Research Topics
Genomes and Genes | S L SmalleySummaryAffiliation: University of California Country: USA Publications
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Publications
Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorderS L Smalley
Department of Psychiatry, UCLA School of Medicine 90024 1759, USA
J Am Acad Child Adolesc Psychiatry 39:1135-43. 2000..To examine familial clustering of attention-deficit/hyperactivity disorder (ADHD), ADHD subtypes, symptoms, and oppositional behaviors in affected sibling pairs (ASPs) and their parents...- Toward localizing genes underlying cerebral asymmetry and mental healthSusan L Smalley
Center for Neurobehavioral Genetics, UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA
Am J Med Genet B Neuropsychiatr Genet 135:79-84. 2005..Because ACA is associated with certain aspects of creativity, such risk genes may also be enhancer genes for creativity... - Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish populationSusan L Smalley
Semel Institute, University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1575-83. 2007..The purpose of the study was to estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its clinical characteristics in the Northern Finland Birth Cohort 1986... - Mindfulness and attention deficit hyperactivity disorderSusan L Smalley
Mindful Awareness Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
J Clin Psychol 65:1087-98. 2009..It further suggests that interventions that increase mindfulness might improve symptoms of ADHD and increase self-directedness and/or self-transcendence... - Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autismSusan L Smalley
Center for Neurobehavioral Genetics and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024USA
Am J Hum Genet 71:959-63. 2002..These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism... - Refining the ADHD phenotype using affected sibling pair familiesS L Smalley
Center for Neurobehavioral Genetics, UCLA Neuropsychiatric Research Institute, Los Angeles, California 90024, USA
Am J Med Genet 105:31-3. 2001.... - Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)J T McCracken
Department of Psychiatry and Biobehavioral Scienes, UCLA Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
Mol Psychiatry 5:531-6. 2000..These data add further support for the role of DRD4 variants conferring increased risk for ADHD, and imply that additional studies of DRD4 and other related genes are needed... - Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5V Kustanovich
Department of Human Genetics, Division of Child and Adolescent Psychiatry, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Mol Psychiatry 9:711-7. 2004..240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with ADHD, with estimated GRRs of 1.7 and 1.37, respectively... - Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effectsS K Loo
Center for Neurobehavioral Genetics, University of California, Los Angeles, USA
Mol Psychiatry 9:485-93. 2004..The eventual identification of genes underlying these unique and shared linkages may increase our understanding of ADHD, RD and the relationship between the two... - Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorderAke T Lu
Department of Human Genetics, University of California, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008..01 for C-G). These observations require replication, however, they suggest that the CNR1 gene may be a risk factor for ADHD and possibly PTSD, and that this gene warrants further investigation for a role in neuropsychiatric disorders... - Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypesRichard D Todd
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Child Psychol Psychiatry 46:1067-73. 2005..The goal of the current study is to test whether population-based ADHD subtypes defined by latent class analysis help resolve issues of variable findings across individual gene association studies... - Relationship of family environment and parental psychiatric diagnosis to impairment in ADHDLeah J Pressman
Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90095-1759, USA
J Am Acad Child Adolesc Psychiatry 45:346-54. 2006..CONCLUSIONS: There are strong links between impairment in children with ADHD and family environment. Different processes and mechanisms may contribute to impairment in different children in the same family... - Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genesSandra K Loo
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
J Child Psychol Psychiatry 49:950-7. 2008..This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD)... - Executive functioning among Finnish adolescents with attention-deficit/hyperactivity disorderSandra K Loo
University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1594-604. 2007..The present study examined cognitive functioning in a population sample of adolescents with and without attention-deficit/hyperactivity disorder (ADHD) from the Northern Finland Birth Cohort 1986... - ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHDT Sigi Hale
Division of Child and Adolescent Psychiatry and Center for Neurobehavioral Genetics at the UCLA Semel Institute, 760 Westwood Plaza, Room 47 448, Los Angeles, CA 90095, United States
J Psychiatr Res 44:605-15. 2010..Previous studies have shown increased rightward alpha asymmetry in ADHD. We tested whether this was more pronounced in ADHD children with increased ADHD family loading... - CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysisJames J McGough
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine
J Am Acad Child Adolesc Psychiatry 47:1151-7. 2008..We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs... - Rethinking a right hemisphere deficit in ADHDT Sigi Hale
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
J Atten Disord 13:3-17. 2009..If true, RH pathology in ADHD should reflect interhemispherically networked and overactivated functioning. The authors evaluated these assertions... - Cortical activity patterns in ADHD during arousal, activation and sustained attentionSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, United States
Neuropsychologia 47:2114-9. 2009..The goal of the present study is to test whether there are Attention-Deficit Hyperactivity Disorder (ADHD)-related differences in brain electrical activity patterns across arousal, activation and vigilance states... - Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorderSandra K Loo
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 49:368-77. 2010.... - A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorderJames J McGough
