R L Smith

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Valve-sparing aortic root reconstruction
    Robert L Smith
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, PO Box 800709, Charlottesville, VA 22908 0709, USA
    Surg Clin North Am 89:837-44, viii. 2009
  2. doi request reprint Do you need to clamp a patent left internal thoracic artery-left anterior descending graft in reoperative cardiac surgery?
    Robert L Smith
    Department of Surgery, Division of Thoracic Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 87:742-7. 2009
  3. doi request reprint Does body mass index affect infection-related outcomes in the intensive care unit?
    Robert L Smith
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 8:581-8. 2007
  4. ncbi request reprint Prevention of infection in the intensive care unit
    Robert L Smith
    Department of Surgery, University of Virginia, Charlottesville, 22908, USA
    Curr Opin Infect Dis 19:323-6. 2006
  5. ncbi request reprint Hospital-acquired infections in the surgical intensive care: epidemiology and prevention
    R L Smith
    Department of Surgery, University of Virginia, Charlottesville, 22908, USA
    Zentralbl Chir 128:1047-61. 2003
  6. pmc Wound infection after elective colorectal resection
    Robert L Smith
    Department of Surgery, University of Virginia, Building MR 4, Room 3150, Lane Road, Charlottesville, VA 22908, USA
    Ann Surg 239:599-605; discussion 605-7. 2004
  7. ncbi request reprint On a likelihood-based goodness-of-fit test of the beta-binomial model
    S T Garren
    Department of Statistics, University of Virginia, Charlottesville 22903, USA
    Biometrics 56:947-50. 2000
  8. ncbi request reprint A nutrition support team led by general surgeons decreases inappropriate use of total parenteral nutrition on a surgical service
    A R Saalwachter
    University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am Surg 70:1107-11. 2004
  9. ncbi request reprint Contact isolation in surgical patients: a barrier to care?
    Heather L Evans
    Department of Surgery, UVA Health System, Charlottesville, VA 22908, USA
    Surgery 134:180-8. 2003
  10. ncbi request reprint Can we define the ideal duration of antibiotic therapy?
    Traci L Hedrick
    University of Virginia Surgical Infectious Disease Laboratory, Charlottesville, VA 22908, USA
    Surg Infect (Larchmt) 7:419-32. 2006

