G Sluder

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Regulation of cell cycle by the anaphase spindle midzone
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, Massachusetts 01605, USA
    BMC Cell Biol 5:49. 2004
  2. ncbi Centriole duplication: analogue control in a digital age
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Biol Int 34:1239-45. 2010
  3. ncbi Molecular biology. The mad ways of meiosis
    G Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 289:254-5. 2000
  4. ncbi Two-way traffic: centrosomes and the cell cycle
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Nat Rev Mol Cell Biol 6:743-8. 2005
  5. ncbi The good, the bad and the ugly: the practical consequences of centrosome amplification
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Biotech 4, 3d floor, 377 Plantation St, Worcester, MA 01605, USA
    Curr Opin Cell Biol 16:49-54. 2004
  6. ncbi Centrosome duplication: three kinases come up a winner!
    E H Hinchcliffe
    University of Massachusetts Medical School, Department of Cell Biology, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 11:R698-701. 2001
  7. ncbi Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
    E H Hinchcliffe
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Laboratory of Cell Regulation, Wadsworth Center, Albany, NY 12201, USA
    Science 291:1547-50. 2001
  8. ncbi Spindle pole fragmentation due to proteasome inhibition
    Anka G Ehrhardt
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01605, USA
    J Cell Physiol 204:808-18. 2005
  9. ncbi Cell-cycle progression without an intact microtuble cytoskeleton
    Yumi Uetake
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 17:2081-6. 2007
  10. ncbi Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
    E H Hinchcliffe
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 283:851-4. 1999

