on current evidence, IGF-1R and TSHR can be thought of as "partners in crime". Involvement of the former probably transcends disease boundaries, while TSHR may not...
  2. pmc Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
    Terry J Smith
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Pharmacol Rev 62:199-236. 2010
    ....
  3. ncbi request reprint Pathogenesis of Graves' orbitopathy: a 2010 update
    T J Smith
    Departments of Ophthalmology and Visual Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Endocrinol Invest 33:414-21. 2010
    ..As emerging insights into human autoimmunity becomes applied to the study of Graves' disease, we anticipate that improved therapeutic strategies will find their way to our patients with GO...
  4. pmc Potential role for bone marrow-derived fibrocytes in the orbital fibroblast heterogeneity associated with thyroid-associated ophthalmopathy
    T J Smith
    Department of Ophthalmology and Visual Sciences and Division of Metabolism and Endocrine Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Exp Immunol 162:24-31. 2010
    ..These attributes also raise the possibility that they might be useful targets against which therapeutic agents might be aimed...
  5. pmc Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease
    Terry J Smith
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Kellogg Eye Center, Brehm Tower, 1000 Wall Street, Ann Arbor, Michigan 48105, USA
    J Clin Endocrinol Metab 96:3827-37. 2011
    ..Patients with GD have increased frequency of circulating monocyte lineage cells known as fibrocytes. These fibrocytes infiltrate orbital connective tissues in thyroid-associated ophthalmopathy and express functional TSH receptor (TSHR)...
  6. pmc Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-κB
    Erin F Gillespie
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Kellogg Eye Center, Ann Arbor, Michigan 48105, USA
    Invest Ophthalmol Vis Sci 53:7746-53. 2012
    ..The functional consequences of CD40 ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO)...
  7. pmc Human fibrocytes coexpress thyroglobulin and thyrotropin receptor
    Roshini Fernando
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Proc Natl Acad Sci U S A 109:7427-32. 2012
    ..These findings indicate that human fibrocytes express multiple "thyroid-specific" proteins, the levels of which are reduced after they infiltrate tissue. Our observations establish the basis for Tg accumulation in orbital GD...
  8. pmc Divergent expression of IL-1 receptor antagonists in CD34⁺ fibrocytes and orbital fibroblasts in thyroid-associated ophthalmopathy: contribution of fibrocytes to orbital inflammation
    Bin Li
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    J Clin Endocrinol Metab 98:2783-90. 2013
    ..Evidence suggests that orbital susceptibility to TAO may involve IL-1, which is modulated by IL-1 receptor antagonists, designated secreted (sIL-1RA) and intracellular (icIL-1RA)...
  9. pmc Thyroid eye disease: towards an evidence base for treatment in the 21st century
    Erin F Gillespie
    Department of Ophthalmology and Visual Science, University of Michigan Medical School, 1000 Wall Street, Suite 7120, Ann Arbor, MI 48105, USA
    Curr Neurol Neurosci Rep 12:318-24. 2012
    ..In this article, we review evidence from prospective therapeutic trials of several treatment modalities. We focus on moderate to severe active TED...
  10. pmc PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy
    Nupur Raychaudhuri
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e15296. 2010
    ..Orbital tissues become inflamed in TAO, a process in which prostanoids have been implicated. Orbital fibroblasts both generate and respond to PGE(2), underlying the inflammatory phenotype of these cells...
  11. pmc Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production
    Erin F Gillespie
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Kellogg Eye Center, 1000 Wall Street, Ann Arbor, Michigan 48105, USA
    J Clin Endocrinol Metab 97:E740-6. 2012
    ..These cells may be involved in the pathogenesis of thyroid-associated ophthalmopathy (TAO)...
  12. pmc Thyrotropin Regulates IL-6 Expression in CD34(+) Fibrocytes: Clear Delineation of Its cAMP-Independent Actions
    Nupur Raychaudhuri
    Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e75100. 2013
    ..Fibrocytes neither express adenylate cyclase nor generate cAMP and thus these findings are free from any influence of cAMP-related signaling. They identify potential therapeutic targets for TAO. ..
  13. doi request reprint Regulation of IL-1 Receptor Antagonist by TSH in Fibrocytes and Orbital Fibroblasts
    Bin Li
    Department of Ophthalmology and Visual Sciences B L, T J S and Department of Internal Medicine T J S, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105
    J Clin Endocrinol Metab 99:E625-33. 2014
    ..Conclusions: Our findings for the first time directly link activities of the TSH and IL-1 pathways. Furthermore, they identify novel molecular interactions that could be targeted as therapy for TAO. ..