Collaborators

Detail Information

Publications35

  1. doi request reprint Valve-sparing aortic root reconstruction
    Robert L Smith
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, PO Box 800709, Charlottesville, VA 22908 0709, USA
    Surg Clin North Am 89:837-44, viii. 2009
    ..Because of this, it will likely still be a while before these operations are more routinely used by a broader group of surgeons, as compared with the very reproducible Bentall and De Bono repair...
  2. doi request reprint Do you need to clamp a patent left internal thoracic artery-left anterior descending graft in reoperative cardiac surgery?
    Robert L Smith
    Department of Surgery, Division of Thoracic Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 87:742-7. 2009
    ..However, we hypothesized that leaving a patent LITA-left anterior descending (LAD) graft unclamped would not affect mortality from reoperative cardiac surgery...
  3. doi request reprint Does body mass index affect infection-related outcomes in the intensive care unit?
    Robert L Smith
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 8:581-8. 2007
    ..We hypothesized that increasing BMI would be an independent predictor of higher mortality rates in the surgical/trauma ICU...
  4. ncbi request reprint Prevention of infection in the intensive care unit
    Robert L Smith
    Department of Surgery, University of Virginia, Charlottesville, 22908, USA
    Curr Opin Infect Dis 19:323-6. 2006
    ..To review tactics used to prevent intensive care unit infections, particularly ventilator-associated pneumonia and catheter-related bloodstream infections...
  5. ncbi request reprint Hospital-acquired infections in the surgical intensive care: epidemiology and prevention
    R L Smith
    Department of Surgery, University of Virginia, Charlottesville, 22908, USA
    Zentralbl Chir 128:1047-61. 2003
    ..By implementing effective preventative measures and maintaining strict surveillance of ICU infections, we hope to affect the associated morbidity, mortality, and cost that our patients and society bare...
  6. pmc Wound infection after elective colorectal resection
    Robert L Smith
    Department of Surgery, University of Virginia, Building MR 4, Room 3150, Lane Road, Charlottesville, VA 22908, USA
    Ann Surg 239:599-605; discussion 605-7. 2004
    ....
  7. ncbi request reprint On a likelihood-based goodness-of-fit test of the beta-binomial model
    S T Garren
    Department of Statistics, University of Virginia, Charlottesville 22903, USA
    Biometrics 56:947-50. 2000
    ..Other tests and models developed in their article are quite useful and interesting but are not examined herein...
  8. ncbi request reprint A nutrition support team led by general surgeons decreases inappropriate use of total parenteral nutrition on a surgical service
    A R Saalwachter
    University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am Surg 70:1107-11. 2004
    ..1347). The involvement of a surgical NST was associated with a reduction in inappropriate TPN orders without a change in overall use...
  9. ncbi request reprint Contact isolation in surgical patients: a barrier to care?
    Heather L Evans
    Department of Surgery, UVA Health System, Charlottesville, VA 22908, USA
    Surgery 134:180-8. 2003
    ..Contact isolation is commonly used to prevent transmission of resistant organisms. We hypothesized that contact isolation negatively impacts the amount of direct patient care...
  10. ncbi request reprint Can we define the ideal duration of antibiotic therapy?
    Traci L Hedrick
    University of Virginia Surgical Infectious Disease Laboratory, Charlottesville, VA 22908, USA
    Surg Infect (Larchmt) 7:419-32. 2006
    ..We also sought to investigate the difference between a fixed duration of therapy and one based on physiologic measures such as fever and leukocytosis...
  11. ncbi request reprint Cost of Gram-negative resistance
    Heather L Evans
    Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
    Crit Care Med 35:89-95. 2007
    ..We wished to test the hypothesis that rGNR infections are associated with higher resource utilization...
  12. ncbi request reprint Central cannulation is safe in acute aortic dissection repair
    T Brett Reece
    University of Virginia, Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 133:428-34. 2007
    ..We hypothesized that cannulation of the dissected aorta could be done safely with acceptable complication and mortality rates in this high-risk population...
  13. ncbi request reprint Efficacy of protocol implementation on incidence of wound infection in colorectal operations
    Traci L Hedrick
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Am Coll Surg 205:432-8. 2007
    ..We hypothesized that implementation of a multidisciplinary wound management protocol targeting these risk factors would reduce the incidence of SSI...
  14. ncbi request reprint Does prior transfusion worsen outcomes from infection in surgical patients?
    Michael G Hughes
    Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 4:335-43. 2003
    ..The objective of this study was to determine the effect of transfusion on outcomes among infected surgical patients...
  15. ncbi request reprint Single-institutional experience with the surgical infection prevention project in intra-abdominal surgery
    Traci L Hedrick
    Surgical Infectious Disease Laboratory, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 8:425-35. 2007
    ..We hypothesized that institutional implementation of a protocol targeting known risk factors would reduce the incidence of SSI associated with intra-abdominal surgery...
  16. doi request reprint Duration of antibiotic therapy for ventilator-associated pneumonia caused by non-fermentative gram-negative bacilli
    Traci L Hedrick
    University of Virginia Surgical Infectious Disease Laboratory, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 8:589-97. 2007
    ..We recently examined our institutional experience with VAP caused by NFGNB to determine whether shorter courses of antibiotic therapy were associated with higher rates of recurrence...
  17. doi request reprint Differences in early- and late-onset ventilator-associated pneumonia between surgical and trauma patients in a combined surgical or trauma intensive care unit
    Traci L Hedrick
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Trauma 64:714-20. 2008
    ..We sought to compare differences in patient characteristics and outcome between early- and late-onset VAP in trauma and nontrauma surgical patients...
  18. doi request reprint Outbreak of resistant Pseudomonas aeruginosa infections during a quarterly cycling antibiotic regimen
    Traci L Hedrick
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Surg Infect (Larchmt) 9:139-52. 2008
    ..Antibiotic cycling or rotation of antimicrobial agent classes has been proposed to combat antimicrobial resistance...
