Ken R Smith
Affiliation: University of Utah
- BRCA1 and BRCA2 mutations and female fertilityKen R Smith
Department of Family and Consumer Studies, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84102, USA
Curr Opin Obstet Gynecol 25:207-13. 2013..To review recent publications examining BRCA1 and BRCA2 mutations and their relationship with female fertility...
- Effects of BRCA1 and BRCA2 mutations on female fertilityKen R Smith
Department of Family and Consumer Studies, University of Utah, 225 South 1400 East Alfred Emery Building 228, Salt Lake City, UT 84112, USA
Proc Biol Sci 279:1389-95. 2012..Our findings suggest the need to re-examine the wider role played by BRCA1/2 mutations. Elevated fertility of female mutation carriers indicates that they are more fecund despite their elevated post-reproductive mortality risks...
- Fertility intentions following testing for a BRCA1 gene mutationKen R Smith
University of Utah, Salt Lake City, UT, USA
Cancer Epidemiol Biomarkers Prev 13:733-40. 2004..To test whether fertility intentions differed among persons who tested positive, tested negative, or did not know their genetic status for a mutation of the BRCA1 gene...
- Walkability and body mass index density, design, and new diversity measuresKen R Smith
Department of Family and Consumer Studies, 225 S 1400 E RM 228, University of Utah, Salt Lake City UT 84112 0080, USA
Am J Prev Med 35:237-44. 2008..S. have increased interest in community designs that encourage healthy weight. This study relates neighborhood walkability-density, pedestrian-friendly design, and two novel measures of land-use diversity-to residents' excess weight...
- Familial aggregation of survival and late female reproductionKen R Smith
Department of Family and Consumer Studies, University of Utah, Salt Lake City, 84112, USA
J Gerontol A Biol Sci Med Sci 64:740-4. 2009..These results support the hypothesis that late female fertility and slow somatic aging may be promoted by the same genetic variants...
- Effects of childhood and middle-adulthood family conditions on later-life mortality: evidence from the Utah Population Database, 1850-2002Ken R Smith
University of Utah, Salt Lake City, Utah, United States
Soc Sci Med 68:1649-58. 2009..Our measures of familial aggregation of longevity were large and suggest an alternative view of early-life conditions...
- Re-visiting the relationship between neighbourhood environment and BMI: an instrumental variables approach to correcting for residential selection biasCathleen D Zick
Department of Family and Consumer Studies, University of Utah, 225 South 1400 East, Room 220, 84112, Salt Lake City, UT 84112, USA
Int J Behav Nutr Phys Act 10:27. 2013..In cross-sectional studies, non-random residential selection impedes researchers' ability to conclude that neighbourhood environments cause these outcomes...
- Running to the store? The relationship between neighborhood environments and the risk of obesityCathleen D Zick
University of Utah, Salt Lake City, Utah, USA
Soc Sci Med 69:1493-500. 2009..Finally, multiple food options within a neighborhood reduce BMI/obesity risk, relative to no food options, for individuals living in either low-income or non-low neighborhoods...
- Neighborhood design for walking and biking: physical activity and body mass indexBarbara B Brown
Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT 84112 0080, USA
Am J Prev Med 44:231-8. 2013..Neighborhood designs often relate to physical activity and to BMI...
- Physical activity during the transition from adolescence to adulthoodCathleen D Zick
Dept of Family and Consumer Studies and Institute for Public and International Affairs, University of Utah, Salt Lake City, UT 84112, USA
J Phys Act Health 4:125-37. 2007..We examine how age, life course roles, and contextual variables relate to both the composition and the overall level of physical activity in late adolescence and early adulthood...
- Fertility and post-reproductive longevityKen R Smith
Department of Family and Consumer Studies, 225 South 1400 East, Rm 228, University of Utah, Salt Lake City, Utah 84112, USA
Soc Biol 49:185-205. 2002..We find some support for predictions based on evolutionary principles, but we also find evidence that implicates a role for shared marital environments...
- Mixed land use and walkability: Variations in land use measures and relationships with BMI, overweight, and obesityBarbara B Brown
Department of Family and Consumer Studies, 225 S 1400 E RM 228, University of Utah, Salt Lake City, UT 84112 0080, USA
Health Place 15:1130-41. 2009..Thus the presence of walkable land uses, rather than their equal mixture, relates to healthy weight...
- Effects of spouses on distress experienced by BRCA1 mutation carriers over timeJean E Wylie
Resource for Genetic and Epidemiologic Research, School of Medicine, University of Utah, Salt Lake City, 84132, USA
Am J Med Genet C Semin Med Genet 119:35-44. 2003..These findings are an important addition to the literature and will augment clinicians' ability to identify individuals potentially at risk for negative responses to adverse genetic test results...
