John T Slevin

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity
    Don M Gash
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Ann Neurol 63:184-92. 2008
  2. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  3. ncbi request reprint Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    John T Slevin
    Department of Anatomy and Neurobiology, Morris K Udall Parkinson s Disease Research Center of Excellence, University of Kentucky, Lexington 40536 0284, USA
    J Neurosurg 102:216-22. 2005
  4. ncbi request reprint Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal
    John T Slevin
    Department of Anatomy and Neurobiology, The Morris K Udall Parkinson s Disease Research Center of Excellence, and the Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Neurosurg Focus 20:E1. 2006
  5. ncbi request reprint Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal
    John T Slevin
    Department of Neurology, University of Kentucky, Chandler Medical Center, Lexington, Kentucky 40536 0284, USA
    J Neurosurg 106:614-20. 2007
  6. pmc Validation studies of the human movement analysis panel for hand/arm performance
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA
    J Neurosci Methods 165:287-96. 2007
  7. pmc Dopaminergic modulation of memory and affective processing in Parkinson depression
    Lee X Blonder
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY, USA Department of Behavioral Science, University of Kentucky, Lexington, KY, USA Department of Neurology, University of Kentucky, Lexington, KY, USA Electronic address
    Psychiatry Res 210:146-9. 2013
  8. ncbi request reprint Restless legs syndrome
    Melody Ryan
    Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY 40536, USA
    Am J Health Syst Pharm 63:1599-612. 2006
  9. doi request reprint Trichloroethylene and Parkinson disease
    Fariha Zaheer
    Movement Disorders Program, Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 South Limestone Street, Lexington, KY 40536 0284, USA
    Neurol Clin 29:657-65. 2011
  10. pmc Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release
    Elena A Matveeva
    Departments of Molecular and Cellular Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, USA
    Epilepsia 53:157-67. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity
    Don M Gash
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Ann Neurol 63:184-92. 2008
    ..To analyze a cluster of 30 industrial coworkers with Parkinson's disease and parkinsonism subjected to long-term (8-33 years) chronic exposure to trichloroethylene...
  2. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  3. ncbi request reprint Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    John T Slevin
    Department of Anatomy and Neurobiology, Morris K Udall Parkinson s Disease Research Center of Excellence, University of Kentucky, Lexington 40536 0284, USA
    J Neurosurg 102:216-22. 2005
    ..In the present study the authors report on a 6-month unilateral intraputaminal GDNF infusion in 10 patients with advanced Parkinson disease (PD)...
  4. ncbi request reprint Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal
    John T Slevin
    Department of Anatomy and Neurobiology, The Morris K Udall Parkinson s Disease Research Center of Excellence, and the Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    Neurosurg Focus 20:E1. 2006
    ..After the trial was halted by the sponsor, the patients were monitored for an additional year to evaluate the effects of drug withdrawal...
  5. ncbi request reprint Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal
    John T Slevin
    Department of Neurology, University of Kentucky, Chandler Medical Center, Lexington, Kentucky 40536 0284, USA
    J Neurosurg 106:614-20. 2007
    ..After the trial was halted by the drug sponsor, the patients were monitored for an additional 1 year during which the effects of drug withdrawal were evaluated...
  6. pmc Validation studies of the human movement analysis panel for hand/arm performance
    Charles D Smith
    Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40536, USA
    J Neurosci Methods 165:287-96. 2007
    ..The HMAP has a smaller version used in primates, so that measurements made in primate models of disease and its treatment are directly comparable to analogous clinical measurements made in the corresponding human disease...
  7. pmc Dopaminergic modulation of memory and affective processing in Parkinson depression
    Lee X Blonder
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY, USA Department of Behavioral Science, University of Kentucky, Lexington, KY, USA Department of Neurology, University of Kentucky, Lexington, KY, USA Electronic address
    Psychiatry Res 210:146-9. 2013
    ..The opposite pattern emerged for the non-depressed Parkinson's group. The administration of dopaminergic medication to depressed Parkinson patients may carry unintended risks. ..
  8. ncbi request reprint Restless legs syndrome
    Melody Ryan
    Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY 40536, USA
    Am J Health Syst Pharm 63:1599-612. 2006
    ..The signs and symptoms, epidemiology, etiology, pathophysiology, diagnosis, pharmacologic and nonpharmacologic treatments, and options and guidelines for the treatment of restless legs syndrome (RLS) are reviewed...
  9. doi request reprint Trichloroethylene and Parkinson disease
    Fariha Zaheer
    Movement Disorders Program, Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L 445, 740 South Limestone Street, Lexington, KY 40536 0284, USA
    Neurol Clin 29:657-65. 2011
    ..These observations endorse the hypothesis that a variety of environmental risk factors may cause nigrostriatal degeneration and clinical parkinsonism in genetically predisposed individuals...
  10. pmc Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release
    Elena A Matveeva
    Departments of Molecular and Cellular Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, USA
    Epilepsia 53:157-67. 2012
    ..To correlate kindling-associated alterations of the neurotransmitter secretory machinery, glutamate release in the trisynaptic hippocampal excitatory pathway, and the behavioral evolution of kindling-induced epileptogenesis...
  11. pmc Emotional dysfunction in Parkinson's disease
    Lee X Blonder
    Sanders Brown Center on Aging and Departments of Behavioral Science and Neurology, University of Kentucky College of Medicine, Lexington, USA
    Behav Neurol 24:201-17. 2011
    ..In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants...
  12. pmc Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes
    Elena A Matveeva
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Medical Center, Lexington, Kentucky, USA
    Epilepsia 49:1749-58. 2008
    ..The present studies probe the persistence of 7SC accumulation and the effect of the anticonvulsant, levetiracetam (LEV), on 7SC and SNARE regulators...
  13. ncbi request reprint A multicenter, open-label, sequential study comparing preferences for carbidopa-levodopa orally disintegrating tablets and conventional tablets in subjects with Parkinson's disease
    Paul A Nausieda
    Wisconsin Institute for Neurologic and Sleep Disorders, Regional Parkinson Center, Milwaukee, Wisconsin, USA
    Clin Ther 27:58-63. 2005
    ..In these patients, orally disintegrating tablets (ODTs) can be given without water and may provide greater convenience and ease of use than conventional tablets...
  14. ncbi request reprint Research on Parkinson disease
    John T Slevin
    J Neurosurg 102:401. 2005
  15. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  16. ncbi request reprint Reply: GDNF poses troubling questions for doctors, drug maker
    John T Slevin
    Ann Neurol 59:989-90. 2006