Research Topics
Species | Igor SlukvinSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cellsIgor I Slukvin
Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
Cell Cycle 12:720-7. 2013..Here we introduce our recent findings and discuss their implication for defining putative HSC precursor and factors required for activation of self-renewal potential in hematopoietic cells emerging from endothelium...- Endothelial origin of mesenchymal stem cellsIgor I Slukvin
Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health National Primate Research Center, University of Wisconsin Graduate School Madison, WI, USA
Cell Cycle 10:1370-3. 2011.... 
Renin-angiotensin system and hemangioblast development from human embryonic stem cellsIgor I Slukvin
Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
Expert Rev Hematol 2:137-43. 2009..These findings could be exploited for developing novel cellular and drug therapies for hematological and vascular diseases...- Cloning of rhesus monkey LILRsI I Slukvin
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA
Tissue Antigens 67:331-7. 2006..Characterization of rhesus LILRs will facilitate use of this non-human primate model for the study of the functional role(s) of LILRs, including immune regulation through interaction with non-classical MHC class I molecules... - Directed differentiation of human embryonic stem cells into functional dendritic cells through the myeloid pathwayIgor I Slukvin
Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
J Immunol 176:2924-32. 2006..In addition, because ES cells can be expanded without limit, they can be seen as a potential scalable source of cells for DC vaccines or DC-mediated induction of immune tolerance... - Epicardial Origin of Cardiac CFU-FsIgor I Slukvin
National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, WI 53715, USA Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Cell Stem Cell 9:492-3. 2011..In this issue of Cell Stem Cell, Chong et al. (2011) identify cardiac CFU-Fs as cardiac-resident cells of epicardial origin with broad multilineage differentiation potential... - Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cellsDeepika Rajesh
Department of Surgery, University of Wisconsin Medical School, K4 760 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792 7375, USA
Stem Cells 25:490-9. 2007..Although rESCs have the potential for hematopoietic differentiation, they exhibit a pause at the hemangioblast stage of hematopoietic development in culture conditions developed for hESCs... - Hematopoietic and endothelial differentiation of human induced pluripotent stem cellsKyung Dal Choi
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, 53715, USA
Stem Cells 27:559-67. 2009.... - Synovial sarcoma, a primary liver tumor--a case reportPadmini Holla
Department of Pathology, University of Wisconsin, 600 Highland Ave, Madison, WI 53792 7375, USA
Pathol Res Pract 202:385-7. 2006..An 18-year-old female presented with a mass involving the liver which was resected. Microscopically, it was diagnosed as monophasic synovial sarcoma. Cytogenetic study (FISH) revealed translocation t(X; 18), confirming the diagnosis... - Selective expression of NKG2-A and NKG2-C mRNAs and novel alternative splicing of 5' exons in rhesus monkey deciduaR H Kravitz
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA
Immunogenetics 53:69-73. 2001 - Stromal decidualization of endometriosis in the rhesus macaque (Macaca mulatta): a case reportAmy L Usborne
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA
Comp Med 52:167-70. 2002..Subsequent biopsies of similar lesions in other rhesus macaques in the colony being treated with medroxyprogesterone acetate for endometriosis revealed comparable histologic findings... - Phenotypic and functional characterization of rhesus monkey decidual lymphocytes: rhesus decidual large granular lymphocytes express CD56 and have cytolytic activityI I Slukvin
Wisconsin Regional Primate Research Center, University of Wisconsin Medical School, Madison, WI 53715-1299, USA
J Reprod Immunol 50:57-79. 2001..221 targets in cytotoxicity assays. Together, these results suggest that as in human pregnancy, rhesus decidual CD56(bright+) cells represent a distinct lymphocyte subset that belongs to the NK cell lineage... - Dynamic changes in primate endometrial leukocyte populations: differential distribution of macrophages and natural killer cells at the rhesus monkey implantation site and in early pregnancyI I Slukvin
Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715-1299, USA
