CHARLES DENNIS SMITH

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region
    Charles D Smith
    Department of Neurology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0098, USA
    J Alzheimers Dis 31:S49-58. 2012
  2. pmc Structural imaging in early pre-states of dementia
    Charles D Smith
    Alzheimer s Disease Center, Sanders Brown Center on Aging, University of Kentucky, USA
    Biochim Biophys Acta 1822:317-24. 2012
  3. ncbi request reprint Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy
    C D Smith
    Magnetic Resonance Imaging and Spectroscopy Center, Department of Neurology, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurobiol Aging 18:617-22. 1997
  4. ncbi request reprint 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia
    Charles D Smith
    Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536 0098, USA
    Psychopharmacology (Berl) 186:481-5. 2006
  5. doi request reprint Neuroimaging through the course of Alzheimer's disease
    Charles D Smith
    Alzheimer s Disease Center, Sanders Brown Center on Aging, Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0098, USA
    J Alzheimers Dis 19:273-90. 2010
  6. ncbi request reprint Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536 0098, United States
    Neurobiol Aging 28:1075-87. 2007
  7. pmc MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans
    Charles D Smith
    Department of Neurology, University of Kentucky, Lexington, Kentucky, USA
    J Magn Reson Imaging 29:1248-61. 2009
  8. ncbi request reprint Brain structural alterations before mild cognitive impairment
    C D Smith
    MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536
    Neurology 68:1268-73. 2007
  9. pmc White matter diffusion alterations in normal women at risk of Alzheimer's disease
    Charles D Smith
    Department of Neurology, University of Kentucky, Lexington, KY 40536, USA
    Neurobiol Aging 31:1122-31. 2010
  10. pmc Validation studies of the human movement analysis panel for hand/arm performance
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA
    J Neurosci Methods 165:287-96. 2007

Detail Information

Publications51

  1. pmc Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region
    Charles D Smith
    Department of Neurology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0098, USA
    J Alzheimers Dis 31:S49-58. 2012
    ..g., the posterior cingulate, did not show volume loss. These findings provide independent confirmation that volume changes preceding MCI occur in AMTR, a region of overlap between amygdala and anterior hippocampus...
  2. pmc Structural imaging in early pre-states of dementia
    Charles D Smith
    Alzheimer s Disease Center, Sanders Brown Center on Aging, University of Kentucky, USA
    Biochim Biophys Acta 1822:317-24. 2012
    ..This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease...
  3. ncbi request reprint Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy
    C D Smith
    Magnetic Resonance Imaging and Spectroscopy Center, Department of Neurology, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurobiol Aging 18:617-22. 1997
    ..Forward flux may represent a better measure of brain energy function than relative phosphocreatine or adenosine triphosphate levels observable in vivo...
  4. ncbi request reprint 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia
    Charles D Smith
    Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536 0098, USA
    Psychopharmacology (Berl) 186:481-5. 2006
    ..Recent literature suggests that neurosteroid metabolism may be altered in Alzheimer's disease (AD)...
  5. doi request reprint Neuroimaging through the course of Alzheimer's disease
    Charles D Smith
    Alzheimer s Disease Center, Sanders Brown Center on Aging, Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0098, USA
    J Alzheimers Dis 19:273-90. 2010
    ..Imaging results relevant to the conduct of future prevention and early intervention trials are emphasized...
  6. ncbi request reprint Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536 0098, United States
    Neurobiol Aging 28:1075-87. 2007
    ..We did not observe significant gender effects. These findings establish a baseline for comparison with pathologic changes in human brain volume between ages 58 and 95 years...
  7. pmc MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans
    Charles D Smith
    Department of Neurology, University of Kentucky, Lexington, Kentucky, USA
    J Magn Reson Imaging 29:1248-61. 2009
    ..Such pathways are hypothesized to exist because these regions coactivate in functional MRI (fMRI) studies of emotion-valued faces and words, suggesting a functional link that could be mediated by neuronal connections...
  8. ncbi request reprint Brain structural alterations before mild cognitive impairment
    C D Smith
    MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536
    Neurology 68:1268-73. 2007
    ..To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease (AD)...
  9. pmc White matter diffusion alterations in normal women at risk of Alzheimer's disease
    Charles D Smith
    Department of Neurology, University of Kentucky, Lexington, KY 40536, USA
    Neurobiol Aging 31:1122-31. 2010
    ..These findings demonstrate that specific white matter pathways are altered in normal women at increased risk of AD years before the expected onset of cognitive symptoms...
