Research Topics
Species | GARY WILLIAM SMALLSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
What we need to know about age related memory lossGary W Small
UCLA Neuropsychiatric Institute, Suite 88-201, 760 Westwood Plaza, Los Angeles, CA 90024, USA
BMJ 324:1502-5. 2002- Prediction of cognitive decline by positron emission tomography of brain amyloid and tauGary W Small
Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024
Arch Neurol 69:215-22. 2012..To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change... - Defining optimal treatment with cholinesterase inhibitors in Alzheimer's diseaseGary Small
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Alzheimers Dement 7:177-84. 2011..g., oral vs. transdermal), and treatment durations. Regardless of management approach, individuals with AD, their families, and caregivers have a right to a timely diagnosis and access to best available treatment... - The role of neuroimaging in the diagnosis of vascular dementiaG W Small
Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
Acta Neurol Scand Suppl 178:10-4. 2002..Neuroimaging also provides information about location and size of vascular lesions that can lead to a better understanding of symptoms and may help guide therapy... - In vivo brain imaging of tangle burden in humansGary W Small
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
J Mol Neurosci 19:323-7. 2002.... - Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular diseaseGary Small
Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
CNS Drugs 17:905-14. 2003.... - Seeing is believing: neuroimaging adds to our understanding of cerebral pathologyGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Alzheimer s Disease Center, University of California, Los Angeles, California 90024, USA
Curr Opin Psychiatry 19:564-9. 2006..The purpose of this review is to provide background behind these developments and update readers on new findings... - Neuroimaging as a diagnostic tool in dementia with Lewy bodiesGary W Small
Center on Aging, Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90024, USA
Dement Geriatr Cogn Disord 17:25-31. 2004.... - Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 yearsG W Small
UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
Int J Clin Pract 59:473-7. 2005..3 (+/-4.9). Projected mean scores in model-based untreated patients declined below 10 points on the MMSE at about 3 years, while the mean MMSE score of patients who remained on rivastigmine stayed above 10 points for 5 years... - Effects of a 14-day healthy longevity lifestyle program on cognition and brain functionGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Am J Geriatr Psychiatry 14:538-45. 2006..The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints... - Diagnostic issues in dementia: neuroimaging as a surrogate marker of diseaseGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Alzheimer s Disease Center, and Center on Aging, University of California, Los Angeles, Los Angeles, CA, USA
J Geriatr Psychiatry Neurol 19:180-5. 2006..Combining imaging with genetic risk data will likely improve diagnostic accuracy. These new findings warrant reconsideration of current guidelines on the use of neuroimaging in diagnosis and research in dementia... - PET of brain amyloid and tau in mild cognitive impairmentGary W Small
Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, USA
N Engl J Med 355:2652-63. 2006..Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnostics... - A review of compliance to treatment in Alzheimer's disease: potential benefits of a transdermal patchGary Small
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
Curr Med Res Opin 23:2705-13. 2007..Compliance in Alzheimer's disease (AD), a chronic neurodegenerative disease typically afflicting older adults, is especially challenging... - Current and future uses of neuroimaging for cognitively impaired patientsGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
Lancet Neurol 7:161-72. 2008.... - Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled studyGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
Am J Geriatr Psychiatry 16:999-1009. 2008.... - Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementiaGary W Small
Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024, USA
Arch Gen Psychiatry 66:81-7. 2009..Here we investigated whether known risk factors for Alzheimer disease and dementia are associated with FDDNP-PET binding... - Your brain on Google: patterns of cerebral activation during internet searchingGary W Small
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
Am J Geriatr Psychiatry 17:116-26. 2009.... - Vascular dementia: galantamine (Reminyl) as an emerging therapeutic optionG W Small
Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
Acta Neurol Scand Suppl 178:4-5. 2002 - The impact of symptom severity on the cost of Alzheimer's diseaseGary W Small
Center on Aging, University of California Los Angeles, 90024, USA
J Am Geriatr Soc 50:321-7. 2002..ITo examine the economic impact of Alzheimer's disease (AD) as the disease progresses on patients' medical costs and caregivers' productivity... - Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer's diseaseG W Small
Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California at Los Angeles, 90024, USA
Int J Geriatr Psychiatry 16:1071-7. 2001..No previous study has focused on subjective memory complaints and depressive symptoms in the same subject population at genetic risk for Alzheimer's disease... - Investigations into geriatric psychiatry challenges: AAGP Senior Investigator Award 2000G W Small
Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, the Alzheimer s Disease Center, and the Center on Aging, University of California at Los Angeles, USA