- Are you what your mother weighs? Evaluating the impact of maternal weight trajectories on youth overweightLori Kowaleski-Jones
Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT, 84112 0080, USA
Matern Child Health J 14:680-6. 2010..Maternal weight histories offer additional insights about the youth's home environment that are associated with the risk of a youth being overweight...
- Twinning in humans: maternal heterogeneity in reproduction and survivalShannen L Robson
Department of Anthropology, University of Utah, Salt Lake City, UT, USA
Proc Biol Sci 278:3755-61. 2011..From the largest historical sample of twinning mothers yet published, we conclude that bearing twins is more likely for those with a robust phenotype and is a useful index of maternal heterogeneity...
- Marital fertility and income: moderating effects of the Church of Jesus Christ of Latter-day Saints religion in UtahJoseph B Stanford
Department of Family and Preventive Medicine, University of Utah, UT, USA
J Biosoc Sci 45:239-48. 2013..The LDS religion's pronatalist stance probably encourages childbearing among those with higher income...
- Harvesting more than vegetables: the potential weight control benefits of community gardeningCathleen D Zick
Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT 84112, USA
Am J Public Health 103:1110-5. 2013..We examined the association of participation in community gardening with healthy body weight...
- Genetic testing for a BRCA1 mutation: prophylactic surgery and screening behavior in women 2 years post testingJeffrey R Botkin
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113, USA
Am J Med Genet A 118:201-9. 2003..Oophorectomy was obtained by a large proportion of carrier women in contrast to mastectomy which was not utilized within the first 2 years following testing...
- Association between telomere length in blood and mortality in people aged 60 years or olderRichard M Cawthon
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Lancet 361:393-5. 2003..0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases...
- Longevity and correlated frailty in multigenerational familiesGilda Garibotti
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
J Gerontol A Biol Sci Med Sci 61:1253-61. 2006..143 and 0.186, respectively. Through simulations, we also show a greater reduction in the bias of parameter estimates for fixed covariates through the use of the correlated frailty model...
- Double impact: what sibling data can tell us about the long-term negative effects of parental divorceNicholas H Wolfinger
Department of Family and Consumer Studies, University of Utah, Salt Lake City 84112 0080, USA
Soc Biol 50:58-76. 2003..These findings were unchanged when controlling for a number of differences both between and within sibships. Also, the negative effects of parental divorce largely do not vary according to respondent characteristics...
- Communication analysis of BRCA1 genetic counselingLee Ellington
University of Utah College of Nursing, 10 S 2000 E, Salt Lake City, UT 84112 5880, USA
J Genet Couns 14:377-86. 2005..We found that participant gender, presence of a client companion, and counselor identity influence session communication...
- Familial effects of BRCA1 genetic mutation testing: changes in perceived family functioningAntoinette M Stroup
Utah Cancer Registry, Suite 106B, 650 Komas Drive, Salt Lake City, UT 84108, USA
Cancer Epidemiol Biomarkers Prev 16:135-41. 2007..In fact, it is other life circumstances that exist at the time of the genetic testing process that seem to influence the degree to which families adjust to the experience and test results...
- Moderate to vigorous physical activity and weight outcomes: does every minute count?Jessie X Fan
Department of Family and Consumer Studies, University of Utah, 225 South 1400 East, AEB 228, Salt Lake City, UT 84112 0080, USA
Am J Health Promot 28:41-9. 2013..The purpose of this study was to test if moderate to vigorous physical activity (MVPA) in less than the recommended ≥10-minute bouts related to weight outcomes...
- A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional lociRichard A Kerber
Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
PLoS ONE 7:e34746. 2012..Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for variation in human lifespan have had limited success...
- Historical trends of survival among widows and widowersGeraldine P Mineau
Department of Oncological Sciences, University of Utah, Salt Lake City 84112 5550, USA
Soc Sci Med 54:245-54. 2002....
- Marriage and divorce among young adult cancer survivorsAnne C Kirchhoff
Center for Children s Cancer Research, Huntsman Cancer Institute, Salt Lake City, UT, USA
J Cancer Surviv 6:441-50. 2012..We examined marital outcomes among cancer survivors diagnosed during early adulthood from the 2009 Behavioral Risk Factor Surveillance System dataset...
- Mortality and fertility rates in humans and chimpanzees: How within-species variation complicates cross-species comparisonsKristen Hawkes
Department of Anthropology, University of Utah, Salt Lake City, 84112 0600, USA
Am J Hum Biol 21:578-86. 2009..We report these puzzles using data from nine human populations and both wild and captive chimpanzees, and suggest that systematic differences in the heterogeneity of surviving adults may explain them...