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine, University of California, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 48:1155-64. 2009..This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD)... - Atypical alpha asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, United States
Neuropsychologia 47:2082-8. 2009..The current study explores whether increased rightward alpha asymmetry is also evident in adults with ADHD... - Mindfulness meditation training in adults and adolescents with ADHD: a feasibility studyLidia Zylowska
University of California Los Angeles, Los Angeles, CA, USA
J Atten Disord 11:737-46. 2008..In recent years, mindfulness meditation has been proposed to improve attention, reduce stress, and improve mood. This study tests the feasibility of an 8-week mindfulness training program for adults and adolescents with ADHD... - Atypical EEG beta asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Neuropsychologia 48:3532-9. 2010..The current study investigates whether this ABL characteristic occurs in adults with ADHD absent comorbid language impairment... - Preliminary report of familial clustering of EEG measures in ADHDSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 147:107-9. 2008..Cognitive task performance did not exhibit familial clustering in our sample. EEG measures (i.e., alpha power) recorded during cognitive activation is a strongly familial trait in ADHD and may be a putative endophenotype for ADHD... - Familial association and frequency of learning disabilities in ADHD sibling pair familiesMelissa Del'Homme
Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, 300 UCLA Medical Plaza, Suite 1416, Los Angeles, CA 90095 6967, USA
J Abnorm Child Psychol 35:55-62. 2007..Despite the high comorbidity of ADHD and LD among parents, the presence of ADHD in the parents did not predict child LD supporting independent familial factors underlying ADHD and LD... - Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex familiesJames J McGough
Center for Neurobehavioral Genetics, David Geffen School of Medicine, Suite 1414, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Am J Psychiatry 162:1621-7. 2005..Patterns of psychiatric comorbidity were assessed in adults with and without attention deficit hyperactivity disorder (ADHD) identified through a genetic study of families containing multiple children with ADHD... - Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorderV Kustanovich
Department of Human Genetics, UCLA School of Medicine, University of California, Los Angeles, USA
Mol Psychiatry 8:309-15. 2003..027) when paternal transmissions were evaluated... - Social functioning difficulties in ADHD: association with PDD riskErika Carpenter Rich
Center for Neurobehavioral Genetics, University of California, Los Angeles, USA
Clin Child Psychol Psychiatry 14:329-44. 2009..51) than Peer Rejection (beta = .29) factors. Social Immaturity was also associated with a greater number of hyperactive symptoms while high Peer Rejection was associated with increased aggression and lower IQ in the ADHD children... - Temperament and character profiles and the dopamine D4 receptor gene in ADHDDeborah E Lynn
UCLA Department of Child and Adolescent Psychiatry, 10850 Wilshire Blvd, Suite 200, Los Angeles, CA 90024, USA
Am J Psychiatry 162:906-13. 2005..This study was designed to investigate the link among attention deficit hyperactivity disorder (ADHD) in adults, novelty-seeking temperament, and the 48-base pair (bp) dopamine D4 receptor (DRD4) gene variant... - Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11Matthew N Ogdie
Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
Am J Hum Genet 75:661-8. 2004..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size... - A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11Matthew N Ogdie
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA
Am J Hum Genet 72:1268-79. 2003..Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism... - ADHD symptoms and subtypes: relationship between childhood and adolescent symptomsTuula Hurtig
University of Oulu, Finland
J Am Acad Child Adolesc Psychiatry 46:1605-13. 2007..To study attention-deficit/hyperactivity disorder (ADHD) symptoms and DSM-IV subtypes in childhood and adolescence... - Subtypes versus severity differences in attention-deficit/hyperactivity disorder in the Northern Finnish Birth CohortGitta H Lubke
University of Notre Dame, Notre Dame, IN, USA
J Am Acad Child Adolesc Psychiatry 46:1584-93. 2007.... - A genomewide scan for loci involved in attention-deficit/hyperactivity disorderSimon E Fisher
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
Am J Hum Genet 70:1183-96. 2002..Two of the regions highlighted in the present study, 2q24 and 16p13, coincided with the top linkage peaks reported by a recent genome-scan study of autistic sib pairs... - ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2Emma S Nyman
National Public Health Institute, Helsinki, Finland
J Am Acad Child Adolesc Psychiatry 46:1614-21. 2007..This study tests a series of allelic variants within such candidate genes to determine their potential influence on ADHD susceptibility... - Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypesNaomi Lowe
Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 74:348-56. 2004..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes... - Maternal smoking and hyperactivity in 8-year-old childrenArto J Kotimaa
Clinic of Child Psychiatry, University Hospital of Oulu, Finland
J Am Acad Child Adolesc Psychiatry 42:826-33. 2003..To investigate the association between maternal smoking during pregnancy and hyperactivity in 8-year-old children... - Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)James M Swanson
Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
J Child Adolesc Psychopharmacol 17:635-46. 2007....
Research Grants
- DETECTION OF SUSCEPTIBILITY GENES IN ADHDSusan Smalley; Fiscal Year: 2007..Successful completion of these specific aims will lay the foundation for determining where to look for specific risk genes using SNP/association methodologies as well as identifying potential gene to brain pathways in ADHD. ..
- Genetic Influences on ADHD in a Finnish Birth CohortSusan Smalley; Fiscal Year: 2005..abstract_text> ..
- DETECTION OF SUSCEPTIBILITY GENES IN ADHDSusan Smalley; Fiscal Year: 2002..3. Identify the modifying role sex has in the expression of ADHD susceptibility genes -specifically to test the hypotheses that a gene located on the X chromosome modifies ADHD expression. ..