MARTHA OR MARTY SLATTERY

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Diet composition and risk of overweight and obesity in women living in the southwestern United States
    Maureen A Murtaugh
    Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    J Am Diet Assoc 107:1311-21. 2007
  2. pmc Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 21:1237-45. 2010
  3. pmc SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study
    Andrew J Pellatt
    University of Utah, Department of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e80554. 2013
  4. doi request reprint The influence of genetic ancestry and ethnicity on breast cancer survival associated with genetic variation in the TGF-β-signaling pathway: The Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, UT, 84108, USA
    Cancer Causes Control 25:293-307. 2014
  5. doi request reprint Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Nutr Cancer 65:729-38. 2013
  6. pmc Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, UT 84108, USA
    Breast Cancer Res Treat 140:587-601. 2013
  7. pmc Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e63165. 2013
  8. pmc Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Int J Cancer 132:2928-39. 2013
  9. pmc MAP kinase genes and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Carcinogenesis 33:2398-408. 2012
  10. pmc JAK/STAT/SOCS-signaling pathway and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Mol Carcinog 52:155-66. 2013

Research Grants

  1. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2009
  2. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
  3. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  4. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
  5. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  6. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
  7. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1993
  8. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  9. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  10. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007

Detail Information

Publications86

  1. ncbi request reprint Diet composition and risk of overweight and obesity in women living in the southwestern United States
    Maureen A Murtaugh
    Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    J Am Diet Assoc 107:1311-21. 2007
    ..We assessed the association of dietary patterns and macronutrient composition with overweight and obesity in Hispanic and non-Hispanic white women...
  2. pmc Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 21:1237-45. 2010
    ..68 95% CI 0.47, 0.98; p linear trend 0.03). These data suggest that diet and lifestyle factors are associated with specific types of rectal tumor mutations and epigenetic changes. Findings need confirmation in other studies...
  3. pmc SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study
    Andrew J Pellatt
    University of Utah, Department of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e80554. 2013
    ..GPX4 was significantly associated with breast cancer survival among those with the highest NA ancestry (PARTP = 0.05) only. Our data suggest that SEPP1 alters breast cancer risk among women with higher levels of NA ancestry. ..
  4. doi request reprint The influence of genetic ancestry and ethnicity on breast cancer survival associated with genetic variation in the TGF-β-signaling pathway: The Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, UT, 84108, USA
    Cancer Causes Control 25:293-307. 2014
    ..Our data suggest that genetic variation in the TGF-β signaling pathway influences breast cancer survival. Associations were similar when the analyses were stratified by genetic ancestry or by self-reported ethnicity...
  5. doi request reprint Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Nutr Cancer 65:729-38. 2013
    ..These data suggest that dietary factors involved in inflammation and oxidative stress interact with MAPK-signaling genes to alter risk of colorectal cancer. ..
  6. pmc Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, 383 Colorow, Salt Lake City, UT 84108, USA
    Breast Cancer Res Treat 140:587-601. 2013
    ..Genetic variation in ERBB2 and FGF1 appear to be associated with survival after diagnosis with breast cancer. ..
  7. pmc Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e63165. 2013
    ..0041) with MMP2 having the strongest gene association (p(artp) = 0.0007). Our findings suggest that genetic variation in MMP genes influence breast cancer development and survival in this genetically admixed population...
  8. pmc Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Int J Cancer 132:2928-39. 2013
    ..53 and 2.12). Differences in association also were observed by percentage of native ancestry and menopausal status. Results support the hypothesis that genetic variation in BMPs is associated with breast cancer in this admixed population...
  9. pmc MAP kinase genes and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Carcinogenesis 33:2398-408. 2012
    ..These data suggest that genetic variation in the MAPK-signaling pathway influences colorectal cancer risk and survival after diagnosis. Associations may be modified by lifestyle factors that influence inflammation and oxidative stress...
