Neil R Smalheiser

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc The search for endogenous siRNAs in the mammalian brain
    Neil R Smalheiser
    University of Illinois at Chicago, Psychiatric Institute MC912, Chicago, IL 60612, USA
    Exp Neurol 235:455-63. 2012
  2. pmc Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, University of Illinois Chicago, 1601 W Taylor Street MC912, Chicago, IL 60612, USA
    Biochim Biophys Acta 1779:678-81. 2008
  3. pmc Anne O'Tate: A tool to support user-driven summarization, drill-down and browsing of PubMed search results
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Biomed Discov Collab 3:2. 2008
  4. pmc Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, University of Illinois Chicago, 1601 W Taylor Street MC912, Chicago, IL 60612, USA
    Neurosci Res 62:236-9. 2008
  5. pmc Synaptic enrichment of microRNAs in adult mouse forebrain is related to structural features of their precursors
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, 1601 W, Taylor Street, Chicago, IL 60612, USA
    Biol Direct 3:44. 2008
  6. pmc Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, 1601W Taylor Street, Chicago, IL 60612, USA
    Comput Methods Programs Biomed 94:190-7. 2009
  7. pmc microRNA regulation of synaptic plasticity
    Neil R Smalheiser
    Department of Psychiatry and UIC Psychiatric Institute, MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Neuromolecular Med 11:133-40. 2009
  8. pmc Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus
    Neil R Smalheiser
    Department of Psychiatry and UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    ASN Neuro 2:e00028. 2010
  9. pmc Endogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination training
    Neil R Smalheiser
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    RNA 17:166-81. 2011
  10. pmc Exosomal transfer of proteins and RNAs at synapses in the nervous system
    Neil R Smalheiser
    University of Illinois Chicago, UIC Psychiatric Institute MC912, 1601 W, Taylor Street, Chicago, IL 60612, USA
    Biol Direct 2:35. 2007

