Research Topics
| Earl SmithSummaryAffiliation: University of Houston Country: USA Publications
Research Grants
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Detail Information
Publications
Wave aberrations in rhesus monkeys with vision-induced ametropiasRamkumar Ramamirtham
College of Optometry, University of Houston, 505 J Davis Armistead Building, Houston, TX 77204 2020, USA
Vision Res 47:2751-66. 2007..The results from our study suggest that the higher amounts of wave aberrations observed in ametropic humans are likely to be a consequence, rather than a cause, of abnormal refractive development...
Does peripheral retinal input explain the promising myopia control effects of corneal reshaping therapy (CRT or ortho-K) & multifocal soft contact lenses?Earl L Smith
University of Houston College of Optometry, Houston, USA
Ophthalmic Physiol Opt 33:379-84. 2013..By their nature, views expressed in each section of the Point-Counterpoint article are those of the author concerned and may not reflect the views of all of the authors...- Protective effects of high ambient lighting on the development of form-deprivation myopia in rhesus monkeysEarl L Smith
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 53:421-8. 2012..To test this hypothesis, the effects of high ambient lighting on vision-induced myopia in monkeys were determined... - Relative peripheral hyperopic defocus alters central refractive development in infant monkeysEarl L Smith
College of Optometry, University of Houston, Houston, TX 77204 2020, USA
Vision Res 49:2386-92. 2009..These results show that peripheral refractive errors can have a substantial impact on central refractive development in primates... - Hemiretinal form deprivation: evidence for local control of eye growth and refractive development in infant monkeysEarl L Smith
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 50:5057-69. 2009..To determine whether refractive development in primates is mediated by local retinal mechanisms, the authors examined the effects of hemiretinal form deprivation on ocular growth and the pattern of peripheral refractions in rhesus monkeys... - Effects of foveal ablation on emmetropization and form-deprivation myopiaEarl L Smith
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 48:3914-22. 2007..To test this assumption, the authors determined whether an intact fovea was essential for either normal emmetropization or the vision-induced myopic errors produced by form deprivation... - Peripheral vision can influence eye growth and refractive development in infant monkeysEarl L Smith
College of Optometry, University of Houston, TX 77204, USA
Invest Ophthalmol Vis Sci 46:3965-72. 2005..Given the prominence of central vision in humans, it has been assumed that visual signals from the fovea dominate emmetropization. The purpose of this study was to examine the impact of peripheral vision on emmetropization... 
Effects of brief periods of unrestricted vision on the development of form-deprivation myopia in monkeysEarl L Smith
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 43:291-9. 2002..To characterize the temporal integration properties of the mechanisms responsible for form-deprivation myopia (FDM), the effects of brief daily periods of unrestricted vision on the degree of FDM were investigated in infant monkeys...- Continuous ambient lighting and lens compensation in infant monkeysEarl L Smith
College of Optometry, University of Houston, Texas 77204 2020, USA
Optom Vis Sci 80:374-82. 2003..To test this idea, we investigated the ability of infant monkeys reared with continuous light to compensate for optically imposed changes in refractive error... - Temporal constraints on experimental emmetropization in infant monkeysChea su Kee
College of Optometry, University of Houston, Houston, Texas, USA
Invest Ophthalmol Vis Sci 48:957-62. 2007..To characterize the temporal integration properties of the emmetropization process, the authors investigated the effects of brief daily interruptions of lens wear on the ocular compensation for negative lenses in infant rhesus monkeys... - A comparison of refractive development between two subspecies of infant rhesus monkeys (Macaca mulatta)Ying Qiao-Grider
College of Optometry, University of Houston, Houston, TX 77204 2020, USA
Vision Res 47:1668-81. 2007..Substantial morphological and behavioral differences have been reported between Chinese- and Indian-derived subspecies. The purpose of this study was to compare refractive development in Chinese- and Indian-derived rhesus monkeys... - Peripheral refraction in normal infant rhesus monkeysLi Fang Hung
College of Optometry, University of Houston, Houston, Texas, USA
Invest Ophthalmol Vis Sci 49:3747-57. 2008..To characterize peripheral refractions in infant monkeys... - Binocular deficits associated with early alternating monocular defocus. II. Neurophysiological observationsBin Zhang
