DOUGLAS HAMILTON SMITH

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Roller coasters, g forces, and brain trauma: on the wrong track?
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurotrauma 19:1117-20. 2002
  2. ncbi request reprint Development of transplantable nervous tissue constructs comprised of stretch-grown axons
    Bryan J Pfister
    Department of Neurosurgery, Center for Brain Injury Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Neurosci Methods 153:95-103. 2006
  3. ncbi request reprint Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104 6316, USA
    Neurosci Lett 231:135-8. 1997
  4. ncbi request reprint Protein accumulation in traumatic brain injury
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuromolecular Med 4:59-72. 2003
  5. ncbi request reprint Amyloid beta accumulation in axons after traumatic brain injury in humans
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosurg 98:1072-7. 2003
  6. pmc Stretch growth of integrated axon tracts: extremes and exploitations
    Douglas H Smith
    Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Prog Neurobiol 89:231-9. 2009
  7. ncbi request reprint Diffuse axonal injury in head trauma
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Head Trauma Rehabil 18:307-16. 2003
  8. pmc Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104 6316, USA
    Am J Pathol 153:1005-10. 1998
  9. ncbi request reprint A new strategy to produce sustained growth of central nervous system axons: continuous mechanical tension
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Tissue Eng 7:131-9. 2001
  10. ncbi request reprint Immediate coma following inertial brain injury dependent on axonal damage in the brainstem
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurosurg 93:315-22. 2000

Research Grants

  1. BRAIN INJURY EFFECTS--AGE RELATED COGNITIVE DYSFUNCTION
    Douglas Smith; Fiscal Year: 1999
  2. BRAIN INJURY, AGING AND NEURODEGENERATION IN THE RAT
    Douglas Smith; Fiscal Year: 2004
  3. Pathophysiology of Traumatic Axonal Injury
    Douglas Smith; Fiscal Year: 2007
  4. Pathophysiology of Traumatic Axonal Injury
    Douglas Smith; Fiscal Year: 2007
  5. TBI: Uncovering Mechanisms of AD-like pathology
    DOUGLAS HAMILTON SMITH; Fiscal Year: 2010
  6. Spinal cord repair with nerve constructs
    Douglas Smith; Fiscal Year: 2007
  7. Spinal cord repair with nerve constructs
    Douglas Smith; Fiscal Year: 2009
  8. LONG TERM EFFECTS OF DIFFUSE BRAIN TRAUMA
    Douglas Smith; Fiscal Year: 2002

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Roller coasters, g forces, and brain trauma: on the wrong track?
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurotrauma 19:1117-20. 2002
    ..Accordingly, our findings do not support the contention that current roller coaster rides produce high enough forces to mechanically deform and injure the brain...
  2. ncbi request reprint Development of transplantable nervous tissue constructs comprised of stretch-grown axons
    Bryan J Pfister
    Department of Neurosurgery, Center for Brain Injury Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Neurosci Methods 153:95-103. 2006
    ..Ideally, bridging nerve damage with living axon tracts may serve to establish or promote new functional connections...
  3. ncbi request reprint Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104 6316, USA
    Neurosci Lett 231:135-8. 1997
    ..v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm...
  4. ncbi request reprint Protein accumulation in traumatic brain injury
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuromolecular Med 4:59-72. 2003
    ..In addition, the potential deleterious roles of protein accumulations on functional outcome and progressive neurodegeneration following TBI will be examined...
  5. ncbi request reprint Amyloid beta accumulation in axons after traumatic brain injury in humans
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosurg 98:1072-7. 2003
    ..In the present study, the authors explored the potential relationship between Abeta accumulation in damaged axons and associated Abeta plaque formation...
  6. pmc Stretch growth of integrated axon tracts: extremes and exploitations
    Douglas H Smith
    Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, 105 Hayden Hall, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Prog Neurobiol 89:231-9. 2009
    ..This review provides the first glimpse of the astonishing features of axon tracts undergoing stretch growth and how this natural process can be exploited to facilitate repair of the damaged nervous system...
  7. ncbi request reprint Diffuse axonal injury in head trauma
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Head Trauma Rehabil 18:307-16. 2003
    ..DAI may largely account for the clinical manifestations of brain trauma. However, DAI is extremely difficult to detect noninvasively and is poorly defined as clinical syndrome...
  8. pmc Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104 6316, USA
    Am J Pathol 153:1005-10. 1998
    ..01). These data suggest a mechanistic link between brain trauma and Abeta levels and the death of neurons...
  9. ncbi request reprint A new strategy to produce sustained growth of central nervous system axons: continuous mechanical tension
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Tissue Eng 7:131-9. 2001
    ..We propose that this newfound stretch-induced growth ability of integrated CNS axons may be exploited to produce transplant materials to bridge extensive nerve damage...
