Martha L Slattery

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Cancer Epidemiol Biomarkers Prev 16:747-55. 2007
  2. pmc Transcription factor 7-like 2 polymorphism and colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 17:978-82. 2008
  3. ncbi request reprint Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 14:2936-42. 2005
  4. ncbi request reprint Low-energy reporters: evaluation of potential differential reporting in case-control studies
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 42:173-9. 2002
  5. ncbi request reprint PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, 84108, USA
    Cancer Causes Control 17:239-49. 2006
  6. pmc Tumor markers and rectal cancer: support for an inflammation-related pathway
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Int J Cancer 125:1698-704. 2009
  7. pmc Somatic alterations, metabolizing genes and smoking in rectal cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 125:158-64. 2009
  8. pmc Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Int J Cancer 122:1611-7. 2008
  9. pmc Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors
    Martha L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Nutr Cancer 62:436-42. 2010
  10. pmc Physical activity and breast cancer risk among women in the southwestern United States
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
    Ann Epidemiol 17:342-53. 2007

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Cancer Epidemiol Biomarkers Prev 16:747-55. 2007
    ..04 (for Hispanic/Native American) and SNP rs1800796 or -572G>C]. These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk...
  2. pmc Transcription factor 7-like 2 polymorphism and colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 17:978-82. 2008
    ..78; 95% CI, 0.62-0.98) in a dose-response fashion (P for linear trend across genotypes = 0.03). These data suggest that colon cancer risk associated with the rs7903146 TCF7L2 polymorphism is modified by use of aspirin/NSAIDs...
  3. ncbi request reprint Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 14:2936-42. 2005
    ..71; 95% CI, 2.89-15.6). Our results suggest that the ERbeta gene is more important than ERalpha in the etiology of colorectal cancer...
  4. ncbi request reprint Low-energy reporters: evaluation of potential differential reporting in case-control studies
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 42:173-9. 2002
    ..However, LER appear to differ depending on exposure characteristics that may be importantly associated with cancer...
  5. ncbi request reprint PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, 84108, USA
    Cancer Causes Control 17:239-49. 2006
    ..These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms...
  6. pmc Tumor markers and rectal cancer: support for an inflammation-related pathway
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Int J Cancer 125:1698-704. 2009
    ..Many factors involved in an inflammation-related pathway were associated with TP53 mutations and some dietary factors appeared to be modified by IL6 genotype...
  7. pmc Somatic alterations, metabolizing genes and smoking in rectal cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 125:158-64. 2009
    ..ETS may increase risk of KRAS2 mutations; association with TP53 mutations and ETS may be influenced by NAT2...
  8. pmc Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Int J Cancer 122:1611-7. 2008
    ..VDR polymorphisms interacted with all LEP and LEPR polymorphisms. These data support an association between LEP and colon cancer. They also suggest that the mechanisms linking leptin to colon cancer may be independent of energy balance...
  9. pmc Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors
    Martha L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Nutr Cancer 62:436-42. 2010
    ..These data support an association between calcium and rectal tumors overall as well as specifically with TP53 mutations. However, given the number of comparisons, findings need to be confirmed in other studies...
  10. pmc Physical activity and breast cancer risk among women in the southwestern United States
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
    Ann Epidemiol 17:342-53. 2007
    ..01), while among postmenopausal HAI women, physical activity interacted with body mass index (p value, 0.04). These data suggest that physical activity is important in reducing risk of breast cancer in both NHW and HAI women...
  11. pmc Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Nutr Cancer 63:357-66. 2011
    ....
  12. ncbi request reprint Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 55:35-43. 2006
    ....
  13. ncbi request reprint Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Suite A, 375 Chipeta Way, Salt Lake City, UT 84101, USA
    Cancer Epidemiol Biomarkers Prev 14:1224-9. 2005
    ....
  14. pmc The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Genes Chromosomes Cancer 47:835-44. 2008
    ....
