Kathleen Sluka

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections
    Mamta Gautam
    Graduate Program in Physical and Rehabilitation Science, University of Iowa, 1 252 MEB, Iowa City, IA 52242, USA
    Pain Res Treat 2012:817347. 2012
  2. pmc Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee
    Barbara D Boyan
    Isis Research Network on Musculoskeletal Health, Society for Women s Health Research, 1025 Connecticut Avenue, NW Suite 601, Washington, DC, 20036, USA
    Biol Sex Differ 4:3. 2013
  3. pmc Addressing the gaps: sex differences in osteoarthritis of the knee
    Barbara D Boyan
    Wallace H, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332 0363, USA
    Biol Sex Differ 4:4. 2013
  4. pmc Mechanical contributors to sex differences in idiopathic knee osteoarthritis
    Daniel P Nicolella
    Isis Research Network on Musculoskeletal Health, Society for Women s Health Research, Washington, DC, 20036, USA
    Biol Sex Differ 3:28. 2012
  5. pmc Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial
    Juliana Barbosa Corrêa
    Master s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo UNICID, Sao Paulo, Brazil
    BMC Musculoskelet Disord 14:195. 2013
  6. pmc Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis
    Kathleen A Sluka
    Department of Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Arthritis Rheum 65:1194-202. 2013
  7. pmc Regular physical activity prevents development of chronic pain and activation of central neurons
    Kathleen A Sluka
    Department of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 114:725-33. 2013
  8. pmc Neural and psychosocial contributions to sex differences in knee osteoarthritic pain
    Kathleen A Sluka
    Isis Research Network on Musculoskeletal Health, Iowa City, USA
    Biol Sex Differ 3:26. 2012
  9. doi request reprint Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, The University of Iowa, Iowa City, IA 52242 1190, USA
    Med Sci Sports Exerc 44:420-7. 2012
  10. pmc Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases
    Kunjumon I Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, ON, Canada
    Mol Pain 2:7. 2006

Research Grants

  1. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
  2. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
  3. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2000
  4. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2002
  5. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
  6. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
  7. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
  8. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
  9. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
  10. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 1999

Collaborators

Detail Information

Publications61

  1. pmc ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections
    Mamta Gautam
    Graduate Program in Physical and Rehabilitation Science, University of Iowa, 1 252 MEB, Iowa City, IA 52242, USA
    Pain Res Treat 2012:817347. 2012
    ..However, the current data suggest that ASICs are not involved in maintaining hyperalgesia to repeated intramuscular acid injections...
  2. pmc Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee
    Barbara D Boyan
    Isis Research Network on Musculoskeletal Health, Society for Women s Health Research, 1025 Connecticut Avenue, NW Suite 601, Washington, DC, 20036, USA
    Biol Sex Differ 4:3. 2013
    ..This paper discusses these gaps in knowledge and suggests remedies...
  3. pmc Addressing the gaps: sex differences in osteoarthritis of the knee
    Barbara D Boyan
    Wallace H, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA, 30332 0363, USA
    Biol Sex Differ 4:4. 2013
    ..ABSTRACT: An introduction to the accompanying three papers...
  4. pmc Mechanical contributors to sex differences in idiopathic knee osteoarthritis
    Daniel P Nicolella
    Isis Research Network on Musculoskeletal Health, Society for Women s Health Research, Washington, DC, 20036, USA
    Biol Sex Differ 3:28. 2012
    ..We identify gaps in knowledge related to mechanical influences on the sex differences in knee OA...
  5. pmc Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial
    Juliana Barbosa Corrêa
    Master s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo UNICID, Sao Paulo, Brazil
    BMC Musculoskelet Disord 14:195. 2013
    ..Among the electrophysical treatments, interferential current (IFC) has not been studied in patients with low back pain in a high-quality randomised controlled trial examining not only pain, but pain mechanisms and function...