- Voluntary disclosure of BRCA1 mutation test resultsKen R Smith
Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT 84112, USA
Genet Test 6:89-92. 2002..High rates of disclosure to family members should promote awareness of hereditary cancer risk. Selective disclosure to co-workers and insurers may promote information asymmetries that could affect employment and insurance markets...
- Excess mortality and causes of death in autism spectrum disorders: a follow up of the 1980s Utah/UCLA autism epidemiologic studyDeborah Bilder
Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
J Autism Dev Disord 43:1196-204. 2013....
- Human actuarial aging increases faster when background death rates are lower: a consequence of differential heterogeneity?Kristen Hawkes
Department of Anthropology, University of Utah, Salt Lake City, Utah, USA
Evolution 66:103-14. 2012..Finally, we compare the relationships among mortality parameters of the traditional societies and the historical series, providing further suggestive evidence that differential heterogeneity has strong effects on actuarial aging...
- Greater risk of dementia when spouse has dementia? The Cache County studyMaria C Norton
Department of Family, Consumer, and Human Development Utah State University, Logan, Utah, USA
J Am Geriatr Soc 58:895-900. 2010..To examine the effects of caring for a spouse with dementia on the caregiver's risk for incident dementia...
- Do women stop early? Similarities in fertility decline in humans and chimpanzeesKristen Hawkes
Department of Anthropology, University of Utah, Salt Lake City, Utah 84112 0060, USA
Ann N Y Acad Sci 1204:43-53. 2010..Neither realized fertility nor rates of follicular atresia stand as evidence against the hypothesis that ages at last birth changed little while greater longevity evolved in our lineage...
- Brief communication: Evaluating grandmother effectsKristen Hawkes
Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA
Am J Phys Anthropol 140:173-6. 2009....
- Vulvar mucus observations and the probability of pregnancyJoseph B Stanford
Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah, USA
Obstet Gynecol 101:1285-93. 2003..To assess the day-specific and cycle-specific probabilities of conception leading to clinical pregnancy, in relation to the timing of intercourse and vulvar mucus observations...
- Prenatal care among immigrant and racial-ethnic minority women in a new immigrant destination: exploring the impact of immigrant legal statusKim Korinek
Department of Sociology, University of Utah, 380 S 1530 E, Rm 301, Salt Lake City, UT 84112, United States
Soc Sci Med 72:1695-703. 2011....
- Familial risk of childhood cancer and tumors in the Li-Fraumeni spectrum in the Utah Population Database: implications for genetic evaluation in pediatric practiceKaren Curtin
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT Department of Internal Medicine, University of Utah, Salt Lake City, UT
Int J Cancer 133:2444-53. 2013..We encourage the collection of a family medical history that is routinely updated for all pediatric cancer patients, and that families with early-onset adult cancers or clusters of several cancers are referred for genetic counseling...
- Improving quality of life of children with oral clefts: perspectives of parentsMary Bishop Stone
Division of Medical Genetics, University of Utah, Salt Lake City, Utah 84132, USA
J Craniofac Surg 21:1358-64. 2010..Combining these crucial issues with a life-stage approach provides a framework for intervention that focuses on drivers of quality of life at selected milestones in the life of children with oral clefts...
- Interpersonal responses among sibling dyads tested for BRCA1/BRCA2 gene mutationsHeidi A Hamann
Department of Psychology, Washington State University, Pullman 99164 4820, USA
Health Psychol 27:100-9. 2008..The purpose of this study was to compare sibling pairs with different combinations of BRCA1/BRCA2 test results on measures of affect, interpersonal responses, and physiological reactions...
- Differential fitness costs of reproduction between the sexesDustin J Penn
Konrad Lorenz Institute for Ethology, Austrian Academy of Sciences, Savoyenstrasse 1a, A 1160 Vienna, Austria
Proc Natl Acad Sci U S A 104:553-8. 2007..Our findings help to explain some puzzling aspects of human reproductive physiology and behavior, including the evolution of menopause and fertility declines associated with improvements in women's status (demographic transitions)...
- KINSHIP AND SOCIO-DEMOGRAPHIC DETERMINANTS OF MORTALITYKen Smith; Fiscal Year: 2002..To accomplish the proposed aims, the set of Utah death certificates within the Utah Population Database will be expanded to include about 500,000 death records that cover the period 1904-1995. ..
- The Utah Study of Fertility, Longevity and AgingKen Smith; Fiscal Year: 2007..This study will help to determine whether there are genetic variants associated with familial longevity and how such genes affect the risk of important traits and diseases associated with aging. ..