T J Smith

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. ncbi Squalene: potential chemopreventive agent
    T J Smith
    University of South Carolina, College of Pharmacy, Coker Life Sciences, 700 Sumter Street, Columbia, SC 29208, USA
    Expert Opin Investig Drugs 9:1841-8. 2000
  2. ncbi Effect of organosulfur compounds from garlic and cruciferous vegetables on drug metabolism enzymes
    T J Smith
    Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208, USA
    Drug Metabol Drug Interact 17:23-49. 2000
  3. ncbi Mechanisms of carcinogenesis inhibition by isothiocyanates
    T J Smith
    College of Pharmacy, Coker Life Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, USA
    Expert Opin Investig Drugs 10:2167-74. 2001
  4. ncbi Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic
    C S Yang
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 131:1041S-5S. 2001
  5. ncbi Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Carcinogenesis 18:1577-84. 1997
  6. ncbi Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 19:703-6. 1998
  7. ncbi Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Carcinogenesis 19:667-72. 1998
  8. ncbi Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues
    J Hong
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA
    Biochem Pharmacol 62:1175-83. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Squalene: potential chemopreventive agent
    T J Smith
    University of South Carolina, College of Pharmacy, Coker Life Sciences, 700 Sumter Street, Columbia, SC 29208, USA
    Expert Opin Investig Drugs 9:1841-8. 2000
    ..In order to evaluate the overall implications of squalene to human cancer prevention, further studies are needed to fully identify its protective effects, as well as possible detrimental effects...
  2. ncbi Effect of organosulfur compounds from garlic and cruciferous vegetables on drug metabolism enzymes
    T J Smith
    Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208, USA
    Drug Metabol Drug Interact 17:23-49. 2000
    ....
  3. ncbi Mechanisms of carcinogenesis inhibition by isothiocyanates
    T J Smith
    College of Pharmacy, Coker Life Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC 29208, USA
    Expert Opin Investig Drugs 10:2167-74. 2001
    ..Isothiocyanates may potentially be beneficial in protecting against human carcinogenesis...
  4. ncbi Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic
    C S Yang
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    J Nutr 131:1041S-5S. 2001
    ..The biological activities of garlic and its related compounds at lower concentrations that mimic human consumption remain to be studied further...
  5. ncbi Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Carcinogenesis 18:1577-84. 1997
    ..The patas monkey microsomes appear to more closely resemble human microsomes than mouse or rat enzymes and may better reflect the activation of NNK in humans...
  6. ncbi Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08854 8020, USA
    Carcinogenesis 19:703-6. 1998
    ..These results demonstrate that dietary olive oil and squalene can effectively inhibit NNK-induced lung tumorigenesis...
  7. ncbi Characterization of xenobiotic-metabolizing enzymes and nitrosamine metabolism in the human esophagus
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Carcinogenesis 19:667-72. 1998
    ..Our results suggest that P450s 3A4 and 2E1 are involved in the activation of NNN and NDMA, respectively, in the human esophagus...
  8. ncbi Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues
    J Hong
    Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA
    Biochem Pharmacol 62:1175-83. 2001
    ..g. PGE synthase). The present results indicate that tea polyphenols can affect arachidonic acid metabolism in human colon mucosa and colon tumors, and this action may alter the risk for colon cancer in humans...