  10. pmc JAK/STAT/SOCS-signaling pathway and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Mol Carcinog 52:155-66. 2013
    ..JAK2, SOCS1, STAT1, STAT4, and TYK2 were associated with rectal cancer survival (HRR 2.80 95% CI 1.63,4.80). These data support the importance of the JAK/STAT-signaling pathway in colorectal cancer and suggest targets for intervention...
  11. pmc Oxidative balance and colon and rectal cancer: interaction of lifestyle factors and genes
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Mutat Res 734:30-40. 2012
    ..0008) and rectal cancer (p=0.0018). These results suggest the need to comprehensively evaluate interactions to assess the contribution of risk from both environmental and genetic factors...
  12. pmc Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population
    Martha L Slattery
    University of Utah, Department of Medicine295 Chipeta Way Salt Lake City, Utah 84108, USA
    Carcinogenesis 33:1512-21. 2012
    ..Higher Native American ancestry was associated with reduced breast cancer risk. Breast cancer risk differed by genetic ancestry along with genetic variation in genes involved in inflammation, insulin, and energy homeostasis...
  13. pmc Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e37312. 2012
    ..Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenic process...
  14. pmc Genetic variation in the transforming growth factor-β-signaling pathway, lifestyle factors, and risk of colon or rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Dis Colon Rectum 55:532-40. 2012
    ..The transforming growth factor-β-signaling pathway has been identified as being involved in colorectal cancer...
  15. pmc Toll-like receptor genes and their association with colon and rectal cancer development and prognosis
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 130:2974-80. 2012
    ..Interaction with dietary factors remained significant for rectal cancer after adjustment for multiple comparisons...
  16. pmc Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Nutr Cancer 63:1226-34. 2011
    ....
  17. pmc Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor
    Karen Curtin
    Epidemiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    BMC Med Genet 11:170. 2010
    ..Our objective was to assess its utility to guide statistical analyses of haplotypes within a candidate region (or combined genotypes across candidate genes) beyond that offered by a standard logistic regression approach...
  18. pmc Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
    Carolyn M Hutter
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
    BMC Cancer 10:670. 2010
    ..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...
  19. doi request reprint Analysis of dietary patterns in epidemiological research
    Martha L Slattery
    Department of Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Appl Physiol Nutr Metab 35:207-10. 2010
    ..Additionally, the utilization of dietary patterns as a tool for public health messages is a topic that is unresolved. These issues are discussed in this paper...
  20. pmc Associations among body mass index, waist circumference, and health indicators in American Indian and Alaska Native adults
    Martha L Slattery
    University of Utah, Department of Medicine, Salt Lake City, UT 84108 USA
    Am J Health Promot 24:246-54. 2010
    ..Little is known about obesity-related health issues among American Indian and Alaska Native (AIAN) populations...
  21. pmc Increased risk of colon cancer associated with a genetic polymorphism of SMAD7
    Martha L Slattery
    Departments of Internal Medicine and Pathology, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Res 70:1479-85. 2010
    ..No significant associations were observed for the rs4464148 SNP or other SNPs evaluated in the SMAD7. These results corroborate the findings of GWAS in colon cancer pointing to SMAD7 and reinforce interest in SNPs in this gene...
  22. pmc Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    Cancer Prev Res (Phila) 2:922-30. 2009
    ..Although this discussion of the CHIEF pathway focuses on CRC, we believe that this pathway may play an important role in the etiology of other cancers as well...
  23. pmc Family health history and health behaviors in Alaska native and American Indian people
    Martha L Slattery
    University of Utah, Department of Medicine, Salt Lake City, UT, USA
    J Health Care Poor Underserved 20:678-94. 2009
    ..Family history of diseases among American Indian and Alaska Native (AIAN) people may influence health...
  24. pmc A comparison of colon and rectal somatic DNA alterations
    Martha L Slattery
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 52:1304-11. 2009
    ..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors...
  25. pmc Tumor markers and rectal cancer: support for an inflammation-related pathway
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Int J Cancer 125:1698-704. 2009
    ..Many factors involved in an inflammation-related pathway were associated with TP53 mutations and some dietary factors appeared to be modified by IL6 genotype...
