Lachlan J Smith
Affiliation: University of Pennsylvania
Peck S, O Donnell P, Kang J, Malhotra N, Dodge G, Pacifici M, et al
. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs. Mol Genet Metab. 2015;116:195-203 pubmed publisher
..These results also highlight the importance of early diagnosis and therapeutic intervention to prevent the progression of debilitating skeletal disease in MPS patients. ..
Gorth D, Martin J, Dodge G, Elliott D, Malhotra N, Mauck R, et al
. In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation. J Exp Orthop. 2014;1:15 pubmed publisher
..Microspheres can successfully be delivered to the disc in vivo and retained for a clinically relevant time frame. IL-1ra released from microspheres can effectively prevent IL-1Î²-induced NP glycosaminoglycan loss in vivo. ..
Gullbrand S, Malhotra N, Schaer T, Zawacki Z, Martin J, Bendigo J, et al
. A large animal model that recapitulates the spectrum of human intervertebral disc degeneration. Osteoarthritis Cartilage. 2017;25:146-156 pubmed publisher
..This model may serve as a robust platform for evaluating the efficacy of therapeutics targeted towards varying degrees of disc degeneration. ..
Smith L, Chiaro J, Nerurkar N, Cortes D, Horava S, Hebela N, et al
. Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture. Eur Cell Mater. 2011;22:291-301 pubmed
..IL-1ra significantly attenuated degradative changes induced by IL-1?. These results suggest that this in vitro model represents a reliable and cost-effective platform for evaluating new therapies for disc degeneration. ..
Peck S, Casal M, Malhotra N, Ficicioglu C, Smith L. Pathogenesis and treatment of spine disease in the mucopolysaccharidoses. Mol Genet Metab. 2016;118:232-43 pubmed publisher
Gullbrand S, Schaer T, Agarwal P, Bendigo J, Dodge G, Chen W, et al
. Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. Acta Biomater. 2017;60:201-209 pubmed publisher
..These results support evaluation of this hydrogel as a minimally invasive disc therapeutic in long-term preclinical studies as a precursor to future clinical application in patients with disc degeneration and low back pain. ..
Peck S, McKee K, Tobias J, Malhotra N, Harfe B, Smith L. Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus. Sci Rep. 2017;7:10504 pubmed publisher
..This study represents the first transcriptome-wide analysis of embryonic NDCs. Results suggest signaling and biosynthesis of NDCs change dramatically as a function of developmental stage. ..
Gorth D, Mauck R, Chiaro J, Mohanraj B, Hebela N, Dodge G, et al
. IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1?-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 2012;14:R179 pubmed publisher
..Ongoing studies are focusing on testing IL-1ra microspheres in an in vivo model of disc degeneration, as a prelude to clinical translation. ..