  15. pmc Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Obesity (Silver Spring) 16:339-47. 2008
    ..The association between obesity and breast cancer risk is complex. We examined whether the association between body size and breast cancer risk is modified by interleukin-6 (IL6) genotype...
  16. pmc A comparison of colon and rectal somatic DNA alterations
    Martha L Slattery
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 52:1304-11. 2009
    ..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors...
  17. ncbi request reprint The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84101, USA
    J Nutr 135:179-86. 2005
    ..Genetic susceptibility may modify the associations of some meat or meat preparation factors with the risk of colorectal cancer...
  18. ncbi request reprint Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer
    Martha L Slattery
    University of Utah, Health Research Center, Salt Lake City, USA
    Int J Cancer 118:3140-6. 2006
    ..05) relative to men with fewer than 23 CAG repeats of the AR gene. These data provide support for the role of vitamin D and sunshine exposure in the etiology of colorectal cancer and suggest that AR gene may modulate the association...
  19. ncbi request reprint Energy balance, insulin-related genes and risk of colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Int J Cancer 115:148-54. 2005
    ..Obesity, physical activity and energy intake appear to alter risk of colorectal cancer; however, the risk appears to be minimally influenced by genetic variants evaluated...
  20. pmc Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer
    Maureen A Murtaugh
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 18:153-63. 2007
    ..Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer...
  21. pmc Microsatellite instability and survival in rectal cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Cancer Causes Control 20:1763-8. 2009
    ..Very few studies have evaluated the effect of MSI-H on rectal cancer survival. We assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer...
  22. ncbi request reprint Insulin-like growth factor pathway polymorphisms associated with body size in Hispanic and non-Hispanic white women
    Carol Sweeney
    Health Research Center, Family and Preventive Medicine, University of Utah, Suite A, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 14:1802-9. 2005
    ..These results provide evidence that IGF pathway polymorphisms have functional effects on growth and central obesity and indicate that genotype-phenotype relationships are ethnic specific...
  23. pmc Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Cancer Epidemiol Biomarkers Prev 18:3384-8. 2009
    ..02-1.9). These findings point to the importance of studying tumor mutations when examining DNA repair polymorphisms and cigarette smoke exposure to identify potentially relevant associations with colorectal cancer...
  24. pmc Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 660:12-21. 2009
    ..The important modifying effects of aspirin/NSAIDs on associations with genetic polymorphisms reinforce the underlying role of inflammation in the etiology of colon cancer...
  25. ncbi request reprint Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 120:656-63. 2007
    ..Our data suggest multiple pathways to colon cancer. They do not support a unique role for dietary folate, alcohol, vitamins B(6) and B(12) and methionine in a CpG island methylator phenotype...
  26. ncbi request reprint Associations between apoE genotype and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 26:1422-9. 2005
    ....
  27. pmc Associations among body mass index, waist circumference, and health indicators in American Indian and Alaska Native adults
    Martha L Slattery
    University of Utah, Department of Medicine, Salt Lake City, UT 84108 USA
    Am J Health Promot 24:246-54. 2010
    ..Little is known about obesity-related health issues among American Indian and Alaska Native (AIAN) populations...
  28. pmc Active and passive smoking, IL6, ESR1, and breast cancer risk
    Martha L Slattery
    Division of Epidemiology, Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
    Breast Cancer Res Treat 109:101-11. 2008
    ..01). These data suggest that breast cancer risk is associated with active and passive smoking...
  29. ncbi request reprint ESR1, AR, body size, and breast cancer risk in Hispanic and non-Hispanic white women living in the Southwestern United States
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Breast Cancer Res Treat 105:327-35. 2007
    ..02 and <0.01 respectively). These results suggest differences in risk factors for NHW and Hispanic women. However, they provide only minor support for the role of the AR and ESR1 gene in the etiology of breast cancer...
