Ford A, Dasgupta P, Mikhailenko I, Smith E, Noben Trauth N, Keegan A. Adoptive transfer of IL-4R?+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. BMC Immunol. 2012;13:6 pubmed publisher
..Since an increase in AAM and their products has been observed in patients with asthma exacerbations, these results suggest that AAM may be targeted to alleviate exacerbations. ..
Dasgupta P, Chapoval S, Smith E, Keegan A. Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4R? and STAT6 dependent manner. BMC Immunol. 2011;12:60 pubmed publisher
..Further studies are required to identify other proteins and signaling pathways involved in airway inflammation. ..
Smith E, Shanks K, Lipsky M, DeTolla L, Keegan A, Chapoval S. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. BMC Immunol. 2011;12:30 pubmed publisher
..Our current findings pave the way for further investigations of the role of immune semaphorins in inflammation and their use as potential therapeutic targets for the inflammatory lung conditions. ..