Research Topics
| Stephanie A SmithSummaryAffiliation: University of Illinois Country: USA Publications
| Collaborators
|
Detail Information
Publications
Antithrombotic therapySTEPHANIE ANN SMITH
Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA
Top Companion Anim Med 27:88-94. 2012..These new thromboprophylactic agents may soon be beneficial in management of small animal patients at risk for thrombosis...- Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samplesStephanie A Smith
Department of Biochemistry, College of Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
Am J Vet Res 73:789-98. 2012..To evaluate the components of canine whole blood samples that contribute to results of thromboelastometry (TEM)... - Clot formation in canine whole blood as measured by rotational thromboelastometry is influenced by sample handling and coagulation activatorStephanie A Smith
Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana Champaign, Illinois 61801, USA
Blood Coagul Fibrinolysis 21:692-702. 2010.... - The cell-based model of coagulationStephanie A Smith
Department of Internal Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA
J Vet Emerg Crit Care (San Antonio) 19:3-10. 2009..To review the current model describing coagulation processes, including the critical contributions of cells... 
Polyphosphate is a cofactor for the activation of factor XI by thrombinSharon H Choi
Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, 61801, USA
Blood 118:6963-70. 2011..We therefore propose that polyphosphate is a natural cofactor for factor XI activation in plasma that may help explain the role of factor XI in hemostasis and thrombosis...- Polyphosphate exerts differential effects on blood clotting, depending on polymer sizeStephanie A Smith
Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL, USA
Blood 116:4353-9. 2010..Microbial polyphosphate, which is highly procoagulant, may function in host responses to pathogens... - Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammationJames H Morrissey
Biochemistry Department, University of Illinois, 506 S Mathews Ave, Urbana, IL 61801, USA
Blood 119:5972-9. 2012..The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated... - Polyphosphate enhances fibrin clot structureStephanie A Smith
Departments of Internal Medicine and Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, USA
Blood 112:2810-6. 2008..Polyphosphate may also be useful in enhancing the structure of surgical fibrin sealants... - Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogsCrystal M Hoh
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
Am J Vet Res 72:1038-45. 2011..To evaluate markers of in vivo platelet function (urinary 11-dehydro-thromboxane B(2) [11-dehydroTXB(2)] and 2,3-dinorTXB(2)) and assess their response to administration of 2 commonly used dosages of aspirin in healthy dogs... - Viscoelastic coagulation testing: technology, applications, and limitationsMaureen A McMichael
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Vet Clin Pathol 40:140-53. 2011..This article will provide an overview of the technology, reagents and assays, applications in human and veterinary medicine, and limitations of the 3 viscoelastic POC analyzers in clinical use... - In-vitro hypocoagulability on whole blood thromboelastometry associated with in-vivo expansion of red cell mass in an equine modelMaureen McMichael
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, 1008 West Hazelwood Dr, Urbana, IL 61802, USA
Blood Coagul Fibrinolysis 22:424-30. 2011..In the absence of other indicators of hypocoagulability, this may point to an artifact of thromboelastometry. Alternatively, the data may reflect true in-vivo hypocoagulability in patients with increased circulating RCM... - Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activitiesSharon H Choi
Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
Biochemistry 49:9935-41. 2010..Our findings open up essentially the entire armamentarium of protein chemistry to modifying polyphosphate, which should greatly facilitate studies of its biological roles... 
Hemodynamic effects of methylprednisolone acetate administration in catsTrasida Ployngam
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Ave, Saint Paul, MN 55108, USA
Am J Vet Res 67:583-7. 2006..Any cardiovascular disorders that impair the normal compensatory mechanisms for increased plasma volume may predispose cats to CHF following MPA administration...- Polyphosphate modulates blood coagulation and fibrinolysisStephanie A Smith
Department of Biochemistry, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 103:903-8. 2006.... - Feline arterial thromboembolism: an updateStephanie A Smith
Department of Biochemistry, College of Medicine, 506 South Mathews, MC 714, University of Illinois, Urbana, IL 61801, USA
Vet Clin North Am Small Anim Pract 34:1245-71. 2004..Many questions remain to be answered regarding the ideal management approach for feline ATE. The authors' preferred diagnostic and therapeutic approaches for these difficult patients are detailed in Box. 1... - Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammationStephanie A Smith
Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Blood 120:5103-10. 2012..This study provides proof of principle for polyphosphate inhibitors as antithrombotic/anti-inflammatory agents in vitro and in vivo, with a novel mode of action compared with conventional anticoagulants... - Sensitive fluorescence detection of polyphosphate in polyacrylamide gels using 4',6-diamidino-2-phenylindolStephanie A Smith
Department of Internal Medicine, College of Medicine, University of Illinois at Urbana Champaign, 506 S Mathews, Urbana, IL 61801, USA
Electrophoresis 28:3461-5. 2007..The lower LOD using DAPI negative staining was 4 pmol (0.3 ng) phosphate per band, compared to conventional toluidine blue staining with a lower LOD of 250 pmol per band... - A retrospective study of 19 cases of canine myelofibrosisDouglas J Weiss
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
J Vet Intern Med 16:174-8. 2002..Half of the dogs with secondary myelofibrosis recovered from their cytopenias and were alive from 4 months to 5 years after diagnosis...