Dean P Smith

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila
    Savitha Kalidas
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 33:177-84. 2002
  2. pmc Activation of the T1 neuronal circuit is necessary and sufficient to induce sexually dimorphic mating behavior in Drosophila melanogaster
    David S Ronderos
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 30:2595-9. 2010
  3. ncbi request reprint Odor and pheromone detection in Drosophila melanogaster
    Dean P Smith
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Pflugers Arch 454:749-58. 2007
  4. doi request reprint Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
  5. pmc Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1
    Savitha Kalidas
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390 9111, USA
    Mech Dev 125:475-85. 2008
  6. pmc SNMP is a signaling component required for pheromone sensitivity in Drosophila
    Xin Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 105:10996-1001. 2008
  7. ncbi request reprint A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila
    Tal Soo Ha
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8727-33. 2006
  8. ncbi request reprint Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
  9. pmc LUMP is a putative double-stranded RNA binding protein required for male fertility in Drosophila melanogaster
    Charcacia Sanders
    Department of Pharmacology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e24151. 2011
  10. ncbi request reprint Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum
    Tamara Elmore
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 23:9906-12. 2003

Research Grants

  1. RNA Interference in Drosophila
    Dean Smith; Fiscal Year: 2007
  2. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2007
  3. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2009
  4. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2003
  5. GENETIC ANALYSIS OF OLFACTION
    Dean P Smith; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila
    Savitha Kalidas
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 33:177-84. 2002
    ..elegans. These results demonstrate a simple strategy to knock out gene function in specific cells in living adult Drosophila that can be applied to define the biological function of hundreds of orphan genes and open reading frames...
  2. pmc Activation of the T1 neuronal circuit is necessary and sufficient to induce sexually dimorphic mating behavior in Drosophila melanogaster
    David S Ronderos
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 30:2595-9. 2010
    ..These findings demonstrate that the T1/Or67d circuit is necessary and sufficient to mediate sexually dimorphic courtship behaviors...
  3. ncbi request reprint Odor and pheromone detection in Drosophila melanogaster
    Dean P Smith
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Pflugers Arch 454:749-58. 2007
    ..Because pheromones are used by insects to trigger mating and other behaviors, these insights may herald new approaches to control behavior in pathogenic and agricultural pest insects...
  4. doi request reprint Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
    ..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
  5. pmc Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1
    Savitha Kalidas
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390 9111, USA
    Mech Dev 125:475-85. 2008
    ..We conclude that R2D2 functions beyond its role in RNA interference to include ovarian development in Drosophila...
  6. pmc SNMP is a signaling component required for pheromone sensitivity in Drosophila
    Xin Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 105:10996-1001. 2008
    ..Therefore, pheromone perception in Drosophila should serve as an excellent model to elucidate the role of CD36 members in transmembrane signaling...
  7. ncbi request reprint A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in Drosophila
    Tal Soo Ha
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:8727-33. 2006
    ..Here, we show LUSH are also required in non-T1 neurons misexpressing the receptor to respond to VA. These data provide new insight into the molecular components and neuronal basis of volatile pheromone perception...
  8. ncbi request reprint Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons
    Pingxi Xu
    Department of Pharmacology, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75335, USA
    Neuron 45:193-200. 2005
    ..These studies directly link pheromone-induced behavior with OBP-dependent activation of a subset of olfactory neurons...
  9. pmc LUMP is a putative double-stranded RNA binding protein required for male fertility in Drosophila melanogaster
    Charcacia Sanders
    Department of Pharmacology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e24151. 2011
    ..We show that one dsRNA binding domains (dsRBD) is essential for LUMP function in male fertility. These findings reveal LUMP is a novel factor required for late stages of male germline differentiation...
  10. ncbi request reprint Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum
    Tamara Elmore
    Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 23:9906-12. 2003
    ..These studies demonstrate that a reverse genetic approach can be used to correlate specific olfactory receptors with odor specificity of functional classes of olfactory neurons...
  11. ncbi request reprint Diverse signaling mechanisms mediate volatile odorant detection in Drosophila
    David S Ronderos
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Fly (Austin) 3:290-7. 2009
    ..Some of these mechanisms have not been observed in other animals, suggesting they evolved relatively late along an evolutionary branch that ultimately gave rise to the insects...
  12. ncbi request reprint R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway
    Qinghua Liu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Science 301:1921-5. 2003
    ..These results indicate that R2D2 bridges the initiation and effector steps of the Drosophila RNAi pathway by facilitating siRNA passage from Dicer to RISC...
  13. doi request reprint Insect odorant receptors: channeling scent
    Tal Soo Ha
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Cell 133:761-3. 2008
    ..Two recent studies in Nature (Sato et al., 2008; Wicher et al., 2008) now reveal that these OR-Or83b heterodimers form odorant-gated ion channels, revealing a surprising new mode of olfactory transduction...
  14. ncbi request reprint Functional genomics, fragile X syndrome, and RNA interference
    Savitha Kalidas
    Department of Pharmacology and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, 75390 9111, USA
    Arch Neurol 60:1197-200. 2003
  15. ncbi request reprint Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
    Schoen W Kruse
    Department of Pharmacology, University of Colorado Health Sciences Center, M S C236, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Struct Biol 10:694-700. 2003
    ..Further, these sequences are found in regions of ion channels that are known to confer alcohol sensitivity. We suggest that the alcohol-binding site in LUSH represents a general model for alcohol-binding sites in proteins...
  16. doi request reprint Farnesol-detecting olfactory neurons in Drosophila
    David S Ronderos
    Departments of Pharmacology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, and Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 34:3959-68. 2014
    ....
  17. pmc A spoonful of bitter helps the sugar response go down
    Svetlana Lvovskaya
    Departments of Pharmacology and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    Neuron 79:612-4. 2013
    ..2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the response to sweet taste. ..

Research Grants20

  1. RNA Interference in Drosophila
    Dean Smith; Fiscal Year: 2007
    ..Recovery of enhancer of RNAi mutants may provide enhanced genetic backgrounds to facilitate research on orphan gene function in Drosophila in the post-genomic era. ..
  2. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2007
    ..abstract_text> ..
  3. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2009
    ..We have identified several genes essential for volatile pheromone detection in Drosophila and will elucidate the roles of these factors in pheromone detection. ..
  4. GENETIC ANALYSIS OF OLFACTION
    Dean Smith; Fiscal Year: 2003
    ..abstract_text> ..
  5. GENETIC ANALYSIS OF OLFACTION
    Dean P Smith; Fiscal Year: 2010
    ..We have identified several genes essential for volatile pheromone detection in Drosophila and will elucidate the roles of these factors in pheromone detection. ..