  26. pmc Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 660:12-21. 2009
    ..The important modifying effects of aspirin/NSAIDs on associations with genetic polymorphisms reinforce the underlying role of inflammation in the etiology of colon cancer...
  27. pmc Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Obesity (Silver Spring) 16:339-47. 2008
    ..The association between obesity and breast cancer risk is complex. We examined whether the association between body size and breast cancer risk is modified by interleukin-6 (IL6) genotype...
  28. pmc Development, implementation, and evaluation of a computerized self-administered diet history questionnaire for use in studies of American Indian and Alaskan native people
    Martha L Slattery
    University of Utah, Internal Medicine, Salt Lake City, UT 84108, USA
    J Am Diet Assoc 108:101-9. 2008
    ..The methods developed for collection of dietary data appear to be appropriate for the targeted population and may have usefulness for other populations where collecting dietary data in a self-administered format is desirable...
  29. pmc Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors
    Martha L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Nutr Cancer 62:436-42. 2010
    ..These data support an association between calcium and rectal tumors overall as well as specifically with TP53 mutations. However, given the number of comparisons, findings need to be confirmed in other studies...
  30. pmc Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 31:1604-11. 2010
    ..These data suggest that genetic variation in a predefined candidate pathway for colorectal cancer contributes to both colon and rectal cancer risk. Associations appear to be strongest for CIMP+ and MSI+ tumors...
  31. pmc Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Carcinogenesis 32:1660-7. 2011
    ..83, 95% CI 2.34-10.05) cancer for those in the category having the most at-risk genotypes. These data suggest the importance of IFN-signaling pathway on colon and rectal cancer risk and survival after diagnosis...
  32. pmc Variation in the CYP19A1 gene and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Causes Control 22:955-63. 2011
    ..Our data suggest the importance of CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism...
  33. pmc Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
    Martha L Slattery
    University of Utah, Salt Lake City, UT, 84108, USA
    Breast Cancer Res Treat 129:531-9. 2011
    ..Our data replicated some of the previously reported GWAS findings. Differences in associations were detected for NHW and Hispanic women by menopausal status and by ER/PR status of tumors...
  34. pmc Genetic variation in bone morphogenetic protein and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 130:653-64. 2012
    ..Our data support a role for genetic variation in BMP-related genes in the etiology of colon and rectal cancer. One possible mechanism is via the TGF-β-signaling pathway...
  35. pmc Genetic variation in the transforming growth factor-β signaling pathway and survival after diagnosis with colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Cancer 117:4175-83. 2011
    ..The authors evaluated this pathway in association with survival after a diagnosis of colon or rectal cancer...
  36. pmc MicroRNAs and colon and rectal cancer: differential expression by tumor location and subtype
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Genes Chromosomes Cancer 50:196-206. 2011
    ..These results suggest the importance of miRNAs in colorectal cancer and the need for studies that can confirm these results and provide insight into the diet, lifestyle, and genetic factors that influence miRNA expression...
  37. pmc Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Carcinogenesis 32:318-26. 2011
    ..47 (95% CI 1.58, 35.3). Although the associations need confirmation, the findings and their internal consistency underline the importance of genetic variation in these genes for the etiology of CRC...
  38. pmc Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, Utah 84108, USA
    Cancer Epidemiol Biomarkers Prev 20:57-69. 2011
    ..Smad proteins are central to the function of TGF-β signaling. In this study, we evaluated genetic variation in TGFβ1, TGFβR1, Smad1, Smad2, Smad3, and Smad4 and risk of colon and rectal cancer...
  39. pmc Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 128:2726-34. 2011
    ..These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development...
  40. pmc Alcohol consumption and rectal tumor mutations and epigenetic changes
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 53:1182-9. 2010
    ..In this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed...
