Robert A Smith

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Three main mutational pathways in HIV-2 lead to high-level raltegravir and elvitegravir resistance: implications for emerging HIV-2 treatment regimens
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e45372. 2012
  2. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
  3. doi request reprint Random-scanning mutagenesis
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, WA, USA
    Methods Mol Biol 634:387-97. 2010
  4. pmc Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses
    Robert A Smith
    Department of Pathology, University of Washington, Seattle WA, USA
    Retrovirology 7:112. 2010
  5. pmc Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance
    Robert A Smith
    Department of Pathology, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98133, USA
    J Infect Dis 199:1323-6. 2009
  6. pmc Phenotypic susceptibility of HIV-2 to raltegravir: integrase mutations Q148R and N155H confer raltegravir resistance
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, Washington 98109, USA
    AIDS 25:2235-41. 2011
  7. ncbi request reprint Lethal mutagenesis of HIV
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, WA 18195, USA
    Virus Res 107:215-28. 2005
  8. pmc Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro
    Robert A Smith
    University of Washington, Department of Pathology, K 046 HSB, Box 357705, 1959 NE Pacific St, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 52:329-32. 2008
  9. pmc Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase
    Robert A Smith
    Department of Pathology, University of Washington, K 084 HSB, Box 357705, 1959 NE Pacific St, Seattle, 98195, USA
    J Virol 80:7169-78. 2006
  10. pmc HIV-2 integrase variation in integrase inhibitor-naïve adults in Senegal, West Africa
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e22204. 2011

Detail Information

Publications72

  1. pmc Three main mutational pathways in HIV-2 lead to high-level raltegravir and elvitegravir resistance: implications for emerging HIV-2 treatment regimens
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 7:e45372. 2012
    ..These findings preclude the sequential use of raltegravir and elvitegravir (or vice versa) for HIV-2 treatment and provide important information for clinical monitoring of integrase inhibitor resistance in HIV-2-infected individuals...
  2. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
    ..In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type...
  3. doi request reprint Random-scanning mutagenesis
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, WA, USA
    Methods Mol Biol 634:387-97. 2010
    ..This technique is known as "random-scanning mutagenesis" and is illustrated herein using examples from our studies of a conserved polymerase motif in HIV-1 reverse transcriptase...
  4. pmc Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses
    Robert A Smith
    Department of Pathology, University of Washington, Seattle WA, USA
    Retrovirology 7:112. 2010
    ..These findings raise important questions regarding the provenance of XMRV and its potential connection to human disease...
  5. pmc Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance
    Robert A Smith
    Department of Pathology, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98133, USA
    J Infect Dis 199:1323-6. 2009
    ..These data suggest that current NRTI-based regimens are suboptimal for treating HIV-2 infection...
  6. pmc Phenotypic susceptibility of HIV-2 to raltegravir: integrase mutations Q148R and N155H confer raltegravir resistance
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, Washington 98109, USA
    AIDS 25:2235-41. 2011
    ..Our objectives were to directly compare the susceptibilities of HIV-1 and HIV-2 to raltegravir and to examine the role of mutations in HIV-2 integrase in emergent raltegravir resistance...
  7. ncbi request reprint Lethal mutagenesis of HIV
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, WA 18195, USA
    Virus Res 107:215-28. 2005
    ..Here, we review the concept of extinguishing HIV infection by "lethal mutagenesis" and consider the utility of this new approach in combination with conventional antiretroviral strategies...
  8. pmc Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro
    Robert A Smith
    University of Washington, Department of Pathology, K 046 HSB, Box 357705, 1959 NE Pacific St, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 52:329-32. 2008
    ..These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection...
  9. pmc Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase
    Robert A Smith
    Department of Pathology, University of Washington, K 084 HSB, Box 357705, 1959 NE Pacific St, Seattle, 98195, USA
    J Virol 80:7169-78. 2006
    ..Our results suggest that motif B influences RT-deoxynucleoside triphosphate interactions at multiple steps in the catalytic cycle of polymerization...
  10. pmc HIV-2 integrase variation in integrase inhibitor-naïve adults in Senegal, West Africa
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e22204. 2011
    ..There is a paucity of data on genotypic variation in HIV-2 integrase that might confer intrinsic or transmitted INI resistance...
