J R Sladek
Affiliation: University of Colorado Health Sciences Center
- Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primateJ R Sladek
Department of Pediatrics, The University of Colorado School of Medicine, Aurora, CO 80045, USA
Cell Transplant 17:427-44. 2008..Further study will assess the degree to which this approach can be used to restore motor balance in the nonhuman primate following neural transplantation...
- Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome miceD S Kern
Department of Pediatrics, University of Colorado Denver, 12800 E 19th Avenue, Aurora, CO 80045, USA
Cell Transplant 20:371-9. 2011..Lastly, it is speculated that the unique abilities of NSC to migrate and express growth factors might be a contributing factor to reducing tau/reelin accumulation in aging DS and AD...
- Biocompatibility of PEG-based hydrogels in primate brainK B Bjugstad
Department Pediatrics, University Colorado Denver and Health Sciences Center, Aurora, CO 80045, USA
Cell Transplant 17:409-15. 2008....
- Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's diseaseKimberly B Bjugstad
Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Exp Neurol 211:362-9. 2008..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
- Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsD Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:12175-80. 2007..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
- Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestationBret A Morrow
Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
Exp Neurol 204:802-7. 2007..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation...
- Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonismTimothy J Collier
Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
Neurobiol Dis 26:56-65. 2007....
- Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measuresKimberly B Bjugstad
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
Cell Transplant 14:183-92. 2005..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
- Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
- Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonismTimothy J Collier
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Exp Neurol 191:S60-7. 2005..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging...
- Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian ratsKathy Steece-Collier
Department of Neurological Science, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Mov Disord 18:1442-54. 2003....