Stephanie A Smith

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Sensitive fluorescence detection of polyphosphate in polyacrylamide gels using 4',6-diamidino-2-phenylindol
    Stephanie A Smith
    Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews, Urbana, IL 61801, USA
    Electrophoresis 28:3461-5. 2007
  2. ncbi request reprint Feline arterial thromboembolism: an update
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, 506 South Mathews, MC 714, University of Illinois, Urbana, IL 61801, USA
    Vet Clin North Am Small Anim Pract 34:1245-71. 2004
  3. pmc Polyphosphate as a general procoagulant agent
    S A Smith
    Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 6:1750-6. 2008
  4. pmc Polyphosphate is a cofactor for the activation of factor XI by thrombin
    Sharon H Choi
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 61801, USA
    Blood 118:6963-70. 2011
  5. pmc Polyphosphate exerts differential effects on blood clotting, depending on polymer size
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Blood 116:4353-9. 2010
  6. pmc Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
    James H Morrissey
    Biochemistry Department, University of Illinois, 506 S Mathews Ave, Urbana, IL 61801, USA
    Blood 119:5972-9. 2012
  7. pmc Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Blood 120:5103-10. 2012
  8. doi request reprint Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Am J Vet Res 73:789-98. 2012
  9. pmc Polyphosphate enhances fibrin clot structure
    Stephanie A Smith
    Departments of Internal Medicine and Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, USA
    Blood 112:2810-6. 2008
  10. doi request reprint Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses
    Kate F McGovern
    College of Veterinary Medicine, University of Illinois, 1008 WHazelwood Drive, Urbana, IL 61802, USA
    J Vet Emerg Crit Care (San Antonio) 22:550-7. 2012

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Sensitive fluorescence detection of polyphosphate in polyacrylamide gels using 4',6-diamidino-2-phenylindol
    Stephanie A Smith
    Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews, Urbana, IL 61801, USA
    Electrophoresis 28:3461-5. 2007
    ..The lower LOD using DAPI negative staining was 4 pmol (0.3 ng) phosphate per band, compared to conventional toluidine blue staining with a lower LOD of 250 pmol per band...
  2. ncbi request reprint Feline arterial thromboembolism: an update
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, 506 South Mathews, MC 714, University of Illinois, Urbana, IL 61801, USA
    Vet Clin North Am Small Anim Pract 34:1245-71. 2004
    ..Many questions remain to be answered regarding the ideal management approach for feline ATE. The authors' preferred diagnostic and therapeutic approaches for these difficult patients are detailed in Box. 1...
  3. pmc Polyphosphate as a general procoagulant agent
    S A Smith
    Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Thromb Haemost 6:1750-6. 2008
    ..Polyphosphate is secreted by activated platelets and we recently showed that it accelerates blood clotting, chiefly by triggering the contact pathway and promoting factor (F) V activation...
  4. pmc Polyphosphate is a cofactor for the activation of factor XI by thrombin
    Sharon H Choi
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 61801, USA
    Blood 118:6963-70. 2011
    ..We therefore propose that polyphosphate is a natural cofactor for factor XI activation in plasma that may help explain the role of factor XI in hemostasis and thrombosis...
  5. pmc Polyphosphate exerts differential effects on blood clotting, depending on polymer size
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Blood 116:4353-9. 2010
    ..Microbial polyphosphate, which is highly procoagulant, may function in host responses to pathogens...
  6. pmc Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation
    James H Morrissey
    Biochemistry Department, University of Illinois, 506 S Mathews Ave, Urbana, IL 61801, USA
    Blood 119:5972-9. 2012
    ..The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated...
  7. pmc Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation
    Stephanie A Smith
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Blood 120:5103-10. 2012
    ..This study provides proof of principle for polyphosphate inhibitors as antithrombotic/anti-inflammatory agents in vitro and in vivo, with a novel mode of action compared with conventional anticoagulants...
  8. doi request reprint Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Am J Vet Res 73:789-98. 2012
    ..To evaluate the components of canine whole blood samples that contribute to results of thromboelastometry (TEM)...
  9. pmc Polyphosphate enhances fibrin clot structure
    Stephanie A Smith
    Departments of Internal Medicine and Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, USA
    Blood 112:2810-6. 2008
    ..Polyphosphate may also be useful in enhancing the structure of surgical fibrin sealants...
