H C Smith

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Base-modification mRNA editing through deamination--the good, the bad and the unregulated
    H C Smith
    Department of Pathology, University of Rochester, NY 14642, USA
    Trends Genet 12:418-24. 1996
  2. pmc Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase
    M P Sowden
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 341:639-45. 1999
  3. pmc APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers
    C A Galloway
    University of Rochester, School of Medicine and Dentistry, Department of Biochemistry and Biophysics, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 398:38-43. 2010
  4. ncbi request reprint Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat
    T L Phung
    Department of Biochemistry, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Metabolism 45:1056-8. 1996
  5. pmc Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization
    M P Sowden
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 359:697-705. 2001
  6. pmc Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase
    G S Dance
    Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Nucleic Acids Res 29:1772-80. 2001
  7. ncbi request reprint Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis
    A Giangreco
    Department of Biochemistry and Biophysics, James P. Wilmot Cancer Center, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14623, USA
    Biochem Biophys Res Commun 289:1162-7. 2001
  8. pmc The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing
    G R Skuse
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Nucleic Acids Res 24:478-85. 1996

Collaborators

  • Y Yang
  • G R Skuse
  • A Kumar
  • M P Sowden
  • C A Galloway
  • A Giangreco
  • G S Dance
  • J Krucinska
  • J D Sparks
  • C E Sparks
  • T L Phung
  • P Beemiller
  • I Mikityansky
  • D V Mater
  • I S Mian
  • T A Garrow
  • H L Collins

Detail Information

Publications8

  1. ncbi request reprint Base-modification mRNA editing through deamination--the good, the bad and the unregulated
    H C Smith
    Department of Pathology, University of Rochester, NY 14642, USA
    Trends Genet 12:418-24. 1996
    ..The data suggest that there are multiple editing complexes or 'editosomes', which manifest editing-site preferences due to their macromolecular composition...
  2. pmc Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase
    M P Sowden
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 341:639-45. 1999
    ..Results suggest that apo B-mRNA abundance in McA cells is related to the expression of BHMT, an enzyme important in homocysteine metabolism...
  3. pmc APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers
    C A Galloway
    University of Rochester, School of Medicine and Dentistry, Department of Biochemistry and Biophysics, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 398:38-43. 2010
    ..Our study predicted that the C to U editosome may be assembled on the mooring sequence of apoB mRNA as a dimer of ACF bound to a dimer of APOBEC-1...
  4. ncbi request reprint Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat
    T L Phung
    Department of Biochemistry, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Metabolism 45:1056-8. 1996
    ..In contrast, the hepatic mRNA encoding APOBEC-1, the catalytic subunit of the RNA editing activity, demonstrated an increased abundance of 1.8-fold in obese Zucker rats versus lean controls...
  5. pmc Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization
    M P Sowden
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem J 359:697-705. 2001
    ..We propose that pre-mRNA passage through the temporal or spatial restriction point where they become committed to spliceosome assembly contributes regulatory information for subsequent editosome activity...
  6. pmc Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase
    G S Dance
    Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Nucleic Acids Res 29:1772-80. 2001
    ..We propose that CDD1 be designated an orphan C-->U editase until its native RNA substrate, if any, can be identified and that it be added to the CDAR (cytidine deaminase acting on RNA) family of editing enzymes...
  7. ncbi request reprint Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis
    A Giangreco
    Department of Biochemistry and Biophysics, James P. Wilmot Cancer Center, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14623, USA
    Biochem Biophys Res Commun 289:1162-7. 2001
    ..It is proposed that the level of editing activity observed in hepatocytes may be the end result of positive and negative regulatory proteins...
  8. pmc The neurofibromatosis type I messenger RNA undergoes base-modification RNA editing
    G R Skuse
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Nucleic Acids Res 24:478-85. 1996
    ..Unlike apoB, NF1 editing did not demonstrate dependence on rate-limiting quantities of APOBEC-1 (the apoB editing catalytic subunit) suggesting that different trans-acting factors may be involved in the two editing processes...