Am J Geriatr Psychiatry 8:276-83. 2000..The eventual goal is to translate the clinical research discoveries into modern clinical practice... - Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's diseaseG W Small
Center on Aging and Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 97:6037-42. 2000..These results indicate that the combination of cerebral metabolic rates and genetic risk factors provides a means for preclinical AD detection that will assist in response monitoring during experimental treatments... - Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 alleleG W Small
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024 1759, USA
Am J Psychiatry 156:1035-8. 1999.... - Brain-imaging surrogate markers for detection and prevention of age-related memory lossGary W Small
Department of Psychiatry and Biobehavioral Sciences and the Center on Aging, University of California, Los Angeles School of Medicine, USA
J Mol Neurosci 19:17-21. 2002.... - FDDNP binding using MR derived cortical surface mapsH D Protas
Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Neuroimage 49:240-8. 2010.... - Estrogen use and brain metabolic change in older adults. A preliminary reportN L Rasgon
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, The Neuropsychiatric Institute, Los Angeles, CA 90095, USA
Psychiatry Res 107:11-8. 2001..These findings suggest that estrogen use may protect against regional cerebral metabolic decline in postmenopausal women... - Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcomeD H Silverman
Ahmanson Biological Imaging Center, CHS AR 144, Department of Molecular and Medical Pharmacology, University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 6942, USA
JAMA 286:2120-7. 2001..Deficits in cerebral glucose utilization have been identified in patients with cognitive dysfunction attributed to various disease processes, but their prognostic and diagnostic value remains to be defined... - In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrileE D Agdeppa
Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, The David Geffen School of Medicine at UCLA, Box 956948, Los Angeles, CA 90095, USA
Neuroscience 117:723-30. 2003.... - Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriersA C Burggren
David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, 760 Westwood Plaza B8 169, Los Angeles, CA 90095, USA
Neuroimage 41:1177-83. 2008.... - Amyloid imaging in distinguishing atypical prion disease from Alzheimer diseaseA L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Neurology 69:283-90. 2007..To compare the in vivo uptake of two amyloid-binding PET agents, PIB and FDDNP, in human subjects with a prion protein (PrP) gene (PRNP) mutation that produces a clinical syndrome similar to Alzheimer disease (AD)... - Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's diseaseE D Agdeppa
Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Neurosci 21:RC189. 2001.... - Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndromeLinda D Nelson
Department of Psychiatry and Biobehavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles 90024, USA
Arch Neurol 68:768-74. 2011..For reference, [(18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants... - Estrogen replacement therapy and antidepressant response to sertraline in older depressed womenL S Schneider
Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA
Am J Geriatr Psychiatry 9:393-9. 2001..The results provide preliminary evidence that ERT use (without progesterone) in older depressed women may augment the antidepressant response to sertraline in terms of quality of life and general improvement... - Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefitsDaniel H S Silverman
Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
J Nucl Med 43:253-66. 2002..The precise diagnostic role of PET and its economic impact in this context, however, have not been systematically examined previously... - Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerizationKooresh Shoghi-Jadid
Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1766, USA
Nucl Med Biol 32:337-51. 2005.... - Efficacy of rivastigmine in Alzheimer's disease patients with rapid disease progression: results of a meta-analysisMartin R Farlow
Indiana University School of Medicine, Indianapolis, IN 46202 5111, USA
Dement Geriatr Cogn Disord 20:192-7. 2005..In a recent retrospective analysis, treatment effects of rivastigmine were more pronounced in AD patients with rapid cognitive decline than in those with slow cognitive decline. This warranted further investigation... - Serotonin 1A receptors in the living brain of Alzheimer's disease patientsVladimir Kepe
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:702-7. 2006.... - Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PETDaniel H S Silverman
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
Mol Genet Metab 80:350-5. 2003..4). These data indicate that evaluation of brain metabolism by PET in appropriately selected patients may improve the accuracy of clinical prognostic assessment... - Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer diseaseKooresh Shoghi-Jadid
Division of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA, USA
Am J Geriatr Psychiatry 10:24-35. 2002..0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments... - Spectral simulation methodology for calibration transfer of near-infrared spectraYusuf Sulub
Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
Appl Spectrosc 61:406-13. 2007..For instruments A and B, respectively, augmentation with measured spectra of nine samples lowers the SEP values to 0.64 and 0.85 mM... - Visualizing pathology deposits in the living brain of patients with Alzheimer's diseaseVladimir Kepe
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