  10. doi request reprint Assessment of acute moderate hyperglycemia on traditional and thromboelastometry coagulation parameters in healthy adult horses
    Kate F McGovern
    College of Veterinary Medicine, University of Illinois, 1008 WHazelwood Drive, Urbana, IL 61802, USA
    J Vet Emerg Crit Care (San Antonio) 22:550-7. 2012
    ..To determine whether experimentally induced acute moderate hyperglycemia is associated with coagulation activation in healthy adult horses...
  11. pmc Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities
    Sharon H Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 49:9935-41. 2010
    ..Our findings open up essentially the entire armamentarium of protein chemistry to modifying polyphosphate, which should greatly facilitate studies of its biological roles...
  12. pmc Factor VII and protein C are phosphatidic acid-binding proteins
    Narjes Tavoosi
    Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA
    Biochemistry 52:5545-52. 2013
    ..We conclude that factor VII and protein C bind preferentially to monoester phosphates, which may have implications for the function of these proteases in vivo. ..
  13. doi request reprint In-vitro hypocoagulability on whole blood thromboelastometry associated with in-vivo expansion of red cell mass in an equine model
    Maureen McMichael
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 1008 West Hazelwood Dr, Urbana, IL 61802, USA
    Blood Coagul Fibrinolysis 22:424-30. 2011
    ..In the absence of other indicators of hypocoagulability, this may point to an artifact of thromboelastometry. Alternatively, the data may reflect true in-vivo hypocoagulability in patients with increased circulating RCM...
  14. doi request reprint Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs
    Crystal M Hoh
    Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Am J Vet Res 72:1038-45. 2011
    ..To evaluate markers of in vivo platelet function (urinary 11-dehydro-thromboxane B(2) [11-dehydroTXB(2)] and 2,3-dinorTXB(2)) and assess their response to administration of 2 commonly used dosages of aspirin in healthy dogs...
  15. doi request reprint Viscoelastic coagulation testing: technology, applications, and limitations
    Maureen A McMichael
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Vet Clin Pathol 40:140-53. 2011
    ..This article will provide an overview of the technology, reagents and assays, applications in human and veterinary medicine, and limitations of the 3 viscoelastic POC analyzers in clinical use...
  16. doi request reprint Clot formation in canine whole blood as measured by rotational thromboelastometry is influenced by sample handling and coagulation activator
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana Champaign, Illinois 61801, USA
    Blood Coagul Fibrinolysis 21:692-702. 2010
    ....
  17. pmc Polyphosphate modulates blood coagulation and fibrinolysis
    Stephanie A Smith
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:903-8. 2006
    ....
  18. doi request reprint Microparticles in stored canine RBC concentrates
    Jennifer M Herring
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
    Vet Clin Pathol 42:163-9. 2013
    ..As blood ages during storage, progressive alterations in the structure and function of the cells occur. Changes in cell membranes may lead to formation of microparticles (MPs) in stored blood...
  19. doi request reprint The cell-based model of coagulation
    Stephanie A Smith
    Department of Internal Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA
    J Vet Emerg Crit Care (San Antonio) 19:3-10. 2009
    ..To review the current model describing coagulation processes, including the critical contributions of cells...
  20. ncbi request reprint Arterial thromboembolism in cats: acute crisis in 127 cases (1992-2001) and long-term management with low-dose aspirin in 24 cases
    Stephanie A Smith
    Department of Small Animal Clinical Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Vet Intern Med 17:73-83. 2003
    ..Adverse effects were less frequent and milder for the lower dosage...
  21. pmc Heparin is procoagulant in the absence of antithrombin
    Stephanie A Smith
    Thromb Haemost 100:160-2. 2008
  22. ncbi request reprint Hemodynamic effects of methylprednisolone acetate administration in cats
    Trasida Ployngam
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Ave, Saint Paul, MN 55108, USA
    Am J Vet Res 67:583-7. 2006
    ..To investigate the mechanisms by which corticosteroid administration may predispose cats to congestive heart failure (CHF)...
  23. ncbi request reprint Hypercalcemia due to latrogenic secondary hypoadrenocorticism and diabetes mellitus in a cat
    Stephanie A Smith
    Department of Clinical Sciences College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA
    J Am Anim Hosp Assoc 38:41-4. 2002
    ..The hypercalcemia resolved with glucocorticoid supplementation and correction of the dehydration. The diabetes mellitus and adrenal insufficiency both resolved within 9 weeks...