Martyn T Smith

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
  2. ncbi Advances in understanding benzene health effects and susceptibility
    Martyn T Smith
    Superfund Research Program, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Annu Rev Public Health 31:133-48 2 p following 148. 2010
  3. ncbi Benzene exposure and risk of non-Hodgkin lymphoma
    Martyn T Smith
    Center for Occupational and Environmental Health, School of Public Health, 216 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 16:385-91. 2007
  4. ncbi Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
  5. ncbi Misuse of genomics in assigning causation in relation to benzene exposure
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-7356, USA
    Int J Occup Environ Health 14:144-6. 2008
  6. ncbi Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
  7. ncbi Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 48:467-74. 2007
  8. ncbi Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
  9. ncbi Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
  10. ncbi Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005

Research Grants

  1. HEALTH EFFECTS OF TOXIC SUBSTANCES
    Martyn Smith; Fiscal Year: 2004
  2. Genetic Susceptibility to Non-Hodgkins Lymphoma
    Martyn Smith; Fiscal Year: 2006
  3. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 2007
  4. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 1993
  5. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 2003

Collaborators

Detail Information

Publications100

  1. ncbi Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  2. ncbi Advances in understanding benzene health effects and susceptibility
    Martyn T Smith
    Superfund Research Program, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Annu Rev Public Health 31:133-48 2 p following 148. 2010
    ..There is probably no safe level of exposure to benzene, and all exposures constitute some risk in a linear, if not supralinear, and additive fashion...
  3. ncbi Benzene exposure and risk of non-Hodgkin lymphoma
    Martyn T Smith
    Center for Occupational and Environmental Health, School of Public Health, 216 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 16:385-91. 2007
    ..We conclude that, overall, the evidence supports an association between occupational benzene exposure and NHL...
  4. ncbi Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  5. ncbi Misuse of genomics in assigning causation in relation to benzene exposure
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-7356, USA
    Int J Occup Environ Health 14:144-6. 2008
  6. ncbi Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
    ..We are currently investigating potential mechanisms for this induction of selective aneuploidy...
  7. ncbi Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 48:467-74. 2007
    ..However, they do not rule out the possibility that other rearrangements of the MLL gene at chromosome 11q23 may be induced by benzene...
  8. ncbi Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  9. ncbi Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
    ..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway...
  10. ncbi Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  11. ncbi Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Blood 104:2155-62. 2004
    ..The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL...
  12. ncbi Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
    ..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis...
  13. ncbi Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California
    Melinda C Aldrich
    University of California Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94720 7380, USA
    Cancer Epidemiol Biomarkers Prev 15:578-81. 2006
    ..The mechanistic basis for this 2-fold variation in frequency of TEL-AML1 may be due to ethnic-specific risk factors or genetics and should be explored further...
  14. ncbi Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
    ..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified...
  15. ncbi Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
    PLoS ONE 3:e2816. 2008
    ..Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms...
  16. ncbi Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 14:2391-401. 2005
    ..These results suggest that PRL, CYP17A1, and COMT may be relevant genetic loci for non-Hodgkin lymphoma and indicate a possible role for prolactin and estrogen in lymphoma pathogenesis...
  17. ncbi Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  18. ncbi Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Br J Haematol 129:618-21. 2005
    ..44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis...
  19. ncbi Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
    ..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene...
  20. ncbi Evidence that humans metabolize benzene via two pathways
    Stephen M Rappaport
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
    Environ Health Perspect 117:946-52. 2009
    ..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels...
  21. ncbi Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  22. ncbi Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  23. ncbi Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  24. ncbi Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma
    Matthew S Forrest
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Br J Haematol 134:180-3. 2006
