Arne Slungaard

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Platelet factor 4: a chemokine enigma
    Arne Slungaard
    Int J Biochem Cell Biol 37:1162-7. 2005
  2. ncbi request reprint Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
    Arne Slungaard
    Department of Medicine, Section of Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 102:146-51. 2003
  3. pmc Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Weiyu Zhang
    Department of Medicine, University of Minnesota, 420 Delaware St SE, MMC508, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 30:1000-6. 2010
  4. ncbi request reprint Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation
    Jian guo Wang
    Department of Medicine, Hematology, Oncology and Transplantation Division and The Vascular Biology Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 177:8714-22. 2006
  5. ncbi request reprint Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level
    Irina V Nesmelova
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:4948-58. 2005
  6. ncbi request reprint Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes
    Jianguo Wang
    Medicine Department and Vascular Biology Center, University of Minnesota, Minnealpoles, Minnesota 55455, USA
    J Biol Chem 282:28408-18. 2007
  7. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
  8. pmc The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states
    Jian guo Wang
    Hematology, Oncology, and Transplantation Section, Department of Medicine, and the Vascular Biology Center, University of Minnesota, Minneapolis, USA
    Blood 107:558-65. 2006
  9. pmc The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice
    Robert P Hebbel
    Vascular Biology Center and the Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 115:2483-90. 2010
  10. ncbi request reprint Platelet factor 4 modulation of the thrombomodulin-protein C system
    Arne Slungaard
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Crit Care Med 32:S331-5. 2004

Detail Information

Publications21

  1. ncbi request reprint Platelet factor 4: a chemokine enigma
    Arne Slungaard
    Int J Biochem Cell Biol 37:1162-7. 2005
    ..Preliminary studies with a just-described PF4 knockout mouse line support a role for PF4 in platelet-dependent thrombosis in vivo...
  2. ncbi request reprint Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
    Arne Slungaard
    Department of Medicine, Section of Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 102:146-51. 2003
    ..These findings suggest that PF4 may play a previously unsuspected physiologic role in enhancing APC generation...
  3. pmc Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Weiyu Zhang
    Department of Medicine, University of Minnesota, 420 Delaware St SE, MMC508, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 30:1000-6. 2010
    ..This study investigated whether and how acadesine inhibits tissue factor (TF) expression and thrombus formation...
  4. ncbi request reprint Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation
    Jian guo Wang
    Department of Medicine, Hematology, Oncology and Transplantation Division and The Vascular Biology Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 177:8714-22. 2006
    ..These results suggest that phagocyte peroxidases function to amplify inflammation through a novel, HOSCN-specific oxidant mechanism...
  5. ncbi request reprint Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level
    Irina V Nesmelova
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:4948-58. 2005
    ..This concept, in turn, has implications for designing chemokine/cytokine variants with modified biological properties...
  6. ncbi request reprint Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes
    Jianguo Wang
    Medicine Department and Vascular Biology Center, University of Minnesota, Minnealpoles, Minnesota 55455, USA
    J Biol Chem 282:28408-18. 2007
    ..We conclude that histone deacetylases, particularly HDAC3, play a hitherto unsuspected role in regulating TF expression and raise the possibility that HDACi might be a novel therapy for thrombotic disorders...
  7. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
    ..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care...
  8. pmc The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states
    Jian guo Wang
    Hematology, Oncology, and Transplantation Section, Department of Medicine, and the Vascular Biology Center, University of Minnesota, Minneapolis, USA
    Blood 107:558-65. 2006
    ....
  9. pmc The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice
    Robert P Hebbel
    Vascular Biology Center and the Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 115:2483-90. 2010
    ..We suggest that SAHA possibly could provide true, multimodality, salubrious effects for prevention and treatment of the chronic vasculopathy of sickle cell anemia...
  10. ncbi request reprint Platelet factor 4 modulation of the thrombomodulin-protein C system
    Arne Slungaard
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Crit Care Med 32:S331-5. 2004
    ..To review published studies of the influence of platelet factor 4 (PF4) and other cationic proteins on the generation of activated protein C (APC) by the thrombomodulin-protein C system...
  11. pmc Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor
    Navneet S Majhail
    Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:282-9. 2008
    ..A careful review of existing comorbidities is necessary when considering older patients for HCT...
  12. doi request reprint Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomas
    Erica D Warlick
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1025-32. 2011
    ....
  13. ncbi request reprint Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Jeffrey S Miller
    Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 105:3051-7. 2005
    ..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT...
  14. ncbi request reprint Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia
    Omer Aras
    Departments of Medicine Hematology, Oncology and Transplantation and Vascular Biology Center, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 103:4545-53. 2004
    ..MP-associated TF PCA was highly correlated with whole-blood TF PCA and total number of circulating MPs, and whole-blood TF PCA was highly correlated with TF mRNA levels...
  15. ncbi request reprint Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation
    Poh Lin Tan
    Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 46:630-6. 2006
    ..GVHD prophylaxis consisted of cyclosporine and short course methylprednisolone...
  16. pmc Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone
    Jeffrey S Miller
    Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 110:2761-3. 2007
    ..This trial was registered at www.clinicaltrials.gov as no. NCT00303693 and www.cancer.gov/clinicaltrials as no. NCT00167180...
  17. ncbi request reprint Role of eosinophil peroxidase in host defense and disease pathology
    Jianguo Wang
    University of Minnesota, Department of Medicine, Section of Hematology, Oncology and Transplantation and The Vascular Biology Center, Minneapolis, MN, USA
    Arch Biochem Biophys 445:256-60. 2006
    ....
  18. ncbi request reprint Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis
    Arkadiusz Z Dudek
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, Stem Cell Institute, Minneapolis, MN, USA
    Blood 101:4687-94. 2003
    ....
  19. ncbi request reprint Long-term results of autologous stem cell transplantation for primary refractory or relapsed Hodgkin's lymphoma
    Navneet S Majhail
    Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 12:1065-72. 2006
    ..A risk-adapted approach should be followed in determining treatment options for patients with PR REF and REL HL...
  20. pmc Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge
    M Anna Kowalska
    Division of Hematology, The Children s Hospital of Philadelphia, PA 19104, USA
    Blood 110:1903-5. 2007
    ..These studies suggest that endogenous PF4 release may have biologic consequences for APC generation and survival in clinical sepsis. Infusions of PF4-rich platelets may be an effective strategy to improve outcome in this setting...
  21. ncbi request reprint Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
    Yi Feng Xia
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 173:4207-17. 2004
    ..Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions...