A Slominski

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes
    Zorica Janjetovic
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5988. 2009
  2. ncbi Expression of genes coding melatonin and serotonin receptors in rodent skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave, Room 519, Memphis, TN 38163, USA
    Biochim Biophys Acta 1680:67-70. 2004
  3. pmc Differential expression of HPA axis homolog in the skin
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, HSC, Memphis, TN 38163, USA
    Mol Cell Endocrinol 265:143-9. 2007
  4. ncbi Melanin pigmentation in mammalian skin and its hormonal regulation
    Andrzej Slominski
    Dept of Pathology, Suite 599, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Physiol Rev 84:1155-228. 2004
  5. pmc A nervous breakdown in the skin: stress and the epidermal barrier
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA
    J Clin Invest 117:3166-9. 2007
  6. pmc Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells
    Andrzej Slominski
    Department of Pathology, Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Int J Cancer 124:1470-7. 2009
  7. pmc CRH functions as a growth factor/cytokine in the skin
    A Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 206:780-91. 2006
  8. pmc Differential expression of a cutaneous corticotropin-releasing hormone system
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, 5th Floor, Memphis, TN 38163, USA
    Endocrinology 145:941-50. 2004
  9. ncbi Tryptophan hydroxylase expression in human skin cells
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave, 519 Memphis, TN 38163, USA
    Biochim Biophys Acta 1639:80-6. 2003
  10. pmc Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e4309. 2009

Collaborators

Detail Information

Publications72

  1. pmc 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes
    Zorica Janjetovic
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5988. 2009
    ....
  2. ncbi Expression of genes coding melatonin and serotonin receptors in rodent skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave, Room 519, Memphis, TN 38163, USA
    Biochim Biophys Acta 1680:67-70. 2004
    ..Mouse skin and hamster melanomas also expressed 5HT2B and 5HT7. We identified two novel isoforms of MT1A and 5HT7...
  3. pmc Differential expression of HPA axis homolog in the skin
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, HSC, Memphis, TN 38163, USA
    Mol Cell Endocrinol 265:143-9. 2007
    ..Thus, differential, CRH-driven responses of defined cutaneous cell populations reproduce key features of the central HPA axis at the tissue/single cell levels...
  4. ncbi Melanin pigmentation in mammalian skin and its hormonal regulation
    Andrzej Slominski
    Dept of Pathology, Suite 599, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA
    Physiol Rev 84:1155-228. 2004
    ..Indeed, the significance of melanogenesis extends beyond the mere assignment of a color trait...
  5. pmc A nervous breakdown in the skin: stress and the epidermal barrier
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA
    J Clin Invest 117:3166-9. 2007
    ..Thus, this study provides what I believe to be the first mechanistic link between psychological stress and increased susceptibility to microbial infection...
  6. pmc Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells
    Andrzej Slominski
    Department of Pathology, Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Int J Cancer 124:1470-7. 2009
    ..Thus, the inhibition of melanogenesis might represent a valid therapeutic target for the management of advanced melanotic melanomas...
  7. pmc CRH functions as a growth factor/cytokine in the skin
    A Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 206:780-91. 2006
    ..In conclusion, CRH and related peptides can couple CRH-R1 to any of diverse signal transduction pathways; they also regulate cell viability and proliferation in cell type and growth condition-dependent manners...
  8. pmc Differential expression of a cutaneous corticotropin-releasing hormone system
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, 5th Floor, Memphis, TN 38163, USA
    Endocrinology 145:941-50. 2004
    ..The adnexal location of CRH-R2 suggests a role for the receptor in hair growth. The differential interspecies CRH signaling expression pattern probably reflects adaptation to species-specific skin function determinants...
  9. ncbi Tryptophan hydroxylase expression in human skin cells
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave, 519 Memphis, TN 38163, USA
    Biochim Biophys Acta 1639:80-6. 2003
    ..We conclude that while the TPH mRNA and protein are widely expressed in cultured normal and pathological epidermal and dermal skin cells, in vivo TPH expression is predominantly restricted to cells of melanocytic origin...