College of Optometry, University of Houston, Houston, Texas 77204-2020, USA
J Neurophysiol 90:3012-23. 2003.... - Recovery from form-deprivation myopia in rhesus monkeysYing Qiao-Grider
College of Optometry, University of Houston, Houston, Texas 77204-2020, USA
Invest Ophthalmol Vis Sci 45:3361-72. 2004..However, the potential for recovery appears to depend on when unrestricted vision is restored, the severity of the deprivation-induced axial elongation, and possibly the method used to produce FDM... - Vitreal glutamate concentration in monkeys with experimental glaucomaLouvenia Carter-Dawson
Department of Ophthalmology and Visual Science, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 43:2633-7. 2002..To investigate the hypothesis that the pathophysiology for the death of retinal ganglion cells in glaucoma involves excitotoxic effects from elevated concentrations of vitreal glutamate... - Normal ocular development in young rhesus monkeys (Macaca mulatta)Ying Qiao-Grider
College of Optometry, University of Houston, Houston, TX 77204 2020, USA
Vision Res 47:1424-44. 2007..The purpose of this study was to characterize normal ocular development in infant monkeys and to establish both qualitative and quantitative relationships between human and monkey refractive development... - The relationship between nerve fiber layer and perimetry measurementsRonald S Harwerth
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 48:763-73. 2007.... - Scaling the structure--function relationship for clinical perimetryRonald S Harwerth
College of Optometry, University of Houston, Houston, Texas 77096 2020, USA
Acta Ophthalmol Scand 83:448-55. 2005..The present study was undertaken to compare linear and logarithmic transformations, which have been proposed for correlating the perimetric defects and neural losses of glaucoma... - Temporal integration for stereoscopic visionRonald S Harwerth
College of Optometry, University of Houston, 505 J Davis Armistead Building, Houston, TX 77204 2020, USA
Vision Res 43:505-17. 2003..In addition, increased integration time does not account for the elevated stereothresholds of subjects with abnormal binocular vision... - Astigmatism in monkeys with experimentally induced myopia or hyperopiaChea su Kee
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Optom Vis Sci 82:248-60. 2005..This study examines the frequency and characteristics of astigmatism in infant monkeys that developed axial ametropias as a result of altered early visual experience... - Binocular deficits associated with early alternating monocular defocus. I. Behavioral observationsJanice M Wensveen
University of Houston, College of Optometry, Houston, Texas 77204 2020, USA
J Neurophysiol 90:3001-11. 2003.... - Effects of optically imposed astigmatism on emmetropization in infant monkeysChea su Kee
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 45:1647-59. 2004..Although astigmatism is prevalent during early infancy, the influence of astigmatism on early refractive development is unclear. This study was undertaken to determine the effects of astigmatism on emmetropization in monkeys... - Glutathione content is altered in Müller cells of monkey eyes with experimental glaucomaLouvenia Carter-Dawson
Department of Ophthalmology and Visual Science, University of Texas Houston Health Science Center, 6431 Fannin, Suite 7 024, Houston, TX 77030, USA
Neurosci Lett 364:7-10. 2004..The presence of more glutathione in Müller cells of glaucomatous retinas is consistent with an increase in extracellular glutamate and an increase in transport and metabolism of glutamate... - Visual field defects and neural losses from experimental glaucomaRonald S Harwerth
College of Optometry, University of Houston, 505 J Davis Armistead Building, TX 77204 2020, USA
Prog Retin Eye Res 21:91-125. 2002..These experimental findings from glaucoma in monkeys provide fundamental data that should be applicable to improving methods for assessing glaucomatous optic neuropathy in patients... - Neural losses correlated with visual losses in clinical perimetryRonald S Harwerth
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 45:3152-60. 2004..The purpose of the present study was to investigate the neural and sensitivity losses from experimental glaucoma to establish the framework for a quantitative model for the structure-function relationships of standard clinical perimetry... - Effects of optical defocus on refractive development in monkeys: evidence for local, regionally selective mechanismsEarl L Smith
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 51:3864-73. 2010..To characterize the influence of optical defocus on ocular shape and the pattern of peripheral refraction in infant rhesus monkeys... - Brief daily periods of unrestricted vision can prevent form-deprivation amblyopiaJanice M Wensveen
College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
