Shelley Smith

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF
    S D Smith
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Med Genet 37:446-8. 2000
  2. pmc Etiologies and molecular mechanisms of communication disorders
    Shelley D Smith
    Department of Pediatrics and Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198 5960, USA
    J Dev Behav Pediatr 31:555-63. 2010
  3. ncbi request reprint Genes, language development, and language disorders
    Shelley D Smith
    Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198 5456, USA
    Ment Retard Dev Disabil Res Rev 13:96-105. 2007
  4. pmc Approach to epigenetic analysis in language disorders
    Shelley D Smith
    University of Nebraska Medical Center, Omaha, NE, USA
    J Neurodev Disord 3:356-64. 2011
  5. ncbi request reprint TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Hum Genet 118:87-90. 2005
  6. ncbi request reprint Gene x Environment interactions in speech sound disorder predict language and preliteracy outcomes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race Street, Denver, CO 80209, USA
    Dev Psychopathol 19:1047-72. 2007
  7. ncbi request reprint Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses
    Karen E Deffenbacher
    Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, NE Medical Center MMI Rm 3085, Omaha, NE 68198 5455, USA
    Hum Genet 115:128-38. 2004
  8. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
  9. pmc DCDC2 is associated with reading disability and modulates neuronal development in the brain
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:17053-8. 2005
  10. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002

Research Grants

  1. The Molecular Biology of Neurosensory Systems
    Shelley Smith; Fiscal Year: 2007
  2. IDENTIFICATION OF GENES INFLUENCING DYSLEXIA
    Shelley Smith; Fiscal Year: 2001
  3. The Molecular Biology of Neurosurgery Systems
    Shelley D Smith; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. pmc Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF
    S D Smith
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Med Genet 37:446-8. 2000
    ....
  2. pmc Etiologies and molecular mechanisms of communication disorders
    Shelley D Smith
    Department of Pediatrics and Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198 5960, USA
    J Dev Behav Pediatr 31:555-63. 2010
    ..When combined with careful phenotypic studies, molecular genetic studies have the potential to refine the clinical definitions of communication disorders and influence their remediation...
  3. ncbi request reprint Genes, language development, and language disorders
    Shelley D Smith
    Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198 5456, USA
    Ment Retard Dev Disabil Res Rev 13:96-105. 2007
    ..Understanding these processes can form the basis for refined procedures for diagnosis and treatment...
  4. pmc Approach to epigenetic analysis in language disorders
    Shelley D Smith
    University of Nebraska Medical Center, Omaha, NE, USA
    J Neurodev Disord 3:356-64. 2011
    ....
  5. ncbi request reprint TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Hum Genet 118:87-90. 2005
    ..Alternatively, the published findings of association with markers in EKN1 may reflect linkage disequilibrium with variation in another gene(s) in the region...
  6. ncbi request reprint Gene x Environment interactions in speech sound disorder predict language and preliteracy outcomes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race Street, Denver, CO 80209, USA
    Dev Psychopathol 19:1047-72. 2007
    ..The direction of these interactions and possible interpretations are explored in the discussion...
  7. ncbi request reprint Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses
    Karen E Deffenbacher
    Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, NE Medical Center MMI Rm 3085, Omaha, NE 68198 5455, USA
    Hum Genet 115:128-38. 2004
    ..The results of the association study have thereby allowed us to significantly reduce the number of possible candidate genes and to prioritize genes for further mutation screening...
  8. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
    ..In addition, the QTL effect may be largely limited to the severe range of reading disability...
  9. pmc DCDC2 is associated with reading disability and modulates neuronal development in the brain
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:17053-8. 2005
    ..The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD...
  10. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002
    ..This is the first report of QTL-based genome-wide scanning for a human cognitive trait...
  11. ncbi request reprint Neuropsychology and genetics of speech, language, and literacy disorders
    Robin L Peterson
    Department of Psychology, University of Denver, 2155 South Race Street, Denver, CO 80208, USA
    Pediatr Clin North Am 54:543-61, vii. 2007
    ..Research across levels of analysis is progressing rapidly to promote understanding not only of each disorder by itself but also of the relationships of the three disorders to each other...
  12. ncbi request reprint Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Psychiatr Genet 12:35-41. 2002
    ..Our study outlines the approach necessary for the identification of genetic variants causing dyslexia susceptibility in an epidemiological population of dyslexics...
  13. ncbi request reprint Breakthroughs in the search for dyslexia candidate genes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race St, Denver, CO 80208, USA
    Trends Mol Med 12:333-41. 2006
    ..When causal variants are identified, they will need to be considered within a multifactorial framework, which is likely to involve gene-gene and gene-environment interactions, to make accurate predictions of diagnostic status...
  14. ncbi request reprint Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes
    Richard D Todd
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Child Psychol Psychiatry 46:1067-73. 2005
    ..The goal of the current study is to test whether population-based ADHD subtypes defined by latent class analysis help resolve issues of variable findings across individual gene association studies...
  15. ncbi request reprint Linkage of speech sound disorder to reading disability loci
    Shelley D Smith
    University of Nebraska Medical Center, USA
    J Child Psychol Psychiatry 46:1057-66. 2005
    ..The present study tested whether SSD is linked to replicated risk loci for RD...
  16. ncbi request reprint Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder
    Erik G Willcutt
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet 114:260-8. 2002
    ....
  17. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
  18. ncbi request reprint DFNA2/KCNQ4 and its manifestations
    Els M R De Leenheer
    Department of Otorhinolaryngology, University Medical Centre Nijmegen, The Netherlands
    Adv Otorhinolaryngol 61:41-6. 2002
  19. ncbi request reprint Differential genetic etiology of reading component processes as a function of IQ
    Valerie S Knopik
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Behav Genet 32:181-98. 2002
    ....

Research Grants10

  1. The Molecular Biology of Neurosensory Systems
    Shelley Smith; Fiscal Year: 2007
    ..The result will be a continuing, self-sustaining, and competitive research Center that will stimulate excellence in all three participating institutions and throughout the State. ..
  2. IDENTIFICATION OF GENES INFLUENCING DYSLEXIA
    Shelley Smith; Fiscal Year: 2001
    ..Linkage and association analysis will be used to verify that a candidate gene effects reading disability in the 175 nuclear families. ..
  3. The Molecular Biology of Neurosurgery Systems
    Shelley D Smith; Fiscal Year: 2010
    ....