Genomes and Genes
MARTHA OR MARTY SLATTERY
Affiliation: University of Utah
- Slattery M, Wolff R, Curtin K, Fitzpatrick F, Herrick J, Potter J, et al. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. Mutat Res. 2009;660:12-21 pubmed publisher..The important modifying effects of aspirin/NSAIDs on associations with genetic polymorphisms reinforce the underlying role of inflammation in the etiology of colon cancer. ..
- Slattery M, Wolff R, Lundgreen A. A pathway approach to evaluating the association between the CHIEF pathway and risk of colorectal cancer. Carcinogenesis. 2015;36:49-59 pubmed publisher..21, 95% confidence interval (CI): 4.72, 8.16] and rectal (OR = 7.82, 95% CI: 5.26, 11.62) cancer. We conclude that elements of the CHIEF pathway are important for CRC risk. ..
- Slattery M, Baumgartner K, Giuliano A, Byers T, Herrick J, Wolff R. Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States. Breast Cancer Res Treat. 2011;129:531-9 pubmed publisher..Our data replicated some of the previously reported GWAS findings. Differences in associations were detected for NHW and Hispanic women by menopausal status and by ER/PR status of tumors. ..
- Slattery M, Wolff E, Hoffman M, Pellatt D, Milash B, Wolff R. MicroRNAs and colon and rectal cancer: differential expression by tumor location and subtype. Genes Chromosomes Cancer. 2011;50:196-206 pubmed publisher..These results suggest the importance of miRNAs in colorectal cancer and the need for studies that can confirm these results and provide insight into the diet, lifestyle, and genetic factors that influence miRNA expression. ..
- Suyundikov A, Stevens J, Corcoran C, Herrick J, Wolff R, Slattery M. Incorporation of subject-level covariates in quantile normalization of miRNA data. BMC Genomics. 2015;16:1045 pubmed publisher..When any subject-level covariates are available, the weighted quantile normalization method should be used over the conventional quantile normalization method. ..
- Stevens J, Herrick J, Wolff R, Slattery M. Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer. BMC Cancer. 2017;17:707 pubmed publisher..Our results will serve as a publicly-available resource to provide clarifying information about various factors associated with the direction and significance of tumor-normal differential expression of microRNAs in colorectal cancer. ..
- Slattery M, Lundgreen A, Herrick J, Caan B, Potter J, Wolff R. Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-?-signaling pathway. Carcinogenesis. 2011;32:318-26 pubmed publisher..47 (95% CI 1.58, 35.3). Although the associations need confirmation, the findings and their internal consistency underline the importance of genetic variation in these genes for the etiology of CRC. ..
- Slattery M. Analysis of dietary patterns in epidemiological research. Appl Physiol Nutr Metab. 2010;35:207-10 pubmed publisher..Additionally, the utilization of dietary patterns as a tool for public health messages is a topic that is unresolved. These issues are discussed in this paper. ..
- Slattery M, Herrick J, Curtin K, Samowitz W, Wolff R, Caan B, et al. Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. Cancer Res. 2010;70:1479-85 pubmed publisher..No significant associations were observed for the rs4464148 SNP or other SNPs evaluated in the SMAD7. These results corroborate the findings of GWAS in colon cancer pointing to SMAD7 and reinforce interest in SNPs in this gene. ..
- Slattery M, Curtin K, Wolff R, Boucher K, Sweeney C, Edwards S, et al. A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum. 2009;52:1304-11 pubmed publisher..Overall, rectal and distal colon tumors share similar mutational frequencies which are different from those observed in proximal colon tumors. ..
- Slattery M, Curtin K, Sweeney C, Wolff R, Baumgartner R, Baumgartner K, et al. Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk. Obesity (Silver Spring). 2008;16:339-47 pubmed publisher..27, 817) when compared with women with a WHR <0.8 and the rs1800795 GG genotype (P interaction 0.01). These data suggest that IL-6 genotypes may influence breast cancer risk in conjunction with central adiposity. ..
- Sharafeldin N, Slattery M, Liu Q, Franco Villalobos C, Caan B, Potter J, et al. Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. Int J Environ Res Public Health. 2017;14: pubmed publisher..GEIs between angiogenesis genes and smoking, alcohol, and animal protein impact rectal cancer risk. Our results support the importance of considering the biologic hypothesis to characterize GEIs associated with cancer outcomes. ..
- Slattery M, Lundgreen A, Bondurant K, Wolff R. Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. Carcinogenesis. 2011;32:1660-7 pubmed publisher..83, 95% CI 2.34-10.05) cancer for those in the category having the most at-risk genotypes. These data suggest the importance of IFN-signaling pathway on colon and rectal cancer risk and survival after diagnosis. ..
