Gary W Small

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Use of neuroimaging to detect early brain changes in people at genetic risk for Alzheimer's disease
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Center on Aging, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
    Adv Drug Deliv Rev 54:1561-6. 2002
  2. pmc Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
    Gary W Small
    Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024, USA
    Arch Gen Psychiatry 66:81-7. 2009
  3. pmc Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people
    Markus Donix
    Center for Cognitive Neurosciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:565-73. 2012
  4. pmc Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 16:999-1009. 2008
  5. ncbi request reprint PET of brain amyloid and tau in mild cognitive impairment
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, USA
    N Engl J Med 355:2652-63. 2006
  6. pmc Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Rm B2 085E CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 37:575-88. 2010
  7. pmc Prediction of cognitive decline by positron emission tomography of brain amyloid and tau
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Arch Neurol 69:215-22. 2012
  8. ncbi request reprint Effects of a 14-day healthy longevity lifestyle program on cognition and brain function
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 14:538-45. 2006
  9. pmc Differential FDDNP PET patterns in nondemented middle-aged and older adults
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:397-406. 2009
  10. pmc Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging
    Lojze M Smid
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:261-74. 2013

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Use of neuroimaging to detect early brain changes in people at genetic risk for Alzheimer's disease
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Center on Aging, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
    Adv Drug Deliv Rev 54:1561-6. 2002
    ....
  2. pmc Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
    Gary W Small
    Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024, USA
    Arch Gen Psychiatry 66:81-7. 2009
    ..Here we investigated whether known risk factors for Alzheimer disease and dementia are associated with FDDNP-PET binding...
  3. pmc Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people
    Markus Donix
    Center for Cognitive Neurosciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:565-73. 2012
    ..Our aim was to determine the influence of APOE genotype and family history status on cognitive performance in healthy individuals...
  4. pmc Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 16:999-1009. 2008
    ....
  5. ncbi request reprint PET of brain amyloid and tau in mild cognitive impairment
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, USA
    N Engl J Med 355:2652-63. 2006
    ..Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnostics...
  6. pmc Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Rm B2 085E CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 37:575-88. 2010
    ..Subcortical white matter is known to be relatively unaffected by amyloid deposition in Alzheimer's disease (AD). We investigated the use of subcortical white matter as a reference region to quantify [(18)F]FDDNP binding in the human brain...
  7. pmc Prediction of cognitive decline by positron emission tomography of brain amyloid and tau
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Arch Neurol 69:215-22. 2012
    ..To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change...
  8. ncbi request reprint Effects of a 14-day healthy longevity lifestyle program on cognition and brain function
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 14:538-45. 2006
    ..The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints...
  9. pmc Differential FDDNP PET patterns in nondemented middle-aged and older adults
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:397-406. 2009
    ....
  10. pmc Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging
    Lojze M Smid
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:261-74. 2013
    ..This work offers a mapping brain model applicable to all imaging probes for verification of imaging results with Aβ and/or tau neuropathology brain distribution using immunohistochemistry, fluorescence microscopy, and autoradiography...
  11. pmc Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:493-502. 2009
    ....
  12. pmc Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism
    Markus Donix
    David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, Los Angeles, CA 90095, USA
    Neuroimage 53:37-43. 2010
    ..This finding is consistent with the hypothesis that carrying the APOE-4 allele renders subjects at a higher risk for developing Alzheimer's disease...
  13. pmc Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    Int Psychogeriatr 24:1076-84. 2012
    ..Here we investigate whether degree of self-reported memory impairment is associated with FDDNP-PET binding levels in persons without dementia...
  14. ncbi request reprint 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease
    Eric D Agdeppa
    Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:404-17. 2003
    ..Therefore it is anticipated that a new vision for prevention, early diagnosis and treatment of Alzheimer's disease would be rapidly developing...
  15. pmc Brain network local interconnectivity loss in aging APOE-4 allele carriers
    Jesse A Brown
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:20760-5. 2011
    ..05). This genotype-specific pattern of structural connectivity change with age thus appears related to changes in gross cortical structure and cognition, potentially affecting the rate and/or spatial distribution of AD-related pathology...
  16. doi request reprint Dissecting molecular mechanisms in the living brain of dementia patients
    Jorge R Barrio
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Acc Chem Res 42:842-50. 2009
    ....
  17. pmc Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease
    Nanthia A Suthana
    Center for Cognitive Neurosciences, Semel Institute, University of California, Los Angeles, CA 90095 7039, USA
    Neuroimage 53:1077-84. 2010
    ....