  10. pmc Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e4309. 2009
    ..The 5-7 dienal intermediates of the pathway can be a source of biologically active vitamin D3 derivatives after delivery to or production in the skin, an organ intermittently exposed to solar radiation...
  11. pmc A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Health Science Center, Memphis, TN, USA
    Eur J Biochem 271:4178-88. 2004
    ..This novel pathway has the potential to generate a variety of molecules depending on local steroidogenic activity and access to UVB...
  12. pmc Molecular cloning and initial characterization of African green monkey (Cercopithecus aethiops) corticotropin releasing factor receptor type 1 (CRF1) from COS-7 cells
    Andrzej T Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Gene 389:154-62. 2007
    ....
  13. ncbi CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Ave Room 519, Memphis, TN 38103, USA
    Am J Physiol Endocrinol Metab 288:E701-6. 2005
    ..This pattern demonstrates the fractal nature of the response to stress with similar activation sequence at the single-cell and whole body levels...
  14. pmc Corticotropin releasing hormone and the skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Front Biosci 11:2230-48. 2006
    ..The accumulated evidence indicates that cutaneous CRH is also a component of a local structure organized similarly to the hypothalamo-pituitary-adrenal axis...
  15. ncbi Melatonin in the skin: synthesis, metabolism and functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee HSC, Memphis, TN, USA
    Trends Endocrinol Metab 19:17-24. 2008
    ..In this way, melatonin actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity...
  16. pmc On the role of melatonin in skin physiology and pathology
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, TN 38103, USA
    Endocrine 27:137-48. 2005
    ..Furthermore, melatonin could have a role in protection against solar radiation or even in the management of skin diseases...
  17. pmc Neuroendocrine system of the skin
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Dermatology 211:199-208. 2005
    ..These endocrine factors would represent an exquisite regulatory layer addressed at restricting maximally the effect of noxious agents in the skin to preserve local and consequently global homeostasis...
  18. ncbi Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA
    Chem Biol 12:931-9. 2005
    ....
  19. pmc The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Health Science Center, Memphis, TN 38163, USA
    FEBS J 272:4080-90. 2005
    ..Additional vitamin D3 metabolites arise from the action of other enzymes in adrenal mitochondria. These findings appear to define novel metabolic pathways involving vitamin D3 that remain to be characterized...
  20. ncbi CRH stimulates POMC activity and corticosterone production in dermal fibroblasts
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, 930 Madison Avenue 519, Memphis, TN 38163, USA
    J Neuroimmunol 162:97-102. 2005
    ..However, it diverges from the HPA organization in its distal step, where CRH and ACTH stimulate production of corticosterone, instead of cortisol...
  21. ncbi The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
    Andrzej Slominski
    Department of Pathology, University of Tennessee, Memphis, Tennessee, USA
    FASEB J 19:176-94. 2005
    ..Slominski, A. J., Wortsman, J., Tobin, D. J. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun...
  22. pmc Hair follicle pigmentation
    Andrzej Slominski
    Department of Pathology, University of Tennessee, Memphis, Tennessee 38163, USA
    J Invest Dermatol 124:13-21. 2005
    ..Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color...
  23. pmc An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    FEBS J 273:2891-901. 2006
    ..Thus, P450scc can metabolize vitamin D2 to generate novel products, with intrinsic biological activity (at least in keratinocytes)...
  24. ncbi Functional activity of serotoninergic and melatoninergic systems expressed in the skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Cell Physiol 196:144-53. 2003
    ..Thus, skin cells represent a true target for the products of the serotoninergic/melatoninergic cutaneous pathway with their actions modulating cell proliferation or viability...
  25. ncbi Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors
    A Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    FASEB J 15:1678-93. 2001
    ..In such a CRH/POMC system, the CRH-Rs may be a central element...
  26. ncbi Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin
    A Slominski
    Department of Pathology, University of Tennessee, Memphis 38163, USA
    J Clin Endocrinol Metab 85:3582-8. 2000
    ..Direct identification of these peptides is consistent with translation of the corresponding genes, and it also suggests intermediate pituitary lobe-like POMC peptide processing...
