Igor Slukvin

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Cell Cycle 12:720-7. 2013
  2. pmc Endothelial origin of mesenchymal stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health National Primate Research Center, University of Wisconsin Graduate School Madison, WI, USA
    Cell Cycle 10:1370-3. 2011
  3. ncbi request reprint Renin-angiotensin system and hemangioblast development from human embryonic stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
    Expert Rev Hematol 2:137-43. 2009
  4. ncbi request reprint Cloning of rhesus monkey LILRs
    I I Slukvin
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA
    Tissue Antigens 67:331-7. 2006
  5. ncbi request reprint Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 176:2924-32. 2006
  6. ncbi request reprint Epicardial Origin of Cardiac CFU-Fs
    Igor I Slukvin
    National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, WI 53715, USA Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Cell Stem Cell 9:492-3. 2011
  7. pmc Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
    Kyung Dal Choi
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, 53715, USA
    Stem Cells 27:559-67. 2009
  8. ncbi request reprint Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells
    Deepika Rajesh
    Department of Surgery, University of Wisconsin Medical School, K4 760 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792 7375, USA
    Stem Cells 25:490-9. 2007
  9. ncbi request reprint Synovial sarcoma, a primary liver tumor--a case report
    Padmini Holla
    Department of Pathology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792 7375, USA
    Pathol Res Pract 202:385-7. 2006
  10. ncbi request reprint Selective expression of NKG2-A and NKG2-C mRNAs and novel alternative splicing of 5' exons in rhesus monkey decidua
    R H Kravitz
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA
    Immunogenetics 53:69-73. 2001

Research Grants

Collaborators

  • Austin Hughes
  • Junying Yu
  • James Thomson
  • Giorgia Salvagiotto
  • N Otting
  • Ronald E Bontrop
  • Thaddeus Golos
  • Maxim A Vodyanik
  • Kyung Dal Choi
  • Christian M Metallo
  • Deepika Rajesh
  • Padmini Holla
  • E E Breburda
  • Amy L Usborne
  • R H Kravitz
  • J A Urvater
  • Kim Smuga-Otto
  • Maxim Vodyanik
  • William Rehrauer
  • Sean P Palecek
  • Juan J de Pablo
  • Aimen F Shaaban
  • Don P Wolf
  • Nachimuthu Chinnasamy
  • Shoukhrat M Mitalipov
  • G R Hafez
  • Munci Kalayoglu
  • S V Dambaeva
  • Jack A Bork
  • Iris B Bolton
  • R L Grendell
  • R Rudersdorf
  • D I Watkins
  • J H Loehrke
  • M S Piekarczyk