  18. ncbi request reprint Visualizing pathology deposits in the living brain of patients with Alzheimer's disease
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Methods Enzymol 412:144-60. 2006
    ..In contrast, control subjects have uniformly low levels of [F-18]FDDNP binding in all areas, which is comparable to that of cerebellum...
  19. doi request reprint PET scanning of brain tau in retired national football league players: preliminary findings
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 21:138-44. 2013
    ....
  20. pmc Vascular risk and FDDNP-PET influence cognitive performance
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    J Alzheimers Dis 35:147-57. 2013
    ..These findings suggest that even mild cerebrovascular risk may influence the extent of cognitive dysfunction in pre-dementia, along with amyloid-β and tau burden...
  21. pmc Current and future uses of neuroimaging for cognitively impaired patients
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
    Lancet Neurol 7:161-72. 2008
    ....
  22. pmc Serotonin 1A receptors in the living brain of Alzheimer's disease patients
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:702-7. 2006
    ....
  23. pmc Family history of Alzheimer's disease and hippocampal structure in healthy people
    Markus Donix
    Center for Cognitive Neurosciences, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Semel Institute, Los Angeles, CA 90095, USA
    Am J Psychiatry 167:1399-406. 2010
    ..The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment...
  24. pmc Movement correction method for human brain PET images: application to quantitative analysis of dynamic 18F-FDDNP scans
    Mirwais Wardak
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 51:210-8. 2010
    ....
  25. doi request reprint The memory fitness program: cognitive effects of a healthy aging intervention
    Karen J Miller
    Division of Geriatric Psychiatry, Memory and Aging Research Center, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:514-23. 2012
    ..Age-related memory decline affects a large proportion of older adults. Cognitive training, physical exercise, and other lifestyle habits may help to minimize self-perception of memory loss and a decline in objective memory performance...
  26. pmc Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroimage 60:241-51. 2012
    ..In this work, we have characterized a relative-equilibrium-based (RE) graphical method against the Logan analysis for parametric imaging and region-of-interest (ROI) analysis...
  27. pmc [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 43:565-75. 2011
    ..These results corroborate previous analyses of [F-18]FDDNP PET imaging in clinical populations...
  28. ncbi request reprint Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization
    Kooresh Shoghi-Jadid
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1766, USA
    Nucl Med Biol 32:337-51. 2005
    ....
  29. doi request reprint PET of brain prion protein amyloid in Gerstmann-Sträussler-Scheinker disease
    Vladimir Kepe
    David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 6948, USA
    Brain Pathol 20:419-30. 2010
    ....
  30. doi request reprint Healthy behavior and memory self-reports in young, middle-aged, and older adults
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, UCLA Longevity Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024, USA
    Int Psychogeriatr 25:981-9. 2013
    ..However, less is known about the potential link between healthy behaviors and mild memory symptoms that may precede dementia in different age groups...
  31. doi request reprint Positron emission tomography scans obtained for the evaluation of cognitive dysfunction
    Daniel H S Silverman
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Semin Nucl Med 38:251-61. 2008
    ....
  32. pmc Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 10911 Weyburn Avenue, Los Angeles, CA 90095, USA
    Mol Imaging Biol 12:218-24. 2010
    ..The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly...
  33. ncbi request reprint Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PET
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    Mol Genet Metab 80:350-5. 2003
    ..4). These data indicate that evaluation of brain metabolism by PET in appropriately selected patients may improve the accuracy of clinical prognostic assessment...
  34. pmc Psychological well-being and regional brain amyloid and tau in mild cognitive impairment
    Stephen T Chen
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA Electronic address
    Am J Geriatr Psychiatry 22:362-9. 2014
    ..To determine whether psychological well-being in people with mild cognitive impairment (MCI), a risk state for Alzheimer disease (AD), is associated with in vivo measures of brain pathology...
  35. pmc PET imaging of neuropathology in tauopathies: progressive supranuclear palsy
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:145-53. 2013
    ..In this work, we evaluate in vivo [18F]FDDNP labeling of brain neuropathology, primarily tau fibrillar aggregates, in patients with progressive supranuclear palsy (PSP), a human tauopathy usually lacking amyloid-β deposits...
  36. ncbi request reprint In vivo brain imaging of tangle burden in humans
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
    J Mol Neurosci 19:323-7. 2002
    ....