  27. ncbi Malignant melanoma
    A Slominski
    Department of Pathology, University of Tennessee Health Sciences Center, Memphis 38163, USA
    Arch Pathol Lab Med 125:1295-306. 2001
    ..The rapidly developing fields of melanoma research are revolutionizing the current concepts on melanoma etiology and pathogenesis and are introducing newer diagnostic techniques and potential therapeutic approaches...
  28. ncbi Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    FEBS Lett 511:102-6. 2002
    ..Thus, human melanoma cells can synthesize and metabolize Ser and Mel...
  29. ncbi Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes
    Andrzej Slominski
    Department of Pathology, Health Science Center, University of Tennessee, Memphis, Tennessee 38163, USA
    J Invest Dermatol 118:310-5. 2002
    ..As distinct from the adrenal cortex, production of A, B, Aldo, 18OHdeoxycorticosterone, or F in keratinocytes was absent or below limits of detectability...
  30. ncbi Neuroendocrinology of the skin
    A Slominski
    Department of Pathology, University of Tennessee, Memphis 38163, USA
    Endocr Rev 21:457-87. 2000
    ..Therefore, we suggest that the skin neuroendocrine system acts by preserving and maintaining the skin structural and functional integrity and, by inference, systemic homeostasis...
  31. pmc Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin
    Andrzej Slominski
    Departments of Pathology, and Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Invest Dermatol 119:1449-55. 2002
    ..We conclude that the expanding list of neuroendocrine elements expressed in the skin supports a strong role for this system in cutaneous biology...
  32. ncbi Self-regulated endocrine systems in the skin
    A Slominski
    Department of Pathology, University of Tennessee, Memphis, TN 38163, USA
    Minerva Endocrinol 28:135-43. 2003
    ..Ultimately, the skin neuroendocrine system would act to preserve cutaneous structural and functional integrity to maintain systemic homeostasis...
  33. pmc Neuroendocrine activity of the melanocyte
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Exp Dermatol 18:760-3. 2009
    ..Such capabilities have defined melanocytes as neuroendocrine cells that not only coordinate cutaneous but also can affect a global homeostasis...
  34. ncbi Serotoninergic and melatoninergic systems are fully expressed in human skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    FASEB J 16:896-8. 2002
    ..NAS identity was confirmed further by LC/MS in keratinocytes. In conclusion, we provide evidence that the human skin expresses intrinsic serotonin and melatonin biosynthetic pathways...
  35. ncbi Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines
    T W Fischer
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Int J Oncol 29:665-72. 2006
    ..The intensity of the oncostatic response to melatonin could be related to the cell-line specific pattern of melatonin cellular receptors and cytosolic binding protein expression...
  36. ncbi Hair cycle-dependent production of ACTH in mouse skin
    A Slominski
    Department of Pathology, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Biochim Biophys Acta 1448:147-52. 1998
    ..In conclusion, we suggest that local production of ACTH may represent a regulatory element in the control of skin functions including hair growth...
  37. ncbi Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells
    A Slominski
    Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA
    FEBS Lett 455:364-6. 1999
    ..This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone...
  38. ncbi Production of POMC, CRH-R1, MC1, and MC2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin
    G Ermak
    Department of Pathology and Laboratory Medicine, Albany Medical College, New York 12208, USA
    J Invest Dermatol 108:160-5. 1997
    ..These results support the hypothesis that murine hair growth and attendant melanogenesis can be regulated through coordinated changes in local expression of POMC, MC1-R, and tyrosinase genes...
  39. ncbi Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin
    A Slominski
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    FEBS Lett 374:113-6. 1995
    ..CRH mRNA is transcribed in cultured melanocytes but not in keratinocytes. It is proposed that an equivalent of the 'hypothalamus-pituitary axis' composed of the CRH-CRHR-POMC loop is conserved in mammalian skin...
  40. ncbi The skin produces urocortin
    A Slominski
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Clin Endocrinol Metab 85:815-23. 2000
    ..In conclusion, we now demonstrate that human skin and mouse skin as well as cultured keratinocytes and melanoma cells exhibit functional expression of the urocortin gene with actual production of urocortin peptide...
