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Genomes and GenesSpecies | M L SlatterySummaryAffiliation: University of Utah Country: USA Publications
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Publications
Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancerM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
Cancer Res 61:126-30. 2001..HRT in these older women may, again, reduce the risk of unstable tumors. A model for the way in which estrogens (endogenous, exogenous, and obesity-associated) modify the risk of MSI+ tumors is proposed...- Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, USA
J Natl Cancer Inst 92:1831-6. 2000..It is unknown whether lifestyle factors associated with colon cancer, such as physical activity, body size, cigarette smoking, or use of aspirin and/or nonsteroidal anti-inflammatory drugs, contribute to MSI in sporadic tumors... - Use of archival tissue in epidemiologic studies: collection procedures and assessment of potential sources of biasM L Slattery
University of Utah, Department of Family and Preventive Medicine, School of Medicine, Salt Lake City 84117, USA
Mutat Res 432:7-14. 2000..However, we were less likely to be able to extract DNA if the case was diagnosed at a more advanced disease stage or at the earliest disease. Potential bias from exclusion of those with the most advanced disease stage is discussed... - Carotenoids and colon cancerM L Slattery
University of Utah Medical School, Salt Lake City, USA
Am J Clin Nutr 71:575-82. 2000..However, except for beta-carotene, little is known about how dietary carotenoids are associated with common cancers, including colon cancer... - Lifestyle factors and Ki-ras mutations in colon cancer tumorsM L Slattery
Health Research Centre, Department of Family and Preventive Medicine, 375 Chipeta Way, Suite A, University of Utah, Salt Lake City, UT 84108, USA
Mutat Res 483:73-81. 2001..Given the limited information available on what causes Ki-ras mutations, the information generated from this study indicates that these factors previously associated with colon cancer work through other disease pathways... - Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population levelW S Samowitz
Departments of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Cancer Epidemiol Biomarkers Prev 10:917-23. 2001..We conclude that microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level... - Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United StatesM L Slattery
University of Utah, Salt Lake City, Utah 84108, USA
Breast Cancer Res Treat 104:197-209. 2007..An insulin-related pathway to breast cancer has been hypothesized... - NAT2, GSTM-1, cigarette smoking, and risk of colon cancerM L Slattery
University of Utah School of Medicine, Salt Lake City 84108, USA
Cancer Epidemiol Biomarkers Prev 7:1079-84. 1998..The lack of an association does not rule out the possibility of other genetic polymorphisms interacting with cigarette smoke to cause colon cancer, nor does it take into account individual phenotypic variability... - Trans-fatty acids and colon cancerM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
Nutr Cancer 39:170-5. 2001..It seems prudent to avoid consuming partially hydrogenated fats, since no increased risk was observed for the cis form of fatty acids, while suggestions of increased risk from trans-fatty acids exist for subsets of the population... - Are dietary factors involved in DNA methylation associated with colon cancer?M L Slattery
Department of Oncological Sciences, University of Utah, Salt Lake City 84108, USA
Nutr Cancer 28:52-62. 1997..4, 95% CI = 0.9-2.3; women OR = 2.0, 95% CI = 1.0-3.8). Findings from this study provide only limited support for previously reported associations between dietary factors involved in DNA methylation and risk of colon cancer... - Dietary intake and microsatellite instability in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA
Int J Cancer 93:601-7. 2001..Most other dietary factors do not appear operate exclusively in the MSI+ disease pathway... - Risk of colon cancer associated with a family history of cancer or colorectal polyps: the diet, activity, and reproduction in colon cancer studyR A Kerber
Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, USA
Int J Cancer 78:157-60. 1998..A family history of colorectal polyps also increased risk by about the same amount as a family history of colorectal cancer. The increased risk associated with a family history of polyps did not appear to decrease with age... - Physical activity and colorectal cancerM L Slattery
Health Research Center, University of Utah, Salt Lake City 84108, USA
Am J Epidemiol 158:214-24. 2003..39, 0.78 for men; OR = 0.44, 95% CI: 0.30, 0.67 for women). In summary, physical activity was associated with reduced risk of rectal cancer in these data. The reduced risk was similar to that previously observed for colon cancer... - Family history and colorectal cancer: predictors of riskM L Slattery
Department of Family and Preventive Medicine, Health Research Center, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
Cancer Causes Control 14:879-87. 2003..We also evaluate diet and lifestyle factors associated with developing colorectal cancer among participants with a positive family history... - GSTM-1 and NAT2 and genetic alterations in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, 375 Chipeta Way, Suite A, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 13:527-34. 2002..CONCLUSIONS: These data provide support that diet and cigarette smoking may be associated with specific disease pathways, although GSTM-1 and NAT2 do not independently appear to alter susceptibility to these diet and lifestyle factors... 