  6. pmc Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis
    Kathleen A Sluka
    Department of Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Arthritis Rheum 65:1194-202. 2013
    ..The purpose of this study was to test whether ASIC-3-deficient mice with arthritis have altered inflammation and pain relative to controls...
  7. pmc Regular physical activity prevents development of chronic pain and activation of central neurons
    Kathleen A Sluka
    Department of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Appl Physiol (1985) 114:725-33. 2013
    ..Thus physical inactivity is a risk factor for development of chronic pain and may set the nervous system to respond in an exaggerated way to low-intensity muscle insults...
  8. pmc Neural and psychosocial contributions to sex differences in knee osteoarthritic pain
    Kathleen A Sluka
    Isis Research Network on Musculoskeletal Health, Iowa City, USA
    Biol Sex Differ 3:26. 2012
    ..This review explores the neural and psychosocial factors that contribute to knee OA pain with an emphasis on differences between the sexes and gaps in knowledge...
  9. doi request reprint Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, The University of Iowa, Iowa City, IA 52242 1190, USA
    Med Sci Sports Exerc 44:420-7. 2012
    ..We tested whether exercise enhances hyperalgesia through activation of N-methyl D-aspartate (NMDA) receptors in the NRO/NRP...
  10. pmc Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases
    Kunjumon I Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, ON, Canada
    Mol Pain 2:7. 2006
    ..Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers. Therefore, we conducted the present work to test the role of AC1 and AC8 in both acute persistent and chronic muscle pain...
  11. pmc Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement
    Shalome M Tonelli
    College of Nursing, University of Iowa, Iowa City, IA, USA
    Biol Sex Differ 2:12. 2011
    ..abstract:..
  12. ncbi request reprint Transcutaneous electrical nerve stimulation: basic science mechanisms and clinical effectiveness
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Sciences Graduate Program, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, IA 52242, USA
    J Pain 4:109-21. 2003
    ..However, the clinical efficacy of TENS will remain equivocal until the publication of sufficient numbers of high quality, randomized, controlled clinical trials...
  13. ncbi request reprint Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, 1 242 Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Pain 106:229-39. 2003
    ..Therefore, interfering with ASIC3 might be of benefit in treatment or prevention of chronic hyperalgesia...
  14. pmc Increased release of serotonin in the spinal cord during low, but not high, frequency transcutaneous electric nerve stimulation in rats with joint inflammation
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, 52242, USA
    Arch Phys Med Rehabil 87:1137-40. 2006
    ..To determine the release pattern of serotonin and noradrenaline in the spinal cord in response to transcutaneous electric nerve stimulation (TENS) delivered at low or high frequency...
  15. ncbi request reprint High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn
    K A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurochem 95:1794-801. 2005
    ..Thus, we conclude that high-frequency TENS activates delta-opioid receptors consequently reducing the increased release of glutamate and aspartate in the spinal cord...
  16. pmc ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation
    Kathleen A Sluka
    Graduate Program in Physical Therapy and Rehabilitation Science, 1 252 Medical Education Bldg, The University of Iowa, Iowa City, IA 52242, USA
    Pain 129:102-12. 2007
    ..Thus, ASIC3 in primary afferent fibers innervating muscle is critical to development of hyperalgesia that results from muscle insult...
  17. ncbi request reprint Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats
    K A Sluka
    Physical Therapy Graduate Program, College of Medicine, University of Iowa, Iowa City 52242, USA
    Pain 71:157-64. 1997
    ..These data suggest that calcium channels are important for the development of mechanical hyperalgesia and allodynia that occurs following capsaicin injection...
  18. ncbi request reprint Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint
    K A Sluka
    Physical Therapy Graduate Program, College of Medicine, University of Iowa, Iowa 52242, USA
    Pain 77:97-102. 1998
    ..Thus, clinically, the choice to use TENS may depend on patient symptoms; specifically TENS should be effective in reducing referred or radiating pain...
  19. ncbi request reprint Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation
    K A Sluka
    Physical Therapy Graduate Program, Neuroscience Graduate Program, University of Iowa, Iowa City, Iowa, USA
    J Pharmacol Exp Ther 287:232-7. 1998
    ..Thus, N-type calcium channels contribute to both the development and maintenance of secondary heat hyperalgesia while P-type calcium channels are only involved during development of hyperalgesia...
  20. ncbi request reprint Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats
    K A Sluka
    Neuroscience Graduate Program, The University of Iowa, Iowa City, Iowa, USA
    J Pharmacol Exp Ther 289:840-6. 1999
    ..Thus, low-frequency TENS produces antihyperalgesia through mu opioid receptors and high-frequency TENS produces antihyperalgesia through delta opioid receptors in the spinal cord...
  21. ncbi request reprint Low frequency TENS is less effective than high frequency TENS at reducing inflammation-induced hyperalgesia in morphine-tolerant rats
    K A Sluka
    Physical Therapy, The University of Iowa, Iowa City 52241, USA
    Eur J Pain 4:185-93. 2000
    ..These results suggest that patients who are tolerant to morphine may respond better to high frequency TENS than to low frequency TENS...
  22. ncbi request reprint Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia
    K A Sluka
    Physical Therapy Graduate Program, 2600 Steindler Bldg, University of Iowa, Iowa City, Iowa 52242, USA
    Muscle Nerve 24:37-46. 2001
    ..2. Thus, this new model of widespread, chronic muscle-induced pain is unrelated to tissue damage and is not maintained by continued primary afferent input from the site of injury...
  23. ncbi request reprint Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint
    K A Sluka
    Physical Therapy Graduate Program and Neuroscience Graduate Program, College of Medicine, University of Iowa, Iowa City 52242, USA
    Eur J Pain 5:81-7. 2001
    ..The antihyperalgesic effect of joint mobilization lasted 30 min. Thus, joint mobilization (9 or 15 min duration) produces a significant reversal of secondary mechanical hyperalgesia induced by intra-articular injection of capsaicin...
  24. ncbi request reprint Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, Neuroscience Graduate Program, Pain Research Program, University of Iowa, 2600 Steindler Building, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 302:1146-50. 2002
    ..Thus, activation of mu- and delta-, but not kappa-, opioid receptors in the spinal cord reduces mechanical hyperalgesia following repeated intramuscular injection of acid, thus validating the use of this new model of chronic muscle pain...
  25. pmc Fatiguing exercise enhances hyperalgesia to muscle inflammation
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, Pain Research Program, University of Iowa, Iowa City, IA 52241, USA
    Pain 148:188-97. 2010
    ..We suggest that this effect is sex-dependent and involves mechanisms in the brainstem to result in an enhanced hyperalgesia...
  26. ncbi request reprint Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, Neuroscience Graduate Program, Pain Research Program, 2600 Steindler Bldg, University of Iowa, Iowa City, IA 52242, USA
    Pain 100:183-90. 2002
    ..It would thus be expected that one would reduce the side effects of clonidine and enhance analgesic efficacy with combinations of pharmaceutical and non-pharmaceutical treatments...
  27. ncbi request reprint Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats
    K A Sluka
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA 52242, USA
    J Pain 7:602-7. 2006
    ..Therefore, joint mobilization reduces hyperalgesia induced by chronic inflammation of muscle and joint...
  28. pmc Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia
    K A Sluka
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52241, USA
    Mol Pain 2:13. 2006
    ..Therefore, we hypothesized that spinal activation of PKC 1) mediates the late phase of hyperalgesia 1 week after muscle insult, and 2) produces mechanical hyperalgesia through activation of NMDA and non-NMDA glutamate receptors...
  29. pmc Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats
    Priyanka M Hingne
    Graduate Program in Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 9:217-25. 2008
    ..Treatment with MK-801 reversed this cross-tolerance at spinal opioid receptors. In summary, blockade of NMDA receptors prevents analgesic tolerance to daily TENS by preventing tolerance at spinal opioid receptors...
  30. pmc Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis
    Masahiko Ikeuchi
    Physical Therapy and Rehabilitation Science Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 10:336-42. 2009
    ..Specifically, we propose that ASIC3 upregulation along with CGRP and phenotypic change in ASIC3-immunoreactive neurons without CGRP are responsible for the development of secondary hyperalgesia after carrageenan-induced arthritis...
  31. ncbi request reprint Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections
    Marie K Hoeger-Bement
    Graduate Program in Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 23:5437-45. 2003
    ..The mechanical hyperalgesia and phosphorylation of CREB depend on early activation of the cAMP pathway during the first 24 hr but are independent of the cAMP pathway by 1 week after intramuscular injection of acid...
  32. ncbi request reprint Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration
    Prasant Chandran
    Graduate Program in Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, 2600 Steindler Building, University of Iowa, Iowa City, IA 52242, USA
    Pain 102:195-201. 2003
    ..t. administered mu- and delta-opioid agonists, respectively. Clinically, it can be inferred that a treatment schedule of repeated daily TENS administration should be avoided to possibly obviate the induction of tolerance...
  33. ncbi request reprint Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats
    Takeshi Yokoyama
    Graduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, Iowa 52242 1190, USA
    J Pain 8:422-9. 2007
    ..PERSPECTIVE: This study shows that pregabalin reduces both cutaneous and muscle hyperalgesia in inflammatory and noninflammatory models of muscle pain. Thus, pregabalin may be an effective treatment for people with chronic muscle pain...
  34. ncbi request reprint Characterization of a method for measuring primary hyperalgesia of deep somatic tissue
    David A Skyba
    Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 6:41-7. 2005
    ..Thus, we report a consistent and convenient method to measure primary hyperalgesia in deep tissues of rats. The measured hyperalgesia originates in the inflamed tissues and has no measurable contribution from skin...
  35. pmc ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury
    Roxanne Y Walder
    Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 11:210-8. 2010
    ..A-317567 reverses both the primary and the secondary hyperalgesia induced by carrageenan muscle inflammation. Thus, peripherally located ASIC1 and ASIC3 play different roles in the development of hyperalgesia after muscle inflammation...
  36. pmc Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats
    Luis F Da Silva
    Graduate Program in Physical Therapy and Rehabilitation Sciences, Neuroscience Graduate Program, Pain Research Program, The University of Iowa, Iowa City
    J Pain 11:378-87. 2010
    ..These results suggest that NMDA receptors in the RVM mediate both muscle and cutaneous hypersensitivity, but those in the NGC mediate only cutaneous hypersensitivity after muscle insult...
  37. pmc Muscle fatigue increases the probability of developing hyperalgesia in mice
    Takeshi Yokoyama
    Physical Therapy and Rehabilitation Science Graduate Program, Department of Pathology, Pain Research Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 8:692-9. 2007
    ..Clinically, this could relate to the development of pain from such conditions as repetitive strain injury, and may relate to the interrelationship between chronic pain and fatigue...
  38. pmc Enhanced muscle fatigue occurs in male but not female ASIC3-/- mice
    Lynn A Burnes
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1347-55. 2008
    ..Also, differences in expression of ASIC3 and the development of exercise-induced fatigue could explain the female predominance in clinical syndromes of pain that include muscle fatigue...
  39. ncbi request reprint Differences in waveform characteristics have no effect on the anti-hyperalgesia produced by transcutaneous electrical nerve stimulation (TENS) in rats with joint inflammation
    Priyanka M Hingne
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, IA 52242, USA
    J Pain 8:251-5. 2007
    ..This suggests that clinicians can select different waveforms to provide comfort during treatment but that reduction in pain is not a factor for waveform selection...
  40. ncbi request reprint Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation
    Lisa Ainsworth
    Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, IA 52242, USA
    Pain 120:182-7. 2006
    ....
  41. ncbi request reprint Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, Neuroscience Graduate Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 6:673-80. 2005
    ..We conclude that large diameter primary afferent fibers from deep tissue are required and that activation of cutaneous afferents is not sufficient for TENS-induced antihyperalgesia...