Invest Ophthalmol Vis Sci 47:2468-77. 2006.... - Postnatal development of onset transient responses in macaque V1 AND V2 neuronsBin Zhang
University of Houston, College of Optometry, Houston, TX, USA
J Neurophysiol 100:1476-87. 2008.... - Prevalence of astigmatism in infant monkeysChea-Su Kee
College of Optometry, University of Houston, 505 J Davis Armistead Building, Houston, TX 7704-2020, USA
Vision Res 42:1349-59. 2002..The low prevalence of astigmatism during early development suggests that astigmatism does not provide an essential cue for vision-dependent eye growth in infant primates... - Monochromatic ocular wave aberrations in young monkeysRamkumar Ramamirtham
College of Optometry, University of Houston, Houston, TX 77204-2020, USA
Vision Res 46:3616-33. 2006.... - Astigmatism in infant monkeys reared with cylindrical lensesChea-Su Kee
College of Optometry, University of Houston, 505 J Davis Armistead Building, Houston, TX 77204-2020, USA
Vision Res 43:2721-39. 2003..Our results indicate that visual experience can alter corneal shape, but there was no evidence that primates have an active, visually regulated "sphericalization" mechanism... - Topographic map reorganization in cat area 17 after early monocular retinal lesionsKazuki Matsuura
College of Optometry, University of Houston, TX 77204-2020, USA
Vis Neurosci 19:85-96. 2002.... - Directional bias of neurons in V1 and V2 of strabismic monkeys: temporal-to-nasal asymmetry?Ichiro Watanabe
College of Optometry, University of Houston, TX 77204, USA
Invest Ophthalmol Vis Sci 46:3899-905. 2005..In the current study, the hypothesis that this eye movement anomaly reflects a similar asymmetry in the directional response properties of neurons in the early stages of cortical processing was examined... - Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosaAbhiram S Vilupuru
College of Optometry, University of Houston, TX 77204 2020, USA
J Opt Soc Am A Opt Image Sci Vis 24:1417-25. 2007..The AOSLO provides high-quality images of the lamina cribrosa and may have potential as a tool for early identification of glaucoma... - Effects of the duration of early strabismus on the binocular responses of neurons in the monkey visual cortex (V1)Takafumi Mori
College of Optometry, University of Houston, Houston, Texas 77204-2020, USA
Invest Ophthalmol Vis Sci 43:1262-9. 2002.... - Delayed maturation of receptive field center/surround mechanisms in V2Bin Zhang
College of Optometry, University of Houston, Houston, TX 77204-2020, USA
Proc Natl Acad Sci U S A 102:5862-7. 2005.... - Rapid plasticity of binocular connections in developing monkey visual cortex (V1)Bin Zhang
College of Optometry, University of Houston, 505 J. Davis Armistead Building, Houston, TX 77204-2020, USA
Proc Natl Acad Sci U S A 102:9026-31. 2005.... - Compensation for experimentally induced hyperopic anisometropia in adolescent monkeysXingwu Zhong
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Peoples Republic of China
Invest Ophthalmol Vis Sci 45:3373-9. 2004..Consequently, conditions that result in consistent hyperopic defocus could potentially contribute to the development of juvenile onset myopia in children... - Image defocus modulates activity of bipolar and amacrine cells in macaque retinaXingwu Zhong
Department of Cell Biology and Anatomy, Neuroscience Research Group and Lions' Sight Centre, University of Calgary Faculty of Medicine, Alberta, Canada
Invest Ophthalmol Vis Sci 45:2065-74. 2004..CONCLUSIONS: This was the first evidence of focus-dependent activation of bipolar as well as amacrine cells in a primate retina. Focus-sensitive neurons are candidates for roles in vision-dependent regulation of eye growth...
Research Grants
- OPTICALLY INDUCED ANISOMETROPIAEarl L Smith; Fiscal Year: 2010..The results of these studies will potentially provide the foundation for new treatment and management strategies for human refractive errors. ..
- OPTICALLY INDUCED ANISOMETROPIAEarl Smith; Fiscal Year: 2005..Moreover, these investigation will help determine the extent to which refractive errors need to be corrected in young infants in order to avoid the development of sensory disorders. ..
- OPTICALLY INDUCED ANISOMETROPIAEarl Smith; Fiscal Year: 2007..The results of these studies will potentially provide the foundation for new treatment and management strategies for human refractive errors. ..
- OPTICALLY INDUCED ANISOMETROPIAEarl Smith; Fiscal Year: 2007..The results of these studies will potentially provide the foundation for new treatment and management strategies for human refractive errors. ..
- OPTICALLY INDUCED ANISOMETROPIA IN MONKEYSEarl Smith; Fiscal Year: 1993....
- OPTICALLY INDUCED ANISOMETROPIAEarl Smith; Fiscal Year: 1999..Moreover, these investigation will help determine the extent to which refractive errors need to be corrected in young infants in order to avoid the development of sensory disorders. ..