  30. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..1, 95% CI = 1.3-3.4 versus AA/high risk; P-interaction = 0.03). These results provide only limited support for a role of polymorphisms in one-carbon metabolism in the etiology of CIMP colon cancer...
  31. ncbi request reprint Diet composition and risk of overweight and obesity in women living in the southwestern United States
    Maureen A Murtaugh
    Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    J Am Diet Assoc 107:1311-21. 2007
    ..We assessed the association of dietary patterns and macronutrient composition with overweight and obesity in Hispanic and non-Hispanic white women...
  32. pmc Alcohol consumption and rectal tumor mutations and epigenetic changes
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Dis Colon Rectum 53:1182-9. 2010
    ..In this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed...
  33. pmc Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors
    Carol Sweeney
    Health Sciences Center, University of Utah, Salt Lake City, UT, USA
    Genes Chromosomes Cancer 48:1-9. 2009
    ..The oncogenetic tree model assumptions are appropriate for the observed heterogeneity of colon tumors, and the model produces a useful visual schematic of the sequence of events in pathways of colon carcinogenesis...
  34. ncbi request reprint PPARgamma, energy balance, and associations with colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City 84108, USA
    Nutr Cancer 51:155-61. 2005
    ..These data do not support the hypothesis that the P12A PPARgamma polymorphism is associated with colon or rectal cancer through regulation of energy balance...
  35. pmc Diet and colorectal cancer: analysis of a candidate pathway using SNPS, haplotypes, and multi-gene assessment
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Nutr Cancer 63:1226-34. 2011
    ....
  36. pmc Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Carcinogenesis 31:1604-11. 2010
    ..These data suggest that genetic variation in a predefined candidate pathway for colorectal cancer contributes to both colon and rectal cancer risk. Associations appear to be strongest for CIMP+ and MSI+ tumors...
  37. ncbi request reprint Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Causes Control 15:863-72. 2004
    ..01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk...
  38. pmc CDX2 VDR polymorphism and colorectal cancer
    Martha L Slattery
    Department of Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 16:2752-5. 2007
    ..71; 95% CI, 0.52-0.97) but not colon cancer. These data suggest that haplotype analysis that encompasses different domains of the VDR gene might further our understanding of associations between the VDR gene and colon and rectal cancer...
  39. ncbi request reprint Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Clin Gastroenterol Hepatol 4:894-901. 2006
    ....
  40. pmc Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Int J Cancer 132:2928-39. 2013
    ..53 and 2.12). Differences in association also were observed by percentage of native ancestry and menopausal status. Results support the hypothesis that genetic variation in BMPs is associated with breast cancer in this admixed population...
  41. pmc Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
    Martha L Slattery
    University of Utah, Salt Lake City, UT, 84108, USA
    Breast Cancer Res Treat 129:531-9. 2011
    ..Our data replicated some of the previously reported GWAS findings. Differences in associations were detected for NHW and Hispanic women by menopausal status and by ER/PR status of tumors...
  42. ncbi request reprint Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 595:117-24. 2006
    ....
  43. pmc Diet patterns and breast cancer risk in Hispanic and non-Hispanic white women: the Four-Corners Breast Cancer Study
    Maureen A Murtaugh
    Division of Epidemiology, Department of Internal Medicine, University of Utah, Provo, UT, USA
    Am J Clin Nutr 87:978-84. 2008
    ..There is a lower incidence of breast cancer among Hispanic women than among non-Hispanic white women. Little is known about the role of diet in this difference...
  44. pmc Factors associated with response to a follow-up postal questionnaire in a cohort of American Indians
    Sandra L Edwards
    Division of Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT 84132, USA
    Prev Med 48:596-9. 2009
    ..The aim of the study was to collect pilot data on response rates to a follow-up postal questionnaire in a cohort of American Indians living in the Southwestern United States. We tested the effect of questionnaire length on response...
  45. ncbi request reprint Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004
    ..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway...