  41. pmc CDX2 VDR polymorphism and colorectal cancer
    Martha L Slattery
    Department of Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 16:2752-5. 2007
    ..71; 95% CI, 0.52-0.97) but not colon cancer. These data suggest that haplotype analysis that encompasses different domains of the VDR gene might further our understanding of associations between the VDR gene and colon and rectal cancer...
  42. pmc A prospective cohort of American Indian and Alaska Native people: study design, methods, and implementation
    M L Slattery
    Department of Internal Medicine, The University of Utah, Salt Lake City, UT 84108, USA
    Am J Epidemiol 166:606-15. 2007
    ..The study has focused on involvement of American Indian and Alaska Native communities in development and implementation and on provision of feedback to participants and communities...
  43. pmc Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Int J Cancer 122:1611-7. 2008
    ..VDR polymorphisms interacted with all LEP and LEPR polymorphisms. These data support an association between LEP and colon cancer. They also suggest that the mechanisms linking leptin to colon cancer may be independent of energy balance...
  44. pmc Vitamin D receptor gene (VDR) associations with cancer
    Martha L Slattery
    Department of Epidemiology, University of Utah School of Medicine, 30 North 1900 East, AC 230, Salt Lake City, UT 84117, USA
    Nutr Rev 65:S102-4. 2007
  45. pmc Active and passive smoking, IL6, ESR1, and breast cancer risk
    Martha L Slattery
    Division of Epidemiology, Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
    Breast Cancer Res Treat 109:101-11. 2008
    ..01). These data suggest that breast cancer risk is associated with active and passive smoking...
  46. pmc Microsatellite instability and survival in rectal cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Cancer Causes Control 20:1763-8. 2009
    ..Very few studies have evaluated the effect of MSI-H on rectal cancer survival. We assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer...
  47. ncbi request reprint Diet activity, and lifestyle associations with p53 mutations in colon tumors
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Epidemiol Biomarkers Prev 11:541-8. 2002
    ..These data suggest that components of a Western-style diet such as high consumption of red meat and foods that increase glycemic load are associated with a p53 disease pathway...
  48. pmc Physical activity and breast cancer risk among women in the southwestern United States
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
    Ann Epidemiol 17:342-53. 2007
    ..01), while among postmenopausal HAI women, physical activity interacted with body mass index (p value, 0.04). These data suggest that physical activity is important in reducing risk of breast cancer in both NHW and HAI women...
  49. ncbi request reprint Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 595:117-24. 2006
    ....
  50. ncbi request reprint Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Epidemiol Biomarkers Prev 12:882-9. 2003
    ..This association may be influenced by GSTM-1 genotype. Furthermore, exposure to cigarette smoke of others may increase risk of rectal cancer among men who do not smoke...
  51. ncbi request reprint Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 46:166-71. 2003
    ..However, both physical activity and energy intake were significantly associated with rectal cancer risk. These data suggest that energy expenditure and energy intake alter rectal cancer risk through mechanisms other than energy balance...
  52. pmc The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Genes Chromosomes Cancer 47:835-44. 2008
    ....
  53. ncbi request reprint Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Gastroenterology 129:837-45. 2005
    ....
  54. ncbi request reprint Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk
    Susan L Neuhausen
    Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Prostate 64:168-74. 2005
    ..We hypothesized that functional polymorphisms in INS, IRS1, IRS2, and IGF1 may be associated with prostate cancer...
  55. ncbi request reprint Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Clin Gastroenterol Hepatol 4:894-901. 2006
    ....
  56. ncbi request reprint MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer
    Karen Curtin
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 13:285-92. 2004
    ..The possible interaction with hormone-replacement therapy warrants additional investigation...
  57. ncbi request reprint Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 120:2226-32. 2007
    ..This study provides some support for associations between TS genotype and colon cancer tumor characteristics...
  58. pmc MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Carcinog 48:989-94. 2009
    ..Age at diagnosis, family history, and alcohol use did not interact with MSH6 G39E and CIMP. The MSH6 G39E germline polymorphism may be associated with CIMP+ colon cancer...