Methods Enzymol 412:144-60. 2006..In contrast, control subjects have uniformly low levels of [F-18]FDDNP binding in all areas, which is comparable to that of cerebellum... - Positron emission tomography scans obtained for the evaluation of cognitive dysfunctionDaniel H S Silverman
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Semin Nucl Med 38:251-61. 2008.... - Blank augmentation protocol for improving the robustness of multivariate calibrationsKirsten E Kramer
Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
Appl Spectrosc 61:497-506. 2007..79 mM when the augmented PLS model is applied to data collected 176 days after the collection of the calibration spectra. Without updating, the original PLS model produces a seriously degraded SEP of 13.4 mM... - 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's diseaseEric D Agdeppa
Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mol Imaging Biol 5:404-17. 2003..Therefore it is anticipated that a new vision for prevention, early diagnosis and treatment of Alzheimer's disease would be rapidly developing... - Object naming and semantic fluency among individuals with genetic risk for Alzheimer's diseaseKaren J Miller
Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, the Alzheimer s Disease Center, and the Center on Aging, University of California at Los Angeles, Los Angeles 90024 1759, USA
Int J Geriatr Psychiatry 20:128-36. 2005..This study longitudinally examined the object naming and semantic fluency of individuals who are at risk for developing Alzheimer's disease (AD) by virtue of having APOE-4 or a family history of AD... - Estrogen use and brain metabolic change in postmenopausal womenNatalie L Rasgon
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Neurobiol Aging 26:229-35. 2005..We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study... - An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementiaTimo Erkinjuntti
Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
Clin Ther 25:1765-82. 2003.... - MMSE items predict cognitive decline in persons with genetic risk for Alzheimer's diseaseLinda M Ercoli
Department of Psychiatry and Biobehavioral Sciences, and Neuropsychiatric Institute, University of California at Los Angeles, 90024, USA
J Geriatr Psychiatry Neurol 16:67-73. 2003..Performance on a subset of MMSE items, combined with APOE-4 genotype, may aid in identifying high-risk persons for research or follow-up... - Multivariate calibration standardization across instruments for the determination of glucose by Fourier transform near-infrared spectrometryLin Zhang
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, USA
Anal Chem 75:5905-15. 2003..Diagnostic procedures are presented for use with the GMR algorithm that forecasts the successful calibration transfer with spectrometer C and the unsatisfactory results with spectrometer B... - Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditionsDaniel H S Silverman
Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles 90095-6942, USA
Am J Psychiatry 159:1482-8. 2002 - Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitorsMichael W Jann
Department of Clinical and Administrative Sciences, Southern School of Pharmacy, Mercer University, Atlanta, Georgia 30341, USA
Clin Pharmacokinet 41:719-39. 2002..The increased information available to clinicians can optimise the use of these agents in the management of patients with Alzheimer's disease... - Hippocampal atrophy in persons with age-associated memory impairment: volumetry within a common spaceMichael S Mega
Department of Neurology and Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Psychosom Med 64:487-92. 2002..The objective of this study is to demonstrate the assessment of hippocampal atrophy within a standard brain atlas for persons with age-associated memory impairment (AAMI) compared with cognitively intact elderly... - Age at onset in two common neurodegenerative diseases is genetically controlledYi-Ju Li
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 70:985-93. 2002..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases... - Academic highlights: emerging therapeutic strategies in Alzheimer's diseaseGeorge T Grossberg
Departments of Psychiatry and Internal Medicine, St. Louis University Health Center and Wohl Clinic, St. Louis, MO, USA
J Clin Psychiatry 65:255-66; quiz 283-4. 2004 - Calibration standardization algorithm for partial least-squares regression: application to the determination of physiological levels of glucose by near-infrared spectroscopyLin Zhang
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens 45701, USA
Anal Chem 74:4097-108. 2002..A similar improvement in the prediction performance of the 2000 test set is obtained after standardization with the 1996 database (SEP = 0.70 mM)... - Use of neuroimaging to detect early brain changes in people at genetic risk for Alzheimer's diseaseGary W Small
Department of Psychiatry and Biobehavioral Sciences and the Center on Aging, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
Adv Drug Deliv Rev 54:1561-6. 2002.... - Analysis of European mitochondrial haplogroups with Alzheimer disease riskJoelle M van der Walt
Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Neurosci Lett 365:28-32. 2004..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE... - Mood symptoms and cognitive performance in women estrogen users and nonusers and menKaren J Miller
Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
J Am Geriatr Soc 50:1826-30. 2002..In this study, we explore sex differences for a range of mood symptoms and for neuropsychological performance in men and postmenopausal women and assess the potential influence of estrogen on these measures... - What does imaging add to the management of Alzheimer's disease?Gary W Small
Neuropsychiatric Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