  11. ncbi request reprint Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:26726-34. 2004
    ..This mutational flexibility likely contributes to HIV-1 evolution in response to changing selection pressures in infected individuals...
  12. pmc Validation for clinical use of a novel HIV-2 plasma RNA viral load assay using the Abbott m2000 platform
    Ming Chang
    Department of Laboratory Medicine, Division of Virology, University of Washington, Seattle, United States
    J Clin Virol 55:128-33. 2012
    ..Optimal care of persons infected with human immunodeficiency virus type 2 (HIV-2) requires an accurate assessment of HIV-2 plasma viral load (VL), but no clinically approved quantitative HIV-2 RNA VL assay exists...
  13. pmc Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 48:476-83. 2009
    ..However, the mutations in HIV-2 that confer ARV resistance are not well characterized...
  14. pmc Complex Patterns of Protease Inhibitor Resistance among Antiretroviral Treatment-Experienced HIV-2 Patients from Senegal: Implications for Second-Line Therapy
    Dana N Raugi
    Department of Medicine, Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, Washington, USA
    Antimicrob Agents Chemother 57:2751-60. 2013
    ..These findings suggest that sequential PI-based regimens for HIV-2 treatment may be ineffective...
  15. ncbi request reprint Early detection of breast cancer in countries with limited resources
    Benjamin O Anderson
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Breast J 9:S51-9. 2003
    ..There are tremendous differences among and within countries, and a program to promote early detection must be tailored to each country's unique situation...
  16. ncbi request reprint Breast cancer in limited-resource countries: an overview of the Breast Health Global Initiative 2005 guidelines
    Benjamin O Anderson
    Department of Surgery, University of Washington, Seattle, 98195, USA
    Breast J 12:S3-15. 2006
    ..Future research is needed to better determine how these guidelines can best be implemented in limited-resource settings...
  17. ncbi request reprint The role of MRI in breast cancer screening
    Constance D Lehman
    Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
    J Natl Compr Canc Netw 7:1109-15. 2009
    ..This article describes the peer-reviewed, published clinical research trials evaluating breast MRI in high-risk patients, on which the NCCN guidelines were based, and provides suggestions for future research...
  18. doi request reprint Guideline implementation for breast healthcare in low-income and middle-income countries: overview of the Breast Health Global Initiative Global Summit 2007
    Benjamin O Anderson
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Cancer 113:2221-43. 2008
    ..Curricula for education and training in LMCs should be developed, applied, and studied in LMC-based learning laboratories to aid information transfer of evidence-based BHGI guidelines...
  19. pmc Mutator suppression and escape from replication error-induced extinction in yeast
    Alan J Herr
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 7:e1002282. 2011
    ..Our studies reveal the transient nature of eukaryotic mutators and show that mutator phenotypes are readily suppressed by genetic adaptation. This has implications for the role of mutator phenotypes in cancer...
  20. ncbi request reprint Screening for breast cancer
    Stephen W Duffy
    Cancer Research UK, Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    Surg Oncol Clin N Am 14:671-97. 2005
    ....
  21. ncbi request reprint Breast cancer in limited-resource countries: early detection and access to care
    Robert A Smith
    American Cancer Society, Atlanta, Georgia 30329, USA
    Breast J 12:S16-26. 2006
    ..Ideally, for complete evaluation, such projects require notification of deaths among breast cancer cases and staging of diagnosed tumors...
  22. ncbi request reprint Professional and economic factors affecting access to mammography: a crisis today, or tomorrow? Results from a national survey
    Dione M Farria
    Department of Radiology Breast Imaging, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer 104:491-8. 2005
    ..To gain insight into the practice patterns, use of emerging technologies, and concerns of breast imagers in current practice, the Society of Breast Imaging (SBI) conducted a national survey of breast imaging practices in the U.S...
  23. ncbi request reprint Promoting cancer screening: Learning from experience
    Helen I Meissner
    Applied Cancer Screening Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Cancer 101:1107-17. 2004
    ..The application of the lessons from this extensive knowledge base not only should accelerate the uptake of the effective cancer screening tests currently available, but also can guide future directions for research...