  42. pmc Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, 100 Medical Education Building 1 252, Iowa, IA 52242 1190, USA
    Pain 104:567-77. 2003
    ..Furthermore, 3% carrageenan injected into deep tissues produces hyperalgesia that spreads to the contralateral side, at the same time period as the inflammation transforms from acute to chronic...
  43. pmc Modulation between high- and low-frequency transcutaneous electric nerve stimulation delays the development of analgesic tolerance in arthritic rats
    Josimari M Desantana
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA 52242, USA
    Arch Phys Med Rehabil 89:754-60. 2008
    ..To investigate whether repeated administration of modulating frequency transcutaneous electric nerve stimulation (TENS) prevents development of analgesic tolerance...
  44. pmc Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans
    Laura A Frey Law
    Graduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, 1 252 Medical Education Building, Iowa City, IA 52242, USA
    Pain 140:254-64. 2008
    ..No pain or changes in PPTs occurred in the contralateral leg. These results demonstrate muscle acidosis can lead to local and referred pain and hyperalgesia, with significant sex differences in development of referred pain...
  45. pmc A new transient sham TENS device allows for investigator blinding while delivering a true placebo treatment
    Barbara Rakel
    University of Iowa, College of Nursing, Iowa City, Iowa
    J Pain 11:230-8. 2010
    ..HPTs and pain intensities to tonic heat were not significantly changed. The transient TENS completely blinds investigators to treatment and does not reduce pain, thereby providing a true placebo treatment...
  46. pmc Acid-sensing ion channels: A new target for pain and CNS diseases
    Kathleen A Sluka
    University of Iowa, Iowa City, 52242, USA
    Curr Opin Drug Discov Devel 12:693-704. 2009
    ..However, the development of pharmaceuticals that target ASICs and are suitable for clinical use remains an obstacle. This review provides an update on ASICs and their potential for therapeutic modification in pain and CNS diseases...
  47. pmc Spinal 5-HT(2) and 5-HT(3) receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, College of Medicine 1 252 Medical Education Building, University of Iowa, Iowa City, IA 52242 1190, USA
    Pain 105:205-13. 2003
    ..Furthermore, spinal noradrenergic receptors are not involved in either low or high frequency TENS antihyperalgesia...
  48. ncbi request reprint Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline
    D A Skyba
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
    Pain 98:69-78. 2002
    ..These data suggest that both NMDA and non-NMDA glutamate receptors are involved in the maintenance of chronic, muscle-induced hyperalgesia...
  49. doi request reprint Massage reduces pain perception and hyperalgesia in experimental muscle pain: a randomized, controlled trial
    Laura A Frey Law
    Program in Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, Iowa 52242, USA USA
    J Pain 9:714-21. 2008
    ..Mechanical hyperalgesia was reduced (27.5% reversal) after both the deep massage and superficial touch groups relative to control (increased hyperalgesia by 38.4%). Resting pain did not vary between treatment groups...
  50. doi request reprint Hypoalgesic effect of the transcutaneous electrical nerve stimulation following inguinal herniorrhaphy: a randomized, controlled trial
    Josimari M Desantana
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 9:623-9. 2008
    ..Consequently, the routine use of TENS after inguinal herniorrhaphy is recommended...
  51. doi request reprint High and low frequency TENS reduce postoperative pain intensity after laparoscopic tubal ligation: a randomized controlled trial
    Josimari M Desantana
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA
    Clin J Pain 25:12-9. 2009
    ..Therefore, we studied the effects of TENS on postoperative pain after LS through placement of Yoon fallopian rings in a prospective, randomized, double-blinded, and placebo-controlled study...
  52. ncbi request reprint Transcutaneous electrical nerve stimulation at both high and low frequencies reduces primary hyperalgesia in rats with joint inflammation in a time-dependent manner
    Carol G T Vance
    Graduate Program in Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA 52242, USA
    Phys Ther 87:44-51. 2007
    ..It is possible that TENS is effective on some measures of pain and not on others. The purpose of this study was to test the hypothesis that TENS reduces primary hyperalgesia of the knee induced by joint inflammation...