CNS Spectr 9:20-3. 2004..If neurons can be protected from neurodegenerative damage in early stages, this may preserve patient cognition, function, and quality of life, and may confer considerable societal healthcare benefits... - Specificity of brain activation patterns in people at genetic risk for Alzheimer diseaseAlison C Burggren
Department of Psychiatry and Biobehavioral Sciences, Brain Mapping Division, UCLA School of Medicine, Los Angeles, CA 90095-7085, USA
Am J Geriatr Psychiatry 10:44-51. 2002.... - The Q7R Saitohin gene polymorphism is not associated with Alzheimer diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
Neurosci Lett 347:143-6. 2003..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association... - Parkin mutations and susceptibility alleles in late-onset Parkinson's diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Ann Neurol 53:624-9. 2003..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease... - Association study of Parkin gene polymorphisms with idiopathic Parkinson diseaseSofia A Oliveira
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
Arch Neurol 60:975-80. 2003..CONCLUSIONS: These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD... - Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22William K Scott
Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
Am J Hum Genet 73:1041-51. 2003..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively... - Comparison of combination and first overtone spectral regions for near-infrared calibration models for glucose and other biomolecules in aqueous solutionsJun Chen
Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
Anal Chem 76:5405-13. 2004..The superior selectivity of combination spectra is confirmed by comparing the length of the NAS vectors for each matrix component... - Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopyAirat K Amerov
Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
Anal Chem 77:4587-94. 2005..This result provides evidence that absorption information is needed in order to obtain a glucose calibration model with acceptable performance... - Noninvasive glucose sensingMark A Arnold
Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
Anal Chem 77:5429-39. 2005..A set of publication standards is recommended as a means to enhance progress toward a successful noninvasive monitor... - Pure component selectivity analysis of multivariate calibration models from near-infrared spectraMark A Arnold
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
Anal Chem 76:2583-90. 2004..The proposed procedure demonstrates conclusively that no component of the sucrose or maltose spectrum contributes to the selective measurement of glucose. Analogous conclusions are possible for the sucrose and maltose calibration models... - Remote detection of heated ethanol plumes by airborne passive Fourier transform infrared spectrometryToshiyasu Tarumi
Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701-2979, USA
Appl Spectrosc 57:1432-41. 2003..Further improvements in classification performance are judged to require increased sophistication in the ground-based data collection in order to provide a better match to the infrared backgrounds observed from the air... - Classification of Fourier transform infrared microscopic imaging data of human breast cells by cluster analysis and artificial neural networksLin Zhang
Ohio University, Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Athens, Ohio 45701, USA
Appl Spectrosc 57:14-22. 2003..The robustness of the final classifier is improved through the use of a rejection threshold procedure to prevent classification of outlying pixels... - Remote detection of volatile organic compounds by passive multispectral infrared imaging measurementsMukire J Wabomba
Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
Appl Spectrosc 61:349-58. 2007..Separation of temperature and emissivity by use of the alpha residual calculation is found to reduce false positive detections to a negligible level, and the MNF transform is shown to enhance detection sensitivity... - Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson diseaseYi Ju Li
Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
Hum Mol Genet 12:3259-67. 2003..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders... - Simulated radiance profiles for automating the interpretation of airborne passive multi-spectral infrared imagesYusuf Sulub
Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
Appl Spectrosc 62:1049-59. 2008..Field data collected during controlled releases of ethanol, as well as during a methanol release from an industrial facility, are used to evaluate the methodology...
Research Grants
- FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASEGary Small; Fiscal Year: 2002....
- FUNCTIONAL BRAIN IMAGING & MENTAL DISORDERS IN AGINGGary Small; Fiscal Year: 2002..We hypothesize that a higher cerebral GABA concentration will be significantly related to a decrease in symptom response to divalproex sodium. ..
- MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN ADGary Small; Fiscal Year: 2003....
- Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and DementiaGary Small; Fiscal Year: 2009..Given the many people suffering from these neurodegenerative diseases, the potential impact of this study will be considerable, possibly improving the quality of life for millions of patients and their families. ..
- FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER'SGary Small; Fiscal Year: 2004....
- FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER DISEASEGary Small; Fiscal Year: 1999....
- Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and DementiaGARY WILLIAM SMALL; Fiscal Year: 2010..Given the many people suffering from these neurodegenerative diseases, the potential impact of this study will be considerable, possibly improving the quality of life for millions of patients and their families. ..