Brent J Small

..Overall results suggest that some underlying structural characteristics of word and text recall may be maintained into late life even when significant overall decline is observed...

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..Cause of death failed to modify the magnitude of the cross-sectional and longitudinal deficits. The pattern of results point to the general nature of this phenomenon...

..Our study of 6-year personality development provided both (a). a confirmation of early significant stability findings and (b). unique evidence for significant individual differences in late adulthood...

..In addition to increasing our theoretical understanding of AD development, research on cognition in preclinical AD contributes to the identification of persons at risk of developing AD for purposes of intervention...

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..The goal of the current study was to conduct a meta-analysis of cognitive functioning in breast cancer survivors who were treated with chemotherapy ≥ 6 months previously...

..UFOV and Digit Symbol Substitution subtest, a standard measure of cognitive speed, had similar trajectories of change. The implications of these results are discussed...

..They hypothesized that the general well-being factor would be a mediator between physical and mental health in both groups...

..The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer...

..The results suggest that social resources may be differentially important for cognitive change but that different cognitive domains respond in a similar pattern to social resources...

..Findings suggest considerable heterogeneity in the experience of fatigue following treatment and support the utility of a cognitive-behavioral model in predicting the course of posttreatment fatigue...

..Finally, persons who were misclassified as preclinical AD had fewer years of education and poorer MMSE scores at baseline...

..Changes in cognitive functioning over time were compared in breast cancer survivors treated with chemotherapy plus radiotherapy, breast cancer survivors treated with radiotherapy only, and women with no history of cancer...

..Reported physical activity plays a key role in the independence of older adults and should be particularly promoted in African Americans and during the entire life course...

..Systematic assessment is vital to palliative care, but documentation confirming completion of systematic assessment in hospice settings is often inadequate or absent...

..The current study examined modification of this risk by catechol-O-methyltransferase (COMT) genotype based on evidence in adult populations that the presence of a Val allele is associated with poorer cognitive performance...

..The current study examined changes in multiple domains of cognitive functioning of hematopoietic stem cell transplantation (HSCT) candidates tested pretransplantation, 6 months posttransplantation, and 12 months posttransplantation...

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..Findings suggest that the Fatigue Symptom Inventory can be used to discriminate effectively between individuals with and without clinically meaningful fatigue...

..This study examined the association between negative life events in the past year and cognitive performance in a population of older adults...

..The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance...

..Among the key targets of inquiry in cognitive aging are (1) the description of cognitive changes with advancing age and (2) the association of such cognitive changes with modulating factors in the changing epidemiological context...

..We examine the temporal ordering of changes in lifestyle activities and changes in cognitive neuropsychological performance in older adults...

..The present study sought to determine whether fatigue was greater in women who had completed treatment for early-stage breast cancer relative to a demographically matched comparison group of women with no cancer history...

..A diagnosis of cancer affects not only the patient but also his/her spouse/partner. In addition to facing a life-threatening illness, changes in role and financial threats can impact the dyad...

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..Statistically significant group differences were also present on Trails-B and WAIS-R Digit Symbol performance (p < .001). Overall, these data indicate that deficits in semantic clustering are present in aMCI patients...

..This study compares determinants of a sense of mastery in African American and White older adults...

..Among Caucasians, APOE-epsilon4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-epsilon4 allele in our African-American sample compared to other US-based studies...

..The purpose of this study was to determine whether hospice plus a coping skill training intervention improved family caregivers' QOL, burden, coping, and mastery, compared with hospice plus emotional support, and usual hospice care...

..Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life...

..To test an intervention for hospice caregivers designed to help them better manage symptoms experienced by patients with cancer...

..Broader issues in improving access to hospice care for dementia patients are discussed...

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..However, the clinical utility of these fluency measures is unclear. The aim of this study was to determine what, if any, diagnostic value letter and category fluency provide in differentiating single-domain aMCI from normal cognition...

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..After describing the diagnostic criteria and dementia outcomes associated with MCI, this article discusses several challenges to the study of cognitive impairment before the diagnosis of AD...

..Implications are that assessments of cognitive speed of processing can provide valuable information about the subsequent risk of driving cessation...

..To examine knowledge about hereditary breast and ovarian cancer (HBOC) among Mexican, Puerto Rican, and Cuban women...

..Future research should use prospective longitudinal research designs incorporating appropriate comparison groups to further explore this issue...

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..The purpose of the current study was to compare rates of clinically significant cognitive impairment in men treated with LHRH agonists to a matched sample of healthy men without cancer...

..05). This study provides support for including an exercise component in SM interventions for cancer patients receiving chemotherapy (clinicaltrials.gov identifier: NCT00740038)...

..The present study assessed the impacts of mastery and social resources (social network, social support, and satisfaction with support) on depression and, in particular, whether they modify the link between disability and depression...

..In sum, NT-020 may promote health, proliferation, and maintenance of neurons in the age animals and exert antiinflammatory actions that promote function in the aged stem cell niche...

..Tyrosine kinase inhibitors (TKIs) are now standard treatment for chronic myeloid leukemia (CML). While TKIs have less toxicity than previous treatments, they have side effects that can impact quality of life (QOL)...

..The findings elucidated the mechanisms by which perceived discrimination manifested its psychological outcomes, and suggest ways to reduce adverse consequences associated with discriminatory experiences...

..To evaluate the relationships between quality of life (QOL) and symptom distress, pain intensity, dyspnea intensity, and constipation intensity in people with advanced cancer who were newly admitted to hospice home care...

..To determine the changes in knowledge and attitudes of pain resource nurses (PRNs) as a result of an intensive pain management course...

..However, little is known about how cognitive functioning may impact the self-report of pain or the report of care recipient pain by family caregivers...

..On the basis of the data obtained, the authors argue that analyses of the effect of specific genes in cognition should be accompanied by assessment of performance at a specific level, with due attention to the individual's age...

..In order to improve group classification, future research should consider combining cognitive markers with preclinical indicators from other domains (e.g., biological, clinical, social, genetic) into multivariate prediction models...

..Fatigue is among the most common and distressing symptoms experienced by cancer patients...

..This pattern of findings suggests that the biological aging process exerts negative influences on cognitive functioning beyond those resulting from disease and mortality...

..80, -2.18 to -1.43). We conclude that PD and PDD patients do not have callosal atrophy in contrast to other neurodegenerative diseases, including AD. Callosal atrophy was correlated with dementia severity in patients with AD but not PDD...

..Findings suggest that activity level at one point in time may be a more important predictor of cognition than an individual's changes in activity level...

..The results suggest that clinical diagnosis of dementia made during life may fail to reflect the pathogenic complexity of this condition in very elderly persons...

..The generalized nature of the deficit is consistent with recent observations that multiple brain structures and functions are affected long before the AD diagnosis...

..A possible exception to this pattern is that an increasing number of concomitant health conditions may exacerbate the rate of cognitive decline during the final portion of the preclinical phase in AD...

..These results extend previous findings of similar patterns of cognitive deficits in the early clinical phases of AD and VaD to the preclinical phases of these diseases...

..The accuracy and reliability of this approach is considered for a better understanding of the developmental course of AD in these data, including the potential removal of biases due to subject selection...

..Results suggest a need for greater attention to promoting functioning and psychological well-being among older cancer survivors, even when they may not have obvious cancer-related medical complications...

..This observation suggests that circulatory disturbance is associated with cognitive problems several years before the actual VaD diagnosis...

..The blueberry diet did not affect vessel morphology or density of vessel-associated protein markers but gave rise to significantly increased growth capacity, cytoarchitecture, and the final size of hippocampal grafts...