    ..8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility...
  25. ncbi Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
    ..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers...
  26. ncbi Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
    ....
  27. ncbi A functional TNFRSF5 gene variant is associated with risk of lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Blood 111:4348-54. 2008
    ..These results suggest that the TNFRSF5 -1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings...
  28. ncbi The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells
    Zhiying Ji
    Department of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    Mutagenesis 24:367-72. 2009
    ....
  29. ncbi Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers
    Matthew S Forrest
    School of Public Health, University of California, Berkeley, California 94720-7360, USA
    Environ Health Perspect 113:801-7. 2005
    ..Thus, microarray analysis along with real-time PCR confirmation reveals that altered expressions of CXCL16, ZNF331, JUN, and PF4 are potential biomarkers of benzene exposure...
  30. ncbi Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicology 229:101-13. 2007
    ..Further examination of the role of these genes in dioxin induced-toxicity is warranted...
  31. ncbi Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e14546. 2011
    ..The aim of the present study was to examine the effects of silencing WRN in p53 deficient HL60 and p53 wild-type TK6 hematopoietic cells, in order to further the understanding of WRN-associated tumorigenesis...
  32. ncbi Polymorphisms in ghrelin and neuropeptide Y genes are associated with non-Hodgkin lymphoma
    Danica R Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 14:1251-6. 2005
    ..4; 95% CI, 1.3-4.4), 1258G>A (OR, 2.0; 95% CI, 1.1-3.5), and 5671C>T (OR, 1.8; 95% CI, 1.1-3.0). These results add further support for the hypothesis that SNPs in energy-regulating genes affect risk of NHL...
  33. ncbi Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast
    Matthew North
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e24205. 2011
    ..Many of the yeast genes identified have human orthologs that may modulate human benzene toxicity in a similar manner and could play a role in benzene exposure-related disease...
  34. ncbi Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes
    Luoping Zhang
    School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720-7360, USA
    Mutat Res 558:63-74. 2004
    ..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage...
  35. ncbi An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  36. ncbi Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism
    Kristin E Porter
    School of Public Health, 237A Hildebrand Hall, University of California, Berkeley, CA 94720 7356, USA
    Environ Res 110:580-7. 2010
    ..No other genetic associations were found. These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease...
  37. ncbi Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
    Toxicol Sci 107:367-75. 2009
    ..Our data suggests that WRN plays an important role in the surveillance of and protection against DNA damage induced by HQ. This provides mechanistic support for the link between WRN and benzene-induced hematotoxicity...
  38. ncbi Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
    Christine F Skibola
    237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 171:267-76. 2010
    ..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology...
  39. ncbi Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 13:779-86. 2004
    ....
  40. ncbi Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic
    Christine M Hegedus
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Toxicol Sci 106:74-82. 2008
    ..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity...
  41. ncbi Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate
    Michele Fromowitz
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Mol Mutagen 53:488-91. 2012
    ..In vitro assays, such as the in vitro micronucleus assay, will be essential as international chemical policy is increasingly utilizing green chemistry principles that require more toxicological testing...
  42. ncbi Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism
    Christine M Hegedus
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Proteomics 7:548-57. 2007
    ..This study illustrates that proteome analysis can enhance our understanding of genotype-phenotype relationships. Additional studies are needed to clarify the interaction between the IL6 -174G>C polymorphism and ApoC-I...
  43. ncbi Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources
    Randi A Paynter
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Earl Warren Hall 7360, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 15:2533-6. 2006
    ..We conclude that highly multiplexed Illumina genotyping may be done on gDNA and wgaDNA obtained from whole blood, buccal samples, dried blood spots on Guthrie cards, and possibly even urine samples, with minimal misclassification...
  44. ncbi NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis
    Neela Guha
    Division of Epidemiology, School of Public Health, University of California, Berkeley, California 94704, USA
    Am J Epidemiol 168:1221-32. 2008
    ..Therefore, further research is warranted on the role of NQO1 polymorphisms in the etiology of childhood leukemia, especially among MLL-positive leukemias...