  37. ncbi request reprint Seeing is believing: neuroimaging adds to our understanding of cerebral pathology
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Alzheimer s Disease Center, University of California, Los Angeles, California 90024, USA
    Curr Opin Psychiatry 19:564-9. 2006
    ..The purpose of this review is to provide background behind these developments and update readers on new findings...
  38. ncbi request reprint Brain-imaging surrogate markers for detection and prevention of age-related memory loss
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Center on Aging, University of California, Los Angeles School of Medicine, USA
    J Mol Neurosci 19:17-21. 2002
    ....
  39. pmc Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome
    Linda D Nelson
    Department of Psychiatry and Biobehavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles 90024, USA
    Arch Neurol 68:768-74. 2011
    ..For reference, [(18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants...
  40. doi request reprint Your brain on Google: patterns of cerebral activation during internet searching
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 17:116-26. 2009
    ....
  41. pmc Entorhinal cortex structure and functional MRI response during an associative verbal memory task
    MEREDITH N BRASKIE
    Ahmanson Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Hum Brain Mapp 30:3981-92. 2009
    ..Our results suggest that in healthy older adults, processes that engage frontal regions during memory retrieval are related to ERC structure...
  42. doi request reprint Differential diagnoses and assessment of depression in elderly patients
    Gary W Small
    Memory and Aging Center, Semel Institute for Neuroscience and Human Behavior, and the Geriatric Division of the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Clin Psychiatry 70:e47. 2009
    ..Greater recognition and more aggressive treatment of depression in older patients are needed...
  43. ncbi request reprint What does imaging add to the management of Alzheimer's disease?
    Gary W Small
    Neuropsychiatric Institute, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    CNS Spectr 9:20-3. 2004
    ..If neurons can be protected from neurodegenerative damage in early stages, this may preserve patient cognition, function, and quality of life, and may confer considerable societal healthcare benefits...
  44. ncbi request reprint Diagnostic issues in dementia: neuroimaging as a surrogate marker of disease
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Alzheimer s Disease Center, and Center on Aging, University of California, Los Angeles, Los Angeles, CA, USA
    J Geriatr Psychiatry Neurol 19:180-5. 2006
    ..Combining imaging with genetic risk data will likely improve diagnostic accuracy. These new findings warrant reconsideration of current guidelines on the use of neuroimaging in diagnosis and research in dementia...
  45. pmc Vascular health risks and fMRI activation during a memory task in older adults
    MEREDITH N BRASKIE
    Ahmanson Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurobiol Aging 31:1532-42. 2010
    ..Our results are similar to those in prior AD risk research, and suggest that fMRI reveals an abnormal response to cognitive processes in cognitively intact older adults with increased vascular risk...
  46. pmc Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation through Classification of Alzheimer's Disease Patients
    Moses Q Wilks
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Box 951766, Los Angeles, CA 90095, USA
    Int J Alzheimers Dis 2012:512069. 2012
    ..This suggests that this automated method can remove variance in measurements of PET data and can facilitate accurate, high-throughput image analysis...
  47. doi request reprint Prevention in psychiatry: effects of healthy lifestyle on cognition
    David A Merrill
    Department of Psychiatry and Biobehavioral Sciences, Division of Geriatric Psychiatry, Memory and Aging Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Psychiatr Clin North Am 34:249-61. 2011
    ....
  48. pmc Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates
    Graham B Cole
    Departmentsof Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095 6948, USA
    Proc Natl Acad Sci U S A 107:6222-7. 2010
    ..Because this and other members of this family presenting specificity for SULT1E1 can be labeled with carbon-11 or fluorine-18, in vivo assays of SULT1E1 functional activity are now feasible in humans...
  49. ncbi request reprint Hippocampal atrophy in persons with age-associated memory impairment: volumetry within a common space
    Michael S Mega
    Department of Neurology and Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Psychosom Med 64:487-92. 2002
    ..The objective of this study is to demonstrate the assessment of hippocampal atrophy within a standard brain atlas for persons with age-associated memory impairment (AAMI) compared with cognitively intact elderly...
