Jeffrey B Smith

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro
    Tam Thuan Nguyen
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Interferon Cytokine Res 22:899-909. 2002
  2. ncbi request reprint Glucocorticoid-attenuated response genes induced in the lung during endotoxemia
    Jeffrey B Smith
    Department of Pediatrics, UCLA School of Medicine and Mattel Children s Hospital at UCLA, University of California, 90095, USA
    Am J Physiol Lung Cell Mol Physiol 283:L636-47. 2002
  3. ncbi request reprint Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
  4. ncbi request reprint Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models
    Jeffrey B Smith
    Pediatrics Neonatology, UCLA Center for the Health Sciences, B2 325A, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Am Thorac Soc 1:275-81. 2004
  5. ncbi request reprint A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells
    Yan Hu
    Department of Pediatrics, Mattel Children s Hospital at UCLA and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Biochem Biophys Res Commun 333:253-63. 2005
  6. pmc CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung
    Daniel P Widney
    Division of Neonatology, Department of Pediatrics, David Geffen UCLA School of Medicine, Center for the Health Sciences, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Infect Immun 73:485-93. 2005
  7. pmc Levels of Murine, but Not Human, CXCL13 Are Greatly Elevated in NOD-SCID Mice Bearing the AIDS-Associated Burkitt Lymphoma Cell Line, 2F7
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America UCLA AIDS Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e72414. 2013
  8. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
  9. ncbi request reprint Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment
    Matthew J Ruddy
    Department of Microbiology and Immunology, University at Buffalo, SUNY, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 76:135-44. 2004
  10. ncbi request reprint Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
    Lei Chen
    Department of Pharmacology and Toxicology, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Mol Pharmacol 64:334-45. 2003

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro
    Tam Thuan Nguyen
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Interferon Cytokine Res 22:899-909. 2002
    ..7 and Swiss 3T3 cells. The coordinate expression of the MuGBPs suggests that they share common mechanisms of regulation...
  2. ncbi request reprint Glucocorticoid-attenuated response genes induced in the lung during endotoxemia
    Jeffrey B Smith
    Department of Pediatrics, UCLA School of Medicine and Mattel Children s Hospital at UCLA, University of California, 90095, USA
    Am J Physiol Lung Cell Mol Physiol 283:L636-47. 2002
    ..Our results suggest that a full understanding of glucocorticoid effects on lung inflammation will require elucidation of the roles of an extensive network of glucocorticoid-modulated genes...
  3. ncbi request reprint Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus...
  4. ncbi request reprint Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models
    Jeffrey B Smith
    Pediatrics Neonatology, UCLA Center for the Health Sciences, B2 325A, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Proc Am Thorac Soc 1:275-81. 2004
    ..Future studies using microarrays in this and other inflammation models may identify many additional glucocorticoid-regulated genes potentially important in inflammatory diseases...
  5. ncbi request reprint A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells
    Yan Hu
    Department of Pediatrics, Mattel Children s Hospital at UCLA and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Biochem Biophys Res Commun 333:253-63. 2005
    ..We conclude that LINCR is a novel inflammation-induced ubiquitin E3 ligase expressed in alveolar epithelial type II cells, and discuss its potential role in the lung response to inflammation...
  6. pmc CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung
    Daniel P Widney
    Division of Neonatology, Department of Pediatrics, David Geffen UCLA School of Medicine, Center for the Health Sciences, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Infect Immun 73:485-93. 2005
    ..We conclude that the CXCR3 receptor-ligand system contributes to pulmonary host defense in B. bronchiseptica infection by recruiting lymphocytes and NK cells into the lung...
  7. pmc Levels of Murine, but Not Human, CXCL13 Are Greatly Elevated in NOD-SCID Mice Bearing the AIDS-Associated Burkitt Lymphoma Cell Line, 2F7
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America UCLA AIDS Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e72414. 2013
    ..This mouse model may be useful for future studies on the interactions of the innate immune system and AIDS-BL tumor cells, as well as for the assessment of potential tumor biomarkers for this disease. ..
  8. ncbi request reprint Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection
    Daniel P Widney
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 27 139 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1740, USA
    J Interferon Cytokine Res 25:702-6. 2005
    ....
  9. ncbi request reprint Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment
    Matthew J Ruddy
    Department of Microbiology and Immunology, University at Buffalo, SUNY, 36 Foster Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Leukoc Biol 76:135-44. 2004
    ..This study is the first demonstration of LIX expression in bone cells and has implications for inflammatory bone diseases such as arthritis and periodontal disease...
  10. ncbi request reprint Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
    Lei Chen
    Department of Pharmacology and Toxicology, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Mol Pharmacol 64:334-45. 2003
    ....
  11. pmc An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
    Jeffrey J Yu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA
    Blood 109:3794-802. 2007
    ..These results indicate a nonredundant role for IL-17 in mediating host defense via neutrophil mobilization...

Research Grants5

  1. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..Genes identified in this search are likely to encode pro-inflammatory mediators that participate in a wide range of inflammatory lung diseases in addition to endotoxemia. ..