  24. ncbi request reprint Mammographic screening: a key factor in the control of breast cancer
    Laszlo Tabar
    Department of Mammography, Central Hospital, Fallun, Sweden
    Cancer J 9:15-27. 2003
  25. ncbi request reprint American Cancer Society guidelines for breast cancer screening: update 2003
    Robert A Smith
    Cancer Screening, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 53:141-69. 2003
    ..The new screening recommendations address screening mammography, physical examination, screening older women and women with comorbid conditions, screening women at high risk, and new screening technologies...
  26. ncbi request reprint The mammographic screening trials: commentary on the recent work by Olsen and Gøtzsche
    Stephen Duffy
    J Surg Oncol 81:159-62; discussion 162-6. 2002
  27. ncbi request reprint The ongoing evaluation of breast cancer screening
    Robert A Smith
    Cancer 100:1327-30. 2004
  28. ncbi request reprint The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties
    Stephen W Duffy
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, PO Box 123, Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Cancer 95:458-69. 2002
    ..e., nonattenders) after the initiation of organized screening...
  29. ncbi request reprint Re: Efficacy of breast cancer screening in the community according to risk level
    Stephen W Duffy
    J Natl Cancer Inst 97:1703; author reply 1703-4. 2005
  30. ncbi request reprint American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 57:75-89. 2007
    ..Diagnostic uses of MRI were not considered to be within the scope of this review...
  31. ncbi request reprint Cancer screening in the United States, 2007: a review of current guidelines, practices, and prospects
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 57:90-104. 2007
    ....
  32. ncbi request reprint The evolving role of MRI in the detection and evaluation of breast cancer
    Robert A Smith
    N Engl J Med 356:1362-4. 2007
  33. ncbi request reprint Colorectal cancer screening education, prioritization, and self-perceived preparedness among primary care residents: data from a national survey
    Amy S Oxentenko
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Cancer Educ 22:208-18. 2007
    ....
  34. ncbi request reprint Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, QLD, Australia
    Cancer Lett 255:77-84. 2007
    ..372 and 0.655, respectively). Androgen receptor mRNA also remained unaffected (p=0.174)...
  35. doi request reprint Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 134:1570-95. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  36. ncbi request reprint Absence of a pharmacokinetic interaction between entecavir and adefovir
    Marc Bifano
    Bristol Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543 4000, USA
    J Clin Pharmacol 47:1327-34. 2007
    ..Entecavir and adefovir were well tolerated when administered in combination. Therefore, the pharmacokinetic data generated in this study indicate that entecavir and adefovir can be coadministered without the need for dosage adjustment...
  37. ncbi request reprint American Cancer Society guidelines for the early detection of cancer, 2003
    Robert A Smith
    Cancer Control Sciences Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 53:27-43. 2003
    ....
  38. ncbi request reprint Patient-centered prevention strategies for cardiovascular disease, cancer and diabetes
    Kathryn A Taubert
    American Heart Association, Dallas, TX 75231, USA
    Nat Clin Pract Cardiovasc Med 4:656-66. 2007
    ..Finally, we discuss the appropriate role of cardiology health-care providers with respect to risks for other chronic conditions and occult disease...
  39. ncbi request reprint Colorectal cancer screening: a comparison of 35 initiatives in 17 countries
    Victoria S Benson
    Cancer Epidemiology Unit, University of Oxford, England, United Kingdom
    Int J Cancer 122:1357-67. 2008
    ..In conclusion, this is the first investigation describing the delivery of CRC screening protocols to various populations. The work of the ICRCSN is enabling valuable information to be shared and a common nomenclature to be established...
  40. doi request reprint Revised colorectal screening guidelines: joint effort of the American Cancer Society, U.S. Multisociety Task Force on Colorectal Cancer, and American College of Radiology
    Elizabeth G McFarland
    Radiology 248:717-20. 2008
  41. doi request reprint Cancer screening in the United States, 2008: a review of current American Cancer Society guidelines and cancer screening issues
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 58:161-79. 2008
    ....
  42. ncbi request reprint Colorectal cancer screening perceptions and practices: results from a national survey of gastroenterology, surgery and radiology trainees
    Amy S Oxentenko
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Cancer Educ 22:219-26. 2007
    ....
  43. doi request reprint Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  44. ncbi request reprint American Cancer Society Guideline for human papillomavirus (HPV) vaccine use to prevent cervical cancer and its precursors
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Altanta, GA, USA
    CA Cancer J Clin 57:7-28. 2007
    ..They address the use of prophylactic HPV vaccines, including who should be vaccinated and at what age, as well as a summary of policy and implementation issues. Implications for screening are also discussed...