- Slattery M, Mullany L, Sakoda L, Samowitz W, Wolff R, Stevens J, et al. The NF-?B signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression. J Cancer Res Clin Oncol. 2018;144:269-283 pubmed publisher..Focusing on the genes and their associated miRNAs within the entire signalling pathway provides a comprehensive understanding of this complex pathway as it relates to CRC and offers insight into potential therapeutic agents. ..
- Slattery M, Mullany L, Sakoda L, Wolff R, Samowitz W, Herrick J. Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients. Apoptosis. 2018;23:237-250 pubmed publisher..BIRC5, CTSS, and CSF2R all had seed-region matches with miRNAs that would favor apoptosis. Our study identifies several miRNA associated with apoptosis-related genes, that if validated, could be important therapeutic targets. ..
- Slattery M, John E, Stern M, Herrick J, Lundgreen A, Giuliano A, et al. Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013;140:587-601 pubmed publisher..Genetic variation in ERBB2 and FGF1 appear to be associated with survival after diagnosis with breast cancer. ..
- Slattery M, John E, Torres Mejía G, Stern M, Lundgreen A, Hines L, et al. Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities Study. PLoS ONE. 2013;8:e63165 pubmed publisher..0041) with MMP2 having the strongest gene association (p(artp)?=?0.0007). Our findings suggest that genetic variation in MMP genes influence breast cancer development and survival in this genetically admixed population. ..
- Slattery M, Lundgreen A, Wolff R. MAP kinase genes and colon and rectal cancer. Carcinogenesis. 2012;33:2398-408 pubmed publisher..These data suggest that genetic variation in the MAPK-signaling pathway influences colorectal cancer risk and survival after diagnosis. Associations may be modified by lifestyle factors that influence inflammation and oxidative stress. ..
- Slattery M, John E, Torres Mejía G, Lundgreen A, Herrick J, Baumgartner K, et al. Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population. Carcinogenesis. 2012;33:1512-21 pubmed publisher..Higher Native American ancestry was associated with reduced breast cancer risk. Breast cancer risk differed by genetic ancestry along with genetic variation in genes involved in inflammation, insulin, and energy homeostasis. ..
- Slattery M, Lundgreen A, Wolff R, Herrick J, Caan B. Genetic variation in the transforming growth factor-?-signaling pathway, lifestyle factors, and risk of colon or rectal cancer. Dis Colon Rectum. 2012;55:532-40 pubmed publisher..Although the integrity of the pathway can be diminished by a number of high-risk genotypes, this risk can be offset, in part, by maintaining a healthy lifestyle. ..
- Slattery M, Herrick J, Lundgreen A, Fitzpatrick F, Curtin K, Wolff R. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Carcinogenesis. 2010;31:1604-11 pubmed publisher..These data suggest that genetic variation in a predefined candidate pathway for colorectal cancer contributes to both colon and rectal cancer risk. Associations appear to be strongest for CIMP+ and MSI+ tumors. ..
- Slattery M, Wolff R, Herrick J, Caan B, Samowitz W. Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors. Nutr Cancer. 2010;62:436-42 pubmed publisher..These data support an association between calcium and rectal tumors overall as well as specifically with TP53 mutations. However, given the number of comparisons, findings need to be confirmed in other studies. ..
- Slattery M, Wolff R, Herrick J, Caan B, Potter J. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. Int J Cancer. 2008;122:1611-7 pubmed..VDR polymorphisms interacted with all LEP and LEPR polymorphisms. These data support an association between LEP and colon cancer. They also suggest that the mechanisms linking leptin to colon cancer may be independent of energy balance. ..
- Slattery M, Curtin K, Giuliano A, Sweeney C, Baumgartner R, Edwards S, et al. Active and passive smoking, IL6, ESR1, and breast cancer risk. Breast Cancer Res Treat. 2008;109:101-11 pubmed..01). These data suggest that breast cancer risk is associated with active and passive smoking. ..
- Slattery M, Lundgreen A, Herrick J, Kadlubar S, Caan B, Potter J, et al. Variation in the CYP19A1 gene and risk of colon and rectal cancer. Cancer Causes Control. 2011;22:955-63 pubmed publisher..Our data suggest the importance of CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism. ..
- Mullany L, Herrick J, Wolff R, Stevens J, Slattery M. Association of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype. Cancer Epidemiol. 2016;45:98-107 pubmed publisher..Our results suggest that cigarette smoking can alter miRNA expression and, given associations with CIMP high and MSI tumor molecular phenotype, it is possible that smoking influences tumor phenotype through altered miRNA expression. ..
- Slattery M, Wolff R, Herrick J, Curtin K, Caan B, Samowitz W. Alcohol consumption and rectal tumor mutations and epigenetic changes. Dis Colon Rectum. 2010;53:1182-9 pubmed publisher..These data suggest that both alcohol and specific constituents of alcoholic beverages contribute to rectal cancer risk among unique disease pathways. ..