  41. pmc Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes
    T W Fischer
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Pineal Res 44:397-407. 2008
    ..In conclusion, these data provide detailed evidence for specific antiapoptotic mechanisms of melatonin in UVR-induced damage of human keratinocytes...
  42. ncbi Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin
    Alexander Pisarchik
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Invest Dermatol 118:1065-72. 2002
    ....
  43. ncbi Active steroidogenesis in the normal rat skin
    A Slominski
    Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA
    Biochim Biophys Acta 1474:1-4. 2000
    ..Thus, normal rodent skin possesses steroidogenic activity that can be shown using progesterone or DOC as primary substrates...
  44. ncbi Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes
    M E Quevedo
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    In Vitro Cell Dev Biol Anim 37:50-4. 2001
    ..Therefore, similar to its central actions, cutaneous CRH may also he involved in the stress response, but at a highly localized level...
  45. pmc Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Endocrinol 20:2539-47. 2006
    ..In conclusion, UVB induces CRH production in human melanocytes through stimulation of the protein kinase A pathway, with sequential involvement of CRH-CRH receptor 1 in the stimulation of POMC expression...
  46. pmc A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity
    Tae Kang Kim
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Steroids 75:230-9. 2010
    ....
  47. ncbi Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes
    A Slominski
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    FEBS Lett 399:175-6. 1996
    ..The CRF production and secretion is markedly stimulated by ultraviolet B (UVB) radiation. This is the first demonstration that cutaneous melanocytes respond to environmental stress (UVB) through the production of CRF...
  48. ncbi The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin
    A Slominski
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY, 12208, USA
    Biochim Biophys Acta 1289:247-51. 1996
    ..These findings suggest that some components of hypothalamo-pituitary axis are operating in mouse skin...
  49. ncbi ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin
    A Slominski
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    J Clin Endocrinol Metab 81:2746-9. 1996
    ..Thus, molecular elements of the distal loop of the "pituitary-adrenal axis" such as the MC-2, CYP11A1, CYP17 and CYP21A2 genes are expressed in the skin...
  50. ncbi Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis
    T W Fischer
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Pineal Res 40:18-26. 2006
    ..Thus, pretreatment with melatonin led to strong protection against UVB-induced damage in keratinocytes...
  51. pmc Melanocyte receptors: clinical implications and therapeutic relevance
    J Andrew Carlson
    Division of Dermatopathology and Dermatology, Department of Pathology and Laboratory Medicine, Albany Medical College MC 81, 47 New Scotland Avenue, Albany, NY 12208, USA
    Dermatol Clin 25:541-57, viii-ix. 2007
    ..This article reviews the current understanding of melanocyte receptors, their agonists and inhibitors, and their potential to treat the melanocytic pathology...
  52. pmc Molecular and functional characterization of novel CRFR1 isoforms from the skin
    Alexander Pisarchik
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Eur J Biochem 271:2821-30. 2004
    ..This suggests that both protein kinase A and C can be involved in CRF-dependent signal transduction...
  53. ncbi Serotoninergic system in hamster skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, U S A
    J Invest Dermatol 119:934-42. 2002
    ..As serotonin has powerful vasodilator, immunomodulator, and growth factor actions, this pathway could be involved in skin physiology and/or pathology...
  54. pmc Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Endocrinology 146:1245-53. 2005
    ..Whereas the latter implies feedback control of melanogenesis, it is also possible that the two mechanisms operate jointly in hair follicles...
  55. ncbi A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation
    Alexander Pisarchik
    Department of Pathology and Laboratory Medicine, Room 519, University of Tennessee Health Science Center, 930 Madison Ave, Memphis, TN 38163, USA
    Gene 341:199-207. 2004
    ..In summary, we have developed a microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuroendocrine-immune functions of the skin...
  56. ncbi Characterization of the serotoninergic system in the C57BL/6 mouse skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
    Eur J Biochem 270:3335-44. 2003
    ....
  57. pmc Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity
    Wei Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Steroids 75:926-35. 2010
    ....