  45. ncbi Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia
    Ghislaine Scelo
    School of Public Health, University of California Berkeley, Berkeley, California 94704 7380, USA
    Environ Health Perspect 117:133-9. 2009
    ..Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia...
  46. ncbi Association of HLA-DQB1 alleles with risk of follicular lymphoma
    Nicholas K Akers
    School of Public Health, University of California, Berkeley, CA, USA
    Leuk Lymphoma 52:53-8. 2011
    ..51, 95% CI 0.38-0.69; adjusted p-value = 4.46 × 10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association...
  47. ncbi Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
    ..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)...
  48. ncbi Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone
    Noe Galvan
    Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Mutat Res 649:54-61. 2008
    ..Further studies in bone marrow-derived stem or progenitor cells are required to confirm our findings in HeLa cells and expand our ability to extrapolate the results to benzene toxicity in humans...
  49. ncbi Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
    ..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))...
  50. ncbi Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 51:181-91. 2010
    ....
  51. ncbi Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia
    Christine F Skibola
    NFCR Center for Genomics and Nutrition, School of Public Health, and the Department of Nutritional Sciences, University of California, Berkeley, CA 94720-7360, USA
    Blood 99:3786-91. 2002
    ....
  52. ncbi Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Carcinogenesis 33:240-52. 2012
    ..These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment...
  53. ncbi Issues of processing and multiple testing of SELDI-TOF MS proteomic data
    Merrill D Birkner
    Division of Biostatistics, School of Public Health, University of California, Berkeley, USA
    Stat Appl Genet Mol Biol 5:Article11. 2006
    ..Given no sources of unmeasured bias (such as confounding of experimental conditions with disease status), proteins found to be statistically significant using this technique have a low probability of being false positives...
  54. ncbi Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
    Cliona M McHale
    School of Public Health, University of California, Berkeley 94720-7360, USA
    Genes Chromosomes Cancer 37:36-43. 2003
    ..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...
  55. ncbi Selected technologies for measuring acquired genetic damage in humans
    Joe Shuga
    School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 51:851-70. 2010
    ..The technologies discussed in this review will significantly expand our knowledge of acquired genetic mutations and causative mechanisms...
  56. ncbi Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH)
    Patricia A Escobar
    Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, California 94720, USA
    Mutagenesis 22:321-7. 2007
    ..Comet-FISH also appears to be a useful approach for detecting and comparing damage to specific chromosome regions of significance in leukaemogenesis...
  57. ncbi The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro
    Andrew J Olaharski
    Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California, Berkeley, California 94720-7360, USA
    Toxicol Sci 93:341-7. 2006
    ..We conclude that TSA is both a clastogen and aneugen in the TK6 cell line and propose that the observed cytostatic and apoptotic properties of TSA may partially be due to this genotoxicity...
  58. ncbi Formaldehyde and leukemia: an updated meta-analysis and evaluation of bias
    Erika Schwilk
    Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA
    J Occup Environ Med 52:878-86. 2010
    ..Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia...
  59. ncbi Formaldehyde in China: production, consumption, exposure levels, and health effects
    Xiaojiang Tang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Int 35:1210-24. 2009
    ..The lack of quality epidemiological studies and basic data on exposed populations emphasizes the need for more extensive studies on formaldehyde and its related health effects in China...
  60. ncbi Critical windows of exposure to household pesticides and risk of childhood leukemia
    Xiaomei Ma
    School of Public Health, University of California, Berkeley, California 24720, USA
    Environ Health Perspect 110:955-60. 2002
    ..The findings suggest that exposure to household pesticides is associated with an elevated risk of childhood leukemia and further indicate the importance of the timing and location of exposure...
  61. ncbi Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
    Luoping Zhang
    School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
    Mutat Res 681:150-68. 2009
    ..To test these hypotheses, we recommend that future studies apply biomarkers validated for other chemical leukemogens to the study of formaldehyde...
  62. ncbi Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 45:388-96. 2005
    ..These data support the notion that benzene metabolites affect the ploidy status of specific chromosomes more than others and may initiate or promote leukemia induction through these specific effects...