Research Grants

  1. Centrosome reduplication and consequences of cleavage failure/prolonged mitosis
    Greenfield Sluder; Fiscal Year: 2010
  2. Centrosomes in the Control of Mitosis and Interphase
    Greenfield Sluder; Fiscal Year: 2006
  3. CONTROL OF CENTROSOME REPRODUCTION AND MITOTIC PROGRESSI
    Greenfield Sluder; Fiscal Year: 2002
  4. SHARED HIGH RESOLUTION MULTIMODE MICROSCOPE SYSTEM
    Greenfield Sluder; Fiscal Year: 2001
  5. Centrosome reduplication and consequences of cleavage failure/prolonged mitosis
    Greenfield Sluder; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. ncbi Regulation of cell cycle by the anaphase spindle midzone
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, Massachusetts 01605, USA
    BMC Cell Biol 5:49. 2004
    ..Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle...
  2. ncbi Centriole duplication: analogue control in a digital age
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Biol Int 34:1239-45. 2010
    ....
  3. ncbi Molecular biology. The mad ways of meiosis
    G Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 289:254-5. 2000
    ..One of the components of this meiotic spindle checkpoint turns out to be Mad2, which gives the signal to halt meiosis if it looks like unequal chromosome segregation is taking place...
  4. ncbi Two-way traffic: centrosomes and the cell cycle
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Nat Rev Mol Cell Biol 6:743-8. 2005
    ..However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery...
  5. ncbi The good, the bad and the ugly: the practical consequences of centrosome amplification
    Greenfield Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Biotech 4, 3d floor, 377 Plantation St, Worcester, MA 01605, USA
    Curr Opin Cell Biol 16:49-54. 2004
    ..Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state...
  6. ncbi Centrosome duplication: three kinases come up a winner!
    E H Hinchcliffe
    University of Massachusetts Medical School, Department of Cell Biology, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 11:R698-701. 2001
    ..Despite over one hundred years of research, the duplication of the centrosome is a poorly understood process. Three recent papers--exploring three different kinases--may have provided the answer...
  7. ncbi Requirement of a centrosomal activity for cell cycle progression through G1 into S phase
    E H Hinchcliffe
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA, Laboratory of Cell Regulation, Wadsworth Center, Albany, NY 12201, USA
    Science 291:1547-50. 2001
    ..Once the cell is in S phase, these core structures are not needed for the G2-M phase transition...
  8. ncbi Spindle pole fragmentation due to proteasome inhibition
    Anka G Ehrhardt
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01605, USA
    J Cell Physiol 204:808-18. 2005
    ..Together, this leads to the conclusion that the centrosome functions as proteolytic center during mitosis and proteolytic activity at the spindle poles is necessary for maintaining spindle pole integrity...
  9. ncbi Cell-cycle progression without an intact microtuble cytoskeleton
    Yumi Uetake
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 17:2081-6. 2007
    ....
  10. ncbi Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
    E H Hinchcliffe
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 283:851-4. 1999
    ..These results demonstrate that Cdk2-E activity is required for centrosome duplication during S phase and suggest a mechanism that could coordinate centrosome reproduction with cycles of DNA synthesis and mitosis...
  11. ncbi Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells
    Yumi Uetake
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 176:173-82. 2007
    ..Third, we provide evidence that centrosome loss is, functionally, a stress that can act additively with other stresses to arrest cells in G1 in a p38-dependent fashion...
  12. ncbi MdmX regulates transformation and chromosomal stability in p53-deficient cells
    Zdenka Matijasevic
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cell Cycle 7:2967-73. 2008
    ..We also discuss the relationship between chromosomal loss, cell proliferation, and the tumorigenic potential of p53-deficient cells lacking MdmX...
  13. ncbi Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint"
    Yumi Uetake
    Department of Cell Biology, University of Massachusetts Medical School, Biotech 4, 3rd Floor, 377 Plantation St, Worcester, MA 01605, USA
    J Cell Biol 165:609-15. 2004
    ..These observations provide a functional demonstration that the tetraploidy checkpoint does not exist in normal mammalian somatic cells...
  14. ncbi p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy
    Yingwang Liu
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Cancer Res 67:2603-10. 2007
    ..Therefore, our studies highlight a novel function of HPV E6 that may contribute to HPV-induced carcinogenesis and improve our understanding of the onset of the disease...
  15. ncbi De novo formation of centrosomes in vertebrate cells arrested during S phase
    Alexey Khodjakov
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Cell Biol 158:1171-81. 2002
    ..Although clouds of PCM consistently form even when microtubules are completely disassembled by nocodazole, the centrioles are not assembled under these conditions...
  16. ncbi Centriole biogenesis: a tale of two pathways
    Jadranka Loncarek
    Nat Cell Biol 9:736-8. 2007
  17. ncbi Two for two: Cdk2 and its role in centrosome doubling
    Edward H Hinchcliffe
    Department of Biological Sciences, and the Walther Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, IN 46556, USA
    Oncogene 21:6154-60. 2002
  18. ncbi Cyclin E in centrosome duplication and reduplication in sea urchin zygotes
    Bradley J Schnackenberg
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Physiol 217:626-31. 2008
    ..This indicates that centrosome duplication during the G1 arrest is limited by a block to reduplication under conditions permissive for duplication. The cytoplasmic conditions of S phase, however, abrogate this block to reduplication...
  19. ncbi The de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly/maturation
    Sabrina La Terra
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Cell Biol 168:713-22. 2005
    ..By selectively ablating only one centriole at a time, we find that the presence of a single centriole inhibits the assembly of additional centrioles, indicating that centrioles have an activity that suppresses the de novo pathway...

Research Grants16

  1. Centrosome reduplication and consequences of cleavage failure/prolonged mitosis
    Greenfield Sluder; Fiscal Year: 2010
    ..We will determine if worm centrioles are functional in a heterologous cytoplasm and examine the ultrastructure of the daughter centrioles to determine if they have the worm, the frog, or some other structure. ..
  2. Centrosomes in the Control of Mitosis and Interphase
    Greenfield Sluder; Fiscal Year: 2006
    ..We will test if centrosomes can reduplicate within a cell cycle under conditions where cleavage failure is not a factor. ..
  3. CONTROL OF CENTROSOME REPRODUCTION AND MITOTIC PROGRESSI
    Greenfield Sluder; Fiscal Year: 2002
    ..abstract_text> ..
  4. SHARED HIGH RESOLUTION MULTIMODE MICROSCOPE SYSTEM
    Greenfield Sluder; Fiscal Year: 2001
    ..The proposed instrument system will allow these researchers to take their investigations in new directions, obtain novel information, and thus, significantly advance their programs in basic biomedical research. ..
  5. Centrosome reduplication and consequences of cleavage failure/prolonged mitosis
    Greenfield Sluder; Fiscal Year: 2009
    ..We will determine if worm centrioles are functional in a heterologous cytoplasm and examine the ultrastructure of the daughter centrioles to determine if they have the worm, the frog, or some other structure. ..