Placenta 25:297-307. 2004..The distribution of uterine leukocytes vis-Ã -vis trophoblasts at the rhesus monkey implantation site and in early pregnancy suggests different roles for macrophages and uterine NK cells in the response to trophoblast invasion... - Mamu-I: a novel primate MHC class I B-related locus with unusually low variabilityJ A Urvater
Wisconsin Regional Primate Research Center, Department of Genetics, University of Wisconsin, Madison, WI 53715, USA
J Immunol 164:1386-98. 2000..Additionally, no evidence for positive selection on the peptide binding region was observed. Together, these results suggest that Mamu-I is an MHC class I locus in primates that has features of both classical and nonclassical loci... - Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the rhesus macaque: DC-SIGN is a putative marker of the recognition of pregnancyE E Breburda
National Primate Research Center, University of Wisconsin Medical School, University of Wisconsin Madison, 1223 Capitol Court, Madison, WI 53715 1299, USA
Placenta 27:11-21. 2006.... - Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potentialMaxim A Vodyanik
Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53792-8550, USA
Blood 105:617-26. 2005..These data indicate that CD34+ cells generated through hES/OP9 coculture display several features of definitive hematopoietic stem cells... - Human embryonic stem cells reprogram myeloid precursors following cell-cell fusionJunying Yu
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
Stem Cells 24:168-76. 2006..These results indicate that hESCs are capable of reprogramming nuclei from differentiated cells and that hESC hybrid cells provide a new model system for studying the mechanisms of nuclear reprogramming... - Directed differentiation of human embryonic stem cells to dendritic cellsMaxim A Vodyanik
Wisconsin National Primate Research Center, University of Wisconsin Graduate School, Madison, USA
Methods Mol Biol 407:275-93. 2007..Directed differentiation of DCs from hESCs could be useful for studying cellular and molecular mechanisms of DC development and potentially for the generation of antigen-presenting cells for cellular immunotherapy... 
The response of human embryonic stem cell-derived endothelial cells to shear stressChristian M Metallo
Department of Chemical and Biological Engineering, University of Wisconsin Madison, 1415 Engineering Drive, Madison, Wisconsin 53706, USA
Biotechnol Bioeng 100:830-7. 2008..These findings suggest that hEECs are capable of functionally responding to changes in fluid shear stress by modulating gene expression and cell morphology...- Hematoendothelial differentiation of human embryonic stem cellsMaxim A Vodyanik
University of Wisconsin, Madison, Wisconsin, USA
Curr Protoc Cell Biol . 2007..Curr. Protoc... - Induced pluripotent stem cell lines derived from human somatic cellsJunying Yu
Genome Center of Wisconsin, Madison, WI 53706 1580, USA
Science 318:1917-20. 2007.... - Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literatureIgor I Slukvin
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA
Arch Pathol Lab Med 127:1369-72. 2003.... - Immune and trophoblast cells at the rhesus monkey maternal-fetal interfaceThaddeus G Golos
National Primate Research Center and Department of Obstetrics and Gynecology, University of Wisconsin-Madison, USA
Methods Mol Med 122:93-108. 2006..Information on antibodies for these analyses are also provided, which is an important consideration when attempting to use anti-human antibodies for the study of nonhuman primates... - Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation culturesMaxim A Vodyanik
National Primate Research Center, University of Wisconsin Graduate School, Madison, WI 53715, USA
Blood 108:2095-105. 2006..CD34(+)CD43(+)CD45(+)Lin(-) cells were largely devoid of VE-cadherin and KDR expression and had a distinct FLT3(high)GATA3(low)RUNX1(low)PU1(high)MPO(high)IL7RA(high) gene expression profile...
Research Grants
- Hematopoietic commitment of human embryonic stem cellsIgor I Slukvin; Fiscal Year: 2010..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..
- Decidual macrophages in primate pregnancyIgor Slukvin; Fiscal Year: 2007..abstract_text> ..
- Dendritic Cells from Human Embryonic Stem CellsIgor Slukvin; Fiscal Year: 2007....
- Hematopoietic commitment of human embryonic stem cellsIgor Slukvin; Fiscal Year: 2007..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..
- Hematopoietic commitment of human embryonic stem cellsIgor Slukvin; Fiscal Year: 2009..The proposed studies will provide new insight into how the hematopoietic and endothelial lineages develop in humans, and could ultimately lead to novel regenerative therapies for diseases of the blood and vascular system. ..