Detail Information

Publications28

  1. pmc The search for endogenous siRNAs in the mammalian brain
    Neil R Smalheiser
    University of Illinois at Chicago, Psychiatric Institute MC912, Chicago, IL 60612, USA
    Exp Neurol 235:455-63. 2012
    ..I conclude that, despite their apparent low abundance, endogenous siRNAs and noncoding RNA-derived small RNAs are likely to play an important role in regulating synaptic plasticity...
  2. pmc Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, University of Illinois Chicago, 1601 W Taylor Street MC912, Chicago, IL 60612, USA
    Biochim Biophys Acta 1779:678-81. 2008
    ..Finally, I will briefly summarize studies of microRNAs in synaptic fractions of adult mouse forebrain, which may serve as a model for other cell types as well...
  3. pmc Anne O'Tate: A tool to support user-driven summarization, drill-down and browsing of PubMed search results
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Biomed Discov Collab 3:2. 2008
    ....
  4. pmc Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, University of Illinois Chicago, 1601 W Taylor Street MC912, Chicago, IL 60612, USA
    Neurosci Res 62:236-9. 2008
    ..This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function...
  5. pmc Synaptic enrichment of microRNAs in adult mouse forebrain is related to structural features of their precursors
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, 1601 W, Taylor Street, Chicago, IL 60612, USA
    Biol Direct 3:44. 2008
    ..Reviewers: This article was reviewed by I. King Jordan and Jerzy Jurka...
  6. pmc Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE
    Neil R Smalheiser
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago, 1601W Taylor Street, Chicago, IL 60612, USA
    Comput Methods Programs Biomed 94:190-7. 2009
    ..One can also employ two-node searches to search for novel hypotheses. Arrowsmith provides a service that cannot be carried out feasibly via standard PubMed searches or by other available text mining tools...
  7. pmc microRNA regulation of synaptic plasticity
    Neil R Smalheiser
    Department of Psychiatry and UIC Psychiatric Institute, MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Neuromolecular Med 11:133-40. 2009
    ..Thus, locally formed microRNAs may mark the location of previously activated synapses and perform a type of synaptic tagging and capture...
  8. pmc Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus
    Neil R Smalheiser
    Department of Psychiatry and UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    ASN Neuro 2:e00028. 2010
    ..These in vivo results indicate that significant, dynamic and co-ordinated changes in miRNA expression accompany early stages of learning...
  9. pmc Endogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination training
    Neil R Smalheiser
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    RNA 17:166-81. 2011
    ..Further studies are warranted to characterize the role(s) played by endogenous siRNAs and noncoding RNA-derived small RNAs in learning and memory...
  10. pmc Exosomal transfer of proteins and RNAs at synapses in the nervous system
    Neil R Smalheiser
    University of Illinois Chicago, UIC Psychiatric Institute MC912, 1601 W, Taylor Street, Chicago, IL 60612, USA
    Biol Direct 2:35. 2007
    ..Exosomes express cell recognition molecules on their surface that facilitate their selective targeting and uptake into recipient cells...
  11. ncbi request reprint Alu elements within human mRNAs are probable microRNA targets
    Neil R Smalheiser
    University of Illinois Chicago, UIC Psychiatric Institute MC912, 1601 W Taylor Street, Chicago, IL 60612, USA
    Trends Genet 22:532-6. 2006
    ..The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets...
  12. pmc Transcription factor binding sites are highly enriched within microRNA precursor sequences
    Jittima Piriyapongsa
    Genome Institute, National Center for Genetic Engineering and Biotechnology, Klong1, Klong Luang, Pathumthani 12120, Thailand
    Biol Direct 6:61. 2011
    ..However, in the course of analyzing the genomics of human microRNA genes, we noticed that annotated transcription factor binding sites commonly lie within 70- to 110-nt long microRNA small hairpin precursor sequences...
  13. pmc Guidelines for negotiating scientific collaboration
    Neil R Smalheiser
    Department of Psychiatry, University of Illinois, Chicago, Illinois, USA
    PLoS Biol 3:e217. 2005
  14. pmc Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain
    Giovanni Lugli
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurochem 106:650-61. 2008
    ....
  15. doi request reprint Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain
    Giovanni Lugli
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, USA Graduate Program in Neuroscience, University of Illinois at Chicago, Chicago, Illinois, USA
    J Neurochem 123:459-66. 2012
    ..This study supports the notion that miRNA biogenesis occurs locally near synapses in a regulated fashion...
  16. pmc MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects
    Neil R Smalheiser
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e33201. 2012
    ..MicroRNAs (miRNAs) are newly discovered regulators of gene expression that have recently been implicated in a variety of human diseases, including neuropsychiatric diseases...
  17. ncbi request reprint ADAM: another database of abbreviations in MEDLINE
    Wei Zhou
    Department of Psychiatry and Psychiatric Institute, MC912, University of Illinois at Chicago Chicago, IL 60612, USA
    Bioinformatics 22:2813-8. 2006
    ..We have created another abbreviation database, ADAM, which covers commonly used abbreviations and their definitions (or long-forms) within MEDLINE titles and abstracts, including both acronym and non-acronym abbreviations...
  18. ncbi request reprint A quantitative model for linking two disparate sets of articles in MEDLINE
    Vetle I Torvik
    Department of Psychiatry and Psychiatric Institute MC912, University of Illinois Chicago, Chicago, IL 60612, USA
    Bioinformatics 23:1658-65. 2007
    ..A serious stumbling-block has been the lack of a quantitative model for predicting which of the hundreds if not thousands of B-terms computed for a given search are most likely to be relevant to the investigator...
  19. ncbi request reprint Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner
    Giovanni Lugli
    University of Illinois at Chicago, UIC Psychiatric Institute, Chicago, Illinois, USA
    J Neurochem 94:896-905. 2005
    ..This supports the hypothesis that dicer could be involved in synaptic plasticity...
  20. ncbi request reprint Complications in mammalian microRNA target prediction
    Neil R Smalheiser
    Department of Psychiatry and UIC Psychiatric Institute, University of Illinois Chicago, IL, USA
    Methods Mol Biol 342:115-27. 2006
    ..Because new types of miRNAs are still being discovered, this list may not yet be complete...
  21. doi request reprint MicroRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness
    Neil R Smalheiser
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Neuropsychopharmacol 14:1315-25. 2011
    ..Thus, miRNAs participate in the alterations of gene expression networks that underlie the normal (NLH) as well as aberrant (LH) response to repeated shocks...
  22. pmc Mitochondrial small RNAs that are up-regulated in hippocampus during olfactory discrimination training in mice
    Neil R Smalheiser
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mitochondrion 11:994-5. 2011
    ..Small RNAs may link behavioral plasticity to protein synthesis and replication of mitochondria to support dendritic growth, spine stabilization, and synapse formation...
  23. pmc Linking investigators. A centralized linking facility for data sharing and coordination of samples in tissue banks
    Neil R Smalheiser
    Department of Psychiatry MC912, University of Illinois at Chicago, USA
    EMBO Rep 4:108-10. 2003
  24. pmc A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:5479-84. 2003
    ..We conclude that reelin binds with high affinity to integrin receptors expressed in SNSs and thereby activates Arc protein synthesis...
  25. ncbi request reprint Preparing synaptoneurosomes from adult mouse forebrain
    Giovanni Lugli
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
    Methods Mol Biol 936:173-9. 2013
    ..Here, we give the methods used in our laboratory to produce synaptoneurosomes that are suitable for studying RNAs and proteins...
  26. ncbi request reprint Mammalian microRNAs derived from genomic repeats
    Neil R Smalheiser
    University of Illinois at Chicago, UIC Psychiatric Institute, MC 912, 1601 W Taylor Street, Chicago, IL 60612, USA
    Trends Genet 21:322-6. 2005
    ..Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3'-untranslated regions...
  27. pmc A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions
    Neil R Smalheiser
    University of Illinois at Chicago, UIC Psychiatric Institute, MC 912, 1601 W, Taylor Street, room 285 Chicago, IL 60612, USA
    BMC Bioinformatics 5:139. 2004
    ..Several microRNA targets have been identified in lower organisms, but only one mammalian microRNA target has yet been validated experimentally...
  28. pmc Methodological factors influencing measurement and processing of plasma reelin in humans
    Giovanni Lugli
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, MC 912, 1601 W, Taylor Street, Chicago, IL 60612, USA
    BMC Biochem 4:9. 2003
    ..Here we describe the methodological and biological foundation for carrying out and interpreting clinical studies of plasma reelin...