E J Small

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Second-line hormonal therapy for advanced prostate cancer: a shifting paradigm
    E J Small
    Department of Medicine, University of California, San Francisco 94115, USA
    J Clin Oncol 15:382-8. 1997
  2. ncbi request reprint Suramin therapy for patients with symptomatic hormone-refractory prostate cancer: results of a randomized phase III trial comparing suramin plus hydrocortisone to placebo plus hydrocortisone
    E J Small
    University of California at San Francisco Comprehensive Cancer Center, San Francisco 94115, USA
    J Clin Oncol 18:1440-50. 2000
  3. ncbi request reprint Androgen deprivation therapy for patients with clinically localized (stages T1 to T3) prostate cancer and for patients with biochemical recurrence after radical prostatectomy
    G D Grossfeld
    Department of Urology, University of California, San Francisco/Mount Zion Cancer Center, San Francisco, California 94143-0738, USA
    Urology 58:56-64. 2001
  4. ncbi request reprint Intermittent androgen deprivation: update of cycling characteristics in patients without clinically apparent metastatic prostate cancer
    G D Grossfeld
    Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143-0738, USA
    Urology 58:240-5. 2001
  5. ncbi request reprint Pyrazoloacridine for the treatment of hormone-refractory prostate cancer
    E J Small
    Department of Medicine, University of California, San Francisco, USA
    Cancer Invest 16:456-61. 1998
  6. ncbi request reprint New treatment strategies in advanced prostate cancer
    E J Small
    Department of Medicine, University of California San Francisco, USA
    Radiol Clin North Am 38:203-11, ix-x. 2000
  7. ncbi request reprint HER2 protein expression and gene amplification in androgen-independent prostate cancer
    D M Reese
    Urologic Oncology Program, Division of Hematology-Oncology, Comprehensive Cancer Center, University of California, 2356 Sutter St, 5th Floor, San Francisco, CA 94115, USA
    Am J Clin Pathol 116:234-9. 2001
  8. ncbi request reprint Serum prostate-specific antigen decline as a marker of clinical outcome in hormone-refractory prostate cancer patients: association with progression-free survival, pain end points, and survival
    E J Small
    University of California, San Francisco, CA, USA
    J Clin Oncol 19:1304-11. 2001
  9. ncbi request reprint Paclitaxel, estramustine phosphate, and carboplatin in patients with advanced prostate cancer
    W K Kelly
    Genitourinary Oncology Service, Division of Solid Tumor, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021 6007, USA
    J Clin Oncol 19:44-53. 2001
  10. ncbi request reprint Therapy of advanced prostate cancer with granulocyte macrophage colony-stimulating factor
    E J Small
    Department of Medicine, University of California, San Francisco 94115, USA
    Clin Cancer Res 5:1738-44. 1999

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Second-line hormonal therapy for advanced prostate cancer: a shifting paradigm
    E J Small
    Department of Medicine, University of California, San Francisco 94115, USA
    J Clin Oncol 15:382-8. 1997
    ..To discuss the evolution of new concepts in the Use of second-line hormonal therapy for patients with progressive prostate cancer despite androgen deprivation...
  2. ncbi request reprint Suramin therapy for patients with symptomatic hormone-refractory prostate cancer: results of a randomized phase III trial comparing suramin plus hydrocortisone to placebo plus hydrocortisone
    E J Small
    University of California at San Francisco Comprehensive Cancer Center, San Francisco 94115, USA
    J Clin Oncol 18:1440-50. 2000
    ..A prospective randomized clinical trial was designed to evaluate pain and opioid analgesic intake as surrogates for antitumor response in HRPC patients with significant, opioid analgesic-dependent pain...
  3. ncbi request reprint Androgen deprivation therapy for patients with clinically localized (stages T1 to T3) prostate cancer and for patients with biochemical recurrence after radical prostatectomy
    G D Grossfeld
    Department of Urology, University of California, San Francisco/Mount Zion Cancer Center, San Francisco, California 94143-0738, USA
    Urology 58:56-64. 2001
    ..The role of ADT in patients with clinically localized and recurrent prostate cancer, whether it is delivered in a continuous or intermittent fashion, must be determined in randomized, prospective trials...
  4. ncbi request reprint Intermittent androgen deprivation: update of cycling characteristics in patients without clinically apparent metastatic prostate cancer
    G D Grossfeld
    Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143-0738, USA
    Urology 58:240-5. 2001
    ..Longer follow-up with more patients failing IAD will be required before clear patterns of failure emerge in these patients...
  5. ncbi request reprint Pyrazoloacridine for the treatment of hormone-refractory prostate cancer
    E J Small
    Department of Medicine, University of California, San Francisco, USA
    Cancer Invest 16:456-61. 1998
    ..If PSA is used as a marker of response, single-agent PZA appears to lack efficacy in the treatment of HRPC. However, the one unambiguous response, and the favorable toxicity profile observed, may warrant further evaluation of this agent...
  6. ncbi request reprint New treatment strategies in advanced prostate cancer
    E J Small
    Department of Medicine, University of California San Francisco, USA
    Radiol Clin North Am 38:203-11, ix-x. 2000
    ....
  7. ncbi request reprint HER2 protein expression and gene amplification in androgen-independent prostate cancer
    D M Reese
    Urologic Oncology Program, Division of Hematology-Oncology, Comprehensive Cancer Center, University of California, 2356 Sutter St, 5th Floor, San Francisco, CA 94115, USA
    Am J Clin Pathol 116:234-9. 2001
    ..Two (6%) of 36 specimens had gene amplification by FISH. These data suggest that HER2 protein overexpression and gene amplification are relatively uncommon in AIPC...
