D E Smith

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Aspects Med 34:323-36. 2013
  2. pmc Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice
    Bei Yang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 1150 W Medical Center Drive, 4742C Medical Sciences II, Ann Arbor, MI 48109 5633, USA
    Drug Metab Dispos 41:608-14. 2013
  3. pmc Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1
    Yongjun Hu
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 4742C Medical Sciences II, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5633, USA
    Drug Metab Dispos 40:1328-35. 2012
  4. pmc Choroid plexus transport: gene deletion studies
    Richard F Keep
    Department of Neurosurgery, R5018 BSRB, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Fluids Barriers CNS 8:26. 2011
  5. ncbi request reprint Peptide and peptide analog transport systems at the blood-CSF barrier
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 56:1765-91. 2004
  6. pmc Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109 5633, USA
    J Cereb Blood Flow Metab 31:250-61. 2011
  7. pmc Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice
    Dilara Jappar
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Drug Metab Dispos 39:2250-7. 2011
  8. ncbi request reprint Tubular localization and tissue distribution of peptide transporters in rat kidney
    D E Smith
    College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor 48109, USA
    Pharm Res 15:1244-9. 1998
  9. ncbi request reprint PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus
    Hong Shen
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109 0504, USA
    J Pharmacol Exp Ther 315:1101-8. 2005
  10. ncbi request reprint Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice
    Nathan S Teuscher
    Department of Pharmaceutical Sciences, College of Pharmacy, and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurochem 89:375-82. 2004