  10. ncbi request reprint Immediate coma following inertial brain injury dependent on axonal damage in the brainstem
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurosurg 93:315-22. 2000
    ..However, the relationship between the distribution of axonal damage and posttraumatic coma has not been examined. In the present study, the authors examine that relationship...
  11. doi request reprint Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs
    Jun Zhang
    Department of Neurosurgery and Penn Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 210:645-55. 2008
    ..Finally, rFVIIa treatment provided a surprising neuroprotective effect by reducing hippocampal neuron degeneration as well as the extent of DAI...
  12. pmc Long-term survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regeneration
    Jason H Huang
    Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    Tissue Eng Part A 15:1677-85. 2009
    ..These findings demonstrate the promise of living tissue-engineered axonal constructs to bridge major nerve lesions and promote host regeneration, potentially by providing axon-mediated axonal outgrowth and guidance...
  13. pmc Harvested human neurons engineered as live nervous tissue constructs: implications for transplantation. Laboratory investigation
    Jason H Huang
    Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    J Neurosurg 108:343-7. 2008
    ..The authors chose to evaluate human dorsal root ganglion (DRG) neurons due to their robustness in culture...
  14. pmc A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury
    Xiao Han Chen
    Department of Neurosurgery, School of Medicine, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104 6316, USA
    Brain Pathol 19:214-23. 2009
    ..These findings fail to support the premise that progressive plaque pathology after TBI ultimately results in AD...
  15. ncbi request reprint Thromboembolism and delayed cerebral ischemia after subarachnoid hemorrhage: an autopsy study
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
    Neurosurgery 59:781-7; discussion 787-8. 2006
    ..Recent findings have cast doubt on vasospasm as the sole cause of delayed cerebral ischemia after subarachnoid hemorrhage...
  16. ncbi request reprint Coagulopathy in traumatic brain injury
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurocrit Care 1:479-88. 2004
    ..This is an area deserving of more intensive research...
  17. doi request reprint Developing a tissue-engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers
    D Kacy Cullen
    Center for Brain Injury and Repair, Department of Neurosurgery, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Neural Eng 5:374-84. 2008
    ....
  18. doi request reprint Biomechanics of concussion
    David F Meaney
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6392, USA
    Clin Sports Med 30:19-31, vii. 2011
    ..Studies of how these mechanical conditions contribute to the cellular mechanisms of damage in mild traumatic brain injury are reviewed. Finally, future directions for improving understanding concussion biomechanics are discussed...
  19. doi request reprint Dendritic alterations after dynamic axonal stretch injury in vitro
    Hubert Monnerie
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19107, USA
    Exp Neurol 224:415-23. 2010
    ..The data also imply that TAI may alter dendrite structure and plasticity in vivo. An understanding of TAI's effect on dendrites is important since proper dendrite function is crucial for normal brain function and recovery after injury...
  20. pmc Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders
    William M Armstead
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 113:303-12. 2010
    ..Additionally, the role of age will be considered since thrombolytic therapy is being increasingly used in the pediatric population, but there are few basic science studies of CNS injury in pediatric animals...
  21. ncbi request reprint Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice
    Kathryn E Saatman
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Cereb Blood Flow Metab 23:34-42. 2003
    ..These data suggest that early calpain activation may contribute to progressive intraaxonal structural damage, whereas delayed calpain activation may be associated with axonal degeneration...
  22. pmc Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation
    William M Armstead
    Department of Anesthesiology and Critical Care, 3620 Hamilton Walk, JM3, University of Pennsylvania, Philadelphia, PA l9l04, USA
    J Cereb Blood Flow Metab 29:1463-74. 2009
    ..These data suggest that coupling of tPA to RBCs offers a novel approach toward increasing the benefit/risk ratio of thrombolytic therapy for CNS disorders associated with H/I...
  23. pmc Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106, USA
    J Neurotrauma 26:1585-92. 2009
    ..01) and hippocampal cell loss ( p<0.01) in the RBC=tPA group than in all other groups. These results reveal that RBC/tPA is more neuroprotective in experimental TBI than is unbound tPA...
  24. ncbi request reprint Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 54:687-91; discussion 691. 2004
    ..To determine the association between traumatic cerebral ischemia and intravascular thrombosis, a common finding after traumatic brain injury (TBI)...
  25. pmc Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma
    Xiao Han Chen
    Department of Neurosurgery, University of Pennsylvania, 105C Hayden Hall, 3320 SmithWalk, Philadelphia, PA 19104 6316, USA
    Am J Pathol 165:357-71. 2004
    ..The abnormal concentration of these factors may lead to APP proteolysis and Abeta formation within the axonal membrane compartment...