  50. ncbi request reprint Prompt identification of Alzheimer's disease with brain PET imaging of a woman with multiple previous diagnoses of other neuropsychiatric conditions
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology, School of Medicine, University of California, Los Angeles 90095 6942, USA
    Am J Psychiatry 159:1482-8. 2002
  51. pmc What we need to know about age related memory loss
    Gary W Small
    UCLA Neuropsychiatric Institute, Suite 88 201, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    BMJ 324:1502-5. 2002
  52. ncbi request reprint Object naming and semantic fluency among individuals with genetic risk for Alzheimer's disease
    Karen J Miller
    Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, the Alzheimer s Disease Center, and the Center on Aging, University of California at Los Angeles, Los Angeles 90024 1759, USA
    Int J Geriatr Psychiatry 20:128-36. 2005
    ..This study longitudinally examined the object naming and semantic fluency of individuals who are at risk for developing Alzheimer's disease (AD) by virtue of having APOE-4 or a family history of AD...
  53. ncbi request reprint The impact of symptom severity on the cost of Alzheimer's disease
    Gary W Small
    Center on Aging, University of California Los Angeles, 90024, USA
    J Am Geriatr Soc 50:321-7. 2002
    ..ITo examine the economic impact of Alzheimer's disease (AD) as the disease progresses on patients' medical costs and caregivers' productivity...
  54. ncbi request reprint Neuroimaging as a diagnostic tool in dementia with Lewy bodies
    Gary W Small
    Center on Aging, Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90024, USA
    Dement Geriatr Cogn Disord 17:25-31. 2004
    ....
  55. ncbi request reprint Specificity of brain activation patterns in people at genetic risk for Alzheimer disease
    Alison C Burggren
    Department of Psychiatry and Biobehavioral Sciences, Brain Mapping Division, UCLA School of Medicine, Los Angeles, CA 90095 7085, USA
    Am J Geriatr Psychiatry 10:44-51. 2002
    ....
  56. ncbi request reprint Mood symptoms and cognitive performance in women estrogen users and nonusers and men
    Karen J Miller
    Department of Psychiatry and Biobehavioral Sciences, The Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA
    J Am Geriatr Soc 50:1826-30. 2002
    ..In this study, we explore sex differences for a range of mood symptoms and for neuropsychological performance in men and postmenopausal women and assess the potential influence of estrogen on these measures...
  57. doi request reprint Pharmacotherapy and other treatments for elderly patients with depression
    Gary W Small
    Memory and Aging Center, Semel Institute for Neuroscience and Human Behavior, and the Geriatric Division of the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Clin Psychiatry 71:e03. 2010
    ..When choosing therapies for older patients, possible adverse side effects, drug interactions, and patient limitations should guide treatment selection...
  58. ncbi request reprint Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits
    Daniel H S Silverman
    Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
    J Nucl Med 43:253-66. 2002
    ..The precise diagnostic role of PET and its economic impact in this context, however, have not been systematically examined previously...
  59. ncbi request reprint Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    Kooresh Shoghi-Jadid
    Division of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 10:24-35. 2002
    ..0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments...
  60. ncbi request reprint Calibration standardization algorithm for partial least-squares regression: application to the determination of physiological levels of glucose by near-infrared spectroscopy
    Lin Zhang
    Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens 45701, USA
    Anal Chem 74:4097-108. 2002
    ..A similar improvement in the prediction performance of the 2000 test set is obtained after standardization with the 1996 database (SEP = 0.70 mM)...
  61. pmc Age at onset in two common neurodegenerative diseases is genetically controlled
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:985-93. 2002
    ..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...
  62. ncbi request reprint Efficacy of rivastigmine in Alzheimer's disease patients with rapid disease progression: results of a meta-analysis
    Martin R Farlow
    Indiana University School of Medicine, Indianapolis, IN 46202 5111, USA
    Dement Geriatr Cogn Disord 20:192-7. 2005
    ..In a recent retrospective analysis, treatment effects of rivastigmine were more pronounced in AD patients with rapid cognitive decline than in those with slow cognitive decline. This warranted further investigation...
  63. ncbi request reprint Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
    ..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE...
  64. ncbi request reprint Academic highlights: emerging therapeutic strategies in Alzheimer's disease
    George T Grossberg
    Departments of Psychiatry and Internal Medicine, St Louis University Health Center and Wohl Clinic, St Louis, MO, USA
    J Clin Psychiatry 65:255-66; quiz 283-4. 2004
  65. ncbi request reprint Multivariate calibration standardization across instruments for the determination of glucose by Fourier transform near-infrared spectrometry
    Lin Zhang
    Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701, USA
    Anal Chem 75:5905-15. 2003
    ..Diagnostic procedures are presented for use with the GMR algorithm that forecasts the successful calibration transfer with spectrometer C and the unsatisfactory results with spectrometer B...