  58. ncbi Possible mechanisms of hypopigmentation in lichen sclerosus
    J Andrew Carlson
    Department of Pathology, Albany Medical College, New York 12208, USA
    Am J Dermatopathol 24:97-107. 2002
    ..The latter finding may be the pathogenic connection (lichenoid dermatitis of LS triggering an autoimmune reaction to melanocytes) that underlies the documented association of LS with vitiligo...
  59. ncbi Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems
    Tobias W Fischer
    Department of Patholology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Ave, Memphis, Tennessee 38163, USA
    FASEB J 20:1564-6. 2006
    ..The additional biological activity of these individual melatonin metabolites increases the spectrum of potential actions of the recently identified cutaneous melatoninergic system...
  60. pmc Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity
    B Brocato
    Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA
    Placenta 34:983-9. 2013
    ..Metabolic crosstalk between placenta and adipocytes may mediate sequelae of MO. The goal of this study was to elucidate placental and systemic ECB in MO...
  61. ncbi Malignant melanoma 2003: predisposition, diagnosis, prognosis, and staging
    J Andrew Carlson
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    Am J Clin Pathol 120:S101-27. 2003
    ..We review current and potential biomarkers useful for the screening for and prevention, diagnosis, staging, and prognosis of melanoma...
  62. ncbi Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 203:118-26. 2005
    ....
  63. pmc Proopiomelanocortin signaling system is operating in mast cells
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, 38163, USA
    J Invest Dermatol 126:1934-6. 2006
    ..Since at the tissue level mast cells integrate stress responses into the neuroimmune regulatory network, it is likely that the POMC system is involved in mast cells' functions in tissue homeostasis...
  64. pmc Corticotropin-releasing hormone inhibits nuclear factor-kappaB pathway in human HaCaT keratinocytes
    Blazej Zbytek
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    J Invest Dermatol 121:1496-9. 2003
    ..Moreover, corticotropin-releasing hormone inhibited the trans-cription of the nuclear factor-kappaB responsive genes, interleukin-2 and heat shock protein 90...
  65. pmc CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes
    Blazej Zbytek
    J Invest Dermatol 127:730-2. 2007
  66. pmc Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, Tennessee 38163, USA
    J Endocrinol 193:157-69. 2007
    ..Therefore, we suggest that ocular tissue expresses CRF-driven signalling system that follows organisational structure of the HPA axis...
  67. pmc Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    J Endocrinol 181:R1-7. 2004
    ..CRH-dependent stimulation of NF-kappaB activity is consistent with accumulated data about role of this neuropeptide in the regulation of local epidermal homeostasis...
  68. doi Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy
    Anna A Brozyna
    Department of Medical Biology, Nicolaus Copernicus University, Torun, Poland
    Int J Cancer 123:1448-56. 2008
    ..In conclusion, the results of these cell culture experiments give support to a clinical trial of pharmacologically induced decrease in melanin synthesis to enhance the efficacy of radiotherapy in advanced melanomas...
  69. pmc 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Invest Dermatol 128:2271-80. 2008
    ..These data imply that the previously unreported pathway of vitamin D3 metabolism by P450scc may have wider biological implications depending, for example, on the extent of adrenal gland or cutaneous metabolism...
  70. ncbi Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma
    Wei Li
    Department of Pharmaceutical Sciences, College of Pharmacy, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Anticancer Res 27:883-8. 2007
    ..New drugs are urgently needed for improved therapy for melanoma...
  71. pmc CRH inhibits NF-kappa B signaling in human melanocytes
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue 525, Memphis, TN 38163, USA
    Peptides 27:3276-83. 2006
    ..g. through activation of POMC. We suggest that induction of POMC by CRH serves as a feedback mechanism to self-restrict inflammatory response in the skin...
  72. ncbi Transplantable melanomas in gerbils (Meriones unguiculatus). II: melanogenesis
    Przemyslaw M Plonka
    Laboratory for Radiospectroscopy of Cancer and Radiobiology, Institute of Molecular Biology, Jagiellonian University, Krakow, Poland
    Exp Dermatol 12:356-64. 2003
    ..The information generated can be used for defining the roles of melanogenesis and of tyrosinase expression in the regulation of melanoma behavior and the effect of their modification on the course of the disease...