  59. ncbi request reprint Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States)
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah, and Genetic Research, Intermountain Health Care, Salt Lake City 84108, USA
    Cancer Causes Control 13:813-23. 2002
    ..Classification tree analysis is a potentially powerful tool for investigating multilevel interactions. Within the context of colon cancer etiology it may help identify disease pathways and evaluate important interactions of risk factors...
  60. ncbi request reprint The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84101, USA
    J Nutr 135:179-86. 2005
    ..Genetic susceptibility may modify the associations of some meat or meat preparation factors with the risk of colorectal cancer...
  61. ncbi request reprint Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Causes Control 15:863-72. 2004
    ..01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk...
  62. ncbi request reprint p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry
    Karen Curtin
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Appl Immunohistochem Mol Morphol 12:380-6. 2004
    ..Advantages gained by sequencing are its ability to examine specific mutations and the improved ability to discriminate between cases with p 53 mutation and wild type when evaluating associations...
  63. ncbi request reprint CYP1A1, cigarette smoking, and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Am J Epidemiol 160:842-52. 2004
    ..These data support the association between smoking and colon and rectal cancer. Smoking may have a greater impact on colorectal cancer risk based on CYP1A1 genotype; this might further be modified by GSTM1 for rectal cancer risk...
  64. ncbi request reprint Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated...
  65. ncbi request reprint Sex-specific differences in colon cancer associated with p53 mutations
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
    Nutr Cancer 49:41-8. 2004
    ..For these analyses, women were classified as estrogen positive or negative, based on menopausal status and use of hormone replacement therapy (HRT)...
  66. ncbi request reprint Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004
    ..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway...
  67. ncbi request reprint Prognostic significance of p53 mutations in colon cancer at the population level
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 99:597-602. 2002
    ..However, specific classes of mutations, namely, the G245 hot spot mutation and mutations in proximal tumors, are related to significantly worse survival even after adjusting for age and stage...
  68. ncbi request reprint Physical activity and colorectal cancer
    Martha L Slattery
    University of Utah, Health Research Center, Salt Lake City, Utah 84108, USA
    Sports Med 34:239-52. 2004
    ..It has been estimated that 12-14% of colon cancer could be attributed to lack of frequent involvement in vigorous physical activity...
  69. ncbi request reprint Antioxidants, carotenoids, and risk of rectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Am J Epidemiol 159:32-41. 2004
    ..Associations differed by estrogen status for beta-carotene, lycopene, and vitamin E. These results suggest that vitamin E and lycopene may modestly reduce the risk of rectal cancer in women...
  70. ncbi request reprint PPARgamma, energy balance, and associations with colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City 84108, USA
    Nutr Cancer 51:155-61. 2005
    ..These data do not support the hypothesis that the P12A PPARgamma polymorphism is associated with colon or rectal cancer through regulation of energy balance...
  71. pmc Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors
    Carol Sweeney
    Health Sciences Center, University of Utah, Salt Lake City, UT, USA
    Genes Chromosomes Cancer 48:1-9. 2009
    ..The oncogenetic tree model assumptions are appropriate for the observed heterogeneity of colon tumors, and the model produces a useful visual schematic of the sequence of events in pathways of colon carcinogenesis...
  72. ncbi request reprint Oral, injected and implanted contraceptives and breast cancer risk among U.S. Hispanic and non-Hispanic white women
    Carol Sweeney
    Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Int J Cancer 121:2517-23. 2007
    ..Based on a small number of users of contraceptive implants, a significantly increased breast cancer risk was observed; continued surveillance of implant users may be warranted...
  73. pmc Reproductive history in relation to breast cancer risk among Hispanic and non-Hispanic white women
    Carol Sweeney
    Division of Epidemiology, University of Utah, 30 N 1900 E, AC230, Salt Lake City, Utah 841032, USA
    Cancer Causes Control 19:391-401. 2008
    ..To evaluate reproductive history risk factors in breast cancer among Hispanic (HISP) women in the U.S. southwest, a population with approximately 33% lower breast cancer incidence than non-Hispanic whites (NHW)...