  46. ncbi request reprint CYP1A1, cigarette smoking, and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Am J Epidemiol 160:842-52. 2004
    ..These data support the association between smoking and colon and rectal cancer. Smoking may have a greater impact on colorectal cancer risk based on CYP1A1 genotype; this might further be modified by GSTM1 for rectal cancer risk...
  47. ncbi request reprint Association of fluids from beverages with risk of rectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84101, USA
    Nutr Cancer 49:25-31. 2004
    ..Associations of alcohol to risk for rectal cancer may be related to cellular hyperproliferation and may be modified by NSAID use...
  48. ncbi request reprint Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Gastroenterology 129:837-45. 2005
    ....
  49. ncbi request reprint Diet activity, and lifestyle associations with p53 mutations in colon tumors
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Epidemiol Biomarkers Prev 11:541-8. 2002
    ..These data suggest that components of a Western-style diet such as high consumption of red meat and foods that increase glycemic load are associated with a p53 disease pathway...
  50. ncbi request reprint Oral, injected and implanted contraceptives and breast cancer risk among U.S. Hispanic and non-Hispanic white women
    Carol Sweeney
    Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Int J Cancer 121:2517-23. 2007
    ..Based on a small number of users of contraceptive implants, a significantly increased breast cancer risk was observed; continued surveillance of implant users may be warranted...
  51. pmc IL6 genotypes and colon and rectal cancer
    Martha L Slattery
    School of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 18:1095-105. 2007
    ..This study provides further support for inflammation-related factors in the etiology of CRC. Other studies are needed to explore other genes in this and other inflammation-related pathways...
  52. ncbi request reprint Haplotype analysis of common vitamin D receptor variants and colon and rectal cancers
    Carol Sweeney
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 15:744-9. 2006
    ..In this analysis, haplotypes of the VDR influenced risk of colon cancer, but haplotype variables had only slightly better ability to explain case-control differences than genotype variables...
  53. ncbi request reprint Genetic admixture among Hispanics and candidate gene polymorphisms: potential for confounding in a breast cancer study?
    Carol Sweeney
    Department of Internal Medicine Health Research Center, University of Utah, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 16:142-50. 2007
    ..CRRs from simulated scenarios indicated that appreciable confounding by admixture would occur only when within-group candidate SNP allele frequency differences are much larger than any that we observed...
  54. pmc Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Cancer Causes Control 21:1237-45. 2010
    ..68 95% CI 0.47, 0.98; p linear trend 0.03). These data suggest that diet and lifestyle factors are associated with specific types of rectal tumor mutations and epigenetic changes. Findings need confirmation in other studies...
  55. ncbi request reprint Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Breast Cancer Res Treat 102:85-101. 2007
    ..The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women...
  56. pmc Genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e37312. 2012
    ..Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenic process...
  57. pmc MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Carcinog 48:989-94. 2009
    ..Age at diagnosis, family history, and alcohol use did not interact with MSH6 G39E and CIMP. The MSH6 G39E germline polymorphism may be associated with CIMP+ colon cancer...
  58. pmc Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the Breast Cancer Health Disparities Study
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT
    Int J Cancer 134:629-44. 2014
    ..44, 95% CI 0.30-0.65). We observed few interactions between DOBS and angiogenesis-related genes. Our data suggest that dietary factors and genetic variation in angiogenesis-related genes contribute to breast cancer carcinogenesis...
  59. pmc Genetic variation in bone morphogenetic protein and colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 130:653-64. 2012
    ..Our data support a role for genetic variation in BMP-related genes in the etiology of colon and rectal cancer. One possible mechanism is via the TGF-β-signaling pathway...
  60. pmc Variation in the CYP19A1 gene and risk of colon and rectal cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Causes Control 22:955-63. 2011
    ..Our data suggest the importance of CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism...