Collaborators

Detail Information

Publications45

  1. pmc Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Aspects Med 34:323-36. 2013
    ..Whenever possible, the relevance of drug-drug interactions and regulatory mechanisms are evaluated using in vivo studies...
  2. pmc Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice
    Bei Yang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 1150 W Medical Center Drive, 4742C Medical Sciences II, Ann Arbor, MI 48109 5633, USA
    Drug Metab Dispos 41:608-14. 2013
    ..Our findings conclusively demonstrate, using in situ and in vivo validations in genetically modified mice, that PepT1 has a major influence in improving the oral absorption of valacyclovir...
  3. pmc Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1
    Yongjun Hu
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 4742C Medical Sciences II, 1150 W Medical Center Dr, Ann Arbor, MI 48109 5633, USA
    Drug Metab Dispos 40:1328-35. 2012
    ..Finally, the mouse appeared to be a better animal model than the rat for exploring the intestinal absorption and pharmacokinetics of peptides and peptide-like drugs in human...
  4. pmc Choroid plexus transport: gene deletion studies
    Richard F Keep
    Department of Neurosurgery, R5018 BSRB, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Fluids Barriers CNS 8:26. 2011
    ..It also discusses the pros and cons of using KO animals in such studies and the technical approaches that can be used...
  5. ncbi request reprint Peptide and peptide analog transport systems at the blood-CSF barrier
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 56:1765-91. 2004
    ....
  6. pmc Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice
    David E Smith
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109 5633, USA
    J Cereb Blood Flow Metab 31:250-61. 2011
    ..These studies show that PEPT2 knockout can significantly modify the spatial distribution of GlySar and cefadroxil (and presumably other peptides/mimetics and peptide-like drugs) in brain...
  7. pmc Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice
    Dilara Jappar
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Drug Metab Dispos 39:2250-7. 2011
    ..The AUC of GlySar was proportional to dose in both genotypes over 1 to 100 nmol/g, with minor decrements at the two highest doses...
  8. ncbi request reprint Tubular localization and tissue distribution of peptide transporters in rat kidney
    D E Smith
    College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor 48109, USA
    Pharm Res 15:1244-9. 1998
    ..To define the tubular localization and tissue distribution of PEPT1 (low-affinity, high-capacity transporter) and PEPT2 (high-affinity, low-capacity transporter) in rat kidney...
  9. ncbi request reprint PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus
    Hong Shen
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109 0504, USA
    J Pharmacol Exp Ther 315:1101-8. 2005
    ..Located at the apical membrane of choroid plexus epithelium, PEPT2 acts in a unidirectional (as opposed to bidirectional) manner in transporting cefadroxil from CSF into the cell...
  10. ncbi request reprint Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice
    Nathan S Teuscher
    Department of Pharmaceutical Sciences, College of Pharmacy, and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurochem 89:375-82. 2004
    ..These findings elucidate the unique role of PEPT2 in regulating neuropeptide homeostasis at the blood-cerebrospinal fluid interface...
  11. pmc Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine
    Yongun Hu
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Pharm 5:1122-30. 2008
    ..These novel findings provide strong evidence that PEPT1 has a major role in the in vivo oral absorption of dipeptides...
  12. pmc Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice
    Huidi Jiang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurochem 109:1536-43. 2009
    ....
  13. ncbi request reprint Renal transport kinetics of chlorothiazide in the isolated perfused rat kidney
    L J Lee
    College of Pharmacy, University of Michigan, Ann Arbor
    J Pharmacol Exp Ther 247:203-8. 1988
    ..These results suggest that for compounds of low renal extraction, free drug concentrations are the driving force for carrier-mediated tubular secretion...
  14. ncbi request reprint Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice
    Scott M Ocheltree
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Pharm Res 21:1680-5. 2004
    ..To determine the importance of PEPT2 in the uptake of glycylsarcosine (GlySar) and 5-aminolevulinic acid (5-ALA) in mouse choroid plexus whole tissue...
  15. ncbi request reprint Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures
    Jianming Xiang
    Department of Neurosurgery, University of Michigan, 1500 East Medical Center Drive, R5550 Kresge I, Ann Arbor, 48109 0532, USA
    Neurosci Lett 396:225-9. 2006
    ..These results indicate that PEPT2 is the sole transporter involved in the uptake of GlySar into neonatal cultured astrocytes. However, PEPT2 mRNA appears to be absent from two glioma cell lines...
  16. ncbi request reprint Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2
    Yongjun Hu
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Pharm Res 22:1281-6. 2005
    ..The purpose of this research was to determine the polarity and directionality of the PEPT2-mediated uptake and transepithelial transport of the neuropeptide glycyl-L-glutamine (GlyGln) in choroid plexus...
  17. ncbi request reprint Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice
    Hong Shen
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan, USA
    Drug Metab Dispos 35:1209-16. 2007
    ..These findings demonstrate that renal PEPT2 is almost entirely responsible for the reabsorption of cefadroxil in kidney and that choroid plexus PEPT2 limits the exposure of cefadroxil (and perhaps other aminocephalosporins) in CSF...
  18. pmc Influence of the unbound concentration of cefonicid on its renal elimination in isolated perfused rat kidneys
    C A Rodriguez
    College of Pharmacy, University of Michigan, Ann Arbor 48109 1065
    Antimicrob Agents Chemother 35:2395-400. 1991
    ..As a result, changes in plasma protein binding as a result of drug interactions or disease states could significantly influence the tubular transport capability of compounds with low renal extraction...
  19. pmc Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice
    Mohamed A Kamal
    Univeersity of Michigan, Upjohn Center for Clinical Pharmacology, Ann Arbor, Michigan 48109 5633, USA
    Am J Physiol Regul Integr Comp Physiol 296:R986-91. 2009
    ..However, endogenous carnosine levels may be under homeostatic control to maintain systemic and central concentrations under physiological in vivo conditions...
  20. ncbi request reprint Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice
    Scott M Ocheltree
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109 0504, USA
    J Pharmacol Exp Ther 308:462-7. 2004
    ..These findings demonstrate that PEPT2 is the primary transporter responsible for cefadroxil uptake in the choroid plexus. Moreover, the data suggest a role for PEPT2 in the clearance of peptidomimetics from cerebrospinal fluid...
  21. ncbi request reprint Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture
    Cathaleen Shu
    College of Pharmacy, Department of Pharmaceutical Sciences, Upjohn Center for Clinical Pharmacology, University of Michigan, 1310 E Catherine Street, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 301:820-9. 2002
    ..The results suggest that PEPT2 may have a role in the efflux of peptides and/or mimetics from cerebrospinal fluid to the blood...
  22. ncbi request reprint Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures
    C Shu
    College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0504, USA
    Drug Metab Dispos 29:1307-15. 2001
    ....
  23. ncbi request reprint PEPT2-mediated uptake of neuropeptides in rat choroid plexus
    N S Teuscher
