Phillip D Smith

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi Gliadin peptides activate blood monocytes from patients with celiac disease
    Jana Cinova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Clin Immunol 27:201-9. 2007
  2. ncbi Intestinal macrophages: unique effector cells of the innate immune system
    Phillip D Smith
    Department of Medicine Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunol Rev 206:149-59. 2005
  3. pmc Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses
    Phillip D Smith
    Division of Gastroenterology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 Veterans Affairs Medical Center, Birmingham, AL 35233
    J Immunol 193:5604-12. 2014
  4. pmc Intestinal macrophages and response to microbial encroachment
    P D Smith
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mucosal Immunol 4:31-42. 2011
  5. ncbi Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities
    P D Smith
    Department of Medicine, University of Alabama, and Veterans Affairs Medical Center, Birmingham, AL 35294, USA
    J Immunol 167:2651-6. 2001
  6. ncbi Macrophage HIV-1 infection and the gastrointestinal tract reservoir
    Phillip D Smith
    Department of Medicine, University of Alabama at Birmingham, Alabama 35294, USA
    J Leukoc Biol 74:642-9. 2003
  7. pmc Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, United Sates of America
    PLoS Pathog 7:e1002060. 2011
  8. ncbi Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection
    Akhil Maheshwari
    Department of Pediatrics, University of Alabama at Birmingham ZRB 633, 703 19th Street South, Birmingham, AL 35294, USA
    J Leukoc Biol 80:1111-7. 2006
  9. pmc Dendritic cells transmit HIV-1 through human small intestinal mucosa
    Ruizhong Shen
    Departmentsof Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Leukoc Biol 87:663-70. 2010
  10. pmc Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:19593-604. 2010

Research Grants

  1. IMMUNOBIOLOGY OF HIV-1 INFECTION IN MUCOSA
    Phillip Smith; Fiscal Year: 2007
  2. Immunobiology and Prevention of H. pylori Disease
    Phillip Smith; Fiscal Year: 2009