  10. pmc Validation studies of the human movement analysis panel for hand/arm performance
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA
    J Neurosci Methods 165:287-96. 2007
    ..The HMAP has a smaller version used in primates, so that measurements made in primate models of disease and its treatment are directly comparable to analogous clinical measurements made in the corresponding human disease...
  11. ncbi request reprint Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging Spectrometry Center Davis Mills Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    J Neuroimaging 15:271-7. 2005
    ..The authors sought to determine whether known alterations of brain function in normal individuals who are at high risk for Alzheimer's disease (AD) worsen or stay the same after a significant interval of time...
  12. doi request reprint Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease
    C D Smith
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurol Res 30:1091-6. 2008
    ..4 years after the scan. The objective of this study was to show whether accuracy of this predictive model was increased using an advanced segmentation technique...
  13. ncbi request reprint Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 53:1391-6. 1999
    ..To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness...
  14. ncbi request reprint Critical decline in fine motor hand movements in human aging
    C D Smith
    Department of Neurology, Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, USA
    Neurology 53:1458-61. 1999
    ..Slowing of motor movements in human aging is a well-known occurrence, but its biologic basis is poorly understood. Reliable quantitation may refine observations of this phenomenon to better aid research on this entity...
  15. ncbi request reprint White matter volumes and periventricular white matter hyperintensities in aging and dementia
    C D Smith
    Department of Neurology, University of Kentucky Medical Center, Lexington 40536, USA
    Neurology 54:838-42. 2000
    ..To determine the relationship between MRI periventricular white matter hyperintensities, cerebral white matter volumes, neuropathologic findings, and cognitive status in aged individuals...
  16. ncbi request reprint Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task
    C D Smith
    Department of Neurology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroimaging 11:165-70. 2001
    ..No category differences in activation strength in the left temporal lobe were observed. The authors conclude that visual semantic operations may involve visual association cortex in the right temporal lobe in women...
  17. ncbi request reprint A hypothalamic stroke producing recurrent hemihyperhidrosis
    C D Smith
    Magnetic Resonance Imaging and Spectroscopy Center and the Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Neurology 56:1394-6. 2001
    ..MRI indicated a single linear hyperintensity in the right posterior hypothalamus, diminishing on a repeat scan. He continues to have episodes of left unilateral sweating precipitated by exercise or minor infection...
  18. ncbi request reprint Serial MRI findings in a case of primary lateral sclerosis
    Charles D Smith
    Magnetic Resonance Imaging and Spectroscopy Center, Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Neurology 58:647-9. 2002
    ..Cortical motor system degeneration in PLS, whether primary or secondary, may be more extensive than previously believed...
  19. ncbi request reprint Women at risk for AD show increased parietal activation during a fluency task
    C D Smith
    Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA
    Neurology 58:1197-202. 2002
    ..A recent study has shown increased parietal activation in high-risk subjects during a paired associates recall task, which the authors postulated might overlap activation typically observed in verbal fluency...
  20. pmc Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment
    Sarah B Martin
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536 0298, USA
    Neurobiol Aging 31:1099-106. 2010
    ..93). These results show that smaller normalized volumes of anterior medial temporal lobe structures contribute to the development of MCI, a finding which may have implications for identifying seniors at risk for cognitive decline...
  21. pmc Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions
    Xun Liu
    University of Kentucky, Lexington, KY 40536 0098, USA
    J Cogn Neurosci 20:1711-26. 2008
    ..This region is engaged specifically in structural differentiation, a critical component process of object recognition and categorization...
  22. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  23. pmc Human cerebral neuropathology of Type 2 diabetes mellitus
    Peter T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Biochim Biophys Acta 1792:454-69. 2009
    ..These preliminary, correlative, and descriptive studies may help develop new hypotheses about CNDM2. We conclude that more work should be performed on human material in the context of CNDM2...
  24. pmc Aging influences the neural correlates of lexical decision but not automatic semantic priming
    Brian T Gold
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    Cereb Cortex 19:2671-9. 2009
    ....
  25. pmc Association between male gender and cortical Lewy body pathology in large autopsy series
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, Sanders Brown Center on Aging, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:1875-81. 2010
    ..05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design...