  61. pmc Increased risk of colon cancer associated with a genetic polymorphism of SMAD7
    Martha L Slattery
    Departments of Internal Medicine and Pathology, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Res 70:1479-85. 2010
    ..No significant associations were observed for the rs4464148 SNP or other SNPs evaluated in the SMAD7. These results corroborate the findings of GWAS in colon cancer pointing to SMAD7 and reinforce interest in SNPs in this gene...
  62. pmc Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 128:2726-34. 2011
    ..These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development...
  63. pmc Development, implementation, and evaluation of a computerized self-administered diet history questionnaire for use in studies of American Indian and Alaskan native people
    Martha L Slattery
    University of Utah, Internal Medicine, Salt Lake City, UT 84108, USA
    J Am Diet Assoc 108:101-9. 2008
    ..The methods developed for collection of dietary data appear to be appropriate for the targeted population and may have usefulness for other populations where collecting dietary data in a self-administered format is desirable...
  64. pmc Reproductive history in relation to breast cancer risk among Hispanic and non-Hispanic white women
    Carol Sweeney
    Division of Epidemiology, University of Utah, 30 N 1900 E, AC230, Salt Lake City, Utah 841032, USA
    Cancer Causes Control 19:391-401. 2008
    ..To evaluate reproductive history risk factors in breast cancer among Hispanic (HISP) women in the U.S. southwest, a population with approximately 33% lower breast cancer incidence than non-Hispanic whites (NHW)...
  65. ncbi request reprint Sex-specific differences in colon cancer associated with p53 mutations
    Martha L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
    Nutr Cancer 49:41-8. 2004
    ..For these analyses, women were classified as estrogen positive or negative, based on menopausal status and use of hormone replacement therapy (HRT)...
  66. ncbi request reprint Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 120:2226-32. 2007
    ..This study provides some support for associations between TS genotype and colon cancer tumor characteristics...
  67. ncbi request reprint Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women
    Maureen A Murtaugh
    Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84101, USA
    J Nutr 134:776-84. 2004
    ..These data suggest that mutagens such as HCA that form when meat is cooked may be culpable substances in rectal cancer risk, not red meat itself...
  68. ncbi request reprint Antioxidants, carotenoids, and risk of rectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Am J Epidemiol 159:32-41. 2004
    ..Associations differed by estrogen status for beta-carotene, lycopene, and vitamin E. These results suggest that vitamin E and lycopene may modestly reduce the risk of rectal cancer in women...
  69. ncbi request reprint Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    J Natl Cancer Inst 98:1731-8. 2006
    ..We investigated whether the association between smoking and all colon cancers could be explained through induction of CIMP and/or BRAF mutations...
  70. pmc Family health history and health behaviors in Alaska native and American Indian people
    Martha L Slattery
    University of Utah, Department of Medicine, Salt Lake City, UT, USA
    J Health Care Poor Underserved 20:678-94. 2009
    ..Family history of diseases among American Indian and Alaska Native (AIAN) people may influence health...
  71. ncbi request reprint Recruiting Hispanic women for a population-based study: validity of surname search and characteristics of nonparticipants
    Carol Sweeney
    Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA
    Am J Epidemiol 166:1210-9. 2007
    ..Recruitment of Hispanic cases and controls does not appear to be affected by selection bias related to community characteristics...
  72. ncbi request reprint Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA
    Cancer Epidemiol Biomarkers Prev 12:882-9. 2003
    ..This association may be influenced by GSTM-1 genotype. Furthermore, exposure to cigarette smoke of others may increase risk of rectal cancer among men who do not smoke...
  73. ncbi request reprint Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index
    Martha L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
    Nutr Cancer 46:166-71. 2003
    ..However, both physical activity and energy intake were significantly associated with rectal cancer risk. These data suggest that energy expenditure and energy intake alter rectal cancer risk through mechanisms other than energy balance...