    College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor 48109, USA
    Pharm Res 18:807-13. 2001
    ....
  24. ncbi request reprint Developmental expression of PEPT1 and PEPT2 in rat small intestine, colon, and kidney
    H Shen
    College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Pediatr Res 49:789-95. 2001
    ..Our findings suggest that intestinal expression of PEPT1 is induced postpartum, possibly by suckling, and again at the time of weaning, and that the colon may participate in peptide transport early in life...
  25. ncbi request reprint Usefulness of brachial artery reactivity to isometric handgrip exercise in identifying patients at risk and with coronary artery disease
    M Rubenfire
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Cardiol 86:1161-5. 2000
    ..5% for IHG vs 71.6% for occlusion and release, p = 0.086). BA response to IHG may be useful for identifying risk factors, patients at risk and with preclinical CAD, and the assessment of treatment strategies...
  26. ncbi request reprint Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model
    Z Symon
    Department of Radiation Oncology, College of Medicine College of Pharmacy, University of Michigan, Ann Arbor 48109 0010, USA
    Int J Radiat Oncol Biol Phys 50:473-8. 2001
    ....
  27. pmc Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes
    Jianming Xiang
    Department of Neurosurgery, Medical School, University of Michigan, Ann Arbor, Michigan, USA
    Brain Res 1347:11-8. 2010
    ..These processes occur at similar rates and may be linked. This supports the contention that oligopeptide transport may have an impact on the extracellular clearance (and potentially activity) of certain neuropeptides...
  28. ncbi request reprint Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus
    Hong Shen
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:4786-91. 2003
    ..These novel findings provide strong evidence that, under the experimental conditions of this study, PEPT2 is the primary member of the peptide transporter family responsible for dipeptide uptake in choroid plexus tissue...
  29. ncbi request reprint In vivo effects of glycyl-glutamate and glycyl-sarcosine on gabapentin oral absorption in rat
    Theresa V Nguyen
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 24:1538-43. 2007
    ..The objective of this study was to evaluate the in vivo consequences of glycyl-glutamate coadministration on gabapentin oral absorption...
  30. ncbi request reprint PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange
    Theresa V Nguyen
    Deparment of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 24:353-60. 2007
    ..The aims of this study were (1) to determine whether amino acid and dipeptide loading can improve the effective permeability of gabapentin and (2) to characterize the underlying mechanism that is responsible for this interaction...
  31. pmc PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes
    Jianming Xiang
    Department of Neurosurgery, University of Michigan, 5014 BSRB, Ann Arbor, MI 48109 2200, USA
    Brain Res 1122:18-23. 2006
    ..These results demonstrate that PEPT2 is the primary transporter responsible for the astrocytic uptake of ALA and carnosine...
  32. ncbi request reprint Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice
    Scott M Ocheltree
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA
    J Pharmacol Exp Ther 315:240-7. 2005
    ..Thus, PEPT2 may have profound effects on the sensitivity and/or toxicity of peptides and peptide-like drugs...
  33. pmc Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity
    Mohamed A Kamal
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109 5633, USA
    Drug Metab Pharmacokinet 23:236-42. 2008
    ..In the case of 5-aminolevulinic acid, such regional modulation of drug disposition translates directly into significant changes in neurotoxicity...
  34. ncbi request reprint Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain
    Hong Shen
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109 0504, USA
    Mol Pharm 1:248-56. 2004
    ..PEPT2 may also play a role in the regulation of neuropeptide concentrations in extracellular fluid, especially during early development...
  35. ncbi request reprint Effect of angiotensin II-induced changes in perfusion flow rate on chlorothiazide transport in the isolated perfused rat kidney
    D E Smith
    College of Pharmacy, University of Michigan, Ann Arbor 48109 1065
    J Pharmacokinet Biopharm 20:195-207. 1992
    ..These flow-induced changes in intrinsic secretory transport may reflect perturbations other than that of perfusion flow rate alone...
  36. pmc Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney
    Christopher S Lepsy
    Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Antimicrob Agents Chemother 47:689-96. 2003
    ..The effects of the organic cation tetraethylammonium, in which the ER was elevated to 7.53, were likely secondary in nature. The anionic secretory pathway was found to be the predominant mechanism for cefdinir renal excretion...
  37. ncbi request reprint [11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice
    Nabeel B Nabulsi
    Division of Nuclear Medicine, Department of Radiology, School of Medicine, The University of Michigan, Ann Arbor, MI 48109, USA
    Bioorg Med Chem 13:2993-3001. 2005
    ..This study demonstrates using in vivo imaging technique that PepT2 is primarily responsible for renal tubular active reabsorption of Gly-Sar, and provides a new tool for studying tubular peptide reabsorption and clearance...
  38. pmc Transport mechanisms of carnosine in SKPT cells: contribution of apical and basolateral membrane transporters
    Dilara Jappar
    Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pharm Res 26:172-81. 2009
    ....
  39. ncbi request reprint Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity
    Yongjun Hu
    Department of Pharmaceutical Sciences and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA
    J Neurochem 103:2058-65. 2007
    ....
  40. pmc Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation
    Noemi Marina-Garcia
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Immunol 182:4321-7. 2009
    ..These studies provide evidence for a clathrin- and dynamin-dependent endocytosis pathway that mediates MDP uptake and NOD2 activation...
  41. pmc Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner
    G Zheng
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Neurogastroenterol Motil 25:e127-39. 2013
    ..It is unknown whether corticosterone (CORT) plays a role in mediating alterations of epithelial permeability in response to CPS...
  42. ncbi request reprint Transport of 5-aminolevulinic acid between blood and brain
    S R Ennis
    Department of Surgery Neurosurgery, University of Michigan, R5550 Kresge I, Ann Arbor, MI 48109 0532, USA
    Brain Res 959:226-34. 2003
    ....
  43. ncbi request reprint Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes
    Scott M Ocheltree
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 20:1364-72. 2003
    ..To determine the expression and functional activity of proton-coupled oligopeptide transporters (POT) in retinal pigment epithelial (RPE) cells...
  44. ncbi request reprint Effect of diabetes mellitus and insulin on the regulation of the PepT 1 symporter in rat jejunum
    Anwar B Bikhazi
    Department of Physiology, American University of Beirut, Beirut, Lebanon
    Mol Pharm 1:300-8. 2004
    ..In addition, the results suggest a probable role of systemic insulin binding at the vascular site of the jejunal epithelium, and the role that this hormone may be playing in the regulation and probably cellular trafficking of PepT1...
  45. ncbi request reprint New perspectives on ancient Mars
    Sean C Solomon
    Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington, DC 20015, USA
    Science 307:1214-20. 2005
    ..Deep hydrothermal circulation accelerated crustal cooling, preserved variations in crustal thickness, and modified patterns of crustal magnetization...