  8. ncbi request reprint Serum prostate-specific antigen decline as a marker of clinical outcome in hormone-refractory prostate cancer patients: association with progression-free survival, pain end points, and survival
    E J Small
    University of California, San Francisco, CA, USA
    J Clin Oncol 19:1304-11. 2001
    ..The purpose of this study was to determine whether posttreatment declines in PSA were associated with clinical measures of improvement in a randomized phase III trial of suramin plus hydrocortisone versus placebo plus hydrocortisone...
  9. ncbi request reprint Paclitaxel, estramustine phosphate, and carboplatin in patients with advanced prostate cancer
    W K Kelly
    Genitourinary Oncology Service, Division of Solid Tumor, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021 6007, USA
    J Clin Oncol 19:44-53. 2001
    ..To determine the safety and activity of weekly paclitaxel in combination with estramustine and carboplatin (TEC) in patients with advanced prostate cancer...
  10. ncbi request reprint Therapy of advanced prostate cancer with granulocyte macrophage colony-stimulating factor
    E J Small
    Department of Medicine, University of California, San Francisco 94115, USA
    Clin Cancer Res 5:1738-44. 1999
    ....
  11. ncbi request reprint Androgen deprivation therapy in locally advanced and metastatic prostate cancer
    C J Ryan
    Department of Medicine and UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Minerva Urol Nefrol 58:119-26. 2006
    ..In virtually all analyses, patients with high-risk features benefited from early AD when compared to deferred therapy. Consideration of AD is therefore warranted early in the clinical course of high-risk patients...
  12. ncbi request reprint Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells
    E J Small
    Department of Medicine and Urology, University of California San Francisco Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    J Clin Oncol 18:3894-903. 2000
    ..Sequential phase I and phase II trials were performed to determine the safety and efficacy of Provenge and to assess its capacity to break immune tolerance to the normal tissue antigen PAP...
  13. ncbi request reprint Secondary hormonal manipulation of prostate cancer
    K A Harris
    University of California, San Francisco Comprehensive Cancer Center, 1600 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA
    Curr Urol Rep 2:224-30. 2001
    ..This approach is predicated on the recognition that HRPC is a heterogeneous disease, and some patients may respond to alternative hormonal interventions despite the presence of castrate levels of testosterone...
  14. ncbi request reprint An update on prostate cancer research
    E J Small
    University of California, San Francisco, Comprehensive Cancer Center, 94115, USA
    Curr Opin Oncol 12:265-72. 2000
    ..Finally, treatment strategies for patients with androgen-independent disease have also expanded, although novel therapies are required to improve survival in this group of patients...
  15. ncbi request reprint Docetaxel, estramustine, plus trastuzumab in patients with metastatic androgen-independent prostate cancer
    E J Small
    Urologic Oncology Program, University of California, San Francisco Comprehensive Cancer Center, San Francisco, CA 94143-1711, USA
    Semin Oncol 28:71-6. 2001
    ..The response data are too preliminary for speculation about the relative benefits of this 3-drug regimen compared with the combination of only docetaxel and estramustine in this clinical setting...
  16. ncbi request reprint The evolving role of androgen deprivation therapy in the management of prostate cancer
    M R Cooperberg
    Department of Urology, UCSF Mt Zion Comprehensive, Cancer Center, University of California, San Francisco, CA 94115 1711, USA
    Minerva Urol Nefrol 55:219-38. 2003
    ..Finally, contemporary practice pattern data suggest that use of ADT is increasing across patient risk groups, both in contexts where such therapy is well supported by current evidence and in others where it is not...
  17. doi request reprint Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207
    J E Rosenberg
    Division of Hematology and Oncology, University of California, San Francisco Cancer Center, San Francisco, CA 94115, USA
    Ann Oncol 19:946-50. 2008
    ..Response rates to second-line chemotherapy for advanced UC are low and response duration is short. Bortezomib is a proteasome inhibitor with preclinical activity against UC...
  18. ncbi request reprint Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    M E Taplin
    University of Massachusetts Cancer Center, Worcester 01655, USA
    Cancer Res 59:2511-5. 1999
    ..These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment...
  19. ncbi request reprint Prognostic significance of plasma vascular endothelial growth factor levels in patients with hormone-refractory prostate cancer treated on Cancer and Leukemia Group B 9480
    D J George
    Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Clin Cancer Res 7:1932-6. 2001
    ..CONCLUSION: Although these data are exploratory and need to be confirmed in an independent data set, they suggest that VEGF may have clinical significance in patients with HRPC...
  20. ncbi request reprint A multi-institutional phase ii study of SU101, a platelet-derived growth factor receptor inhibitor, for patients with hormone-refractory prostate cancer
    Y J Ko
    Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Massachusetts 02215, USA
    Clin Cancer Res 7:800-5. 2001
    ..PDGF-r expression was detected in 80% of the metastases and 88% of primary prostate cancers. The results of this trial may warrant further clinical studies with other PDGF-r inhibitors...
  21. ncbi request reprint Hormonal treatment for prostate cancer
    K A Harris
    UCSF Comprehensive Cancer Center, 1600 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA
    Expert Opin Investig Drugs 10:493-510. 2001
    ..It has been hoped that the development of alternative hormonal interventions might lead to both enhanced antitumour efficacy as well as improvements in side effect profile...
  22. ncbi request reprint Independent association of angiogenesis index with outcome in prostate cancer
    R Mehta
    Oncotech Incorporated, Irvine, California 92614, USA
    Clin Cancer Res 7:81-8. 2001
    ..Further validation of the angiogenesis index in prostate carcinoma may provide a new tool to stratify patient risk...