  74. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..1, 95% CI = 1.3-3.4 versus AA/high risk; P-interaction = 0.03). These results provide only limited support for a role of polymorphisms in one-carbon metabolism in the etiology of CIMP colon cancer...
  75. ncbi request reprint IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Cancer Epidemiol Biomarkers Prev 16:747-55. 2007
    ..04 (for Hispanic/Native American) and SNP rs1800796 or -572G>C]. These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk...
  76. ncbi request reprint Development and use of touch-screen audio computer-assisted self-interviewing in a study of American Indians
    Sandra L Edwards
    Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Am J Epidemiol 165:1336-42. 2007
    ..These results indicate that the ACASI questionnaire is both an acceptable and a preferable mode of data collection in this population...
  77. ncbi request reprint Leptin and colorectal cancer: an undefined link
    Martha L Slattery
    University of Utah School of Medicine, Suite A, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Nat Clin Pract Gastroenterol Hepatol 4:118-9. 2007
  78. ncbi request reprint APC mutations and other genetic and epigenetic changes in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Mol Cancer Res 5:165-70. 2007
    ..The relationships of APC mutations to other genetic and epigenetic alterations add to the already impressive genetic heterogeneity of colon cancer...
  79. ncbi request reprint Genetic admixture among Hispanics and candidate gene polymorphisms: potential for confounding in a breast cancer study?
    Carol Sweeney
    Department of Internal Medicine Health Research Center, University of Utah, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 16:142-50. 2007
    ..CRRs from simulated scenarios indicated that appreciable confounding by admixture would occur only when within-group candidate SNP allele frequency differences are much larger than any that we observed...
  80. ncbi request reprint PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, 84108, USA
    Cancer Causes Control 17:239-49. 2006
    ..These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms...
  81. ncbi request reprint Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer
    Martha L Slattery
    University of Utah, Health Research Center, Salt Lake City, USA
    Int J Cancer 118:3140-6. 2006
    ..05) relative to men with fewer than 23 CAG repeats of the AR gene. These data provide support for the role of vitamin D and sunshine exposure in the etiology of colorectal cancer and suggest that AR gene may modulate the association...
  82. ncbi request reprint Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 14:2936-42. 2005
    ..71; 95% CI, 2.89-15.6). Our results suggest that the ERbeta gene is more important than ERalpha in the etiology of colorectal cancer...
  83. pmc Validation of a dietary history questionnaire for American Indian and Alaska Native people
    Maureen A Murtaugh
    Division of Epidemiology, Department of Internal Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, Utah 84132, USA
    Ethn Dis 20:429-36. 2010
    ....
  84. ncbi request reprint Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Cancer Res 65:6063-9. 2005
    ....
  85. pmc IL6 genotypes and colon and rectal cancer
    Martha L Slattery
    School of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 18:1095-105. 2007
    ..This study provides further support for inflammation-related factors in the etiology of CRC. Other studies are needed to explore other genes in this and other inflammation-related pathways...
  86. ncbi request reprint Low-energy reporters: evaluation of potential differential reporting in case-control studies
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 42:173-9. 2002
    ..However, LER appear to differ depending on exposure characteristics that may be importantly associated with cancer...

Research Grants39

  1. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2009
    ..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..
  2. DIET, ACTIVITY & REPRODUCTION--RISKS FOR RECTAL CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2002
    ..abstract_text> ..
  3. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  4. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  5. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  6. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1999
    ..We also will store DNA frpom tumor tissue so that as laboratory techniques for analyzing somatic gene mutations necome refined, the associations between dietary intake and other genes, such as APC and DCC, can be assessed in the future. ..
  7. DIET, ACTIVITY & REPRODUCTION AS RISKS FOR COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 1993
    ..Methods have been developed to ensure coordination of study activities...
  8. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  9. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  10. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  11. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    MARTHA OR MARTY L SLATTERY; Fiscal Year: 2010
    ..The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy. ..