Research Grants16

  1. Role of PEPT2 in Peptide/Mimetic Disposition-Dynamics
    David Smith; Fiscal Year: 2009
    ..Results from these studies will improve the safety and efficacy of drugs for infection, hypertension and cancer, and facilitate the development of new drugs for brain disorders (e.g., Alzheimer's disease, AIDS). ..
  2. Role of PEPT2 in Peptide/Mimetic Disposition-Dynamics
    David Smith; Fiscal Year: 2007
    ..Results from these studies will improve the safety and efficacy of drugs for infection, hypertension and cancer, and facilitate the development of new drugs for brain disorders (e.g., Alzheimer's disease, AIDS). ..
  3. Peptide/Mimetic Transport Mechanisms in Choroid Plexus
    David Smith; Fiscal Year: 2005
    ..g., Alzheimer's disease, AIDS dementia, stroke, epilepsy, schizophrenia and cancer) and for providing new strategies in drug design, delivery and targeting to the brain. ..
  4. HETEROGENEITY OF RENAL PEPTIDE TRANSPORTERS
    David Smith; Fiscal Year: 1999
    ..Ultimately, these studies will pave the way for future proposals concerning the regulation of peptide transporters in kidney under physiological and pathological conditions. ..
  5. PROTEIN BINDING/ORGAN PERFUSION AND RENAL DRUG TRANSPORT
    David Smith; Fiscal Year: 1990
    ..In doing so, more rational guidelines will be provided for a prior dosage adjustments of those therapeutic agents whose renal excretion is sensitive to changes in protein binding or renal blood flow...
  6. Role and Relevance of Pept1 in Drug Absorption, Disposition, and Dynamics
    David E Smith; Fiscal Year: 2010
    ..Results from these studies will improve the safety and efficacy of drugs for bacterial and viral infections, hypertension and cancer, and facilitate the development of new drugs using a novel protein target. ..