Collaborators

Detail Information

Publications30

  1. ncbi Gliadin peptides activate blood monocytes from patients with celiac disease
    Jana Cinova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Clin Immunol 27:201-9. 2007
    ..Thus, gliadin activation of HLA-DQ2(+) monocytes leading to chemokine and proinflammatory cytokine production may contribute to the host innate immune response in celiac disease...
  2. ncbi Intestinal macrophages: unique effector cells of the innate immune system
    Phillip D Smith
    Department of Medicine Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunol Rev 206:149-59. 2005
    ....
  3. pmc Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses
    Phillip D Smith
    Division of Gastroenterology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 Veterans Affairs Medical Center, Birmingham, AL 35233
    J Immunol 193:5604-12. 2014
    ..These findings provide additional information toward elucidating the mechanism by which HCMV potentiates bacteria-induced NF-κB-mediated macrophage inflammatory responses, thereby enhancing organ inflammation in HCMV-infected tissues. ..
  4. pmc Intestinal macrophages and response to microbial encroachment
    P D Smith
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mucosal Immunol 4:31-42. 2011
    ..Consequently, resident intestinal macrophages are inflammation adverse, but when the need arises, they receive assistance from newly recruited circulating monocytes...
  5. ncbi Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities
    P D Smith
    Department of Medicine, University of Alabama, and Veterans Affairs Medical Center, Birmingham, AL 35294, USA
    J Immunol 167:2651-6. 2001
    ....
  6. ncbi Macrophage HIV-1 infection and the gastrointestinal tract reservoir
    Phillip D Smith
    Department of Medicine, University of Alabama at Birmingham, Alabama 35294, USA
    J Leukoc Biol 74:642-9. 2003
    ..Elucidating the immunobiology of mucosal HIV-1 infection is critical for understanding disease pathogenesis and ultimately for devising an effective mucosal HIV-1 vaccine...
  7. pmc Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, United Sates of America
    PLoS Pathog 7:e1002060. 2011
    ..Thus, the profound inability of intestinal macrophages to support productive HIV-1 infection is likely the consequence of microenvironmental down-regulation of macrophage HIV-1 receptor/coreceptor expression and NF-κB activation...
  8. ncbi Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection
    Akhil Maheshwari
    Department of Pediatrics, University of Alabama at Birmingham ZRB 633, 703 19th Street South, Birmingham, AL 35294, USA
    J Leukoc Biol 80:1111-7. 2006
    ..These results indicate that CMV blocks stromal product inhibition of HIV-1 infection in macrophages, and this inhibition is mediated, at least in part, by CMV-induced TNF-alpha acting in trans to enhance HIV-1 infection...
  9. pmc Dendritic cells transmit HIV-1 through human small intestinal mucosa
    Ruizhong Shen
    Departmentsof Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Leukoc Biol 87:663-70. 2010
    ....
  10. pmc Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:19593-604. 2010
    ..Our findings implicate stromal transforming growth factor-beta-induced dysregulation of NF-kappaB proteins and Smad signaling in the differentiation of pro-inflammatory blood monocytes into noninflammatory intestinal macrophages...
  11. pmc Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Invest 115:66-75. 2005
    ....
  12. pmc GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium
    Ruizhong Shen
    Division of Gastroenterology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:3648-55. 2010
    ..These findings underscore the potential role of transcytosis blockade in the prevention of HIV-1 transmission across columnar epithelium such as that of the rectum...
  13. pmc Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 83:3258-67. 2009
    ....
  14. pmc Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells
    Diane Bimczok
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:6626-34. 2013
    ..Thus, as shown in other autoimmune and chronic inflammatory diseases, insufficient phagocyte clearance may contribute to the chronic and self-perpetuating inflammation in human H. pylori infection...
  15. ncbi Mucosal IL-8 and TGF-beta recruit blood monocytes: evidence for cross-talk between the lamina propria stroma and myeloid cells
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, 703 19th St South, 35294, USA
    J Leukoc Biol 80:492-9. 2006
    ....
  16. pmc Vaginal myeloid dendritic cells transmit founder HIV-1
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 88:7683-8. 2014
    ..Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission. ..
  17. pmc Early HIV-1 target cells in human vaginal and ectocervical mucosa
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA
    Am J Reprod Immunol 65:261-7. 2011
    ..Further characterization of the parameters of HIV-1 infection in genital mononuclear cells will enhance our understanding of HIV-1 infection in the female genital tract...
  18. pmc Stromal regulation of human gastric dendritic cells restricts the Th1 response to Helicobacter pylori
    Diane Bimczok
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gastroenterology 141:929-38. 2011
    ..To further elucidate the mucosal response to H pylori, we examined whether gastric stromal factors condition DCs to support tolerance to H pylori, analogous to intestinal stromal factor-driven macrophage tolerance to commensal bacteria...
  19. pmc Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Reprod Immunol 83:196-200. 2009
    ..Whether humoral responses to previously or newly encountered antigens are compromised in HIV-1-infected persons is under current investigation...
  20. ncbi Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells
    Gang Meng
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 8:150-6. 2002
    ..Our finding that CCR5+ intestinal epithelial cells select and transfer exclusively R5 viruses indicates a mechanism for the selective transmission of R5 HIV-1 in primary infection acquired through the upper gastrointestinal tract...
  21. pmc Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition
    Milan Raska
    Department of Immunology, Palacky University in Olomouc, Olomouc 77100, Czech Republic
    J Biol Chem 285:20860-9. 2010
    ..These results indicate that gp120 glycans contribute to antibody reactivity and should be considered in HIV-1 vaccine design...
  22. pmc HIV-1 envelope glycan moieties modulate HIV-1 transmission
    Ruizhong Shen
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 88:14258-67. 2014
    ..Env glycosylation should be taken into consideration in the development of vaccine strategies to interdict HIV-1 transmission...
  23. ncbi Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, ZRB 633, 703 19th Street South, Birmingham, AL 35294, USA
    Vaccine 23:901-9. 2005
    ..01). Vaccination with poliovirus vector containing the gene for the B subunit of H. pylori urease provides significant prophylactic and strong therapeutic protection against H. pylori in mice...
  24. pmc Interactions between HIV-1 and mucosal cells in the female reproductive tract
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Reprod Immunol 71:608-17. 2014
    ..Increased understanding of these interactions could illuminate new approaches for interdicting HIV-1 heterosexual transmission. ..
  25. pmc Mucosal correlates of protection in HIV-1-exposed sero-negative persons
    Ruizhong Shen
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Reprod Immunol 72:219-27. 2014
    ..A clear understanding of the mucosal correlates of protection against HIV-1 in HESN persons will provide critical new insights for the development of effective vaccine and microbicide strategies for the prevention of HIV-1 transmission. ..
  26. ncbi Cytokine gene profile in gastric mucosa in Helicobacter pylori infection and Zollinger-Ellison syndrome
    Paul R Harris
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294, USA
    Am J Gastroenterol 97:312-8. 2002
    ..The aim of this study was to elucidate the role of cytokines in these two diseases, as we quantitated proinflammatory cytokine messenger RNA (mRNA) levels in the gastric mucosa from patients with H. pylori infection and ZES...
  27. pmc Human primary gastric dendritic cells induce a Th1 response to H. pylori
    D Bimczok
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mucosal Immunol 3:260-9. 2010
    ..The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori...
  28. ncbi Human cytomegalovirus enhances chemokine production by lipopolysaccharide-stimulated lamina propria macrophages
    Tamara K Redman
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    J Infect Dis 185:584-90. 2002
    ..These findings suggest that mucosal macrophages, via enhanced mediator production, play an important role in intestinal inflammation associated with HCMV infection...
  29. doi Isolation of human monocyte populations
    Larry M Wahl
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2006
    ..This latter procedure can be used to isolate large numbers of purified, nonactivated monocytes...
  30. ncbi Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release
    Thomas Kossmann
    Oral Infection and Immunity Branch, National Institute of Dental and Crainofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 187:534-41. 2003
    ..These findings suggest that CMV infection of astrocytes induces the production of TGF-beta, which in turn enhances productive CMV expression...

Research Grants2

  1. IMMUNOBIOLOGY OF HIV-1 INFECTION IN MUCOSA
    Phillip Smith; Fiscal Year: 2007
    ..3) Determine whether intestinal (lamina propria)lymphocytes participate in the selection of the genotypic minor variant that characterizes the transmitted virus in acutely infected recipients. ..
  2. Immunobiology and Prevention of H. pylori Disease
    Phillip Smith; Fiscal Year: 2009
    ..pylori urease plus IL-10 or FoxP3 (the Tr cell transcription factor) protects mice against H. pylori infection. ..