  63. ncbi Prenatal origin of chromosomal translocations in acute childhood leukemia: implications and future directions
    Cliona M McHale
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Am J Hematol 75:254-7. 2004
    ..This would help to elucidate the molecular pathways involved in the progression from preleukemic clone harboring a translocation to fully disseminated leukemia...
  64. ncbi Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, USA
    Anal Biochem 327:184-99. 2004
    ..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene...
  65. ncbi Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:771-7. 2011
    ..We found that yeast deletion mutants lacking MTQ2 were highly resistant to iAs exposure. The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase...
  66. ncbi Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 7360, USA
    Blood 100:4590-3. 2002
    ..The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children...
  67. ncbi Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15101-6. 2002
    ....
  68. ncbi Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR
    John D Curry
    Division of Immunology, Department of Molecular and Cellular Biology, University of California at Berkley, 439 Life Sciences Addition, Berkeley, CA 94720 3200, USA
    Leuk Res 27:575-82. 2003
    ..No RAG2 expression was detected in these expanded samples, suggesting that the clones bearing the SIL-TAL1 fusion gene may have existed at low levels prior to the ex vivo expansion...
  69. ncbi Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
    Craig Steinmaus
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA
    Toxicol Appl Pharmacol 247:138-45. 2010
    ..These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility...
  70. ncbi Low efficiency of the Moloney murine leukemia virus reverse transcriptase during reverse transcription of rare t(8;21) fusion gene transcripts
    John Curry
    Department of Immunology, Molecular and Cellular Biology, University of California, Berkeley 94720 3200, USA
    Biotechniques 32:768, 770, 772, 754-5. 2002
    ..Levels of nonspecific or background RNA present in the RT reaction reduced the reverse transcriptase's conversion efficiency. This background effect was particularly pronounced when the specific template was present in rare amounts...
  71. ncbi Micronucleus frequency and proliferation in human lymphocytes after exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo
    Nina T Holland
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Mutat Res 521:165-78. 2002
    ..01), in accordance with the in vitro finding of increased RI at low doses...
  72. ncbi Biological sample collection and processing for molecular epidemiological studies
    Nina T Holland
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Mutat Res 543:217-34. 2003
    ....
  73. ncbi Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells
    Christine F Skibola
    School of Public Health, University of California Berkeley, Berkeley, CA, USA
    J Nutr 135:296-300. 2005
    ..4, 31.8, and 40.7 micromol/L, respectively. These data show endocrine modulating effects of kelp at relevant doses and suggest that dietary kelp may contribute to the lower incidence of hormone-dependent cancers among the Japanese...
  74. ncbi The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases
    Andrew J Olaharski
    School of Public Health, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 1:e77. 2005
    ..These findings demonstrate that humans are potentially exposed to epigenetic toxicants that inhibit sirtuin deacetylases...
  75. ncbi The nature of chromosomal aberrations detected in humans exposed to benzene
    Luoping Zhang
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
    Crit Rev Toxicol 32:1-42. 2002
    ..Leukemia cases associated with benzene exposure are, however, more likely to contain clonal chromosome aberrations then those arising de novo in the general population...
  76. ncbi Exposure to infections through day-care attendance and risk of childhood leukaemia
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94704, USA
    Radiat Prot Dosimetry 132:259-66. 2008
    ..A meta-analysis is currently underway, which will provide a quantitative evaluation of the overall consistency and strength of the association between day-care attendance or social contact and risk of childhood ALL...
  77. ncbi Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States)
    Christopher D Jensen
    School of Public Health, 419 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Cancer Causes Control 15:559-70. 2004
    ..Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL...
  78. ncbi A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia
    Kevin Y Urayama
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Int J Epidemiol 39:718-32. 2010
    ..A meta-analysis was conducted to examine the relationship between day-care attendance and risk of childhood ALL, specifically to address whether early-life exposure to infection is protective against ALL...
  79. ncbi Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Ann Occup Hyg 48:105-16. 2004
    ..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects...
  80. ncbi Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia
    Kathryn Sibley
    Leukaemia Research Fund, Epidemiology and Genetics Unit, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Cancer Res 63:4327-30. 2003
