J R Sladek

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate
    J R Sladek
    Department of Pediatrics, The University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Transplant 17:427-44. 2008
  2. ncbi Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice
    D S Kern
    Department of Pediatrics, University of Colorado Denver, 12800 E 19th Avenue, Aurora, CO 80045, USA
    Cell Transplant 20:371-9. 2011
  3. ncbi Biocompatibility of PEG-based hydrogels in primate brain
    K B Bjugstad
    Department Pediatrics, University Colorado Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell Transplant 17:409-15. 2008
  4. ncbi Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
  5. ncbi Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
  6. ncbi Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Exp Neurol 204:802-7. 2007
  7. ncbi Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
  8. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
  9. ncbi Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
  10. ncbi Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005

Research Grants

  1. 9th Internatl Meeting on Neural Transplantation & Repair
    JOHN SLADEK; Fiscal Year: 2005

Detail Information

Publications11

  1. ncbi Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate
    J R Sladek
    Department of Pediatrics, The University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Transplant 17:427-44. 2008
    ..Further study will assess the degree to which this approach can be used to restore motor balance in the nonhuman primate following neural transplantation...
  2. ncbi Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice
    D S Kern
    Department of Pediatrics, University of Colorado Denver, 12800 E 19th Avenue, Aurora, CO 80045, USA
    Cell Transplant 20:371-9. 2011
    ..Lastly, it is speculated that the unique abilities of NSC to migrate and express growth factors might be a contributing factor to reducing tau/reelin accumulation in aging DS and AD...
  3. ncbi Biocompatibility of PEG-based hydrogels in primate brain
    K B Bjugstad
    Department Pediatrics, University Colorado Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell Transplant 17:409-15. 2008
    ....
  4. ncbi Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
    ..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
  5. ncbi Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  6. ncbi Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Exp Neurol 204:802-7. 2007
    ..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation...
  7. ncbi Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism
    Timothy J Collier
    Department of Neurology, University of Cincinnati, PO Box 670525, 265 Albert Sabin Way, Cincinnati, OH 45267, USA
    Neurobiol Dis 26:56-65. 2007
    ....
  8. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
    ..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
  9. ncbi Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
    ..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
  10. ncbi Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism
    Timothy J Collier
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 191:S60-7. 2005
    ..Third, the aging-related chronic increase in combined striatal trophic activity was not attributable to BDNF or GDNF as these molecules either decreased or did not change with aging...
  11. ncbi Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats
    Kathy Steece-Collier
    Department of Neurological Science, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 18:1442-54. 2003
    ....

Research Grants1

  1. 9th Internatl Meeting on Neural Transplantation & Repair
    JOHN SLADEK; Fiscal Year: 2005
    ..Thus, it will provide easier access to a large audience of scientists who may not have been able to attend the prior meetings because of geographical limitations. ..