  74. ncbi request reprint MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer
    Karen Curtin
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 13:285-92. 2004
    ..The possible interaction with hormone-replacement therapy warrants additional investigation...
  75. ncbi request reprint Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States)
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah, and Genetic Research, Intermountain Health Care, Salt Lake City 84108, USA
    Cancer Causes Control 13:813-23. 2002
    ..Classification tree analysis is a potentially powerful tool for investigating multilevel interactions. Within the context of colon cancer etiology it may help identify disease pathways and evaluate important interactions of risk factors...
  76. ncbi request reprint p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry
    Karen Curtin
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Appl Immunohistochem Mol Morphol 12:380-6. 2004
    ..Advantages gained by sequencing are its ability to examine specific mutations and the improved ability to discriminate between cases with p 53 mutation and wild type when evaluating associations...
  77. doi request reprint Analysis of dietary patterns in epidemiological research
    Martha L Slattery
    Department of Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Appl Physiol Nutr Metab 35:207-10. 2010
    ..Additionally, the utilization of dietary patterns as a tool for public health messages is a topic that is unresolved. These issues are discussed in this paper...
  78. ncbi request reprint Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway
    Martha L Slattery
    Health Research Center and Department of Pathology, School of Medicine, University of Utah, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:538-45. 2004
    ..We explore the associations between aspirin/NSAIDs, the insulin-related pathway, and the risk of colorectal cancer...
  79. ncbi request reprint APC mutations and other genetic and epigenetic changes in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Mol Cancer Res 5:165-70. 2007
    ..The relationships of APC mutations to other genetic and epigenetic alterations add to the already impressive genetic heterogeneity of colon cancer...
  80. ncbi request reprint Physical activity and colorectal cancer
    Martha L Slattery
    University of Utah, Health Research Center, Salt Lake City, Utah 84108, USA
    Sports Med 34:239-52. 2004
    ..It has been estimated that 12-14% of colon cancer could be attributed to lack of frequent involvement in vigorous physical activity...
  81. pmc MicroRNAs and colon and rectal cancer: differential expression by tumor location and subtype
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Genes Chromosomes Cancer 50:196-206. 2011
    ..These results suggest the importance of miRNAs in colorectal cancer and the need for studies that can confirm these results and provide insight into the diet, lifestyle, and genetic factors that influence miRNA expression...
  82. pmc Validation of a dietary history questionnaire for American Indian and Alaska Native people
    Maureen A Murtaugh
    Division of Epidemiology, Department of Internal Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, Utah 84132, USA
    Ethn Dis 20:429-36. 2010
    ....
  83. ncbi request reprint Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    Genes Chromosomes Cancer 35:368-71. 2002
    ..We conclude that instability-induced mutations in BAX or TGFBRII do not have a significant impact on the good prognosis of colon cancers with microsatellite instability...
  84. ncbi request reprint Prognostic significance of p53 mutations in colon cancer at the population level
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 99:597-602. 2002
    ..However, specific classes of mutations, namely, the G245 hot spot mutation and mutations in proximal tumors, are related to significantly worse survival even after adjusting for age and stage...
  85. ncbi request reprint Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Cancer Res 65:6063-9. 2005
    ....
  86. ncbi request reprint Leptin and colorectal cancer: an undefined link
    Martha L Slattery
    University of Utah School of Medicine, Suite A, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Nat Clin Pract Gastroenterol Hepatol 4:118-9. 2007
  87. pmc Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 706:13-20. 2011
    ..Our data further suggest that this pathway may lead to CIMP+ and KRAS2-mutated tumors...
  88. ncbi request reprint Development and use of touch-screen audio computer-assisted self-interviewing in a study of American Indians
    Sandra L Edwards
    Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Am J Epidemiol 165:1336-42. 2007
    ..These results indicate that the ACASI questionnaire is both an acceptable and a preferable mode of data collection in this population...