    ..5%; odds ratio, 6.72; 95% confidence interval, 3.13-14.51). These data suggest that variation in the FAS gene promoter may affect FAS gene expression and modulate apoptotic signaling, contributing to an increased risk of AML...
  81. ncbi Environmental and behavioral factors and the risk of non-Hodgkin lymphoma
    Patricia Hartge
    National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:367-8. 2007
  82. ncbi Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16)
    Cliona M McHale
    Blood 101:4640-1. 2003
  83. ncbi The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene
    Richard Albertini
    University of Vermont, Burlington, VT 05401, USA
    Regul Toxicol Pharmacol 37:105-32. 2003
    ..This paper presents the findings of that working group and concludes with 15 simple principles for the use of non-tumor data in cancer risk assessment...
  84. ncbi CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication
    David T Bowen
    Department of Molecular and Cellular Pathology, University of Dundee, Dundee, United Kingdom
    Blood 101:2770-4. 2003
    ....
  85. ncbi A comparison of methods to control type I errors in microarray studies
    Jinsong Chen
    Lawrence Berkeley National Laboratory
    Stat Appl Genet Mol Biol 6:Article28. 2007
    ..Results show that among the three resampling based methods, the QTBD method provides relatively accurate and powerful control in more general circumstances...
  86. ncbi Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults
    Gareth J Morgan
    Academic Unit of Haematology and Oncology, University of Leeds, Leeds, England
    Am J Pharmacogenomics 2:79-92. 2002
    ..The technological challenges imposed by the high throughput of samples required by these studies are currently being addressed...
  87. ncbi In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
    Blood 99:3801-5. 2002
    ....
  88. ncbi Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia
    Shichun Zheng
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
    Cancer Res 64:2000-6. 2004
    ..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL...
  89. ncbi High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia
    Sara Rollinson
    Leukaemia Research Fund Epidemiology and Genetics Unit, School of Medicine, University of Leeds, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:795-800. 2004
    ..76, 95% confidence interval 1.26-2.44). These data suggest that quantitative AS PCR can be used as an efficient screening technique for disease associations of genetic variants in DNA pools made from case-control studies...
  90. ncbi Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, University of York, York, YO10 5DD, UK
    Haematologica 91:1222-7. 2006
    ..Genetic variation in the genes coding for these enzymes (SOD2, GPX1, and CAT, respectively) alters ROS production and therefore may provide a mechanism for the relationship between inflammation and NHL...
  91. ncbi Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  92. ncbi Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  93. ncbi Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes
    Tracy J Lightfoot
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Area 3, Seebohm Rowntree Building YO10 5DD, York, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2999-3003. 2005
    ..Thus, further investigations are warranted in larger series with dietary information to determine the roles that genetics and folic acid status play in the etiology of lymphoma...
  94. ncbi Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:17041-6. 2005
    ....
  95. ncbi Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  96. ncbi Personalized exposure assessment: promising approaches for human environmental health research
    Brenda K Weis
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 113:840-8. 2005
    ..Improved methods for exposure assessment will result in better means of monitoring and targeting intervention and prevention programs...
  97. ncbi Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  98. ncbi Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  99. ncbi Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  100. ncbi RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia
    Sara Rollinson
    Division of Laboratory and Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Leuk Res 31:169-74. 2007
    ..9% versus controls 6.5%, OR 0.61, 95% CI 0.42-0.90). These data suggest that variants in the RAD51 HR gene may modulate genetic predisposition to AML...

Research Grants22

  1. HEALTH EFFECTS OF TOXIC SUBSTANCES
    Martyn Smith; Fiscal Year: 2004
    ..abstract not provided ..
  2. Genetic Susceptibility to Non-Hodgkins Lymphoma
    Martyn Smith; Fiscal Year: 2006
    ..abstract_text> ..
  3. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 2007
    ..The overall goal is to develop new biomarkers of exposure and early effect for benzene and provide new insights into the mechanisms of benzene toxicity. ..
  4. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 1993
    ..These studies should greatly enhance our ability to characterize the risk posed by benzene exposure in humans...
  5. BIOMARKERS OF BENZENE EXPOSURE AND GENOTOXICITY
    Martyn Smith; Fiscal Year: 2003
    ..These studies will contribute to our understanding of the mechanism of benzene-induced leukemia, the risk benzene poses at low doses, and factors associated with susceptibility to this compound. ..