Research Topics

Genomes and Genes

Species

human

A F Smit

Summary

Affiliation: University of Washington

Country: USA

Publications

Interspersed repeats and other mementos of transposable elements in mammalian genomes
A F Smit
Axys Pharmaceuticals, Inc, La Jolla, 92037 1029, USA
Curr Opin Genet Dev 9:657-63. 1999
The origin of interspersed repeats in the human genome
A F Smit
Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
Curr Opin Genet Dev 6:743-8. 1996
Comparative analyses of multi-species sequences from targeted genomic regions
J W Thomas
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 424:788-93. 2003
Tiggers and DNA transposon fossils in the human genome
A F Smit
Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Proc Natl Acad Sci U S A 93:1443-8. 1996
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species
I Y Lee
Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195 7730 USA
Genome Res 8:1022-37. 1998

Collaborators

W James Kent
PHILIP P GREEN
J W Thomas
I Y Lee
W Miller
X Guan
J W Touchman
L Elnitski
M J Lim
P L Laric
R Legaspi
B Maskeri
J T Tran
V V B Maduro
S Granite
C E Lawrence
P J Thomas
S-L Ho
D J Cutler
C A Masiello
D Haussler
D Karolchik
M S Schwartz
R J Weber
G G Bouffard
L-H Zhang
E E Tiongson
J L Vogt
J Gupta
R Pearson
S Stantripop
S M Beckstrom-Sternberg
E D Green
N Akhter
T J Summers
K Osoegawa
K Cariaga
A C Siepel
J C McDowell
K Ayele
M Blanchette
S Y Brooks
M E Portnoy
E Karlins
N F Hansen
C Tsurgeon
L S Wiggins
Q L Maduro
P J de Jong
M C Huang
C P Brinkley
C L Shu
J R Idol
E H Margulies
S Schwartz
S D Mastrian
P Haghighi
J C McCloskey
R W Blakesley
S-Q Lee-Lin
B Zhu
T C Bruen
A C Young
B Zhao
K D Wetherby
M A Walker
N L Dietrich
B Benjamin
A Chakravarti
A B Prasad
R Bevan
M Ankener
H Yao
D Westaway
C Cooper
D Baskin
C Acharya
S B Prusiner
K Wang
J Seto
L Chen
L E Hood

Detail Information

Publications5

Interspersed repeats and other mementos of transposable elements in mammalian genomes
A F Smit
Axys Pharmaceuticals, Inc, La Jolla, 92037 1029, USA
Curr Opin Genet Dev 9:657-63. 1999
..The many new examples of human genes derived from single transposon insertions highlight the large contribution of selfish DNA to genomic evolution...
The origin of interspersed repeats in the human genome
A F Smit
Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
Curr Opin Genet Dev 6:743-8. 1996
..The emerging concept is that only three mechanisms of amplification are responsible for the vast majority of interspersed repeats and that with each autonomous element a number of dependent non-autonomous sequences have co-amplified...
Comparative analyses of multi-species sequences from targeted genomic regions
J W Thomas
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 424:788-93. 2003
..Analysis of transposable element insertions highlights the variation in genome dynamics among these species and confirms the placement of rodents as a sister group to the primates...
Tiggers and DNA transposon fossils in the human genome
A F Smit
Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Proc Natl Acad Sci U S A 93:1443-8. 1996
..We further identified relatively low-copy-number mariner elements in both human and sheep DNA. These belong to two subfamilies previously identified in insect genomes, suggesting lateral transfer between diverse species...
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species
I Y Lee
Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195 7730 USA
Genome Res 8:1022-37. 1998
..2-kb mariner transposable element. (4) We identified sequences in noncoding DNA that are conserved between the three species and may represent biologically functional sites...