Detail Information

Publications24

  1. pmc Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Cell Cycle 12:720-7. 2013
    ..Here we introduce our recent findings and discuss their implication for defining putative HSC precursor and factors required for activation of self-renewal potential in hematopoietic cells emerging from endothelium...
  2. pmc Endothelial origin of mesenchymal stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health National Primate Research Center, University of Wisconsin Graduate School Madison, WI, USA
    Cell Cycle 10:1370-3. 2011
    ....
  3. ncbi request reprint Renin-angiotensin system and hemangioblast development from human embryonic stem cells
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
    Expert Rev Hematol 2:137-43. 2009
    ..These findings could be exploited for developing novel cellular and drug therapies for hematological and vascular diseases...
  4. ncbi request reprint Cloning of rhesus monkey LILRs
    I I Slukvin
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA
    Tissue Antigens 67:331-7. 2006
    ..Characterization of rhesus LILRs will facilitate use of this non-human primate model for the study of the functional role(s) of LILRs, including immune regulation through interaction with non-classical MHC class I molecules...
  5. ncbi request reprint Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathway
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 176:2924-32. 2006
    ..In addition, because ES cells can be expanded without limit, they can be seen as a potential scalable source of cells for DC vaccines or DC-mediated induction of immune tolerance...
  6. ncbi request reprint Epicardial Origin of Cardiac CFU-Fs
    Igor I Slukvin
    National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, WI 53715, USA Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Cell Stem Cell 9:492-3. 2011
    ..In this issue of Cell Stem Cell, Chong et al. (2011) identify cardiac CFU-Fs as cardiac-resident cells of epicardial origin with broad multilineage differentiation potential...
  7. pmc Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
    Kyung Dal Choi
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, 53715, USA
    Stem Cells 27:559-67. 2009
    ....
  8. ncbi request reprint Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells
    Deepika Rajesh
    Department of Surgery, University of Wisconsin Medical School, K4 760 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792 7375, USA
    Stem Cells 25:490-9. 2007
    ..Although rESCs have the potential for hematopoietic differentiation, they exhibit a pause at the hemangioblast stage of hematopoietic development in culture conditions developed for hESCs...
  9. ncbi request reprint Synovial sarcoma, a primary liver tumor--a case report
    Padmini Holla
    Department of Pathology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792 7375, USA
    Pathol Res Pract 202:385-7. 2006
    ..An 18-year-old female presented with a mass involving the liver which was resected. Microscopically, it was diagnosed as monophasic synovial sarcoma. Cytogenetic study (FISH) revealed translocation t(X; 18), confirming the diagnosis...
  10. ncbi request reprint Selective expression of NKG2-A and NKG2-C mRNAs and novel alternative splicing of 5' exons in rhesus monkey decidua
    R H Kravitz
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA
    Immunogenetics 53:69-73. 2001
  11. ncbi request reprint Stromal decidualization of endometriosis in the rhesus macaque (Macaca mulatta): a case report
    Amy L Usborne
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA
    Comp Med 52:167-70. 2002
    ..Subsequent biopsies of similar lesions in other rhesus macaques in the colony being treated with medroxyprogesterone acetate for endometriosis revealed comparable histologic findings...
  12. ncbi request reprint Phenotypic and functional characterization of rhesus monkey decidual lymphocytes: rhesus decidual large granular lymphocytes express CD56 and have cytolytic activity
    I I Slukvin
    Wisconsin Regional Primate Research Center, University of Wisconsin Medical School, Madison, WI 53715-1299, USA
    J Reprod Immunol 50:57-79. 2001
    ..221 targets in cytotoxicity assays. Together, these results suggest that as in human pregnancy, rhesus decidual CD56(bright+) cells represent a distinct lymphocyte subset that belongs to the NK cell lineage...
  13. ncbi request reprint Dynamic changes in primate endometrial leukocyte populations: differential distribution of macrophages and natural killer cells at the rhesus monkey implantation site and in early pregnancy
    I I Slukvin
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715 1299, USA
    Placenta 25:297-307. 2004
    ..The distribution of uterine leukocytes vis-à-vis trophoblasts at the rhesus monkey implantation site and in early pregnancy suggests different roles for macrophages and uterine NK cells in the response to trophoblast invasion...
  14. ncbi request reprint Mamu-I: a novel primate MHC class I B-related locus with unusually low variability
    J A Urvater
    Wisconsin Regional Primate Research Center, Department of Genetics, University of Wisconsin, Madison, WI 53715, USA
    J Immunol 164:1386-98. 2000
    ..Additionally, no evidence for positive selection on the peptide binding region was observed. Together, these results suggest that Mamu-I is an MHC class I locus in primates that has features of both classical and nonclassical loci...
  15. ncbi request reprint Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancy
    E E Breburda
    National Primate Research Center, University of Wisconsin Medical School, University of Wisconsin Madison, 1223 Capitol Court, Madison, WI 53715 1299, USA
    Placenta 27:11-21. 2006
    ....
  16. ncbi request reprint Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential
    Maxim A Vodyanik
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53792 8550, USA
    Blood 105:617-26. 2005
    ..These data indicate that CD34+ cells generated through hES/OP9 coculture display several features of definitive hematopoietic stem cells...
  17. ncbi request reprint Human embryonic stem cells reprogram myeloid precursors following cell-cell fusion
    Junying Yu
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
    Stem Cells 24:168-76. 2006
    ..These results indicate that hESCs are capable of reprogramming nuclei from differentiated cells and that hESC hybrid cells provide a new model system for studying the mechanisms of nuclear reprogramming...
  18. ncbi request reprint Directed differentiation of human embryonic stem cells to dendritic cells
    Maxim A Vodyanik
    Wisconsin National Primate Research Center, University of Wisconsin Graduate School, Madison, USA
    Methods Mol Biol 407:275-93. 2007
    ..Directed differentiation of DCs from hESCs could be useful for studying cellular and molecular mechanisms of DC development and potentially for the generation of antigen-presenting cells for cellular immunotherapy...
  19. doi request reprint The response of human embryonic stem cell-derived endothelial cells to shear stress
    Christian M Metallo
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
    Biotechnol Bioeng 100:830-7. 2008
    ..These findings suggest that hEECs are capable of functionally responding to changes in fluid shear stress by modulating gene expression and cell morphology...
  20. ncbi request reprint Hematoendothelial differentiation of human embryonic stem cells
    Maxim A Vodyanik
    University of Wisconsin, Madison, Wisconsin, USA
    Curr Protoc Cell Biol . 2007
    ..Curr. Protoc...
  21. ncbi request reprint Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
    ....
  22. ncbi request reprint Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literature
    Igor I Slukvin
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA
    Arch Pathol Lab Med 127:1369-72. 2003
    ....
  23. ncbi request reprint Immune and trophoblast cells at the rhesus monkey maternal-fetal interface
    Thaddeus G Golos
    National Primate Research Center and Department of Obstetrics and Gynecology, University of Wisconsin Madison, USA
    Methods Mol Med 122:93-108. 2006
    ..Information on antibodies for these analyses are also provided, which is an important consideration when attempting to use anti-human antibodies for the study of nonhuman primates...
  24. pmc Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures
    Maxim A Vodyanik
    National Primate Research Center, University of Wisconsin Graduate School, Madison, WI 53715, USA
    Blood 108:2095-105. 2006
    ..CD34(+)CD43(+)CD45(+)Lin(-) cells were largely devoid of VE-cadherin and KDR expression and had a distinct FLT3(high)GATA3(low)RUNX1(low)PU1(high)MPO(high)IL7RA(high) gene expression profile...

Research Grants7

  1. Hematopoietic commitment of human embryonic stem cells
    Igor I Slukvin; Fiscal Year: 2010
    ..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..
  2. Decidual macrophages in primate pregnancy
    Igor Slukvin; Fiscal Year: 2007
    ..abstract_text> ..
  3. Dendritic Cells from Human Embryonic Stem Cells
    Igor Slukvin; Fiscal Year: 2007
    ....
  4. Hematopoietic commitment of human embryonic stem cells
    Igor Slukvin; Fiscal Year: 2007
    ..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..
  5. Hematopoietic commitment of human embryonic stem cells
    Igor Slukvin; Fiscal Year: 2009
    ..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..