  45. ncbi request reprint Cancer screening in the USA
    Robert A Smith
    Cancer Screening, Cancer Control Sciences Department, American Cancer Society, Atlanta, GA, USA
    J Med Screen 13:S48-53. 2006
    ..In order to achieve the fullest potential of cancer screening in the most cost-effective manner, screening should be organized, with attention to monitoring the fullest performance of the programme from recruitment to follow-up...
  46. ncbi request reprint American Cancer Society guidelines for the early detection of cancer, 2004
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 54:41-52. 2004
    ..S. maps profiling states based on the proportion of the age-eligible population not recently screened for breast cancer or colorectal cancer...
  47. ncbi request reprint Survey of radiology residents: breast imaging training and attitudes
    Lawrence W Bassett
    Iris Cantor Center for Breast Imaging, Department of Radiology, David Geffen School of Medicine at UCLA and UCLA Jonsson Comprehensive Cancer Center, 200 UCLA Medical Plaza, Rm 165 49, Los Angeles, CA 90095 6952, USA
    Radiology 227:862-9. 2003
    ..To investigate the training and attitudes of residents regarding breast imaging...
  48. ncbi request reprint Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening
    Laszlo Tabar
    Department of Mammography, Central Hospital, Falun, Sweden
    Lancet 361:1405-10. 2003
    ..We aimed to assess the long-term effect of mammographic screening on death from breast cancer, taking into account potential biases from self-selection, changes in breast cancer incidence, and classification of cause of death...
  49. ncbi request reprint Screening for breast cancer
    Liane E Philpotts
    Yale University School of Medicine, Cedar Street, PO Box 208042, New Haven, CT 06520 8042, USA
    Semin Roentgenol 38:19-33. 2003
  50. ncbi request reprint Prevention and early detection clinical trials: opportunities for primary care providers and their patients
    Leslie G Ford
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA
    CA Cancer J Clin 53:82-101. 2003
    ....
  51. ncbi request reprint Emerging technologies in screening for colorectal cancer: CT colonography, immunochemical fecal occult blood tests, and stool screening using molecular markers
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 53:44-55. 2003
    ..Based on recommendations of the Advisory Group, only a minor modification has been made to the ACS's Recommendations for Screening and Surveillance of the Early Detection of Adenomatous Polyps and Colorectal Cancer...
  52. pmc Expression of glucocorticoid and progesterone nuclear receptor genes in archival breast cancer tissue
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, Griffith University Gold Coast, Queensland, Australia
    Breast Cancer Res 5:R9-12. 2003
    ..In order to investigate these findings further, we conducted the present study to determine whether expression levels of the progesterone and glucocorticoid nuclear receptor genes vary in different breast cancer grades...
  53. ncbi request reprint Tobacco money: up in smoke?
    James L Mulshine
    Lancet 360:1979-80; author reply 1981. 2002
  54. ncbi request reprint American Cancer Society guideline for the early detection of cervical neoplasia and cancer
    Debbie Saslow
    Breast and Gynecologic Cancer, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 52:342-62. 2002
    ....
  55. ncbi request reprint Promoting early detection tests for colorectal carcinoma and adenomatous polyps: a framework for action: the strategic plan of the National Colorectal Cancer Roundtable
    Bernard Levin
    Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:1618-28. 2002
    ....
  56. ncbi request reprint Update on effects of screening mammography
    Laszlo Tabar
    Lancet 360:337; author reply 339-40. 2002
  57. ncbi request reprint The mammographic screening trials: commentary on the recent work by Olsen and Gøtzsche
    Stephen W Duffy
    CA Cancer J Clin 52:68-71. 2002
  58. ncbi request reprint Cancer screening and the periodic health examination
    Robert A Smith
    Cancer 100:1553-7. 2004
  59. ncbi request reprint Progression rates of colorectal cancer by Dukes' stage in a high-risk group: analysis of selective colorectal cancer screening
    Jau Min Wong
    Department of Internal Medicine, College of Public Health, National Taiwan University Hospital, No 19 Hsuchow Road, Taipei 100, Taiwan
    Cancer J 10:160-9. 2004
    ..The progression rates of colorectal cancer by Dukes' stage in a high-risk group were estimated and applied to evaluate the efficacy of different screening regimens...