  26. ncbi request reprint Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats
    Kevin D Browne
    Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 201:301-7. 2006
    ..These data may have important implications for TBI patients who are often prescribed NSAIDs for chronic pain...
  27. ncbi request reprint Neutralizing the neurotoxic effects of exogenous and endogenous tPA
    William M Armstead
    Department of Anesthesiology, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 9:1150-5. 2006
    ..These experiments suggest mechanisms to reduce the neurotoxic effects of tPA without compromising its fibrinolytic activity, through the use of selective antagonists and new tPA formulations...
  28. ncbi request reprint Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors
    Akira Iwata
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosci 24:4605-13. 2004
    ..In turn, degradation of the alpha-subunit promotes persistent elevations in [Ca2+]i, fueling additional pathologic changes. These observations may have important implications for developing therapeutic strategies for axonal trauma...
  29. ncbi request reprint Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:61-72. 2004
    ....
  30. ncbi request reprint Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurosurg 97:1373-7. 2002
    ..The authors also investigated the incidence of IC in relation to varying mechanisms, time courses, and severities of TBI and in different species...
  31. ncbi request reprint Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat
    Kevin D Browne
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 77:878-83. 2004
    ..These data also show that the previously reported broad efficacy of MgSO(4) or NPS 1506 observed shortly after brain trauma could not be detected 8 months post-injury...
  32. ncbi request reprint Extreme stretch growth of integrated axons
    Bryan J Pfister
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:7978-83. 2004
    ..These data provide the first evidence that mechanical stimuli can induce extreme "stretch growth" of integrated axon tracts, far exceeding any previously observed limits of axon growth...
  33. ncbi request reprint A device to study the initiation and propagation of calcium transients in cultured neurons after mechanical stretch
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    Ann Biomed Eng 32:1546-58. 2004
    ....
  34. ncbi request reprint Long-term survival and outgrowth of mechanically engineered nervous tissue constructs implanted into spinal cord lesions
    Akira Iwata
    Department of Neurosurgery, Center for Brain Injury Repair, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Tissue Eng 12:101-10. 2006
    ..These results demonstrate the promise of nervous tissue constructs consisting of stretch-grown axons to bridge even extensive spinal cord lesions...
  35. ncbi request reprint Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes
    Akira Iwata
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6316, USA
    J Neuropathol Exp Neurol 61:1056-68. 2002
    ..Together, these data suggest a mechanism that may contribute to long-term neurodegeneration following brain trauma...
  36. pmc Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury
    Tracy J Yuen
    Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosci Res 87:3620-5. 2009
    ..These data suggest that mild TAI induces a form of sodium channelopathy on axons that greatly exaggerates the pathophysiologic response to subsequent mild injuries...
  37. ncbi request reprint The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    Biorheology 40:401-9. 2003
    ..Finally, at the highest levels of stretch, the cell survivability decreases at 24 hrs following the stretch injury. These data show the association between loss in calcium regulation and early signs of neuronal cell death...
  38. ncbi request reprint Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats
    Akira Iwata
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosci Res 82:103-14. 2005
    ..Collectively, these data suggest that ApoE and J play a role in the acute sequelae of brain trauma and reemerge long after the initial insult, potentially to modulate progressive neurodegenerative changes...
  39. pmc Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration
    Min D Tang-Schomer
    Center for Brain Injury and Repair and Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    FASEB J 24:1401-10. 2010
    ..While the disintegration of microtubules allows delayed recovery of the "normal" straight axon morphology, it comes at a great cost by interrupting axonal transport, leading to axonal swelling and degeneration...
  40. ncbi request reprint Apo E genotype not associated with intravascular coagulation in traumatic brain injury
    Sherman C Stein
    Department of Neurosurgery, University of Pennsylvania, 105B Hayden Hall 3320 Smith Walk, Philadelphia, PA 19104 6316, USA
    Neurosci Lett 387:28-31. 2005
    ..The authors explored a possible connection between the apolipoprotein E (Apo E) genotype, coagulopathy and intravascular microthombosis (IMT) in TBI. The predicted association was not confirmed...
  41. ncbi request reprint Neurogenesis and glial proliferation persist for at least one year in the subventricular zone following brain trauma in rats
    Xiao Han Chen
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 20:623-31. 2003
    ..These data suggest that there is a persistent proliferation of neurons and glia in the SVZ following brain trauma that does not diminish during aging as found in non-injured animals...
  42. pmc Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit
    Catherine R von Reyn
    Departments of Bioengineering, Pharmacology, Neurosurgery, Emergency Medicine, and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    J Neurosci 29:10350-6. 2009
    ....