  26. pmc Low sensitivity in clinical diagnoses of dementia with Lewy bodies
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:359-66. 2010
    ..Our data suggest that further work is needed to refine our ability to identify specific aging-related brain disease mechanisms, especially in DLB...
  27. pmc Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 450:336-9. 2009
    ..Our results are not consistent with the idea that the precuneus is involved in a special way with plaques or tangles relative to other areas of neocortex...
  28. pmc Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY, USA
    Brain Pathol 20:66-79. 2010
    ..There was no support for independent association between CILA severity and most evaluated indices including diffuse plaques, argyrophilic grains, heart disease, education level, apolipoprotein E alleles or diabetes...
  29. pmc Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging
    Brian T Gold
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, 40536 0298, USA
    Hum Brain Mapp 31:1249-59. 2010
    ..These results showed that a disrupted functional response in the ventral temporal lobe accurately distinguishes individuals with MCI from NS, a finding which may have implications for identifying seniors at risk for cognitive decline...
  30. pmc Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Acta Neuropathol 121:571-87. 2011
    ..In conclusion, it may be most fruitful to focus attention on specific pathways involved in AD rather than attributing it to an inevitable consequence of aging...
  31. pmc Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, Univerisity of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 68:774-84. 2009
    ..We conclude that NFT+/NP- cases comprise approximately 5% of aged individuals in multiple data sets; these cases are not necessarily within the spectrum of AD...
  32. pmc Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease
    Brian T Gold
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Neuroimage 52:1487-94. 2010
    ..These results suggest that disconnection of MTL-neocortical fiber pathways represents a very early event in the course of AD and suggest that demyelination may represent one contributing mechanism...
  33. pmc African Americans with memory loss: findings from a community clinic in Lexington, Kentucky
    Deborah D Danner
    Sanders Brown Center on Aging, Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Nurs Clin North Am 43:437-47, ix-x. 2008
    ..Maintaining this involvement and responsiveness to the community over the long term is the next challenge for the program...
  34. ncbi request reprint A functional magnetic resonance imaging study in patients with benign essential blepharospasm
    Robert S Baker
    Department of Ophthalmology, University of Kentucky College of Medicine, Lexington, USA
    J Neuroophthalmol 23:11-5. 2003
    ..CONCLUSIONS The activations observed might represent a hyperactive cortical circuit linking visual cortex, limbic system, supplementary motor cortex, cerebellum, and supranuclear motor pathways innervating the periorbital muscles...
  35. ncbi request reprint Regional brain response to faces of humans and dogs
    Lee X Blonder
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536, USA
    Brain Res Cogn Brain Res 20:384-94. 2004
    ..The parahippocampal gyrus/amygdala was the sole site that displayed significant activation to human faces, but not to dog faces or houses...
  36. ncbi request reprint The emotional ramifications of unmet need in dementia caregiving
    Joseph E Gaugler
    Department of Behavioral Science, University of Kentucky, Lexington, Kentucky 40536 0086, USA
    Am J Alzheimers Dis Other Demen 19:369-80. 2004
    ....
  37. ncbi request reprint Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    John T Slevin
    Department of Anatomy and Neurobiology, Morris K Udall Parkinson s Disease Research Center of Excellence, University of Kentucky, Lexington 40536 0284, USA
    J Neurosurg 102:216-22. 2005
    ..In the present study the authors report on a 6-month unilateral intraputaminal GDNF infusion in 10 patients with advanced Parkinson disease (PD)...
  38. ncbi request reprint An unusual complication of cancer treatment for acute lymphoblastic leukemia
    Rosario Maria S Riel-Romero
    Department of Neurology, University of Kentucky, College of Medicine, Lexington, Kentucky, USA
    J Neurooncol 73:269-72. 2005
    ..We report an 11-year-old child who, as supported by both clinical course and neuroimaging studies, developed an unusual complication eight years after completing therapy for acute lymphoblastic leukemia, gliomatosis cerebri...
  39. ncbi request reprint Neuropathologic substrate of mild cognitive impairment
    William R Markesbery
    Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Arch Neurol 63:38-46. 2006
    ..To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD)...
  40. ncbi request reprint Alzheimer's disease and head circumference
    Patricio S Espinosa
    Department of Neurology, Sanders Brown Center on Aging University of Kentucky Alzheimer s Disease Research Center, Lexington, KY 40536 0284, USA
    J Alzheimers Dis 9:77-80. 2006
    ..Larger head circumference (HC) may therefore be associated with later detection and diagnosis of AD. We investigated HC in nondemented individuals and AD patients using cross-sectional and prospective analyses...