  89. ncbi request reprint Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer
    Bette J Caan
    Division of Research, Kaiser Permanente Medical Group, 2000 Broadway, 94612 Oakland, CA, USA
    Breast Cancer Res Treat 99:47-57. 2006
    ..To examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence...
  90. pmc Prevalence and predictors of cancer screening among American Indian and Alaska native people: the EARTH study
    Mary Catherine Schumacher
    Office of Alaska Native Health Research, Alaska Native Tribal Health Consortium, 4000 Ambassador Drive C DCHS, Anchorage, AK 99508, USA
    Cancer Causes Control 19:725-37. 2008
    ....
  91. ncbi request reprint Validation of a historical physical activity questionnaire in middle-aged women
    Katrina D Dubose
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    J Phys Act Health 4:343-55. 2007
    ..Historical physical activity (PA) questionnaires assess relationships between past PA and chronic diseases. The 4-Corner's Historical Physical Activity Questionnaire (HPAQ) was validated in 78 middle-age women...
  92. ncbi request reprint Eating frequency and the risk of colon cancer
    Ashley O Coates
    Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612 2304, USA
    Nutr Cancer 43:121-6. 2002
    ..The increased risk of colon cancer limited to men eating less than three times per day may be due to uncontrolled confounding...
  93. pmc NSAIDs and breast cancer recurrence in a prospective cohort study
    Marilyn L Kwan
    Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA
    Cancer Causes Control 18:613-20. 2007
    ..We examined the association between NSAID use and breast cancer recurrence in a prospective cohort of 2,292 early-stage breast cancer survivors diagnosed from 1997 to 2000 participating in the Life After Cancer Epidemiology (LACE) Study...
  94. pmc Population-based case-control study of diabetes and breast cancer risk in Hispanic and non-Hispanic White women living in US southwestern states
    Dana E Rollison
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Am J Epidemiol 167:447-56. 2008
    ..54, 95% confidence interval: 0.37, 0.79). In this study, diabetes was not associated with breast cancer overall, although the inverse association with gestational diabetes warrants further investigation...
  95. pmc Arthritis prevalence and associations in American Indian and Alaska Native people
    Elizabeth D Ferucci
    Alaska Native Tribal Health Consortium, 4000 Ambassaador Drive, Anchorage, AK 99508, USA
    Arthritis Rheum 59:1128-36. 2008
    ..To investigate the prevalence of arthritis and associations with arthritis in American Indian and Alaska Native populations...
  96. ncbi request reprint Associations of plant food, dairy product, and meat intakes with 15-y incidence of elevated blood pressure in young black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Lyn M Steffen
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Am J Clin Nutr 82:1169-77; quiz 1363-4. 2005
    ..Consumption of plant foods and dairy and meat products may moderate increases in blood pressure...
  97. ncbi request reprint Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis
    Mark A Pereira
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Lancet 365:36-42. 2005
    ..We aimed to investigate the association between reported fast-food habits and changes in bodyweight and insulin resistance over a 15-year period in the USA...
  98. ncbi request reprint Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated...
  99. ncbi request reprint Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk
    Kim Robien
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1350-2. 2005
  100. ncbi request reprint Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk
    Susan L Neuhausen
    Department of Medicine, Division of Epidemiology, University of California Irvine, Irvine, CA 92697 7550, USA
    Prostate 64:168-74. 2005
    ..We hypothesized that functional polymorphisms in INS, IRS1, IRS2, and IGF1 may be associated with prostate cancer...
  101. ncbi request reprint Life After Cancer Epidemiology (LACE) Study: a cohort of early stage breast cancer survivors (United States)
    Bette Caan
    Division of Research, Kaiser Permanente Medical Care Program, 2000 Broadway, Oakland, CA 94612, USA
    Cancer Causes Control 16:545-56. 2005
    ..These data suggest that in the early years post-diagnosis, breast cancer survivors exhibit similar patterns to the general population in many health behaviors...