  43. pmc In-vitro approaches for studying blast-induced traumatic brain injury
    Yung Chia Chen
    Departments of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104, USA
    J Neurotrauma 26:861-76. 2009
    ..These in-vitro models, viewed in combination with in-vivo models and clinical studies, can be used to assess both the mechanisms and possible treatments for this type of trauma...
  44. pmc A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury
    Victoria E Johnson
    Penn Center for Brain Injury and Repair, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 26:1197-202. 2009
    ..Moreover, these findings provide a potential genetic screening test for individuals at high risk of TBI, such as participants in contact sports and military personnel...
  45. doi request reprint A novel neuroprosthetic interface with the peripheral nervous system using artificially engineered axonal tracts
    Niranjan Kameswaran
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Neurol Res 30:1063-7. 2008
    ....
  46. ncbi request reprint Stretch-grown axons retain the ability to transmit active electrical signals
    Bryan J Pfister
    Department of Biomedical Engineering, New Jersey Institute of Technology, Philadelphia, PA 19104, USA
    FEBS Lett 580:3525-31. 2006
    ..Surprisingly, Na and K channel density increased due to stretch-growth, which may represent a natural response to preserve the fidelity of neuronal signaling...
  47. ncbi request reprint Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
    Kunihiro Uryu
    The Center for Neurodegenerative Disease Research, Pathology and Laboratory Medicine, USA
    Exp Neurol 208:185-92. 2007
    ..This process may have important implications for survivors of TBI who have been shown to be at greater risk of developing neurodegenerative diseases...
  48. ncbi request reprint Neural engineering to produce in vitro nerve constructs and neurointerface
    Bryan J Pfister
    Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA
    Neurosurgery 60:137-41; discussion 141-2. 2007
    ..In this article, we describe how this novel neural engineering approach may be used to produce a nervous tissue interface to integrate disconnected motor and sensory functions for external control...
  49. ncbi request reprint Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro
    Nathalie Jette
    Ottawa Health Research Institute, Division of Neuroscience, University of Ottawa, Ottawa, Ontario, Canada
    J Cereb Blood Flow Metab 26:777-86. 2006
    ..Thus, proteolysis of structural and functional proteins will conspire to irreversibly injure central axons and render them nonfunctional, eventually leading to transection, degradation, and Wallerian degeneration...
  50. ncbi request reprint Thalamic nuclei after human blunt head injury
    William L Maxwell
    Department of Anatomy, Division of Neuroscience and Biomedical Systems, University of Glasgow, UK
    J Neuropathol Exp Neurol 65:478-88. 2006
    ..The study provides novel quantitative evidence for differential neuronal loss, with survival after human head injury, from thalamic nuclei associated with different aspects of cortical activation...

Research Grants27

  1. BRAIN INJURY EFFECTS--AGE RELATED COGNITIVE DYSFUNCTION
    Douglas Smith; Fiscal Year: 1999
    ..4) To evaluate the therapeutic efficacy of cognition enhancers on persisting post traumatic cognitive dysfunction in young and aging rats. ..
  2. BRAIN INJURY, AGING AND NEURODEGENERATION IN THE RAT
    Douglas Smith; Fiscal Year: 2004
    ..Success of these studies may reveal mechanistic links between brain trauma, age and neurodegenerative processes and provide a basis for the development of new therapeutic strategies. ..
  3. Pathophysiology of Traumatic Axonal Injury
    Douglas Smith; Fiscal Year: 2007
    ..Collectively, our proposed studies may improve understanding of potential mediators of secondary injury shortly following DAI and provide insight into progressive pathologies induced by brain trauma. ..
  4. Pathophysiology of Traumatic Axonal Injury
    Douglas Smith; Fiscal Year: 2007
    ..Collectively, our proposed studies may improve understanding of potential mediators of secondary injury shortly following DAI and provide insight into progressive pathologies induced by brain trauma. ..
  5. TBI: Uncovering Mechanisms of AD-like pathology
    DOUGLAS HAMILTON SMITH; Fiscal Year: 2010
    ..Here, we propose to examine how TBI may be transformed into a progressive neurodegenerative disease with pathologic features resembling AD. ..
  6. Spinal cord repair with nerve constructs
    Douglas Smith; Fiscal Year: 2007
    ....
  7. Spinal cord repair with nerve constructs
    Douglas Smith; Fiscal Year: 2009
    ..abstract_text> ..
  8. LONG TERM EFFECTS OF DIFFUSE BRAIN TRAUMA
    Douglas Smith; Fiscal Year: 2002
    ..Success of these studies may reveal mechanistic links between brain trauma and neurodegenerative processes and facilitate the development of therapeutic and diagnostic techniques for diffuse brain injury. ..