  19. pmc Reduction in rates of methicillin-resistant Staphylococcus aureus infection after introduction of quarterly linezolid-vancomycin cycling in a surgical intensive care unit
    Robert L Smith
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0709, USA
    Surg Infect (Larchmt) 9:423-31. 2008
    ..Creative interventions may be required to reverse or stabilize this trend...
  20. ncbi request reprint Nature of gram-negative rod antibiotic resistance during antibiotic rotation
    Heather L Evans
    Surgical Infectious Disease Research Laboratory, Department of Surgery, UVA Health System, Charlottesville, VA 22908 1380, USA
    Surg Infect (Larchmt) 6:223-31. 2005
    ..The aim of this study was to characterize the evolution of gram-negative antibiotic resistance during a study of empiric antibiotic rotation...
  21. ncbi request reprint Does the addition of glutamine to enteral feeds affect patient mortality?
    Alison Saalwachter Schulman
    Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
    Crit Care Med 33:2501-6. 2005
    ..The objective was to study in a prospective fashion the effects of adding glutamine to standard or immune-modulated (supplemented with omega-3 fatty acids, beta-carotene, and amino acids such as glutamine and arginine) tube feeds...
  22. ncbi request reprint HCV infection of the transplanted liver: changing CD81 and HVR1 variants immediately after liver transplantation
    Michael G Hughes
    Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia, USA
    Am J Transplant 5:2504-13. 2005
    ..In conclusion, HVR1 quasispecies variants differentially associate with, and infect allografts, after liver transplantation. Additionally, allografts express variable amounts of CD81 after transplantation...
  23. ncbi request reprint Primary human hepatocytes in spheroid formation to study hepatitis C infection
    Tae W Chong
    Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
    J Surg Res 130:52-7. 2006
    ..As hepatocytes are the primary reservoir for the virus in vivo, we report on a model using primary human hepatocytes cultured in spheroid formation...
  24. ncbi request reprint Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit ward
    Michael G Hughes
    Department of Surgery, University of Virginia, Charlottesville 22908, USA
    Crit Care Med 32:53-60. 2004
    ..We hypothesized that this intervention would decrease infectious complications in the non-ICU ward to which these patients were transferred...
  25. ncbi request reprint Comparison of fungal and nonfungal infections in a broad-based surgical patient population
    Michael G Hughes
    Department of Surgery, Surgical Infectious Disease Laboratory, University of Virginia, Charlottesville, Virginia 22908, USA
    Surg Infect (Larchmt) 6:55-64. 2005
    ..Our aim was to compare fungal and nonfungal infections among a diverse surgical patient population...
  26. ncbi request reprint The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:925-32. 2004
    ..This study defines injury progression in terms of function, cytoarchitecture, and inflammation and assesses whether adenosine A 2A receptor activation by ATL-146e limits injury progression...
  27. ncbi request reprint E2 quasispecies specificity of hepatitis C virus association with allografts immediately after liver transplantation
    Michael G Hughes
    University of Virginia, Department of Surgery, Surgical Infectious Disease Laboratory, Charlottesville, VA, USA
    Liver Transpl 10:208-16. 2004
    ..02 and P = 0.04, respectively). Immediately after transplantation but before actual infection, liver allografts select out from the infecting serum inoculum a less heterogeneous, more closely related population of quasispecies variants...
  28. ncbi request reprint Candida albicans and Saccharomyces cerevisiae expressing ALA1/ALS5 adhere to accessible threonine, serine, or alanine patches
    Nand K Gaur
    Research Service, VA Medical Center, Kansas City, MO, University of Kansas School of Medicine, Kansas City, KS, USA
    Cell Commun Adhes 9:45-57. 2002
    ..Thus, Ala1/Als5p recognizes patches of certain amino acids, which must be accessible before adherence will occur...
  29. ncbi request reprint Chromogenic derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products
    Sandra Pipino
    Department of Anatomy, Pharmacology and Forensic Medicine, Medical Pharmacology Section, Via Pietro Giuria 13, 10125 Torino, Italy
    Food Chem Toxicol 42:785-90. 2004
    ..The data suggest that the AHTN-derived chromogenic material is metabolite-related rather than representative of a toxic process, although further work is necessary to confirm this hypothesis...
  30. ncbi request reprint Evaluation of the oral subchronic toxicity of AHTN (7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) in the rat
    Anne Marie Api
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 42:791-801. 2004
    ..Further work on the mechanism of production of the abnormal color is in progress. Based on these results, the 90-day conservative no-observed-effect level (NOAEL) is 1.5 mg/kg body weight/day...
  31. ncbi request reprint Impact of immunomodulatory oligodeoxynucleotides on cytokine production in the lipopolysaccharide-stimulated human whole blood model
    Robert L Smith
    Surgical Infectious Disease Research Laboratory, Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Surgery 136:464-72. 2004
    ..We hypothesized that CpG ODNs would have considerable counterinflammatory effects on LPS-induced cytokine production...
  32. ncbi request reprint Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria
    John R Cashman
    Human BioMolecular Research Institute, San Diego, CA, USA
    Curr Drug Metab 4:151-70. 2003
    ..The remarkable progress in the biochemical, genetic, clinical basis for understanding the trimethylaminuria condition is summarized and points to needs in the treatment of individuals suffering from trimethylaminuria...
  33. pmc Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
    Kay D Macdermot
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:1074-80. 2005
    ..This endeavor will be crucial for gaining insight into the role of FOXP2 in human cognition...
  34. ncbi request reprint Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association
    Robert L Smith
    Division of Biomedical Sciences Section of Molecular Toxicology, Imperial College School of Medicine, South Kensington, London SW7 2AZ, United Kingdom
    Food Chem Toxicol 43:1141-77. 2005
    ....
  35. ncbi request reprint Screening practices of patients presenting for resection of a colorectal neoplasm
    Traci L Hedrick
    University of Virginia Health System, Department of Surgery, P O Box 801380, Charlottesville, VA 22908, USA
    Am Surg 72:89-95. 2006
    ..05). Of patients presenting for surgery, 71 per cent underwent CRC screening. Variability exists in the methods employed for CRC screening. CRC screening facilitates diagnosis at an early stage...