BAT-26 and BAT-40 instability in colorectal adenomas and carcinomas and germline polymorphismsW S Samowitz
Department of Pathology, Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Am J Pathol 154:1637-41. 1999..Polymorphisms in these microsatellites, however, limit their utility in determinations of microsatellite instability without corresponding normal DNA...- A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancerM L Slattery
Department of Family and Preventive Medicine University of Utah, Salt Lake City, 84112, USA
Cancer Res 61:1000-4. 2001..These results suggest that the codon 1,822 variant of the APC gene may have functional significance. Individuals who have the valine/valine variant of this gene may be at reduced risk of colon cancer if they eat a low-fat diet... - Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, 50 North Medical Dr, Salt Lake City, UT 84132, USA
Am J Pathol 158:1517-24. 2001.... - Vitamin E and colon cancer: is there an association?M L Slattery
University of Utah Medical School, Salt Lake City 84108, USA
Nutr Cancer 30:201-6. 1998..80, 95% CI = 0.56-1.15). These data offer only limited support for a protective effect of vitamin E and colon cancer after adjustment for other health and life-style factors... - Uncommon TGFBRI allele is not associated with increased susceptibility to colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Genes Chromosomes Cancer 32:381-3. 2001..We conclude that the 6A TGFBRI allele is not associated with an increased susceptibility to colon cancer at the population level, and that the 6A/6A homozygote is not restricted to individuals with some form of cancer... - The colon cancer burden of genetically defined hereditary nonpolyposis colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Gastroenterology 121:830-8. 2001..We therefore determined by genetic criteria the colon cancer burden associated with HNPCC in a population-based study of 1066 individuals from Utah and California... - Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white womenM L Slattery
Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
Cancer Causes Control 16:1147-57. 2005..These differences could be due to the combined effects of genetic and behavioral factors which could account for ethnic differences in the risk of breast cancer and other chronic diseases... - Dietary fats and colon cancer: assessment of risk associated with specific fatty acidsM L Slattery
University of Utah Medical School, Salt Lake City, USA
Int J Cancer 73:670-7. 1997..Similar associations with family history were noted among men diagnosed at younger ages for MFA, linolenic acid and 20-carbon PFA... - Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States)M L Slattery
Health Research Center, Department of Family and Preventive Medicine, 375 Chipeta Way, Suite A, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 14:75-84. 2003..We further hypothesize that androgens may have similar effects in men given the decline in colon cancer risk associated with BMI with advancing age... - A prospective cohort of American Indian and Alaska Native people: study design, methods, and implementationM L Slattery
Department of Internal Medicine, The University of Utah, Salt Lake City, UT 84108, USA
Am J Epidemiol 166:606-15. 2007..The study has focused on involvement of American Indian and Alaska Native communities in development and implementation and on provision of feedback to participants and communities... - Factors associated with colorectal cancer screening in a population-based study: the impact of gender, health care source, and timeM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake, UT 84108, USA
Prev Med 38:276-83. 2004.... - Contacting controls: are we working harder for similar response rates, and does it make a difference?A Rogers
Health Research Center, Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA
Am J Epidemiol 160:85-90. 2004..The amount of effort required to achieve similar or slightly lower response rates increased over time. This finding may in part depend on demographic characteristics of the population studied... - Intake of fluids and methylxanthine-containing beverages: association with colon cancerM L Slattery
University of Utah School of Medicine, Salt Lake City 84108, USA
Int J Cancer 81:199-204. 1999..68, 95% CI 0.49-0.96). Assessment of the impact of smoking on associations between colon cancer and coffee showed a significant interaction between smoking and coffee for both men and women... - MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumorsC M Ulrich
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Nutr 135:2462-7. 2005..These results suggest a novel mechanism by which MTHFR polymorphisms can affect the risk of colon cancer... - Environmental determinants of urinary kallikrein excretionS C Hunt
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City
Am J Hypertens 6:226-33. 1993....