  41. ncbi request reprint Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal
    John T Slevin
    Department of Anatomy and Neurobiology, The Morris K Udall Parkinson s Disease Research Center of Excellence, and the Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Neurosurg Focus 20:E1. 2006
    ..After the trial was halted by the sponsor, the patients were monitored for an additional year to evaluate the effects of drug withdrawal...
  42. ncbi request reprint Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions
    Brian T Gold
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:6523-32. 2006
    ..These studies provide reproducible evidence for a neural dissociation between three well established components of the lexical-semantic processing system...
  43. pmc Age-related slowing of task switching is associated with decreased integrity of frontoparietal white matter
    Brian T Gold
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky School of Medicine, Lexington, KY 40536 0298, USA
    Neurobiol Aging 31:512-22. 2010
    ..These findings identify decreased integrity of frontoparietal WM as one mechanism contributing to age-related increases in RT switch costs...
  44. pmc Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry
    Sarah B Martin
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA
    Neuropsychologia 45:2874-81. 2007
    ..In addition, these results provide new ecologically relevant evidence for a link between right anterior hippocampus and novelty processing...
  45. ncbi request reprint Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal
    John T Slevin
    Department of Neurology, University of Kentucky, Chandler Medical Center, Lexington, Kentucky 40536 0284, USA
    J Neurosurg 106:614-20. 2007
    ..After the trial was halted by the drug sponsor, the patients were monitored for an additional 1 year during which the effects of drug withdrawal were evaluated...
  46. ncbi request reprint Alien hand syndrome
    Patricio S Espinosa
    Department of Neurology, Kentucky Clinic Room L 445, Lexington, Kentucky 40536 0284, USA
    Neurology 67:E21. 2006
  47. ncbi request reprint Homonymous hemianopsia complicating treatment of postoperative epistaxis
    Patricio S Espinosa
    Department of Neurology, Kentucky Clinic, Lexington, KY 40536 0284, USA
    Neurology 67:1305. 2006
  48. ncbi request reprint Secondary dementia caregiving and its consequences
    Joseph E Gaugler
    Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA
    Am J Alzheimers Dis Other Demen 18:300-8. 2003
    ..Primary and secondary caregivers did not differ significantly in reports of subjective health. The findings suggest that future research and interventions should be inclusive of primary and secondary caregivers...
  49. ncbi request reprint APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD)
    Sarju G Mehta
    Children s Hospital Clinical Genetics and Metabolism, Boston, Massachusetts, and Department of Neurology and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA
    Genet Med 9:9-13. 2007
    ..Modifier genes could account for decreased frontotemporal dementia penetrance. In this study apolipoprotein-E (APOE) was evaluated for this role in IBMPFD families based on its known modifier effect in Alzheimer's disease...
  50. ncbi request reprint The characteristics of dementia caregiving onset
    Joseph E Gaugler
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA
    Am J Alzheimers Dis Other Demen 18:97-104. 2003
    ..The findings describe the complexity of the entry process and its potential association with health-related transitions in the caregiving career...
  51. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...

Research Grants11

  1. Imaging Brain Function/Structure in Presymptomatic FTD
    Charles Smith; Fiscal Year: 2007
    ..These fundamental studies are expected to demonstrate brain network functional alterations and regionally decreased cortical density in rigorously-defined presymptomatic FTD. ..
  2. Detection of presymptomatic Alzheimer's disease by fMRI
    Charles Smith; Fiscal Year: 2007
    ..abstract_text> ..
  3. Detection of presymptomatic Alzheimer's disease by fMRI
    Charles Smith; Fiscal Year: 2006
    ..abstract_text> ..
  4. Detection of presymptomatic Alzheimer's disease by fMRI
    Charles Smith; Fiscal Year: 2003
    ..abstract_text> ..
  5. DETECTION OF PRESYMPTOMATIC ALZHEIMER DISEASE BY FMRI
    Charles Smith; Fiscal Year: 1999
    ..The use of two different strategies for identifying intermediate risk groups may pose some difficulties and interpretation. The primary analyses of fMRI data is group mean data rather date released: 04/04/1997. ..