  66. ncbi request reprint MMSE items predict cognitive decline in persons with genetic risk for Alzheimer's disease
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences, and Neuropsychiatric Institute, University of California at Los Angeles, 90024, USA
    J Geriatr Psychiatry Neurol 16:67-73. 2003
    ..Performance on a subset of MMSE items, combined with APOE-4 genotype, may aid in identifying high-risk persons for research or follow-up...
  67. ncbi request reprint Estrogen use and brain metabolic change in postmenopausal women
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Aging 26:229-35. 2005
    ..We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study...
  68. ncbi request reprint Blank augmentation protocol for improving the robustness of multivariate calibrations
    Kirsten E Kramer
    Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
    Appl Spectrosc 61:497-506. 2007
    ..79 mM when the augmented PLS model is applied to data collected 176 days after the collection of the calibration spectra. Without updating, the original PLS model produces a seriously degraded SEP of 13.4 mM...
  69. ncbi request reprint The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  70. ncbi request reprint Spectral simulation methodology for calibration transfer of near-infrared spectra
    Yusuf Sulub
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 61:406-13. 2007
    ..For instruments A and B, respectively, augmentation with measured spectra of nine samples lowers the SEP values to 0.64 and 0.85 mM...
  71. ncbi request reprint Scattering and absorption effects in the determination of glucose in whole blood by near-infrared spectroscopy
    Airat K Amerov
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:4587-94. 2005
    ..This result provides evidence that absorption information is needed in order to obtain a glucose calibration model with acceptable performance...
  72. ncbi request reprint Noninvasive glucose sensing
    Mark A Arnold
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 77:5429-39. 2005
    ..A set of publication standards is recommended as a means to enhance progress toward a successful noninvasive monitor...
  73. ncbi request reprint Remote detection of heated ethanol plumes by airborne passive Fourier transform infrared spectrometry
    Toshiyasu Tarumi
    Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Ohio University, Athens, Ohio 45701 2979, USA
    Appl Spectrosc 57:1432-41. 2003
    ..Further improvements in classification performance are judged to require increased sophistication in the ground-based data collection in order to provide a better match to the infrared backgrounds observed from the air...
  74. ncbi request reprint Pure component selectivity analysis of multivariate calibration models from near-infrared spectra
    Mark A Arnold
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:2583-90. 2004
    ..The proposed procedure demonstrates conclusively that no component of the sucrose or maltose spectrum contributes to the selective measurement of glucose. Analogous conclusions are possible for the sucrose and maltose calibration models...
  75. doi request reprint Simulated radiance profiles for automating the interpretation of airborne passive multi-spectral infrared images
    Yusuf Sulub
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 62:1049-59. 2008
    ..Field data collected during controlled releases of ethanol, as well as during a methanol release from an industrial facility, are used to evaluate the methodology...
  76. ncbi request reprint Remote detection of volatile organic compounds by passive multispectral infrared imaging measurements
    Mukire J Wabomba
    Optical Science and Technology Center and Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Appl Spectrosc 61:349-58. 2007
    ..Separation of temperature and emissivity by use of the alpha residual calculation is found to reduce false positive detections to a negligible level, and the MNF transform is shown to enhance detection sensitivity...
  77. ncbi request reprint Classification of Fourier transform infrared microscopic imaging data of human breast cells by cluster analysis and artificial neural networks
    Lin Zhang
    Ohio University, Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Clippinger Laboratories, Athens, Ohio 45701, USA
    Appl Spectrosc 57:14-22. 2003
    ..The robustness of the final classifier is improved through the use of a rejection threshold procedure to prevent classification of outlying pixels...
  78. ncbi request reprint Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    Michael W Jann
    Department of Clinical and Administrative Sciences, Southern School of Pharmacy, Mercer University, Atlanta, Georgia 30341, USA
    Clin Pharmacokinet 41:719-39. 2002
    ..The increased information available to clinicians can optimise the use of these agents in the management of patients with Alzheimer's disease...
  79. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  80. ncbi request reprint Comparison of combination and first overtone spectral regions for near-infrared calibration models for glucose and other biomolecules in aqueous solutions
    Jun Chen
    Department of Chemistry and Optical Science and Technology Center, University of Iowa, Iowa City, Iowa 52242, USA
    Anal Chem 76:5405-13. 2004
    ..The superior selectivity of combination spectra is confirmed by comparing the length of the NAS vectors for each matrix component...
  81. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  82. ncbi request reprint An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  83. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
    ..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively...
  84. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...