  53. doi request reprint Increased c-fos immunoreactivity in the spinal cord and brain following spinal cord stimulation is frequency-dependent
    Yumi Maeda
    Graduate Program in Physical Therapy and Rehabilitation Science, 1 242 MEB, Pain Research Program, The University of Iowa, Iowa City, IA 52242 1190, USA
    Brain Res 1259:40-50. 2009
    ..Thus, at the time points examined in this model, low frequency SCS likely activates supraspinal and spinal mechanisms to produce analgesia, while higher frequencies activate spinal mechanisms...
  54. ncbi request reprint A new electrochemical HPLC method for analysis of enkephalins and endomorphins
    Tammy L Lisi
    Graduate Program in Physical Therapy and Rehabilitation Science, The University of Iowa, 1 242 Medical Education Building, Iowa City, IA 52242 1190, USA
    J Neurosci Methods 150:74-9. 2006
    ..Thus, we have developed a method to simultaneously measure enkephalins and endomorphins in small sample volume that allows measurement of these opioid peptides in vivo...
  55. ncbi request reprint Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization
    Fumiaki Saito
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Neuron 38:747-58. 2003
    ..Dystroglycan may be required for the normal maintenance of voltage-gated sodium channels at nodes of Ranvier, possibly by mediating trans interactions between Schwann cell microvilli and the nodal axolemma...
  56. pmc Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain
    Josimari M Desantana
    Physical Therapy and Rehabilitation Science, 1 242 MEB, University of Iowa, Iowa City, IA 52252, USA
    Curr Pain Headache Rep 12:338-43. 2008
    ..These alterations in excitation and inhibition likely drive changes observed in the spinal cord to result in central sensitization, and the consequent pain and hyperalgesia...
  57. ncbi request reprint Excitatory amino acid release in the spinal cord caused by plantar incision in the rat
    Peter K Zahn
    Department of Anesthesia and Intensive Care Medicine, University of Muenster, Von Esmarch Strasse 56, 48149 Muenster, Germany
    Pain 100:65-76. 2002
    ..This profile of EAA release further explains why models of inflammation and chemical irritation do not translate well to human postoperative pain...
  58. ncbi request reprint Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors
    Ellen W King
    Center for Pain Research, University of Minnesota, Minneapolis, MN 55455, USA
    Pain 115:364-73. 2005
    ..This pharmacodynamic response is consistent with previous anatomical observations that alpha2A ARs are expressed on primary afferent neurons and macrophages near injured tissue...
  59. pmc Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model
    Marie K Hoeger Bement
    Department of Physical Therapy, Marquette University, PO Box 1881, Milwaukee, WI 53201, United States
    Neurosci Lett 418:22-7. 2007
    ..These findings suggest that there are region-specific changes in spinothalamic neurons that express p-NR1 and lamina X may play an important role in the modulation of chronic muscle pain...
  60. ncbi request reprint Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner
    Marie K Hoeger Bement
    Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WI 53201, USA
    Arch Phys Med Rehabil 86:1736-40. 2005
    ..To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system...
  61. ncbi request reprint Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats
    Rajan Radhakrishnan
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
    J Pharmacol Exp Ther 313:921-7. 2005
    ..It is possible that the inhibition of ion channels and/or the inhibition of spinally located CAs contribute to the observed antihyperalgesia...

Research Grants19

  1. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..Thus, pharmaceutical agents aimed at inhibition of ASICs are promising in that they not only have the potential to reduce the inflammatory process but also have a direct role in inhibiting musculoskeletal pain. ..
  2. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  3. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2000
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  4. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2002
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  5. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  6. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  7. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. ..
  8. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  9. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  10. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 1999
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  11. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2006
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  12. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2005
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  13. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  14. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2001
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  15. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  16. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2006
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  17. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..