  60. ncbi request reprint Entecavir pharmacokinetics, safety, and tolerability after multiple ascending doses in healthy subjects
    Jing He Yan
    Bristol Myers Squibb, Princeton, NJ 08543 4000, USA
    J Clin Pharmacol 46:1250-8. 2006
    ..Elimination was predominantly through renal excretion, with mean urinary recovery ranging from 62% to 73%. Entecavir was safe and well tolerated when administered at doses ranging from 0.1 mg to 1 mg/d for 14 days...
  61. ncbi request reprint American Cancer Society guidelines for the early detection of cancer, 2006
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 56:11-25; quiz 49-50. 2006
    ....
  62. ncbi request reprint The effect of ravuconazole on the pharmacokinetics of nelfinavir in healthy male volunteers
    Jing He Yan
    Bristol Myers Squibb, PO Box 4000, Princeton, NJ 08542 4000, USA
    J Clin Pharmacol 46:193-200. 2006
    ..The study data indicate that coadministration of ravuconazole did not result in a clinically significant change in the plasma levels of nelfinavir...
  63. ncbi request reprint Mammographic tumor features can predict long-term outcomes reliably in women with 1-14-mm invasive breast carcinoma
    Laszlo Tabar
    Mammography Department, Central Hospital, Falun, Sweden
    Cancer 101:1745-59. 2004
    ..The radiologic images of 1-14-mm invasive breast carcinomas can be classified into 5 separate categories. The use of these mammographic indicators to predict patient outcome has important prognostic and therapeutic implications...
  64. ncbi request reprint Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue
    Robert A Smith
    Genomics Research Centre and Wesley Research Institute, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, QLD 9726, Australia
    Cancer Lett 237:248-55. 2006
    ..This increased expression in late stage breast tumours may have implications to the treatment of breast tumours, particularly those lacking expression of other nuclear receptor genes...
  65. ncbi request reprint Borate-catalyzed reactions of hydrogen peroxide: kinetics and mechanism of the oxidation of organic sulfides by peroxoborates
    D Martin Davies
    Division of Chemical and Forensic Sciences, School of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK
    Chemistry 11:3552-8. 2005
    ..The kinetic parameters, including the lack of reactivity of peroxoboric acid, are discussed in terms of the differences in the transition state of reactions involving peroxoboron species with respect to those of other peroxides...
  66. ncbi request reprint Constant positive airway pressure reduces hypoventilation induced by inhalation anesthesia
    Robert A Smith
    Department of Anesthesiology, University of South Florida College of Medicine, Tampa, FL 33612 4799, USA
    J Clin Anesth 17:44-50. 2005
    ..To discover if reducing respiratory system impedance would increase tidal volume and improve ventilation during inhalation anesthesia...
  67. ncbi request reprint American Cancer Society Guidelines for the Early Detection of Cancer, 2005
    Robert A Smith
    Risk Factor Surveillance, Department of Epidemiology and Research Surveillance, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 55:31-44; quiz 55-6. 2005
    ....
  68. ncbi request reprint A national survey of primary care physicians' methods for screening for fecal occult blood
    Marion R Nadel
    Centers for Disease Control and Prevention and American Cancer Society, Atlanta, Georgia 30341 3717, ISA
    Ann Intern Med 142:86-94. 2005
    ..Although the test is simple, implementation requires adherence to specific techniques of testing and follow-up of abnormal results...
  69. ncbi request reprint The randomized trials of breast cancer screening: what have we learned?
    Robert A Smith
    American Cancer Society, 1599 Clifton Road, NE, Atlanta, GA 30329, USA
    Radiol Clin North Am 42:793-806, v. 2004
    ..The trials of mammographic screening provide conclusive evidence that the policy of offering screening is associated with a significant and substantial reduction in breast cancer mortality...
  70. ncbi request reprint A perspective from countries using organized screening programs
    Anne Miles
    Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Cancer 101:1201-13. 2004
    ....
  71. ncbi request reprint The future of research that promotes cancer screening
    Helen I Meissner
    Applied Cancer Screening Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD 20852, USA
    Cancer 101:1251-9. 2004
    ....
  72. ncbi request reprint American Cancer Society guidelines for the early detection of cancer
    Robert A Smith
    Cancer Control Department, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 52:8-22. 2002
    ....